UniProtKB - Q9Y230 (RUVB2_HUMAN)
RuvB-like 2
RUVBL2
Functioni
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 77 – 84 | ATP | 8 |
GO - Molecular functioni
- 5'-3' DNA helicase activity Source: InterPro
- ADP binding Source: Ensembl
- ATPase binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- beta-catenin binding Source: UniProtKB
- chromatin DNA binding Source: UniProtKB
- DNA helicase activity Source: UniProtKB
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
- TBP-class protein binding Source: UniProtKB
- TFIID-class transcription factor complex binding Source: Ensembl
- transcription corepressor activity Source: UniProtKB
- unfolded protein binding Source: ProtInc
GO - Biological processi
- box C/D snoRNP assembly Source: GO_Central
- cellular response to estradiol stimulus Source: UniProtKB
- cellular response to UV Source: UniProtKB
- chromatin remodeling Source: UniProtKB
- DNA recombination Source: ProtInc
- DNA repair Source: ProtInc
- establishment of protein localization to chromatin Source: UniProtKB
- histone acetylation Source: GO_Central
- histone H2A acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of estrogen receptor binding Source: UniProtKB
- positive regulation of histone acetylation Source: UniProtKB
- positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein folding Source: ProtInc
- regulation of growth Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcriptional activation by promoter-enhancer looping Source: UniProtKB
Keywordsi
Molecular function | Activator, Chromatin regulator, Helicase, Hydrolase |
Biological process | DNA damage, DNA recombination, DNA repair, Growth regulation, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y230 |
Reactomei | R-HSA-171319, Telomere Extension By Telomerase R-HSA-3214847, HATs acetylate histones |
Names & Taxonomyi
Protein namesi | Recommended name: RuvB-like 2 (EC:3.6.4.122 Publications)Alternative name(s): 48 kDa TATA box-binding protein-interacting protein Short name: 48 kDa TBP-interacting protein 51 kDa erythrocyte cytosolic protein Short name: ECP-51 INO80 complex subunit J Repressing pontin 52 Short name: Reptin 52 TIP49b TIP60-associated protein 54-beta Short name: TAP54-beta |
Gene namesi | Name:RUVBL2 Synonyms:INO80J, TIP48, TIP49B ORF Names:CGI-46 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10475, RUVBL2 |
MIMi | 604788, gene |
neXtProti | NX_Q9Y230 |
VEuPathDBi | HostDB:ENSG00000183207.12 |
Subcellular locationi
Nucleus
Other locations
Note: Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.
Cytoskeleton
- centrosome Source: HPA
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- Ino80 complex Source: UniProtKB
- MLL1 complex Source: UniProtKB
- NuA4 histone acetyltransferase complex Source: UniProtKB
- nuclear euchromatin Source: UniProtKB
- nuclear matrix Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- Swr1 complex Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB-SubCell
- R2TP complex Source: UniProtKB
- ribonucleoprotein complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 299 | D → N: Abolishes ATPase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10856 |
OpenTargetsi | ENSG00000183207 |
PharmGKBi | PA34888 |
Miscellaneous databases
Pharosi | Q9Y230, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2062349 |
DrugBanki | DB04216, Quercetin |
Genetic variation databases
BioMutai | RUVBL2 |
DMDMi | 28201890 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000165644 | 2 – 463 | RuvB-like 2Add BLAST | 462 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Cross-linki | 9 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 437 | PhosphoserineCombined sources | 1 | |
Cross-linki | 444 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 456 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-270 CPTAC-271 |
EPDi | Q9Y230 |
jPOSTi | Q9Y230 |
MassIVEi | Q9Y230 |
PaxDbi | Q9Y230 |
PeptideAtlasi | Q9Y230 |
PRIDEi | Q9Y230 |
ProteomicsDBi | 3549 85619 [Q9Y230-1] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00009104 |
PTM databases
iPTMneti | Q9Y230 |
MetOSitei | Q9Y230 |
PhosphoSitePlusi | Q9Y230 |
SwissPalmi | Q9Y230 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000183207, Expressed in testis and 237 other tissues |
ExpressionAtlasi | Q9Y230, baseline and differential |
Genevisiblei | Q9Y230, HS |
Organism-specific databases
HPAi | ENSG00000183207, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Forms homohexameric rings (Probable). Can form a dodecamer with RUVBL1 made of two stacked hexameric rings; however, even though RUVBL1 and RUVBL2 are present in equimolar ratio, the oligomeric status of each hexamer is not known. Oligomerization may regulate binding to nucleic acids and conversely, binding to nucleic acids may affect the dodecameric assembly.
