UniProtKB - Q9Y232 (CDYL_HUMAN)
Chromodomain Y-like protein
CDYL
Functioni
Caution
Catalytic activityi
Kineticsi
- KM=73.75 µM for (2E)-butenoyl-CoA1 Publication
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- crotonyl-CoA hydratase activity Source: UniProtKB
- identical protein binding Source: IntAct
- methylated histone binding Source: UniProtKB
- protein-macromolecule adaptor activity Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- negative regulation of peptidyl-lysine crotonylation Source: UniProtKB
- random inactivation of X chromosome Source: UniProtKB
- spermatid development Source: UniProtKB
- spermatogenesis Source: ProtInc
Keywordsi
Molecular function | Lyase, Repressor |
Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9Y232 |
Names & Taxonomyi
Protein namesi | Recommended name: Chromodomain Y-like protein1 PublicationShort name: CDY-like1 Publication Alternative name(s): Crotonyl-CoA hydratase1 Publication (EC:4.2.1.-1 Publication) |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1811, CDYL |
MIMi | 603778, gene |
neXtProti | NX_Q9Y232 |
VEuPathDBi | HostDB:ENSG00000153046.17 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Other locations
- Chromosome 2 Publications
Note: Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481).2 Publications
Nucleus
- nuclear speck Source: HPA
- nucleus Source: MGI
Other locations
- chromosome Source: UniProtKB
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 205 | S → A: No impact on recruitment to DNA double strand breaks. 1 Publication | 1 | |
Mutagenesisi | 521 | S → A: Abolishes CoA-binding and ability to inhibit histone crotonylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9425 |
OpenTargetsi | ENSG00000153046 |
PharmGKBi | PA26356 |
Miscellaneous databases
Pharosi | Q9Y232, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3879827 |
Genetic variation databases
BioMutai | CDYL |
DMDMi | 150421527 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080221 | 1 – 598 | Chromodomain Y-like proteinAdd BLAST | 598 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 88 | PhosphoserineCombined sources | 1 | |
Modified residuei | 135 | N6,N6,N6-trimethyllysine; by EHMT2; alternate1 Publication | 1 | |
Modified residuei | 135 | N6,N6-dimethyllysine; by EHMT2; alternate1 Publication | 1 | |
Modified residuei | 135 | N6-methyllysine; by EHMT2; alternate1 Publication | 1 | |
Modified residuei | 170 | PhosphoserineCombined sources | 1 | |
Modified residuei | 201 | PhosphoserineCombined sources | 1 | |
Modified residuei | 216 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9Y232 |
jPOSTi | Q9Y232 |
MassIVEi | Q9Y232 |
PaxDbi | Q9Y232 |
PeptideAtlasi | Q9Y232 |
PRIDEi | Q9Y232 |
ProteomicsDBi | 85621 [Q9Y232-1] 85622 [Q9Y232-2] 85623 [Q9Y232-3] 85624 [Q9Y232-4] |
PTM databases
iPTMneti | Q9Y232 |
PhosphoSitePlusi | Q9Y232 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000153046, Expressed in calcaneal tendon and 238 other tissues |
ExpressionAtlasi | Q9Y232, baseline and differential |
Genevisiblei | Q9Y232, HS |
Organism-specific databases
HPAi | ENSG00000153046, Low tissue specificity |
Interactioni
Subunit structurei
Forms multimers and multimerization is required for stable binding to chromatin (PubMed:19808672).
Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity).
Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2 (PubMed:19061646).
Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.
Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2 (PubMed:22009739).
Interacts with CHAF1A and CHAF1B; bridging the CAF-1 complex to the MCM2-7 (MCM) complex (PubMed:28402439).
Interacts with MCM3 and MCM5; bridging the CAF-1 complex to the MCM2-7 (MCM) complex (PubMed:28402439). Recruited to Xist RNA-coated X chromosome (By similarity).
