UniProtKB - Q9Y0A1 (ITPR_CAEEL)
Inositol 1,4,5-trisphosphate receptor itr-1
itr-1
Functioni
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- inositol 1,4,5 trisphosphate binding Source: GO_Central
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: WormBase
- myosin binding Source: WormBase
- phosphatidylinositol binding Source: GO_Central
GO - Biological processi
- defecation Source: WormBase
- embryonic morphogenesis Source: WormBase
- hermaphrodite genitalia morphogenesis Source: UniProtKB
- inositol lipid-mediated signaling Source: WormBase
- male mating behavior Source: WormBase
- multicellular organismal reproductive process Source: WormBase
- muscle contraction Source: WormBase
- oocyte maturation Source: WormBase
- positive regulation of cytosolic calcium ion concentration Source: WormBase
- positive regulation of pharyngeal pumping Source: WormBase
- programmed cell death Source: WormBase
- regulation of cell migration Source: WormBase
- regulation of filopodium assembly Source: WormBase
- regulation of pharyngeal pumping Source: WormBase
- release of sequestered calcium ion into cytosol Source: GO_Central
- rhythmic behavior Source: WormBase
- sperm ejaculation Source: WormBase
Keywordsi
Molecular function | Developmental protein, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-CEL-114508, Effects of PIP2 hydrolysis R-CEL-139853, Elevation of cytosolic Ca2+ levels R-CEL-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-CEL-5578775, Ion homeostasis R-CEL-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Protein family/group databases
TCDBi | 1.A.3.2.16, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol 1,4,5-trisphosphate receptor itr-11 PublicationAlternative name(s): IP3 receptor1 Publication Short name: IP3R1 Publication Short name: InsP3R1 Publication LET-23 fertility effector 11 Publication |
Gene namesi | ORF Names:F33D4.2 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F33D4.2a ; CE37905 ; WBGene00002173 ; itr-1 F33D4.2d ; CE37906 ; WBGene00002173 ; itr-1 F33D4.2e ; CE28017 ; WBGene00002173 ; itr-1 F33D4.2f ; CE28018 ; WBGene00002173 ; itr-1 F33D4.2g ; CE31690 ; WBGene00002173 ; itr-1 F33D4.2h ; CE44684 ; WBGene00002173 ; itr-1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein By similarity2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: WormBase
- endoplasmic reticulum membrane Source: GO_Central
- sarcoplasmic reticulum Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasmic vesicle membrane Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- membrane Source: WormBase
- secretory granule membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 2475 | CytoplasmicSequence analysisAdd BLAST | 2475 | |
Transmembranei | 2476 – 2496 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2497 – 2514 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 2515 – 2535 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2536 – 2572 | CytoplasmicSequence analysisAdd BLAST | 37 | |
Transmembranei | 2573 – 2593 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2594 – 2615 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 2616 – 2636 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2637 – 2735 | CytoplasmicSequence analysisAdd BLAST | 99 | |
Transmembranei | 2736 – 2756 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2757 – 2892 | ExtracellularSequence analysisAdd BLAST | 136 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 103 | G → E in n2559; slow developmental rate to adulthood, absence of ovulation, sterility, absence of defecation cycle and intestinal calcium oscillations. 1 Publication | 1 | |
Mutagenesisi | 371 | R → K in sy331; reduced fertility and brood size. 2 Publications | 1 | |
Mutagenesisi | 557 | R → C in sy290; gain of function. 2-fold increase in ligand affinity. Increased velocity of posterior-to-anterior calcium wave. Reduced fertility, hyperactive spermathecal dilation leading to decreased brood size. 3 Publications | 1 | |
Mutagenesisi | 625 | K → Q: Abolishes ligand binding; when associated with Q-628. 1 Publication | 1 | |
Mutagenesisi | 628 | R → Q: Abolishes ligand binding; when associated with Q-625. 1 Publication | 1 | |
Mutagenesisi | 900 | S → F in sy328; reduced fertility and brood size. 2 Publications | 1 | |
Mutagenesisi | 945 | L → F in sy327; gain of function. Increased velocity of posterior-to-anterior calcium wave and enhanced sheath contractile activity. 2 Publications | 1 | |
Mutagenesisi | 1571 | C → Y in sa73; slow developmental rate to adulthood, reduced brood size, slow intestinal calcium oscillations, slower pharyngeal pumping, longer defecation cycle, defective ovulation, reduced myoepithelial sheath contractility and reduced efficiency of sperm transfer. 8 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424150 | 1 – 2892 | Inositol 1,4,5-trisphosphate receptor itr-1Add BLAST | 2892 |
Proteomic databases
EPDi | Q9Y0A1 |
PaxDbi | Q9Y0A1 |
PeptideAtlasi | Q9Y0A1 |
PRIDEi | Q9Y0A1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | WBGene00002173, Expressed in material anatomical entity and 4 other tissues |
Interactioni
Subunit structurei
Interacts with myo-1, myo-2, unc-54/myo-4 and nmy-2.
