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Entry version 153 (16 Oct 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Inositol 1,4,5-trisphosphate receptor itr-1

Gene

itr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis (PubMed:10499793, PubMed:10610772, PubMed:15194811, PubMed:16186564, PubMed:23671426). Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position (PubMed:10610772). Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity (PubMed:10610772). Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (PubMed:10499793, PubMed:11553721, PubMed:12062062, PubMed:11950942, PubMed:15013747, PubMed:15133127, PubMed:16186564, PubMed:21191812). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (PubMed:9491893, PubMed:15194811, PubMed:16267094, PubMed:15958491). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (PubMed:11950942, PubMed:15498499, PubMed:18369461). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses (PubMed:19730689).17 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-114508 Effects of PIP2 hydrolysis
R-CEL-139853 Elevation of cytosolic Ca2+ levels
R-CEL-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-CEL-5578775 Ion homeostasis
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.2.16 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor itr-11 Publication
Alternative name(s):
IP3 receptor1 Publication
Short name:
IP3R1 Publication
Short name:
InsP3R1 Publication
LET-23 fertility effector 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:itr-1Imported
Synonyms:dec-41 Publication, lfe-11 Publication
ORF Names:F33D4.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
F33D4.2a ; CE37905 ; WBGene00002173 ; itr-1
F33D4.2d ; CE37906 ; WBGene00002173 ; itr-1
F33D4.2e ; CE28017 ; WBGene00002173 ; itr-1
F33D4.2f ; CE28018 ; WBGene00002173 ; itr-1
F33D4.2g ; CE31690 ; WBGene00002173 ; itr-1
F33D4.2h ; CE44684 ; WBGene00002173 ; itr-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2475CytoplasmicSequence analysisAdd BLAST2475
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2476 – 2496HelicalSequence analysisAdd BLAST21
Topological domaini2497 – 2514ExtracellularSequence analysisAdd BLAST18
Transmembranei2515 – 2535HelicalSequence analysisAdd BLAST21
Topological domaini2536 – 2572CytoplasmicSequence analysisAdd BLAST37
Transmembranei2573 – 2593HelicalSequence analysisAdd BLAST21
Topological domaini2594 – 2615ExtracellularSequence analysisAdd BLAST22
Transmembranei2616 – 2636HelicalSequence analysisAdd BLAST21
Topological domaini2637 – 2735CytoplasmicSequence analysisAdd BLAST99
Transmembranei2736 – 2756HelicalSequence analysisAdd BLAST21
Topological domaini2757 – 2892ExtracellularSequence analysisAdd BLAST136

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disrupted defecation rhythm with reduced pharyngeal pumping in the presence of food resulting in constipation. Disrupted reversal/avoidance response to nose touch. Hermaphrodites display endomitotic oocytes following spermathecal dilation defect and defective ovulation. Loss of male fertility due to defects in turning behavior, spicule insertion and sperm transfer.4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi103G → E in n2559; slow developmental rate to adulthood, absence of ovulation, sterility, absence of defecation cycle and intestinal calcium oscillations. 1 Publication1
Mutagenesisi371R → K in sy331; reduced fertility and brood size. 2 Publications1
Mutagenesisi557R → C in sy290; gain of function. 2-fold increase in ligand affinity. Increased velocity of posterior-to-anterior calcium wave. Reduced fertility, hyperactive spermathecal dilation leading to decreased brood size. 3 Publications1
Mutagenesisi625K → Q: Abolishes ligand binding; when associated with Q-628. 1 Publication1
Mutagenesisi628R → Q: Abolishes ligand binding; when associated with Q-625. 1 Publication1
Mutagenesisi900S → F in sy328; reduced fertility and brood size. 2 Publications1
Mutagenesisi945L → F in sy327; gain of function. Increased velocity of posterior-to-anterior calcium wave and enhanced sheath contractile activity. 2 Publications1
Mutagenesisi1571C → Y in sa73; slow developmental rate to adulthood, reduced brood size, slow intestinal calcium oscillations, slower pharyngeal pumping, longer defecation cycle, defective ovulation, reduced myoepithelial sheath contractility and reduced efficiency of sperm transfer. 8 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004241501 – 2892Inositol 1,4,5-trisphosphate receptor itr-1Add BLAST2892

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y0A1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y0A1

PeptideAtlas

More...
PeptideAtlasi
Q9Y0A1

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y0A1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform a is expressed in the anterior cells of the pharyngeal terminal bulb, vulva, rectal epithelial cells, spicule protractor muscles of the proctodeum and male-specific neuron CP8 or CP9. Isoform d is expressed in the spermatheca, excretory cell, amphid socket cells, PDA motor neuron, spicule retractor muscles, gubernaculum retractor muscles, posterior oblique muscles, diagonal muscles and the vas deferens. Also expressed in the intestine, pharynx, pharyngeal isthmus, pharyngeal intestinal valve, somatic gonad, hypodermal cells of the vulva, uterine sheath cells, tail, head, LUA motor neuron and the embryonic epidermis (at protein level).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002173 Expressed in 4 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with myo-1, myo-2, unc-54/myo-4 and nmy-2.