Interacts with EHMT2 and PRDM9; interaction only takes place when PRDM9 is bound to hotspot DNA (By similarity).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ9Y232
With | #Exp. | IntAct |
---|---|---|
H3C12 [P68431] | 5 | EBI-1387386,EBI-79722 |
CDYL - isoform 2 [Q9Y232-2]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-10986891,EBI-10986891 |
TTC9C [Q8N5M4] | 3 | EBI-10986891,EBI-2851213 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114818, 57 interactors |
CORUMi | Q9Y232 |
IntActi | Q9Y232, 34 interactors |
MINTi | Q9Y232 |
STRINGi | 9606.ENSP00000380718 |
Chemistry databases
BindingDBi | Q9Y232 |
Miscellaneous databases
RNActi | Q9Y232, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y232 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y232 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 121 | ChromoPROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 61 – 309 | Interaction with EZH21 PublicationAdd BLAST | 249 | |
Regioni | 362 – 594 | Acetyl-CoA-binding domainSequence analysisAdd BLAST | 233 |
Domaini
Phylogenomic databases
eggNOGi | KOG0016, Eukaryota KOG1911, Eukaryota |
GeneTreei | ENSGT00940000155106 |
HOGENOMi | CLU_009834_24_0_1 |
InParanoidi | Q9Y232 |
OMAi | VIWANEK |
OrthoDBi | 1471901at2759 |
PhylomeDBi | Q9Y232 |
TreeFami | TF313375 |
Family and domain databases
Gene3Di | 1.10.12.10, 1 hit |
InterProi | View protein in InterPro IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR023779, Chromodomain_CS IPR029045, ClpP/crotonase-like_dom_sf IPR001753, Enoyl-CoA_hydra/iso IPR014748, Enoyl-CoA_hydra_C |
Pfami | View protein in Pfam PF00385, Chromo, 1 hit PF00378, ECH_1, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 1 hit |
SUPFAMi | SSF52096, SSF52096, 1 hit SSF54160, SSF54160, 1 hit |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 1 hit PS50013, CHROMO_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTFQASHRSA WGKSRKKNWQ YEGPTQKLFL KRNNVSAPDG PSDPSISVSS
60 70 80 90 100
EQSGAQQPPA LQVERIVDKR KNKKGKTEYL VRWKGYDSED DTWEPEQHLV
110 120 130 140 150
NCEEYIHDFN RRHTEKQKES TLTRTNRTSP NNARKQISRS TNSNFSKTSP
160 170 180 190 200
KALVIGKDHE SKNSQLFAAS QKFRKNTAPS LSSRKNMDLA KSGIKILVPK
210 220 230 240 250
SPVKSRTAVD GFQSESPEKL DPVEQGQEDT VAPEVAAEKP VGALLGPGAE
260 270 280 290 300
RARMGSRPRI HPLVPQVPGP VTAAMATGLA VNGKGTSPFM DALTANGTTN
310 320 330 340 350
IQTSVTGVTA SKRKFIDDRR DQPFDKRLRF SVRQTESAYR YRDIVVRKQD
360 370 380 390 400
GFTHILLSTK SSENNSLNPE VMREVQSALS TAAADDSKLV LLSAVGSVFC
410 420 430 440 450
CGLDFIYFIR RLTDDRKRES TKMAEAIRNF VNTFIQFKKP IIVAVNGPAI
460 470 480 490 500
GLGASILPLC DVVWANEKAW FQTPYTTFGQ SPDGCSTVMF PKIMGGASAN
510 520 530 540 550
EMLLSGRKLT AQEACGKGLV SQVFWPGTFT QEVMVRIKEL ASCNPVVLEE
560 570 580 590
SKALVRCNMK MELEQANERE CEVLKKIWGS AQGMDSMLKY LQRKIDEF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JQG7 | C9JQG7_HUMAN | Chromodomain Y-like protein | CDYL | 171 | Annotation score: | ||