Interacts with the transcriptional activation domain of MYC.
Interacts With ATF2. Component of the RNA polymerase II holoenzyme complex. May also act to bridge the LEF1/TCF1-CTNNB1 complex and TBP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. RUVBL2 interacts with EP400.
Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.
Interacts with NPAT.
Component of the chromatin-remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80.
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Interacts with IGHMBP2.
Interacts with TELO2.
Interacts with HINT1.
Component of a SWR1-like complex.
Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3 (PubMed:20864032).
Interacts with ITFG1 (PubMed:25437307).
Interacts with ZMYND10 (PubMed:29601588).
Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014).
Forms a complex with APPL1 and APPL2 (PubMed:19433865).
Interacts with ZNHIT2 (via HIT-type zinc finger) in the presence of ATP or ADP; shows a stronger interaction in the presence of ADP (PubMed:28561026). The RUVBL1/RUVBL2 complex interacts with ZNHIT1 (via HIT-type zinc finger), ZNHIT3 (via HIT-type zinc finger), ZNHIT6 (via HIT-type zinc finger) and DDX59/ZNHIT5 (via HIT-type zinc finger) in the presence of ADP (PubMed:28561026).
Curated22 PublicationsBinary interactionsi
Hide detailsQ9Y230
GO - Molecular functioni
- ATPase binding Source: Ensembl
- beta-catenin binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: Ensembl
- TBP-class protein binding Source: UniProtKB
- TFIID-class transcription factor complex binding Source: Ensembl
- unfolded protein binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 116067, 362 interactors |
ComplexPortali | CPX-6143, R2TP core co-chaperone complex CPX-6150, R2SP co-chaperone complex CPX-6152, R2SD co-chaperone complex CPX-6153, R2T co-chaperone complex CPX-846, INO80 chromatin remodeling complex CPX-974, SRCAP histone exchanging complex CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | Q9Y230 |
DIPi | DIP-28153N |
IntActi | Q9Y230, 164 interactors |
MINTi | Q9Y230 |
STRINGi | 9606.ENSP00000473172 |
Miscellaneous databases
RNActi | Q9Y230, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y230 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y230 |
Family & Domainsi
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2680, Eukaryota |
GeneTreei | ENSGT00940000153556 |
HOGENOMi | CLU_028311_4_0_1 |
InParanoidi | Q9Y230 |
OMAi | VPFTMIA |
OrthoDBi | 752343at2759 |
PhylomeDBi | Q9Y230 |
TreeFami | TF300469 |
Family and domain databases
Gene3Di | 2.40.50.360, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR027238, RuvB-like IPR041048, RuvB-like_C IPR037942, RUVBL2 IPR042487, RUVBL2_DII IPR010339, TIP49_P-loop |
PANTHERi | PTHR11093, PTHR11093, 1 hit PTHR11093:SF2, PTHR11093:SF2, 1 hit |
Pfami | View protein in Pfam PF06068, TIP49, 1 hit PF17856, TIP49_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL
60 70 80 90 100
AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF
110 120 130 140 150
TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP
160 170 180 190 200
ATGTGSKVGK LTLKTTEMET IYDLGTKMIE SLTKDKVQAG DVITIDKATG
210 220 230 240 250
KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH TVSLHEIDVI
260 270 280 290 300
NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE
310 320 330 340 350
VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL
360 370 380 390 400
