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Protein

Solute carrier family 22 member 13

Gene

SLC22A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • nicotinate transmembrane transporter activity Source: UniProtKB
  • organic cation transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-197264 Nicotinamide salvaging

Protein family/group databases

TCDBi2.A.1.19.17 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 13
Alternative name(s):
Organic cation transporter-like 3
Short name:
ORCTL-3
Gene namesi
Name:SLC22A13
Synonyms:OCTL1, ORCTL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172940.11
HGNCiHGNC:8494 SLC22A13
MIMi604047 gene
neXtProtiNX_Q9Y226

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 138ExtracellularSequence analysisAdd BLAST97
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 167CytoplasmicSequence analysis8
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 195ExtracellularSequence analysis7
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 251ExtracellularSequence analysis6
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 332CytoplasmicSequence analysisAdd BLAST60
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354ExtracellularSequence analysis1
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 397CytoplasmicSequence analysisAdd BLAST22
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 427ExtracellularSequence analysis9
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 452CytoplasmicSequence analysis4
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 478ExtracellularSequence analysis5
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 551CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9390
OpenTargetsiENSG00000172940
PharmGKBiPA32814

Polymorphism and mutation databases

BioMutaiSLC22A13
DMDMi91207263

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307821 – 551Solute carrier family 22 member 13Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y226
PeptideAtlasiQ9Y226
PRIDEiQ9Y226
ProteomicsDBi85612
85613 [Q9Y226-2]

PTM databases

iPTMnetiQ9Y226
PhosphoSitePlusiQ9Y226

Expressioni

Tissue specificityi

Ubiquitous, expressed at low levels.1 Publication

Gene expression databases

BgeeiENSG00000172940 Expressed in 11 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_SLC22A13
ExpressionAtlasiQ9Y226 baseline and differential
GenevisibleiQ9Y226 HS

Organism-specific databases

HPAiHPA035603
HPA035962

Interactioni

Protein-protein interaction databases

BioGridi114790, 3 interactors
STRINGi9606.ENSP00000310241

Structurei

3D structure databases

ProteinModelPortaliQ9Y226
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIC Eukaryota
ENOG410YUFN LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ9Y226
KOiK08209
OMAiPCLMFRP
OrthoDBiEOG091G05AC
PhylomeDBiQ9Y226
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y226-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC
60 70 80 90 100
AVAWVKNHTF NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS
110 120 130 140 150
HRFNETQPCD MGWEYPENRL PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV
160 170 180 190 200
GTLMFGPLCD RIGRKATILA QLLLFTLIGL ATAFVPSFEL YMALRFAVAT
210 220 230 240 250
AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL AGLAYGFRNW
260 270 280 290 300
RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR
310 320 330 340 350
KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG
360 370 380 390 400
LSLQVGDFGL DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG
410 420 430 440 450
GLMCIIIIFI PADLPVVVTM LAVVGKMATA AAFTISYVYS AELFPTILRQ
460 470 480 490 500
TGMGLVGIFS RIGGILTPLV ILLGEYHAAL PMLIYGSLPI VAGLLCTLLP
510 520 530 540 550
ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS PGVAFVSSTY

F
Length:551
Mass (Da):60,862
Last modified:April 4, 2006 - v2
Checksum:i80D69A0D5DDDA447
GO
Isoform 2 (identifier: Q9Y226-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-551: TGMGLVGIFS...GVAFVSSTYF → AWGWWASSHGSGASSHHL

Show »
Length:468
Mass (Da):52,166
Checksum:iE7ACCFA1BDA54040
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4Y1H0Y4Y1_HUMAN
Solute carrier family 22 member 13
SLC22A13
231Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146A → G (PubMed:10072596).Curated1
Sequence conflicti146A → G (PubMed:10231028).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02578743V → I1 PublicationCorresponds to variant dbSNP:rs17853496Ensembl.1
Natural variantiVAR_025788443L → F1 PublicationCorresponds to variant dbSNP:rs17857080Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017830451 – 551TGMGL…SSTYF → AWGWWASSHGSGASSHHL in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010438 mRNA Translation: BAA76350.1
AB026898 Genomic DNA Translation: BAA77625.1
AK315301 mRNA Translation: BAG37706.1
CH471055 Genomic DNA Translation: EAW64527.1
BC035973 mRNA Translation: AAH35973.1
CCDSiCCDS2676.1 [Q9Y226-1]
RefSeqiNP_004247.2, NM_004256.3 [Q9Y226-1]
UniGeneiHs.225941

Genome annotation databases

EnsembliENST00000311856; ENSP00000310241; ENSG00000172940 [Q9Y226-1]
GeneIDi9390
KEGGihsa:9390
UCSCiuc003chz.4 human [Q9Y226-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010438 mRNA Translation: BAA76350.1
AB026898 Genomic DNA Translation: BAA77625.1
AK315301 mRNA Translation: BAG37706.1
CH471055 Genomic DNA Translation: EAW64527.1
BC035973 mRNA Translation: AAH35973.1
CCDSiCCDS2676.1 [Q9Y226-1]
RefSeqiNP_004247.2, NM_004256.3 [Q9Y226-1]
UniGeneiHs.225941

3D structure databases

ProteinModelPortaliQ9Y226
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114790, 3 interactors
STRINGi9606.ENSP00000310241

Protein family/group databases

TCDBi2.A.1.19.17 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9Y226
PhosphoSitePlusiQ9Y226

Polymorphism and mutation databases

BioMutaiSLC22A13
DMDMi91207263

Proteomic databases

PaxDbiQ9Y226
PeptideAtlasiQ9Y226
PRIDEiQ9Y226
ProteomicsDBi85612
85613 [Q9Y226-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311856; ENSP00000310241; ENSG00000172940 [Q9Y226-1]
GeneIDi9390
KEGGihsa:9390
UCSCiuc003chz.4 human [Q9Y226-1]

Organism-specific databases

CTDi9390
DisGeNETi9390
EuPathDBiHostDB:ENSG00000172940.11
GeneCardsiSLC22A13
H-InvDBiHIX0024264
HGNCiHGNC:8494 SLC22A13
HPAiHPA035603
HPA035962
MIMi604047 gene
neXtProtiNX_Q9Y226
OpenTargetsiENSG00000172940
PharmGKBiPA32814
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRIC Eukaryota
ENOG410YUFN LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ9Y226
KOiK08209
OMAiPCLMFRP
OrthoDBiEOG091G05AC
PhylomeDBiQ9Y226
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-197264 Nicotinamide salvaging

Miscellaneous databases

GenomeRNAii9390
PROiPR:Q9Y226
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172940 Expressed in 11 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_SLC22A13
ExpressionAtlasiQ9Y226 baseline and differential
GenevisibleiQ9Y226 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22AD_HUMAN
AccessioniPrimary (citable) accession number: Q9Y226
Secondary accession number(s): B2RCV9, Q8IYG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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