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Entry version 198 (17 Jun 2020)
Sequence version 3 (17 Oct 2006)
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Protein

Protein jagged-2

Gene

JAG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y219

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y219

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
Short name:
hJ2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JAG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184916.8

Human Gene Nomenclature Database

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HGNCi
HGNC:6189 JAG2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602570 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y219

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 1080ExtracellularSequence analysisAdd BLAST1054
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1081 – 1101HelicalSequence analysisAdd BLAST21
Topological domaini1102 – 1238CytoplasmicSequence analysisAdd BLAST137

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3714

Open Targets

More...
OpenTargetsi
ENSG00000184916

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29987

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y219 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
JAG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242598

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000762924 – 1238Protein jagged-2Add BLAST1215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi198 ↔ 207By similarity
Disulfide bondi211 ↔ 223By similarity
Disulfide bondi231 ↔ 240By similarity
Disulfide bondi245 ↔ 256By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi276 ↔ 287By similarity
Disulfide bondi282 ↔ 293By similarity
Disulfide bondi295 ↔ 304By similarity
Disulfide bondi311 ↔ 323By similarity
Disulfide bondi317 ↔ 333By similarity
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi351 ↔ 362By similarity
Disulfide bondi356 ↔ 371By similarity
Disulfide bondi373 ↔ 382By similarity
Disulfide bondi389 ↔ 400By similarity
Disulfide bondi394 ↔ 409By similarity
Disulfide bondi411 ↔ 420By similarity
Disulfide bondi427 ↔ 438By similarity
Disulfide bondi432 ↔ 447By similarity
Disulfide bondi449 ↔ 458By similarity
Disulfide bondi465 ↔ 475By similarity
Disulfide bondi469 ↔ 484By similarity
Disulfide bondi486 ↔ 495By similarity
Disulfide bondi502 ↔ 513By similarity
Disulfide bondi507 ↔ 522By similarity
Disulfide bondi524 ↔ 533By similarity
Disulfide bondi540 ↔ 551By similarity
Disulfide bondi545 ↔ 560By similarity
Disulfide bondi562 ↔ 571By similarity
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi589 ↔ 612Sequence analysis
Disulfide bondi606 ↔ 622Sequence analysis
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi640 ↔ 651By similarity
Disulfide bondi645 ↔ 660By similarity
Disulfide bondi662 ↔ 671By similarity
Disulfide bondi678 ↔ 689By similarity
Disulfide bondi683 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity
Disulfide bondi716 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 747By similarity
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi755 ↔ 766By similarity
Disulfide bondi760 ↔ 775By similarity
Disulfide bondi777 ↔ 786By similarity
Disulfide bondi793 ↔ 804By similarity
Disulfide bondi798 ↔ 813By similarity
Disulfide bondi815 ↔ 824By similarity
Disulfide bondi831 ↔ 842By similarity
Disulfide bondi836 ↔ 851By similarity
Disulfide bondi853 ↔ 862By similarity
Glycosylationi1058N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1123PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y219

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y219

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y219

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y219

PeptideAtlas

More...
PeptideAtlasi
Q9Y219

PRoteomics IDEntifications database

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PRIDEi
Q9Y219

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
85595 [Q9Y219-1]
85596 [Q9Y219-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y219

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y219

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000184916 Expressed in epithelium of mammary gland and 221 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y219 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000184916 Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109918, 23 interactors

Protein interaction database and analysis system

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IntActi
Q9Y219, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328169

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y219 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y219

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 240DSLPROSITE-ProRule annotationAdd BLAST45
Domaini241 – 274EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini275 – 305EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini307 – 345EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini347 – 383EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini385 – 421EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini423 – 459EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini461 – 496EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini498 – 534EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini536 – 572EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini574 – 634EGF-like 10; atypicalPROSITE-ProRule annotationAdd BLAST61
Domaini636 – 672EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini674 – 710EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini712 – 748EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini751 – 787EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini789 – 825EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini827 – 863EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini870 – 944VWFCPROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004732_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y219

KEGG Orthology (KO)

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KOi
K21635

Identification of Orthologs from Complete Genome Data

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OMAi
GAFRCFC

Database of Orthologous Groups

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OrthoDBi
72177at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y219

TreeFam database of animal gene trees

More...
TreeFami
TF351835

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR033108 Jag2
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom

The PANTHER Classification System

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PANTHERi
PTHR24049:SF18 PTHR24049:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 10 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 2 hits
PF07657 MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02059 JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 16 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 8 hits
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: Q9Y219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC
60 70 80 90 100
DGDGRTTRAG GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG
110 120 130 140 150
NSFYLPPAGA AGDRARARAR AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD
160 170 180 190 200
WDNDTTPNEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE
210 220 230 240 250
NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN
260 270 280 290 300
LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG
310 320 330 340 350
GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA
360 370 380 390 400
CTSNPCANGG SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC
410 420 430 440 450
VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCI
460 470 480 490 500
PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELERD
510 520 530 540 550
ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC EPSPCRNGAR
560 570 580 590 600
CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT
610 620 630 640 650
AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT
660 670 680 690 700
CIDEVDAFRC FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC
710 720 730 740 750
DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCAVA
760 770 780 790 800
KNSSCLPNPC VNGGTCVGSG ASFSCICRDG WEGRTCTHNT NDCNPLPCYN
810 820 830 840 850
GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR
860 870 880 890 900
CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD
910 920 930 940 950
CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG
960 970 980 990 1000
AEEPPSTPCL PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA
1010 1020 1030 1040 1050
TRAVARDRLL VLLCDRASSG ASAVEVAVSF SPARDLPDSS LIQGAAHAIV
1060 1070 1080 1090 1100
AAITQRGNSS LLLAVTEVKV ETVVTGGSST GLLVPVLCGA FSVLWLACVV
1110 1120 1130 1140 1150
LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER PGGHKDVLYQ
1160 1170 1180 1190 1200
CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK
1210 1220 1230
FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE
Length:1,238
Mass (Da):133,367
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23B4FCD7D2891EF7
GO
Isoform Short (identifier: Q9Y219-2) [UniParc]FASTAAdd to basket
Also known as: HJAG2.del-E6

The sequence of this isoform differs from the canonical sequence as follows:
     424-461: Missing.