LDRLLIVSTT PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR
410 420 430 440 450
YAIQLITAAS LVCRKRKGTE VQVDDIKRVY SLFLDESRST QYMKEYQDAF
460
LFNELKGETM DTS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R0Y3 | M0R0Y3_HUMAN | RuvB-like helicase | RUVBL2 | 354 | Annotation score: | ||
X6R2L4 | X6R2L4_HUMAN | RuvB-like helicase | RUVBL2 | 259 | Annotation score: | ||
M0QXI6 | M0QXI6_HUMAN | RuvB-like helicase | RUVBL2 | 109 | Annotation score: | ||
M0R0Z0 | M0R0Z0_HUMAN | RuvB-like 2 | RUVBL2 | 50 | Annotation score: | ||
A0A1W2PS48 | A0A1W2PS48_HUMAN | RuvB-like 2 | RUVBL2 | 50 | Annotation score: | ||
M0QXZ7 | M0QXZ7_HUMAN | RuvB-like 2 | RUVBL2 hCG_16214 | 39 | Annotation score: | ||
M0QYD8 | M0QYD8_HUMAN | RuvB-like 2 | RUVBL2 hCG_16214 | 44 | Annotation score: | ||
A0A1W2PS22 | A0A1W2PS22_HUMAN | RuvB-like 2 | RUVBL2 | 39 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 214 | D → N in AAD34041 (PubMed:10810093).Curated | 1 | |
Sequence conflicti | 257 – 258 | FL → YV AA sequence (PubMed:10882073).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056584 | 1 – 45 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18417 mRNA Translation: CAB46270.1 AB024301 mRNA Translation: BAA76708.1 AF155138 mRNA Translation: AAD38073.1 AF124607 mRNA Translation: AAF87087.1 AF151804 mRNA Translation: AAD34041.1 Frameshift. AL136743 mRNA Translation: CAB66677.1 AK057498 mRNA Translation: BAG51921.1 AK074542 mRNA Translation: BAC11048.1 CR533507 mRNA Translation: CAG38538.1 AC008687 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52426.1 CH471177 Genomic DNA Translation: EAW52430.1 BC000428 mRNA Translation: AAH00428.1 BC004531 mRNA Translation: AAH04531.1 BC008355 mRNA Translation: AAH08355.1 Frameshift. |
CCDSi | CCDS42588.1 [Q9Y230-1] |
PIRi | T46313 |
RefSeqi | NP_001308120.1, NM_001321191.1 [Q9Y230-2] NP_006657.1, NM_006666.2 [Q9Y230-1] XP_011524632.1, XM_011526330.1 [Q9Y230-2] |
Genome annotation databases
Ensembli | ENST00000595090; ENSP00000473172; ENSG00000183207 [Q9Y230-1] |
GeneIDi | 10856 |
KEGGi | hsa:10856 |
UCSCi | uc002plr.2, human [Q9Y230-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18417 mRNA Translation: CAB46270.1 AB024301 mRNA Translation: BAA76708.1 AF155138 mRNA Translation: AAD38073.1 AF124607 mRNA Translation: AAF87087.1 AF151804 mRNA Translation: AAD34041.1 Frameshift. AL136743 mRNA Translation: CAB66677.1 AK057498 mRNA Translation: BAG51921.1 AK074542 mRNA Translation: BAC11048.1 CR533507 mRNA Translation: CAG38538.1 AC008687 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52426.1 CH471177 Genomic DNA Translation: EAW52430.1 BC000428 mRNA Translation: AAH00428.1 BC004531 mRNA Translation: AAH04531.1 BC008355 mRNA Translation: AAH08355.1 Frameshift. |
CCDSi | CCDS42588.1 [Q9Y230-1] |
PIRi | T46313 |
RefSeqi | NP_001308120.1, NM_001321191.1 [Q9Y230-2] NP_006657.1, NM_006666.2 [Q9Y230-1] XP_011524632.1, XM_011526330.1 [Q9Y230-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CQA | NMR | - | A | 132-213 | [»] | |
2XSZ | X-ray | 3.00 | D/E/F | 2-133 | [»] | |
D/E/F | 238-463 | [»] | ||||
3UK6 | X-ray | 2.95 | A/B/C/D/E/F/G/H/I/J/K/L | 1-132 | [»] | |
A/B/C/D/E/F/G/H/I/J/K/L | 239-463 | [»] | ||||
5OAF | electron microscopy | 4.06 | B/D/F | 1-463 | [»] | |
6FO1 | electron microscopy | 3.57 | D/E/F | 1-463 | [»] | |
6H7X | X-ray | 2.89 | A | 1-463 | [»] | |
