UniProtKB - Q9Y224 (RTRAF_HUMAN)
RNA transcription, translation and transport factor protein
RTRAF
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
- RNA binding Source: UniProtKB
- RNA polymerase II complex binding Source: UniProtKB
GO - Biological processi
- negative regulation of protein kinase activity Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- RNA transport Source: UniProtKB
- tRNA splicing, via endonucleolytic cleavage and ligation Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000087302-MONOMER |
PathwayCommonsi | Q9Y224 |
Reactomei | R-HSA-6784531, tRNA processing in the nucleus |
Names & Taxonomyi
Protein namesi | Recommended name: RNA transcription, translation and transport factor proteinImportedAlternative name(s): CLE7 homolog Short name: CLE Short name: hCLE1 Publication |
Gene namesi | ORF Names:CGI-99 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23169, RTRAF |
MIMi | 610858, gene |
neXtProti | NX_Q9Y224 |
VEuPathDBi | HostDB:ENSG00000087302.8 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytosol
- cytosol 2 Publications
Cytoskeleton
- centrosome 1 Publication
Other locations
- perinuclear region 1 Publication
Note: May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).2 Publications
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: (Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902).2 Publications
Cytoskeleton
- centrosome Source: UniProtKB
- mitotic spindle Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- tRNA-splicing ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51637 |
OpenTargetsi | ENSG00000087302 |
PharmGKBi | PA134953268 |
Miscellaneous databases
Pharosi | Q9Y224, Tbio |
Genetic variation databases
BioMutai | RTRAF |
DMDMi | 20138086 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089956 | 1 – 244 | RNA transcription, translation and transport factor proteinAdd BLAST | 244 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 20 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 62 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 98 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9Y224 |
jPOSTi | Q9Y224 |
MassIVEi | Q9Y224 |
MaxQBi | Q9Y224 |
PaxDbi | Q9Y224 |
PeptideAtlasi | Q9Y224 |
PRIDEi | Q9Y224 |
ProteomicsDBi | 85609 |
TopDownProteomicsi | Q9Y224 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9Y224 |
PTM databases
iPTMneti | Q9Y224 |
MetOSitei | Q9Y224 |
PhosphoSitePlusi | Q9Y224 |
SwissPalmi | Q9Y224 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000087302, Expressed in secondary oocyte and 237 other tissues |
ExpressionAtlasi | Q9Y224, baseline and differential |
Genevisiblei | Q9Y224, HS |
Organism-specific databases
HPAi | ENSG00000087302, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (Probable).
Interacts with FAM98A (via N- and C-terminus) (PubMed:28040436).
Interacts with NIN; which may prevent phosphorylation of NIN (PubMed:15147888).
Interacts with POLR2A (PubMed:16950395).
Component of a tRNA-splicing ligase complex with FAM98B, DDX1 and RTCB (PubMed:21311021, PubMed:24870230, PubMed:24608264).
1 Publication6 Publications(Microbial infection) Interacts with influenza A virus (IAV) RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP (PubMed:21900157, PubMed:26864902). Associates with IAV polymerase complexes both in the nucleus and cytosol (PubMed:26864902). Associates with IAV ribonucleoproteins (vRNP) packaged in virions (PubMed:26864902).
Interacts with hepatitis C virus core protein p19 (PubMed:21823664).