A0A669KAZ7 | A0A669KAZ7_HUMAN | Chromodomain Y-like protein | CDYL | 18 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 205 | S → N in BAF84290 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 291 | D → N in BAG59526 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 443 | V → L in BAF84290 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 558 | N → S in BAG59526 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 584 | M → T in AAI19683 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 591 | L → M in AAI19683 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032936 | 2 | T → A1 PublicationCorresponds to variant dbSNP:rs3812179Ensembl. | 1 | |
Natural variantiVAR_032937 | 9 | S → P1 PublicationCorresponds to variant dbSNP:rs3812178Ensembl. | 1 | |
Natural variantiVAR_032938 | 48 | V → A1 PublicationCorresponds to variant dbSNP:rs13196069Ensembl. | 1 | |
Natural variantiVAR_032939 | 60 | A → G1 PublicationCorresponds to variant dbSNP:rs28360500Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026382 | 1 – 289 | Missing in isoform 3. 1 PublicationAdd BLAST | 289 | |
Alternative sequenceiVSP_041025 | 1 – 186 | Missing in isoform 4. 1 PublicationAdd BLAST | 186 | |
Alternative sequenceiVSP_026383 | 1 – 54 | Missing in isoform 2. 2 PublicationsAdd BLAST | 54 | |
Alternative sequenceiVSP_026384 | 55 – 62 | AQQPPALQ → MASEELYE in isoform 2. 2 Publications | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF081258 mRNA Translation: AAD22734.1 AF081259 mRNA Translation: AAD22735.1 AK291601 mRNA Translation: BAF84290.1 AK296985 mRNA Translation: BAG59526.1 AL022725 Genomic DNA No translation available. AL356747 Genomic DNA No translation available. AL359643 Genomic DNA No translation available. BC061516 mRNA Translation: AAH61516.1 BC108725 mRNA Translation: AAI08726.1 BC119682 mRNA Translation: AAI19683.1 AL050164 mRNA Translation: CAB43304.1 Sequence problems. |
CCDSi | CCDS4491.2 [Q9Y232-2] CCDS47364.1 [Q9Y232-4] |
PIRi | T08789 |
RefSeqi | NP_001137442.1, NM_001143970.1 [Q9Y232-4] NP_001137443.1, NM_001143971.1 [Q9Y232-4] NP_004815.3, NM_004824.3 [Q9Y232-2] |
Genome annotation databases
Ensembli | ENST00000328908; ENSP00000330512; ENSG00000153046 [Q9Y232-1] ENST00000343762; ENSP00000340908; ENSG00000153046 [Q9Y232-4] ENST00000397588; ENSP00000380718; ENSG00000153046 [Q9Y232-2] ENST00000449732; ENSP00000394076; ENSG00000153046 [Q9Y232-4] |
GeneIDi | 9425 |
KEGGi | hsa:9425 |
UCSCi | uc003mwi.4, human [Q9Y232-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF081258 mRNA Translation: AAD22734.1 AF081259 mRNA Translation: AAD22735.1 AK291601 mRNA Translation: BAF84290.1 AK296985 mRNA Translation: BAG59526.1 AL022725 Genomic DNA No translation available. AL356747 Genomic DNA No translation available. AL359643 Genomic DNA No translation available. BC061516 mRNA Translation: AAH61516.1 BC108725 mRNA Translation: AAI08726.1 BC119682 mRNA Translation: AAI19683.1 AL050164 mRNA Translation: CAB43304.1 Sequence problems. |
CCDSi | CCDS4491.2 [Q9Y232-2] CCDS47364.1 [Q9Y232-4] |
PIRi | T08789 |
RefSeqi | NP_001137442.1, NM_001143970.1 [Q9Y232-4] NP_001137443.1, NM_001143971.1 [Q9Y232-4] NP_004815.3, NM_004824.3 [Q9Y232-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DNT | NMR | - | A | 63-119 | [»] | |