Also interacts with iri-1.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
42664, 13 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F33D4.2a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini192 – 246MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini319 – 379MIR 2PROSITE-ProRule annotationAdd BLAST61
Domaini386 – 466MIR 3PROSITE-ProRule annotationAdd BLAST81
Domaini490 – 551MIR 4PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni357 – 361Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni625 – 628Inositol 1,4,5-trisphosphate binding1 Publication4
Regioni689 – 691Inositol 1,4,5-trisphosphate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.By similarity2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.Sequence analysis

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3533 Eukaryota
ENOG410XR97 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167397

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007660

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y0A1

KEGG Orthology (KO)

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KOi
K04958

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRHAPYK

Database of Orthologous Groups

More...
OrthoDBi
94996at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y0A1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779 INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919 MIR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform a1 Publication (identifier: Q9Y0A1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPSYGRVRK KVSIISIPEF VPEHYEYENE TTASGGASGG GSTRIEFDFD
60 70 80 90 100
DFEEQIMRKS SMALPSRKLT IANSIDHGNN GNLHIGDIIS LYTESSSNQE
110 120 130 140 150
QRGFLSTLGL VDDRCIVELK DGRPESPPKK FRDCLFKVCP VNRYAAQKHL
160 170 180 190 200
WTEQKRFQTG DSMFDDDLMN KLKVAADKER EENESEFQKT LGNVIQYGSM
210 220 230 240 250
VQLLHVKSNK YITVQKNSPA KRERNAMKVY LDRAGNEGSW FIIEPAYKHY
260 270 280 290 300
AIGDNVSAGN KISLIPNSVS TTQAGHVKSQ LHLSSFNLLD HQSAAEVNCL
310 320 330 340 350
NEPTEWQVFM FLLFDENQQN SVKSGDVVRL FHADQQTFLT LDTIPKQNPP
360 370 380 390 400
TDVVFLRMTN RPSAADATSS RALWEVQVVQ TNAYRGGTAK WNKAYRFKHL
410 420 430 440 450
ATDMYLSAEP SQVQVKPAMN GRRASLIYSK TNNPMAMYSD GPNGVTNEST
460 470 480 490 500
DTTQQNIPSV WVLGPTKSEF PEEDANLLFQ LDPSTFMKSN KEVPRRSYVR
510 520 530 540 550
LLHQSSDKWV HATNATEKQN LHYSSKNEKG WVKVICEKNR VDKETFALLP
560 570 580 590 600
VNPDEVRDLD FANDACKALR NFIKLIKIGQ VISKESINST TQLLIDCILF
610 620 630 640 650
VTNSSDHLAD PLKISDFSPS RDRQKLLREQ EVLNQVFLLL KAPFLPRQGT
660 670 680 690 700
TELGPLLSSP SELSDSRNEI FKTMFQLCYC LLKYSQVSYR KNQEFLAEKF
710 720 730 740 750
GEIQEQIGFD LMAEDTMTAV LHNNPKLLEK YVKTPHVERF VELVRNNRQG
760 770 780 790 800
KFLDYLADLC VCRGEANKKI QELICTSVLS SKHRDIFMDT KIIDGEIEVG
810 820 830 840 850
WAPNFRKLVD IAEGAKSNSD DAEHLDYYRH QLDLLSQMCQ EQQYLAIDPP
860 870 880 890 900
PERRLMNISQ QLPAELVLQC MSDNRLPYDL RGSFTRLMLH LHVVRGSPMS
910 920 930 940 950
AIRHARLWWS IPENVNVSTY ESVSVEAYSD GSRMRIGEGI AHKVLATVET
960 970 980 990 1000
YLMGLRNQSM EERQSVNSSK LTYEIVNLAK ALAQFNFYSF NDLLQLTQNL
1010 1020 1030 1040 1050
LAIINEGPAT EQVPSHRAMV NAIRNMSKSM MRGGNKENSK DLAKTPSVTA
1060 1070 1080 1090 1100
EEAGRTKEGR ALNVKTKLIV AEILQFVMDV RRDYRITMAL SWFKNVFPCD
1110 1120 1130 1140 1150
EDGSLMHSAS INERMASELY DAIYRSSGHE LHLDGRDGQL LLAILLQMTM
1160 1170 1180 1190 1200
