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Protein

E3 ubiquitin-protein ligase Su(dx)

Gene

Su(dx)

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation.2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei917Glycyl thioester intermediateCurated1

GO - Molecular functioni

  • Notch binding Source: UniProtKB
  • protein domain specific binding Source: FlyBase
  • ubiquitin protein ligase activity Source: GO_Central
  • ubiquitin-protein transferase activity Source: FlyBase

GO - Biological processi

  • imaginal disc-derived leg joint morphogenesis Source: UniProtKB
  • imaginal disc-derived wing margin morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: UniProtKB
  • lipid storage Source: FlyBase
  • negative regulation of Notch signaling pathway Source: FlyBase
  • Notch signaling pathway Source: FlyBase
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  • protein ubiquitination Source: FlyBase
  • pupal development Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulation of protein localization Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Transferase
Biological processNotch signaling pathway, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DME-1253288 Downregulation of ERBB4 signaling
R-DME-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9Y0H4
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase Su(dx) (EC:2.3.2.26)
Alternative name(s):
HECT-type E3 ubiquitin transferase Su(dx)
Protein suppressor of deltex
Gene namesi
Name:Su(dx)
ORF Names:CG4244
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003557 Su(dx)

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203311 – 949E3 ubiquitin-protein ligase Su(dx)Add BLAST949

Proteomic databases

PaxDbiQ9Y0H4
PRIDEiQ9Y0H4

Expressioni

Tissue specificityi

Expressed in pupal wings, at the boundary between vein and intervein territories.1 Publication

Gene expression databases

BgeeiFBgn0003557
ExpressionAtlasiQ9Y0H4 baseline and differential
GenevisibleiQ9Y0H4 DM

Interactioni

Subunit structurei

Interacts with N.1 Publication

GO - Molecular functioni

  • Notch binding Source: UniProtKB
  • protein domain specific binding Source: FlyBase

Protein-protein interaction databases

BioGridi59611, 21 interactors
IntActiQ9Y0H4, 10 interactors
STRINGi7227.FBpp0077495

Structurei

Secondary structure

1949
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi477 – 482Combined sources6
Beta strandi485 – 488Combined sources4
Turni489 – 491Combined sources3
Beta strandi492 – 497Combined sources6
Turni498 – 501Combined sources4
Beta strandi502 – 507Combined sources6
Turni511 – 513Combined sources3
Helixi516 – 519Combined sources4
Beta strandi528 – 532Combined sources5
Turni533 – 535Combined sources3
Beta strandi536 – 541Combined sources6
Turni542 – 545Combined sources4
Beta strandi546 – 552Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TK7NMR-A474-554[»]
2JMFNMR-A515-557[»]
ProteinModelPortaliQ9Y0H4
SMRiQ9Y0H4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y0H4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 129C2PROSITE-ProRule annotationAdd BLAST94
Domaini363 – 396WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini395 – 428WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini477 – 510WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini521 – 554WW 4PROSITE-ProRule annotationAdd BLAST34
Domaini615 – 949HECTPROSITE-ProRule annotationAdd BLAST335

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi261 – 271Poly-GlnAdd BLAST11
Compositional biasi456 – 460Poly-Gln5

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00760000118966
InParanoidiQ9Y0H4
KOiK05633
OMAiPGWEIRK
OrthoDBiEOG091G0SS8
PhylomeDBiQ9Y0H4