3 PublicationsBinary interactionsi
Hide detailsQ9Y224
GO - Molecular functioni
- identical protein binding Source: IntAct
- RNA polymerase II complex binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119650, 128 interactors |
CORUMi | Q9Y224 |
IntActi | Q9Y224, 64 interactors |
MINTi | Q9Y224 |
STRINGi | 9606.ENSP00000261700 |
Miscellaneous databases
RNActi | Q9Y224, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4380, Eukaryota |
GeneTreei | ENSGT00390000005163 |
HOGENOMi | CLU_075085_0_0_1 |
InParanoidi | Q9Y224 |
OMAi | PMRILRL |
OrthoDBi | 1239557at2759 |
PhylomeDBi | Q9Y224 |
TreeFami | TF323606 |
Family and domain databases
InterProi | View protein in InterPro IPR019265, RTRAF |
PANTHERi | PTHR15924, PTHR15924, 1 hit |
Pfami | View protein in Pfam PF10036, RLL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MFRRKLTALD YHNPAGFNCK DETEFRNFIV WLEDQKIRHY KIEDRGNLRN
60 70 80 90 100
IHSSDWPKFF EKYLRDVNCP FKIQDRQEAI DWLLGLAVRL EYGDNAEKYK
110 120 130 140 150
DLVPDNSKTA DNATKNAEPL INLDVNNPDF KAGVMALANL LQIQRHDDYL
160 170 180 190 200
VMLKAIRILV QERLTQDAVA KANQTKEGLP VALDKHILGF DTGDAVLNEA
210 220 230 240
AQILRLLHIE ELRELQTKIN EAIVAVQAII ADPKTDHRLG KVGR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V4C6 | G3V4C6_HUMAN | RNA transcription, translation and ... | RTRAF | 193 | Annotation score: | ||
G3V4E7 | G3V4E7_HUMAN | RNA transcription, translation and ... | RTRAF | 68 | Annotation score: | ||
H0YJB9 | H0YJB9_HUMAN | RNA transcription, translation and ... | RTRAF | 129 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF100755 mRNA Translation: AAD43019.1 AF151857 mRNA Translation: AAD34094.1 BC001722 mRNA Translation: AAH01722.1 |
CCDSi | CCDS9705.1 |
RefSeqi | NP_057123.1, NM_016039.2 |
Genome annotation databases
Ensembli | ENST00000261700; ENSP00000261700; ENSG00000087302 |
GeneIDi | 51637 |
KEGGi | hsa:51637 |
UCSCi | uc010aod.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF100755 mRNA Translation: AAD43019.1 AF151857 mRNA Translation: AAD34094.1 BC001722 mRNA Translation: AAH01722.1 |
CCDSi | CCDS9705.1 |
RefSeqi | NP_057123.1, NM_016039.2 |
3D structure databases
SMRi | Q9Y224 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119650, 128 interactors |
CORUMi | Q9Y224 |
IntActi | Q9Y224, 64 interactors |
MINTi | Q9Y224 |
STRINGi | 9606.ENSP00000261700 |
PTM databases
iPTMneti | Q9Y224 |
MetOSitei | Q9Y224 |
PhosphoSitePlusi | Q9Y224 |
SwissPalmi | Q9Y224 |
Genetic variation databases
BioMutai | RTRAF |
DMDMi | 20138086 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9Y224 |
Proteomic databases
EPDi | Q9Y224 |
jPOSTi | Q9Y224 |
MassIVEi | Q9Y224 |
MaxQBi | Q9Y224 |
PaxDbi | Q9Y224 |
PeptideAtlasi | Q9Y224 |
PRIDEi | Q9Y224 |
ProteomicsDBi | 85609 |
TopDownProteomicsi | Q9Y224 |
Protocols and materials databases
Antibodypediai | 10723, 271 antibodies |
DNASUi | 51637 |
Genome annotation databases
Ensembli | ENST00000261700; ENSP00000261700; ENSG00000087302 |
GeneIDi | 51637 |
KEGGi | hsa:51637 |
UCSCi | uc010aod.4, human |
Organism-specific databases
CTDi | 51637 |
DisGeNETi | 51637 |
GeneCardsi | RTRAF |
HGNCi | HGNC:23169, RTRAF |
HPAi | ENSG00000087302, Low tissue specificity |
MIMi | 610858, gene |
neXtProti | NX_Q9Y224 |
OpenTargetsi | ENSG00000087302 |
PharmGKBi | PA134953268 |
VEuPathDBi | HostDB:ENSG00000087302.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4380, Eukaryota |
GeneTreei | ENSGT00390000005163 |
HOGENOMi | CLU_075085_0_0_1 |
InParanoidi | Q9Y224 |
OMAi | PMRILRL |
OrthoDBi | 1239557at2759 |
PhylomeDBi | Q9Y224 |
TreeFami | TF323606 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000087302-MONOMER |
PathwayCommonsi | Q9Y224 |
Reactomei | R-HSA-6784531, tRNA processing in the nucleus |
Miscellaneous databases
BioGRID-ORCSi | 51637, 430 hits in 861 CRISPR screens |
ChiTaRSi | C14orf166, human |
GeneWikii | C14orf166 |
GenomeRNAii | 51637 |
Pharosi | Q9Y224, Tbio |
PROi | PR:Q9Y224 |
RNActi | Q9Y224, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087302, Expressed in secondary oocyte and 237 other tissues |
ExpressionAtlasi | Q9Y224, baseline and differential |
Genevisiblei | Q9Y224, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019265, RTRAF |
PANTHERi | PTHR15924, PTHR15924, 1 hit |
Pfami | View protein in Pfam PF10036, RLL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTRAF_HUMAN | |
Accessioni | Q9Y224Primary (citable) accession number: Q9Y224 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families