SDYPPLTSIA LKVFFRHFTQ YQELLEDLKQ VQLLVSNNDV ENYRQIDRDL
1210 1220 1230 1240 1250
FILKNLTEKS ELWVHGDRHH SIDTKEVDEK ERTTEHDLLD HDLKSPRAFD
1260 1270 1280 1290 1300
SGDSMEALMA VLNEHYPSIR NECLQLLNRL LIKDDRNDAA VALQELSDKA
1310 1320 1330 1340 1350
PLIAYPLIRQ MLVRLTGMCY RKGDPKPDTM NQQLLKNMRV YEVVLEFISV
1360 1370 1380 1390 1400
PHDKKHDHDM MKLITLSHEF LRSFCKTNKE NQSRLYKFIS YEKDAKEGML
1410 1420 1430 1440 1450
RVETIEEVGT LVAIFRNNRE LASNVPEELI AHIVGLIEHN SRNPIFLELL
1460 1470 1480 1490 1500
QALVCVYDKE IESGQEKVAN EICAASDEVR QLYVDNASFE ELEAMMKDEK
1510 1520 1530 1540 1550
ESKGRSSDSR RKLKYHIELV RLLAMCTRGK NGNTELKCAS QIPMDHIVRV
1560 1570 1580 1590 1600
VTAKQCLVEV KTVYLQLLLH CYIDTDAEMK DAYKTEYVDH ILNNLLEDIR
1610 1620 1630 1640 1650
SLRVEKLTGA ETATLEHYIC HTVTEVLIKF FEAPYSALQQ AKVDVHHHKK
1660 1670 1680 1690 1700
TFSEVLLELT YLEKGKLRGS KSSRNWYRVA ECIKRLTKWA EEHNITLPAT
1710 1720 1730 1740 1750
LAGPQMSGQT SVRQKWQQAA SSAKWIGIGK RLNRQNTLNP GHRLYGTSNS
1760 1770 1780 1790 1800
MTEHTSANVV TCYHMMIGEF KFYLHPLHAA EGSVLVEVLH TPELLFPEGS
1810 1820 1830 1840 1850
ALRDQCARGG VVAKLIQHCK TLMQNKQDNL CARVLQTLCK MCDCTKQQLT
1860 1870 1880 1890 1900
HQGQQLRQLL LQRYFGHHNN HHPPLDRQQS KIGEVIEAVK EKKEETWSQE
1910 1920 1930 1940 1950
RDLYAIQCKL NDAGASDLVT DIIIMEPSRE IFLKAIHLAR ALLHEGNDKV
1960 1970 1980 1990 2000
QHSFYMRMKQ KDIHEPFFKA ILTRIQTAQN RLKSDMMSCS DSKPKVSLSA
2010 2020 2030 2040 2050
TVSRRSSTVL TPLIDAGDTG FNGALFEVPQ QVRHPSISEM SQLSNDLTHS
2060 2070 2080 2090 2100
IPDLAPYQDE EKSTDALPPE VALVEPILRV LQLLCENHNS LLQNFLRKQS
2110 2120 2130 2140 2150
DRTNHNLVSE TLSFLDTVCG STKGSLGVFG EIGEHNFSLI TQTLATLTEF
2160 2170 2180 2190 2200
CQGPCHENQN TMAMQENGLN IIISLVLNEI KPLADDHMEL ALEIKSQASK
2210 2220 2230 2240 2250
LLLAIMESRH DGENANRVLR NMANMSGGPK QLVHAIKQAY EMTNSNHHML
2260 2270 2280 2290 2300
KSISRDLFRQ AEDDLKKKSG PQITVNTVTL PEINVDASGI VSIHTEKNIS
2310 2320 2330 2340 2350
SSLDDKFNDD DIPSVDPREV GHNIYILAHQ LAIHDGELEI WLDGSDEKKD
2360 2370 2380 2390 2400
DLTREALNYY KERTAQIEIV RRDRTLERVV FPINDICSYL TKDTKDYVYN
2410 2420 2430 2440 2450
NTERDNQGSK VTEFFDEWET MYHEMIWQRK LQDRKWLSWC AFRLPLWTRL
2460 2470 2480 2490 2500
SFHFAFIVNA LVARYYPLPE HSNSSISLGN LYSWFAVFSS FLLAHYLRHD
2510 2520 2530 2540 2550
KIYLHKTSLL ILASLCFLLL SSIGVTLTLY IFGILQLVNK IVHVVAFVSN
2560 2570 2580 2590 2600
KGLEDRPIAE ILACRNLHYL LVYLFICILG LLVHPMIYCI LLFDIIFTEE
2610 2620 2630 2640 2650
TLQNVIASVT RNYQSIVWTG LLALILLYFF SILGFLYFRH DFYLEVDPVE
2660 2670 2680 2690 2700
NDSSATISSG IPSETCPSEG CPGLQPSEKD DNDDEKKVKS CETLWMCILQ
2710 2720 2730 2740 2750
TGYQGLRNGG GIGDVLRNPA PWEDMFIWRV AYDMTFFVVL IVIVLNLIFG
2760 2770 2780 2790 2800
VIIDTFGDLR AEKNEKEQIL KNNCFICGLD RSRFDNRSVT FETHRETEHN
2810 2820 2830 2840 2850
IWHYLYYIVM LQIKDETEFT GPESYVAQCV KDRNLDWFPR MQALSLQDSE
2860 2870 2880 2890
LDTDQSEVKQ MKDQLLQMMT LMREIISQNE ESRAFMEQFQ PR
Note: Produced by alternative promoter usage.1 Publication
Length:2,892
Mass (Da):330,837
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1C598FE554B83CF
GO
Isoform d1 Publication (identifier: Q9Y0A1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: Produced by alternative promoter usage.1 Publication
Show »
Length:2,836
Mass (Da):324,566
Checksum:i3A2385BC8AC870F9
GO
Isoform e2 Publications (identifier: Q9Y0A1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
     423-430: RASLIYSK → PPLLSALSQKSRPMLER
     1853-1853: G → GHRVYNSSVEKG
     1998-2006: Missing.