Also interacts with iri-1.
2 PublicationsGO - Molecular functioni
- myosin binding Source: WormBase
Protein-protein interaction databases
BioGRIDi | 42664, 21 interactors |
STRINGi | 6239.F33D4.2a |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 192 – 246 | MIR 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 319 – 379 | MIR 2PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 386 – 466 | MIR 3PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 490 – 551 | MIR 4PROSITE-ProRule annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 357 – 361 | Inositol 1,4,5-trisphosphate bindingBy similarity | 5 | |
Regioni | 625 – 628 | Inositol 1,4,5-trisphosphate binding1 Publication | 4 | |
Regioni | 689 – 691 | Inositol 1,4,5-trisphosphate bindingBy similarity | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3533, Eukaryota |
GeneTreei | ENSGT00940000167397 |
InParanoidi | Q9Y0A1 |
OMAi | MKLAHQF |
OrthoDBi | 94996at2759 |
PhylomeDBi | Q9Y0A1 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 4 hits |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNPSYGRVRK KVSIISIPEF VPEHYEYENE TTASGGASGG GSTRIEFDFD
60 70 80 90 100
DFEEQIMRKS SMALPSRKLT IANSIDHGNN GNLHIGDIIS LYTESSSNQE
110 120 130 140 150
QRGFLSTLGL VDDRCIVELK DGRPESPPKK FRDCLFKVCP VNRYAAQKHL
160 170 180 190 200
WTEQKRFQTG DSMFDDDLMN KLKVAADKER EENESEFQKT LGNVIQYGSM
210 220 230 240 250
VQLLHVKSNK YITVQKNSPA KRERNAMKVY LDRAGNEGSW FIIEPAYKHY
260 270 280 290 300
AIGDNVSAGN KISLIPNSVS TTQAGHVKSQ LHLSSFNLLD HQSAAEVNCL
310 320 330 340 350
NEPTEWQVFM FLLFDENQQN SVKSGDVVRL FHADQQTFLT LDTIPKQNPP
360 370 380 390 400
TDVVFLRMTN RPSAADATSS RALWEVQVVQ TNAYRGGTAK WNKAYRFKHL
410 420 430 440 450
ATDMYLSAEP SQVQVKPAMN GRRASLIYSK TNNPMAMYSD GPNGVTNEST
460 470 480 490 500
DTTQQNIPSV WVLGPTKSEF PEEDANLLFQ LDPSTFMKSN KEVPRRSYVR
510 520 530 540 550
LLHQSSDKWV HATNATEKQN LHYSSKNEKG WVKVICEKNR VDKETFALLP
560 570 580 590 600
VNPDEVRDLD FANDACKALR NFIKLIKIGQ VISKESINST TQLLIDCILF
610 620 630 640 650
VTNSSDHLAD PLKISDFSPS RDRQKLLREQ EVLNQVFLLL KAPFLPRQGT
660 670 680 690 700
TELGPLLSSP SELSDSRNEI FKTMFQLCYC LLKYSQVSYR KNQEFLAEKF
710 720 730 740 750
GEIQEQIGFD LMAEDTMTAV LHNNPKLLEK YVKTPHVERF VELVRNNRQG
760 770 780 790 800
KFLDYLADLC VCRGEANKKI QELICTSVLS SKHRDIFMDT KIIDGEIEVG
810 820 830 840 850
WAPNFRKLVD IAEGAKSNSD DAEHLDYYRH QLDLLSQMCQ EQQYLAIDPP
860 870 880 890 900
PERRLMNISQ QLPAELVLQC MSDNRLPYDL RGSFTRLMLH LHVVRGSPMS
910 920 930 940 950
AIRHARLWWS IPENVNVSTY ESVSVEAYSD GSRMRIGEGI AHKVLATVET
960 970 980 990 1000
YLMGLRNQSM EERQSVNSSK LTYEIVNLAK ALAQFNFYSF NDLLQLTQNL
1010 1020 1030 1040 1050
LAIINEGPAT EQVPSHRAMV NAIRNMSKSM MRGGNKENSK DLAKTPSVTA
1060 1070 1080 1090 1100
EEAGRTKEGR ALNVKTKLIV AEILQFVMDV RRDYRITMAL SWFKNVFPCD
1110 1120 1130 1140 1150