2GTR | X-ray | 1.90 | A/B/C | 338-598 | [»] | |
SMRi | Q9Y232 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114818, 57 interactors |
CORUMi | Q9Y232 |
IntActi | Q9Y232, 34 interactors |
MINTi | Q9Y232 |
STRINGi | 9606.ENSP00000380718 |
Chemistry databases
BindingDBi | Q9Y232 |
ChEMBLi | CHEMBL3879827 |
PTM databases
iPTMneti | Q9Y232 |
PhosphoSitePlusi | Q9Y232 |
Genetic variation databases
BioMutai | CDYL |
DMDMi | 150421527 |
Proteomic databases
EPDi | Q9Y232 |
jPOSTi | Q9Y232 |
MassIVEi | Q9Y232 |
PaxDbi | Q9Y232 |
PeptideAtlasi | Q9Y232 |
PRIDEi | Q9Y232 |
ProteomicsDBi | 85621 [Q9Y232-1] 85622 [Q9Y232-2] 85623 [Q9Y232-3] 85624 [Q9Y232-4] |
Protocols and materials databases
ABCDi | Q9Y232, 2 sequenced antibodies |
Antibodypediai | 24514, 248 antibodies |
Genome annotation databases
Ensembli | ENST00000328908; ENSP00000330512; ENSG00000153046 [Q9Y232-1] ENST00000343762; ENSP00000340908; ENSG00000153046 [Q9Y232-4] ENST00000397588; ENSP00000380718; ENSG00000153046 [Q9Y232-2] ENST00000449732; ENSP00000394076; ENSG00000153046 [Q9Y232-4] |
GeneIDi | 9425 |
KEGGi | hsa:9425 |
UCSCi | uc003mwi.4, human [Q9Y232-1] |
Organism-specific databases
CTDi | 9425 |
DisGeNETi | 9425 |
GeneCardsi | CDYL |
HGNCi | HGNC:1811, CDYL |
HPAi | ENSG00000153046, Low tissue specificity |
MIMi | 603778, gene |
neXtProti | NX_Q9Y232 |
OpenTargetsi | ENSG00000153046 |
PharmGKBi | PA26356 |
VEuPathDBi | HostDB:ENSG00000153046.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0016, Eukaryota KOG1911, Eukaryota |
GeneTreei | ENSGT00940000155106 |
HOGENOMi | CLU_009834_24_0_1 |
InParanoidi | Q9Y232 |
OMAi | VIWANEK |
OrthoDBi | 1471901at2759 |
PhylomeDBi | Q9Y232 |
TreeFami | TF313375 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y232 |
Miscellaneous databases
BioGRID-ORCSi | 9425, 38 hits in 887 CRISPR screens |
ChiTaRSi | CDYL, human |
EvolutionaryTracei | Q9Y232 |
GenomeRNAii | 9425 |
Pharosi | Q9Y232, Tbio |
PROi | PR:Q9Y232 |
RNActi | Q9Y232, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153046, Expressed in calcaneal tendon and 238 other tissues |
ExpressionAtlasi | Q9Y232, baseline and differential |
Genevisiblei | Q9Y232, HS |
Family and domain databases
Gene3Di | 1.10.12.10, 1 hit |
InterProi | View protein in InterPro IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR023779, Chromodomain_CS IPR029045, ClpP/crotonase-like_dom_sf IPR001753, Enoyl-CoA_hydra/iso IPR014748, Enoyl-CoA_hydra_C |
Pfami | View protein in Pfam PF00385, Chromo, 1 hit PF00378, ECH_1, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 1 hit |
SUPFAMi | SSF52096, SSF52096, 1 hit SSF54160, SSF54160, 1 hit |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 1 hit PS50013, CHROMO_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDYL_HUMAN | |
Accessioni | Q9Y232Primary (citable) accession number: Q9Y232 Secondary accession number(s): A8K6D6 Q9Y424 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | June 26, 2007 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references