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd00201 WW, 4 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR024928 E3_ub_ligase_SMURF1
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00632 HECT, 1 hit
PF00397 WW, 4 hits
PIRSFiPIRSF001569 E3_ub_ligase_SMURF1, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00119 HECTc, 1 hit
SM00456 WW, 4 hits
SUPFAMiSSF51045 SSF51045, 4 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 3 hits
PS50020 WW_DOMAIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q9Y0H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGNGLPAG AASGGMEAGQ TVNGAGSASP TPTSSSGAGA SGSANQGYHQ
60 70 80 90 100
LSVTIEEASL RNNGFLKPNP YVELLIDSKS KRKTDLVKNS YLPKWNEEFT
110 120 130 140 150
VLITPNSTLH FKVLDHSSFR KDAMLGERII NLAHILQHYN GRCEFLELTI
160 170 180 190 200
DLFVTSKSDN RQTKSGELVA ILNGLKLDMS KLQIQPVAGQ QNGNPPVQAV
210 220 230 240 250
NPSVVSDAAA GRSCMIYGGV RARMRLRSSS GNSNGGETRS PLPNGGGDHR
260 270 280 290 300
RSTQAPPVWE QQQQQSQNQQ QPLRMVNGSG AAVPQTAPYP QQPPAPALAR
310 320 330 340 350
PLTQVYGALP ENTQPAAVYL PAGGGAAVGP PGVAGPPIEQ PGVGLPVSQS
360 370 380 390 400
TDPQLQTQPA DDEPLPAGWE IRLDQYGRRY YVDHNTRSTY WEKPTPLPPG
410 420 430 440 450
WEIRKDGRGR VYYVDHNTRK TTWQRPNSER LMHFQHWQGQ RAHVVSQGNQ
460 470 480 490 500
RYLYSQQQQQ PTAVTAQVTQ DDEDALGPLP DGWEKKIQSD NRVYFVNHKN
510 520 530 540 550
RTTQWEDPRT QGQEVSLINE GPLPPGWEIR YTAAGERFFV DHNTRRTTFE
560 570 580 590 600
DPRPGAPKGA KGVYGVPRAY ERSFRWKLSQ FRYLCQSNAL PSHIKITVTR
610 620 630 640 650
QTLFEDSYHQ IMRLPAYELR RRLYIIFRGE EGLDYGGVSR EWFFLLSHEV
660 670 680 690 700
LNPMYCLFEY ANKNNYSLQI NPASYVNPDH LQYFKFIGRF IAMALYHGRF
710 720 730 740 750
IYSGFTMPFY KRMLNKKLTI KDIETIDPEF YNSLIWVKDN NIDECGLELW
760 770 780 790 800
FSVDFEVLGQ IIHHELKENG EKERVTEENK EEYITLMTEW RMTRGIEQQT
810 820 830 840 850
KTFLEGFNEV VPLEWLKYFD ERELELILCG MQDVDVEDWQ RNTIYRHYNR
860 870 880 890 900
NSKQVVWFWQ FVRETDNEKR ARLLQFVTGT CRVPVGGFAE LMGSNGPQRF
910 920 930 940
CIEKVGKETW LPRSHTCFNR LDLPPYKSYD QLVEKLTFAI EETEGFCQE
Length:949
Mass (Da):107,966
Last modified:November 1, 1999 - v1
Checksum:i74B17A8B05AC6E6B
GO

Sequence cautioni

The sequence AAL39551 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152865 mRNA Translation: AAD38975.1
AE014134 Genomic DNA Translation: AAF51311.1
AE014134 Genomic DNA Translation: AAN10440.1
BT021390 mRNA Translation: AAX33538.1
AY069406 mRNA Translation: AAL39551.1 Different initiation.
RefSeqiNP_001259898.1, NM_001272969.1
NP_001259899.1, NM_001272970.1
NP_476753.1, NM_057405.3
NP_722753.1, NM_164448.2
NP_722754.1, NM_164449.2
UniGeneiDm.2146

Genome annotation databases

EnsemblMetazoaiFBtr0077822; FBpp0077495; FBgn0003557
FBtr0077823; FBpp0077496; FBgn0003557
FBtr0077824; FBpp0077497; FBgn0003557
FBtr0334778; FBpp0306832; FBgn0003557
FBtr0339529; FBpp0308612; FBgn0003557
GeneIDi33379
KEGGidme:Dmel_CG4244
UCSCiCG4244-RC d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiSUDX_DROME
AccessioniPrimary (citable) accession number: Q9Y0H4
Secondary accession number(s): A4UZZ3, Q0E8U5, Q8T0C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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