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Protein
Submitted name:

PTEN2

Gene

Pten

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: FlyBase
  • phosphoprotein phosphatase activity Source: FlyBase
  • protein serine/threonine phosphatase activity Source: FlyBase
  • protein tyrosine/serine/threonine phosphatase activity Source: FlyBase
  • protein tyrosine phosphatase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-1660499 Synthesis of PIPs at the plasma membrane
R-DME-1855204 Synthesis of IP3 and IP4 in the cytosol
R-DME-199418 Negative regulation of the PI3K/AKT network
R-DME-202424 Downstream TCR signaling
R-DME-5689880 Ub-specific processing proteases
R-DME-8948747 Regulation of PTEN localization
R-DME-8948751 Regulation of PTEN stability and activity

Names & Taxonomyi

Protein namesi
Submitted name:
PTEN2Imported
Gene namesi
Name:PtenImported
Synonyms:PTENImported
ORF Names:CG5671Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0026379 Pten

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9Y0B5

Expressioni

Gene expression databases

BgeeiFBgn0026379 Expressed in 32 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ9Y0B5 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9Y0B5
SMRiQ9Y0B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 193Phosphatase tensin-typeInterPro annotationAdd BLAST173
Domaini181 – 337C2 tensin-typeInterPro annotationAdd BLAST157

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
OrthoDBiEOG091G09VG

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y0B5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANTISLMSN VIRNVVSKKR IRYKEKGYDL DLTYINDNII AMGYPAPDKL
60 70 80 90 100
EGLFRNRLED VFKLLEENHA QHYKIYNLCS ERSYDVAKFR GRVAVYPFDD
110 120 130 140 150
HNPPTIELIQ RFCSDVDMWL KEDSSNVVAV HCKAGKGRTG TMICAYLVFS
160 170 180 190 200
GIKKSADEAL AWYDEKRTKD RKGVTIPSQR RYVQYFSKLV CSSVPYSKVS
210 220 230 240 250
LNVCEIRFSE SSCVQNLGMV ECSISVLHDS ATENAKPDRL KTLPIDFQKS
260 270 280 290 300
FVLTIKPSIP VSGDVKFELT KKSPDKIICH FWLNTFFVRN YSPCESDGTV
310 320 330 340 350
NKYIHTLSKS EIDDVHKDSE HKRFSEEFKI SIVFEAENFS NDVQAEASEK
360 370 380 390 400
ERNENVLNFE RSDYDSLSPN CYAEKKVLTA IVNDNTTKSQ TIETLDHKDI
410 420 430 440 450
VTKIQYDTST NSKNTSTACK RKQPNSKTLL PSLNDSTKEE IKRNHIFNQP
460 470 480 490 500
SIKKTDLIKW QNSEVHITRS INENKNINYN SYITCKQSSP KFNCGTEDGE
510
EDWESGESTY L
Length:511
Mass (Da):58,650
Last modified:November 1, 1999 - v1
Checksum:i10AB4A19D3DC04D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161258 mRNA Translation: AAD45363.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161258 mRNA Translation: AAD45363.1

3D structure databases

ProteinModelPortaliQ9Y0B5
SMRiQ9Y0B5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9Y0B5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0026379 Pten

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
OrthoDBiEOG091G09VG

Enzyme and pathway databases

ReactomeiR-DME-1660499 Synthesis of PIPs at the plasma membrane
R-DME-1855204 Synthesis of IP3 and IP4 in the cytosol
R-DME-199418 Negative regulation of the PI3K/AKT network
R-DME-202424 Downstream TCR signaling
R-DME-5689880 Ub-specific processing proteases
R-DME-8948747 Regulation of PTEN localization
R-DME-8948751 Regulation of PTEN stability and activity

Gene expression databases

BgeeiFBgn0026379 Expressed in 32 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ9Y0B5 baseline and differential

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9Y0B5_DROME
AccessioniPrimary (citable) accession number: Q9Y0B5
Secondary accession number(s): Q9U469
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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