EDGSLMHSAS INERMASELY DAIYRSSGHE LHLDGRDGQL LLAILLQMTM
1160 1170 1180 1190 1200
SDYPPLTSIA LKVFFRHFTQ YQELLEDLKQ VQLLVSNNDV ENYRQIDRDL
1210 1220 1230 1240 1250
FILKNLTEKS ELWVHGDRHH SIDTKEVDEK ERTTEHDLLD HDLKSPRAFD
1260 1270 1280 1290 1300
SGDSMEALMA VLNEHYPSIR NECLQLLNRL LIKDDRNDAA VALQELSDKA
1310 1320 1330 1340 1350
PLIAYPLIRQ MLVRLTGMCY RKGDPKPDTM NQQLLKNMRV YEVVLEFISV
1360 1370 1380 1390 1400
PHDKKHDHDM MKLITLSHEF LRSFCKTNKE NQSRLYKFIS YEKDAKEGML
1410 1420 1430 1440 1450
RVETIEEVGT LVAIFRNNRE LASNVPEELI AHIVGLIEHN SRNPIFLELL
1460 1470 1480 1490 1500
QALVCVYDKE IESGQEKVAN EICAASDEVR QLYVDNASFE ELEAMMKDEK
1510 1520 1530 1540 1550
ESKGRSSDSR RKLKYHIELV RLLAMCTRGK NGNTELKCAS QIPMDHIVRV
1560 1570 1580 1590 1600
VTAKQCLVEV KTVYLQLLLH CYIDTDAEMK DAYKTEYVDH ILNNLLEDIR
1610 1620 1630 1640 1650
SLRVEKLTGA ETATLEHYIC HTVTEVLIKF FEAPYSALQQ AKVDVHHHKK
1660 1670 1680 1690 1700
TFSEVLLELT YLEKGKLRGS KSSRNWYRVA ECIKRLTKWA EEHNITLPAT
1710 1720 1730 1740 1750
LAGPQMSGQT SVRQKWQQAA SSAKWIGIGK RLNRQNTLNP GHRLYGTSNS
1760 1770 1780 1790 1800
MTEHTSANVV TCYHMMIGEF KFYLHPLHAA EGSVLVEVLH TPELLFPEGS
1810 1820 1830 1840 1850
ALRDQCARGG VVAKLIQHCK TLMQNKQDNL CARVLQTLCK MCDCTKQQLT
1860 1870 1880 1890 1900
HQGQQLRQLL LQRYFGHHNN HHPPLDRQQS KIGEVIEAVK EKKEETWSQE
1910 1920 1930 1940 1950
RDLYAIQCKL NDAGASDLVT DIIIMEPSRE IFLKAIHLAR ALLHEGNDKV
1960 1970 1980 1990 2000
QHSFYMRMKQ KDIHEPFFKA ILTRIQTAQN RLKSDMMSCS DSKPKVSLSA
2010 2020 2030 2040 2050
TVSRRSSTVL TPLIDAGDTG FNGALFEVPQ QVRHPSISEM SQLSNDLTHS
2060 2070 2080 2090 2100
IPDLAPYQDE EKSTDALPPE VALVEPILRV LQLLCENHNS LLQNFLRKQS
2110 2120 2130 2140 2150
DRTNHNLVSE TLSFLDTVCG STKGSLGVFG EIGEHNFSLI TQTLATLTEF
2160 2170 2180 2190 2200
CQGPCHENQN TMAMQENGLN IIISLVLNEI KPLADDHMEL ALEIKSQASK
2210 2220 2230 2240 2250
LLLAIMESRH DGENANRVLR NMANMSGGPK QLVHAIKQAY EMTNSNHHML
2260 2270 2280 2290 2300
KSISRDLFRQ AEDDLKKKSG PQITVNTVTL PEINVDASGI VSIHTEKNIS
2310 2320 2330 2340 2350
SSLDDKFNDD DIPSVDPREV GHNIYILAHQ LAIHDGELEI WLDGSDEKKD
2360 2370 2380 2390 2400
DLTREALNYY KERTAQIEIV RRDRTLERVV FPINDICSYL TKDTKDYVYN
2410 2420 2430 2440 2450
NTERDNQGSK VTEFFDEWET MYHEMIWQRK LQDRKWLSWC AFRLPLWTRL
2460 2470 2480 2490 2500
SFHFAFIVNA LVARYYPLPE HSNSSISLGN LYSWFAVFSS FLLAHYLRHD
2510 2520 2530 2540 2550
KIYLHKTSLL ILASLCFLLL SSIGVTLTLY IFGILQLVNK IVHVVAFVSN
2560 2570 2580 2590 2600
KGLEDRPIAE ILACRNLHYL LVYLFICILG LLVHPMIYCI LLFDIIFTEE
2610 2620 2630 2640 2650
TLQNVIASVT RNYQSIVWTG LLALILLYFF SILGFLYFRH DFYLEVDPVE
2660 2670 2680 2690 2700
NDSSATISSG IPSETCPSEG CPGLQPSEKD DNDDEKKVKS CETLWMCILQ
2710 2720 2730 2740 2750
TGYQGLRNGG GIGDVLRNPA PWEDMFIWRV AYDMTFFVVL IVIVLNLIFG
2760 2770 2780 2790 2800
VIIDTFGDLR AEKNEKEQIL KNNCFICGLD RSRFDNRSVT FETHRETEHN
2810 2820 2830 2840 2850
IWHYLYYIVM LQIKDETEFT GPESYVAQCV KDRNLDWFPR MQALSLQDSE
2860 2870 2880 2890