6HTS | electron microscopy | 4.80 | B/D/F | 1-463 | [»] | |
6IGM | electron microscopy | 4.00 | B/D/F | 1-463 | [»] | |
6K0R | X-ray | 2.50 | D/E/F/J/K/L | 1-133 | [»] | |
D/E/F/J/K/L | 238-463 | [»] | ||||
6QI8 | electron microscopy | 3.75 | D/E/F | 1-463 | [»] | |
6QI9 | electron microscopy | 4.63 | D/E/F | 1-463 | [»] | |
SMRi | Q9Y230 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116067, 362 interactors |
ComplexPortali | CPX-6143, R2TP core co-chaperone complex CPX-6150, R2SP co-chaperone complex CPX-6152, R2SD co-chaperone complex CPX-6153, R2T co-chaperone complex CPX-846, INO80 chromatin remodeling complex CPX-974, SRCAP histone exchanging complex CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | Q9Y230 |
DIPi | DIP-28153N |
IntActi | Q9Y230, 164 interactors |
MINTi | Q9Y230 |
STRINGi | 9606.ENSP00000473172 |
Chemistry databases
ChEMBLi | CHEMBL2062349 |
DrugBanki | DB04216, Quercetin |
PTM databases
iPTMneti | Q9Y230 |
MetOSitei | Q9Y230 |
PhosphoSitePlusi | Q9Y230 |
SwissPalmi | Q9Y230 |
Genetic variation databases
BioMutai | RUVBL2 |
DMDMi | 28201890 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00009104 |
Proteomic databases
CPTACi | CPTAC-270 CPTAC-271 |
EPDi | Q9Y230 |
jPOSTi | Q9Y230 |
MassIVEi | Q9Y230 |
PaxDbi | Q9Y230 |
PeptideAtlasi | Q9Y230 |
PRIDEi | Q9Y230 |
ProteomicsDBi | 3549 85619 [Q9Y230-1] |
Protocols and materials databases
Antibodypediai | 3244, 391 antibodies |
DNASUi | 10856 |
Genome annotation databases
Ensembli | ENST00000595090; ENSP00000473172; ENSG00000183207 [Q9Y230-1] |
GeneIDi | 10856 |
KEGGi | hsa:10856 |
UCSCi | uc002plr.2, human [Q9Y230-1] |
Organism-specific databases
CTDi | 10856 |
DisGeNETi | 10856 |
GeneCardsi | RUVBL2 |
HGNCi | HGNC:10475, RUVBL2 |
HPAi | ENSG00000183207, Tissue enhanced (testis) |
MIMi | 604788, gene |
neXtProti | NX_Q9Y230 |
OpenTargetsi | ENSG00000183207 |
PharmGKBi | PA34888 |
VEuPathDBi | HostDB:ENSG00000183207.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2680, Eukaryota |
GeneTreei | ENSGT00940000153556 |
HOGENOMi | CLU_028311_4_0_1 |
InParanoidi | Q9Y230 |
OMAi | VPFTMIA |
OrthoDBi | 752343at2759 |
PhylomeDBi | Q9Y230 |
TreeFami | TF300469 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y230 |
Reactomei | R-HSA-171319, Telomere Extension By Telomerase R-HSA-3214847, HATs acetylate histones |
Miscellaneous databases
BioGRID-ORCSi | 10856, 768 hits in 881 CRISPR screens |
ChiTaRSi | RUVBL2, human |
EvolutionaryTracei | Q9Y230 |
GeneWikii | RUVBL2 |
GenomeRNAii | 10856 |
Pharosi | Q9Y230, Tbio |
PROi | PR:Q9Y230 |
RNActi | Q9Y230, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183207, Expressed in testis and 237 other tissues |
ExpressionAtlasi | Q9Y230, baseline and differential |
Genevisiblei | Q9Y230, HS |
Family and domain databases
Gene3Di | 2.40.50.360, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR027238, RuvB-like IPR041048, RuvB-like_C IPR037942, RUVBL2 IPR042487, RUVBL2_DII IPR010339, TIP49_P-loop |
PANTHERi | PTHR11093, PTHR11093, 1 hit PTHR11093:SF2, PTHR11093:SF2, 1 hit |
Pfami | View protein in Pfam PF06068, TIP49, 1 hit PF17856, TIP49_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RUVB2_HUMAN | |
Accessioni | Q9Y230Primary (citable) accession number: Q9Y230 Secondary accession number(s): B3KQ59 Q9Y361 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 229 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families