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Length:1,200
Mass (Da):129,235
Checksum:iC74AA0EE201D5FA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8 – 12RLPRR → AFPPA in AAB71189 (PubMed:9315665).Curated5
Sequence conflicti119A → P in AAB71189 (PubMed:9315665).Curated1
Sequence conflicti129L → F in AAB71189 (PubMed:9315665).Curated1
Sequence conflicti384L → SA in CAA74706 (PubMed:9486542).Curated1
Sequence conflicti424 – 426ANE → VND in AAB71189 (PubMed:9315665).Curated3
Sequence conflicti1235A → V in AAB61285 (PubMed:10079256).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028113501E → K3 PublicationsCorresponds to variant dbSNP:rs1057744Ensembl.1
Natural variantiVAR_048986538D → N. Corresponds to variant dbSNP:rs9972231Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001395424 – 461Missing in isoform Short. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF020201 mRNA Translation: AAB71189.1
AF003521 mRNA Translation: AAB61285.1
AF029778 mRNA Translation: AAB84215.1
AF029779 mRNA Translation: AAB84216.1
AF111170 Genomic DNA Translation: AAD15562.1
Y14330 mRNA Translation: CAA74706.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9998.1 [Q9Y219-1]
CCDS9999.1 [Q9Y219-2]

NCBI Reference Sequences

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RefSeqi
NP_002217.3, NM_002226.4 [Q9Y219-1]
NP_660142.1, NM_145159.2 [Q9Y219-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331782; ENSP00000328169; ENSG00000184916 [Q9Y219-1]
ENST00000347004; ENSP00000328566; ENSG00000184916 [Q9Y219-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3714

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3714

UCSC genome browser

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UCSCi
uc001yqg.4 human [Q9Y219-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020201 mRNA Translation: AAB71189.1
AF003521 mRNA Translation: AAB61285.1
AF029778 mRNA Translation: AAB84215.1
AF029779 mRNA Translation: AAB84216.1
AF111170 Genomic DNA Translation: AAD15562.1
Y14330 mRNA Translation: CAA74706.1
CCDSiCCDS9998.1 [Q9Y219-1]
CCDS9999.1 [Q9Y219-2]
RefSeqiNP_002217.3, NM_002226.4 [Q9Y219-1]
NP_660142.1, NM_145159.2 [Q9Y219-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MW5X-ray2.70A27-309[»]
5MW7X-ray2.80A27-348[»]
5MWFX-ray2.80A/B/C/D/E/F27-309[»]
SMRiQ9Y219
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109918, 23 interactors
IntActiQ9Y219, 17 interactors
STRINGi9606.ENSP00000328169

PTM databases

iPTMnetiQ9Y219
PhosphoSitePlusiQ9Y219

Polymorphism and mutation databases

BioMutaiJAG2
DMDMi116242598

Proteomic databases

EPDiQ9Y219
jPOSTiQ9Y219
MassIVEiQ9Y219
PaxDbiQ9Y219
PeptideAtlasiQ9Y219
PRIDEiQ9Y219
ProteomicsDBi85595 [Q9Y219-1]
85596 [Q9Y219-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14930 453 antibodies

Genome annotation databases

EnsembliENST00000331782; ENSP00000328169; ENSG00000184916 [Q9Y219-1]
ENST00000347004; ENSP00000328566; ENSG00000184916 [Q9Y219-2]
GeneIDi3714
KEGGihsa:3714
UCSCiuc001yqg.4 human [Q9Y219-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3714
DisGeNETi3714
EuPathDBiHostDB:ENSG00000184916.8

GeneCards: human genes, protein and diseases

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GeneCardsi
JAG2
HGNCiHGNC:6189 JAG2
HPAiENSG00000184916 Tissue enhanced (skin)
MIMi602570 gene
neXtProtiNX_Q9Y219
OpenTargetsiENSG00000184916
PharmGKBiPA29987

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00940000160944
HOGENOMiCLU_004732_0_0_1
InParanoidiQ9Y219
KOiK21635
OMAiGAFRCFC
OrthoDBi72177at2759
PhylomeDBiQ9Y219
TreeFamiTF351835

Enzyme and pathway databases

ReactomeiR-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
SignaLinkiQ9Y219
SIGNORiQ9Y219

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3714 3 hits in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
JAG2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
JAG2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3714
PharosiQ9Y219 Tbio

Protein Ontology

More...
PROi
PR:Q9Y219
RNActiQ9Y219 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184916 Expressed in epithelium of mammary gland and 221 other tissues
GenevisibleiQ9Y219 HS

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR033108 Jag2
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PANTHERiPTHR24049:SF18 PTHR24049:SF18, 1 hit
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 10 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 2 hits
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 16 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 8 hits
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJAG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y219
Secondary accession number(s): Q9UE17
, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 17, 2006
Last modified: June 17, 2020
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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