LDTDQSEVKQ MKDQLLQMMT LMREIISQNE ESRAFMEQFQ PR
The sequence of this isoform differs from the canonical sequence as follows:
1-46: Missing.
47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
423-430: RASLIYSK → PPLLSALSQKSRPMLER
1853-1853: G → GHRVYNSSVEKG
1998-2006: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-46: Missing.
47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
1731-1759: RLNRQNTLNPGHRLYGTSNSMTEHTSANV → PVITLVVETQSSKYAQSWSSTLWNIKLYD
1760-2892: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-46: Missing.
47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
1730-1730: K → KMSQDSQSDYDSDSSQGPCQIS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053337 | 1 – 56 | Missing in isoform d. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_053338 | 1 – 46 | Missing in isoform e, isoform f, isoform g and isoform h. 2 PublicationsAdd BLAST | 46 | |
Alternative sequenceiVSP_053339 | 47 – 61 | FDFDD…MRKSS → MDYDYRRRVLERNIG in isoform e, isoform f, isoform g and isoform h. 2 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_053340 | 423 – 430 | RASLIYSK → PPLLSALSQKSRPMLER in isoform e. 1 Publication | 8 | |
Alternative sequenceiVSP_053341 | 1730 | K → KMSQDSQSDYDSDSSQGPCQ IS in isoform h. Curated | 1 | |
Alternative sequenceiVSP_053342 | 1731 – 1759 | RLNRQ…TSANV → PVITLVVETQSSKYAQSWSS TLWNIKLYD in isoform g. CuratedAdd BLAST | 29 | |
Alternative sequenceiVSP_053345 | 1760 – 2892 | Missing in isoform g. CuratedAdd BLAST | 1133 | |
Alternative sequenceiVSP_053343 | 1853 | G → GHRVYNSSVEKG in isoform e. 1 Publication | 1 | |
Alternative sequenceiVSP_053344 | 1998 – 2006 | Missing in isoform e. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF168688 mRNA Translation: AAF05302.1 AJ243179 mRNA Translation: CAB45860.1 AJ243180 mRNA Translation: CAB45861.1 AJ243181 mRNA Translation: CAB45862.1 AJ243182 mRNA Translation: CAB45863.1 FO080445 Genomic DNA Translation: CCD63763.1 FO080445 Genomic DNA Translation: CCD63764.1 FO080445 Genomic DNA Translation: CCD63765.1 FO080445 Genomic DNA Translation: CCD63766.1 FO080445 Genomic DNA Translation: CCD63767.1 FO080445 Genomic DNA Translation: CCD63775.1 |
RefSeqi | NP_001023170.1, NM_001027999.3 [Q9Y0A1-1] NP_001023171.1, NM_001028000.3 [Q9Y0A1-2] NP_001023172.1, NM_001028001.2 [Q9Y0A1-3] NP_001023173.1, NM_001028002.2 [Q9Y0A1-4] NP_001023174.1, NM_001028003.2 NP_001255305.1, NM_001268376.1 [Q9Y0A1-6] |
Genome annotation databases
EnsemblMetazoai | F33D4.2a.1; F33D4.2a.1; WBGene00002173 [Q9Y0A1-1] F33D4.2d.1; F33D4.2d.1; WBGene00002173 [Q9Y0A1-2] F33D4.2e.1; F33D4.2e.1; WBGene00002173 [Q9Y0A1-3] F33D4.2f.1; F33D4.2f.1; WBGene00002173 [Q9Y0A1-4] F33D4.2g.1; F33D4.2g.1; WBGene00002173 [Q9Y0A1-5] F33D4.2h.1; F33D4.2h.1; WBGene00002173 [Q9Y0A1-6] |