Note: Produced by alternative promoter usage and alternative splicing.2 Publications
Show »
Length:2,857
Mass (Da):327,200
Checksum:i8B991F12BEC94E2F
GO
Isoform f2 Publications (identifier: Q9Y0A1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG

Note: Produced by alternative promoter usage and alternative splicing.2 Publications
Show »
Length:2,846
Mass (Da):325,914
Checksum:i0186413338AB3BA2
GO
Isoform gCurated (identifier: Q9Y0A1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
     1731-1759: RLNRQNTLNPGHRLYGTSNSMTEHTSANV → PVITLVVETQSSKYAQSWSSTLWNIKLYD
     1760-2892: Missing.

Note: Produced by alternative promoter usage and alternative splicing.Curated
Show »
Length:1,713
Mass (Da):196,076
Checksum:i5FEDC945C48A2A2C
GO
Isoform hCurated (identifier: Q9Y0A1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
     1730-1730: K → KMSQDSQSDYDSDSSQGPCQIS

Note: Produced by alternative promoter usage and alternative splicing.Curated
Show »
Length:2,867
Mass (Da):328,162
Checksum:iADC0DFB98DF8150C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0533371 – 56Missing in isoform d. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0533381 – 46Missing in isoform e, isoform f, isoform g and isoform h. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_05333947 – 61FDFDD…MRKSS → MDYDYRRRVLERNIG in isoform e, isoform f, isoform g and isoform h. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_053340423 – 430RASLIYSK → PPLLSALSQKSRPMLER in isoform e. 1 Publication8
Alternative sequenceiVSP_0533411730K → KMSQDSQSDYDSDSSQGPCQ IS in isoform h. Curated1
Alternative sequenceiVSP_0533421731 – 1759RLNRQ…TSANV → PVITLVVETQSSKYAQSWSS TLWNIKLYD in isoform g. CuratedAdd BLAST29
Alternative sequenceiVSP_0533451760 – 2892Missing in isoform g. CuratedAdd BLAST1133
Alternative sequenceiVSP_0533431853G → GHRVYNSSVEKG in isoform e. 1 Publication1
Alternative sequenceiVSP_0533441998 – 2006Missing in isoform e. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF168688 mRNA Translation: AAF05302.1
AJ243179 mRNA Translation: CAB45860.1
AJ243180 mRNA Translation: CAB45861.1
AJ243181 mRNA Translation: CAB45862.1
AJ243182 mRNA Translation: CAB45863.1
FO080445 Genomic DNA Translation: CCD63763.1
FO080445 Genomic DNA Translation: CCD63764.1
FO080445 Genomic DNA Translation: CCD63765.1
FO080445 Genomic DNA Translation: CCD63766.1
FO080445 Genomic DNA Translation: CCD63767.1
FO080445 Genomic DNA Translation: CCD63775.1