GeneIDi | 177546 |
KEGGi | cel:CELE_F33D4.2 |
UCSCi | F33D4.2a.2, c. elegans |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF168688 mRNA Translation: AAF05302.1 AJ243179 mRNA Translation: CAB45860.1 AJ243180 mRNA Translation: CAB45861.1 AJ243181 mRNA Translation: CAB45862.1 AJ243182 mRNA Translation: CAB45863.1 FO080445 Genomic DNA Translation: CCD63763.1 FO080445 Genomic DNA Translation: CCD63764.1 FO080445 Genomic DNA Translation: CCD63765.1 FO080445 Genomic DNA Translation: CCD63766.1 FO080445 Genomic DNA Translation: CCD63767.1 FO080445 Genomic DNA Translation: CCD63775.1 |
RefSeqi | NP_001023170.1, NM_001027999.3 [Q9Y0A1-1] NP_001023171.1, NM_001028000.3 [Q9Y0A1-2] NP_001023172.1, NM_001028001.2 [Q9Y0A1-3] NP_001023173.1, NM_001028002.2 [Q9Y0A1-4] NP_001023174.1, NM_001028003.2 NP_001255305.1, NM_001268376.1 [Q9Y0A1-6] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 42664, 21 interactors |
STRINGi | 6239.F33D4.2a |
Protein family/group databases
TCDBi | 1.A.3.2.16, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family |
Proteomic databases
EPDi | Q9Y0A1 |
PaxDbi | Q9Y0A1 |
PeptideAtlasi | Q9Y0A1 |
PRIDEi | Q9Y0A1 |
Genome annotation databases
EnsemblMetazoai | F33D4.2a.1; F33D4.2a.1; WBGene00002173 [Q9Y0A1-1] F33D4.2d.1; F33D4.2d.1; WBGene00002173 [Q9Y0A1-2] F33D4.2e.1; F33D4.2e.1; WBGene00002173 [Q9Y0A1-3] F33D4.2f.1; F33D4.2f.1; WBGene00002173 [Q9Y0A1-4] F33D4.2g.1; F33D4.2g.1; WBGene00002173 [Q9Y0A1-5] F33D4.2h.1; F33D4.2h.1; WBGene00002173 [Q9Y0A1-6] |
GeneIDi | 177546 |
KEGGi | cel:CELE_F33D4.2 |
UCSCi | F33D4.2a.2, c. elegans |
Organism-specific databases
CTDi | 177546 |
WormBasei | F33D4.2a ; CE37905 ; WBGene00002173 ; itr-1 F33D4.2d ; CE37906 ; WBGene00002173 ; itr-1 F33D4.2e ; CE28017 ; WBGene00002173 ; itr-1 F33D4.2f ; CE28018 ; WBGene00002173 ; itr-1 F33D4.2g ; CE31690 ; WBGene00002173 ; itr-1 F33D4.2h ; CE44684 ; WBGene00002173 ; itr-1 |
Phylogenomic databases
eggNOGi | KOG3533, Eukaryota |
GeneTreei | ENSGT00940000167397 |
InParanoidi | Q9Y0A1 |
OMAi | MKLAHQF |
OrthoDBi | 94996at2759 |
PhylomeDBi | Q9Y0A1 |
Enzyme and pathway databases
Reactomei | R-CEL-114508, Effects of PIP2 hydrolysis R-CEL-139853, Elevation of cytosolic Ca2+ levels R-CEL-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-CEL-5578775, Ion homeostasis R-CEL-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
PROi | PR:Q9Y0A1 |
Gene expression databases
Bgeei | WBGene00002173, Expressed in material anatomical entity and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITPR_CAEEL | |
Accessioni | Q9Y0A1Primary (citable) accession number: Q9Y0A1 Secondary accession number(s): D3NQ87 Q9Y0A0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 16, 2013 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families