NCBI Reference Sequences

More...
RefSeqi
NP_001023170.1, NM_001027999.3 [Q9Y0A1-1]
NP_001023171.1, NM_001028000.3 [Q9Y0A1-2]
NP_001023172.1, NM_001028001.2 [Q9Y0A1-3]
NP_001023173.1, NM_001028002.2 [Q9Y0A1-4]
NP_001023174.1, NM_001028003.2 [Q9Y0A1-5]
NP_001255305.1, NM_001268376.1 [Q9Y0A1-6]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F33D4.2a.1; F33D4.2a.1; WBGene00002173 [Q9Y0A1-1]
F33D4.2d.1; F33D4.2d.1; WBGene00002173 [Q9Y0A1-2]
F33D4.2e.1; F33D4.2e.1; WBGene00002173 [Q9Y0A1-3]
F33D4.2f.1; F33D4.2f.1; WBGene00002173 [Q9Y0A1-4]
F33D4.2g.1; F33D4.2g.1; WBGene00002173 [Q9Y0A1-5]
F33D4.2h.1; F33D4.2h.1; WBGene00002173 [Q9Y0A1-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177546

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F33D4.2

UCSC genome browser

More...
UCSCi
F33D4.2a.2 c. elegans

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168688 mRNA Translation: AAF05302.1
AJ243179 mRNA Translation: CAB45860.1
AJ243180 mRNA Translation: CAB45861.1
AJ243181 mRNA Translation: CAB45862.1
AJ243182 mRNA Translation: CAB45863.1
FO080445 Genomic DNA Translation: CCD63763.1
FO080445 Genomic DNA Translation: CCD63764.1
FO080445 Genomic DNA Translation: CCD63765.1
FO080445 Genomic DNA Translation: CCD63766.1
FO080445 Genomic DNA Translation: CCD63767.1
FO080445 Genomic DNA Translation: CCD63775.1
RefSeqiNP_001023170.1, NM_001027999.3 [Q9Y0A1-1]
NP_001023171.1, NM_001028000.3 [Q9Y0A1-2]
NP_001023172.1, NM_001028001.2 [Q9Y0A1-3]
NP_001023173.1, NM_001028002.2 [Q9Y0A1-4]
NP_001023174.1, NM_001028003.2 [Q9Y0A1-5]
NP_001255305.1, NM_001268376.1 [Q9Y0A1-6]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi42664, 13 interactors
STRINGi6239.F33D4.2a

Protein family/group databases

TCDBi1.A.3.2.16 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Proteomic databases

EPDiQ9Y0A1
PaxDbiQ9Y0A1
PeptideAtlasiQ9Y0A1
PRIDEiQ9Y0A1

Genome annotation databases

EnsemblMetazoaiF33D4.2a.1; F33D4.2a.1; WBGene00002173 [Q9Y0A1-1]
F33D4.2d.1; F33D4.2d.1; WBGene00002173 [Q9Y0A1-2]
F33D4.2e.1; F33D4.2e.1; WBGene00002173 [Q9Y0A1-3]
F33D4.2f.1; F33D4.2f.1; WBGene00002173 [Q9Y0A1-4]
F33D4.2g.1; F33D4.2g.1; WBGene00002173 [Q9Y0A1-5]
F33D4.2h.1; F33D4.2h.1; WBGene00002173 [Q9Y0A1-6]
GeneIDi177546
KEGGicel:CELE_F33D4.2
UCSCiF33D4.2a.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177546
WormBaseiF33D4.2a ; CE37905 ; WBGene00002173 ; itr-1
F33D4.2d ; CE37906 ; WBGene00002173 ; itr-1
F33D4.2e ; CE28017 ; WBGene00002173 ; itr-1
F33D4.2f ; CE28018 ; WBGene00002173 ; itr-1
F33D4.2g ; CE31690 ; WBGene00002173 ; itr-1
F33D4.2h ; CE44684 ; WBGene00002173 ; itr-1

Phylogenomic databases

eggNOGiKOG3533 Eukaryota
ENOG410XR97 LUCA
GeneTreeiENSGT00940000167397
HOGENOMiHOG000007660
InParanoidiQ9Y0A1
KOiK04958
OMAiPRHAPYK
OrthoDBi94996at2759
PhylomeDBiQ9Y0A1

Enzyme and pathway databases

ReactomeiR-CEL-114508 Effects of PIP2 hydrolysis
R-CEL-139853 Elevation of cytosolic Ca2+ levels
R-CEL-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-CEL-5578775 Ion homeostasis
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9Y0A1

Gene expression databases

BgeeiWBGene00002173 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPR_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y0A1
Secondary accession number(s): D3NQ87
, G5EBF6, Q8MXI9, Q9U3B3, Q9Y0A0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: November 1, 1999
Last modified: October 16, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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