Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y0A1 (ITPR_CAEEL)

Entry version 153 (16 Oct 2019)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Inositol 1,4,5-trisphosphate receptor itr-1

Gene

itr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis (PubMed:10499793, PubMed:10610772, PubMed:15194811, PubMed:16186564, PubMed:23671426). Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position (PubMed:10610772). Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity (PubMed:10610772). Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (PubMed:10499793, PubMed:11553721, PubMed:12062062, PubMed:11950942, PubMed:15013747, PubMed:15133127, PubMed:16186564, PubMed:21191812). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (PubMed:9491893, PubMed:15194811, PubMed:16267094, PubMed:15958491). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (PubMed:11950942, PubMed:15498499, PubMed:18369461). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses (PubMed:19730689).17 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-114508 Effects of PIP2 hydrolysis
R-CEL-139853 Elevation of cytosolic Ca2+ levels
R-CEL-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-CEL-5578775 Ion homeostasis
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.3.2.16 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor itr-11 Publication
Alternative name(s):
IP3 receptor1 Publication
Short name:
IP3R1 Publication
Short name:
InsP3R1 Publication
LET-23 fertility effector 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:itr-1Imported
Synonyms:dec-41 Publication, lfe-11 Publication
ORF Names:F33D4.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...WormBasei		F33D4.2a ; CE37905 ; WBGene00002173 ; itr-1
F33D4.2d ; CE37906 ; WBGene00002173 ; itr-1
F33D4.2e ; CE28017 ; WBGene00002173 ; itr-1
F33D4.2f ; CE28018 ; WBGene00002173 ; itr-1
F33D4.2g ; CE31690 ; WBGene00002173 ; itr-1
F33D4.2h ; CE44684 ; WBGene00002173 ; itr-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2475CytoplasmicSequence analysisAdd BLAST2475
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2476 – 2496HelicalSequence analysisAdd BLAST21
Topological domaini2497 – 2514ExtracellularSequence analysisAdd BLAST18
Transmembranei2515 – 2535HelicalSequence analysisAdd BLAST21
Topological domaini2536 – 2572CytoplasmicSequence analysisAdd BLAST37
Transmembranei2573 – 2593HelicalSequence analysisAdd BLAST21
Topological domaini2594 – 2615ExtracellularSequence analysisAdd BLAST22
Transmembranei2616 – 2636HelicalSequence analysisAdd BLAST21
Topological domaini2637 – 2735CytoplasmicSequence analysisAdd BLAST99
Transmembranei2736 – 2756HelicalSequence analysisAdd BLAST21
Topological domaini2757 – 2892ExtracellularSequence analysisAdd BLAST136

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disrupted defecation rhythm with reduced pharyngeal pumping in the presence of food resulting in constipation. Disrupted reversal/avoidance response to nose touch. Hermaphrodites display endomitotic oocytes following spermathecal dilation defect and defective ovulation. Loss of male fertility due to defects in turning behavior, spicule insertion and sperm transfer.4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi103G → E in n2559; slow developmental rate to adulthood, absence of ovulation, sterility, absence of defecation cycle and intestinal calcium oscillations. 1 Publication1
Mutagenesisi371R → K in sy331; reduced fertility and brood size. 2 Publications1
Mutagenesisi557R → C in sy290; gain of function. 2-fold increase in ligand affinity. Increased velocity of posterior-to-anterior calcium wave. Reduced fertility, hyperactive spermathecal dilation leading to decreased brood size. 3 Publications1
Mutagenesisi625K → Q: Abolishes ligand binding; when associated with Q-628. 1 Publication1
Mutagenesisi628R → Q: Abolishes ligand binding; when associated with Q-625. 1 Publication1
Mutagenesisi900S → F in sy328; reduced fertility and brood size. 2 Publications1
Mutagenesisi945L → F in sy327; gain of function. Increased velocity of posterior-to-anterior calcium wave and enhanced sheath contractile activity. 2 Publications1
Mutagenesisi1571C → Y in sa73; slow developmental rate to adulthood, reduced brood size, slow intestinal calcium oscillations, slower pharyngeal pumping, longer defecation cycle, defective ovulation, reduced myoepithelial sheath contractility and reduced efficiency of sperm transfer. 8 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004241501 – 2892Inositol 1,4,5-trisphosphate receptor itr-1Add BLAST2892

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y0A1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y0A1

PeptideAtlas

More...PeptideAtlasi		Q9Y0A1

PRoteomics IDEntifications database

More...PRIDEi		Q9Y0A1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform a is expressed in the anterior cells of the pharyngeal terminal bulb, vulva, rectal epithelial cells, spicule protractor muscles of the proctodeum and male-specific neuron CP8 or CP9. Isoform d is expressed in the spermatheca, excretory cell, amphid socket cells, PDA motor neuron, spicule retractor muscles, gubernaculum retractor muscles, posterior oblique muscles, diagonal muscles and the vas deferens. Also expressed in the intestine, pharynx, pharyngeal isthmus, pharyngeal intestinal valve, somatic gonad, hypodermal cells of the vulva, uterine sheath cells, tail, head, LUA motor neuron and the embryonic epidermis (at protein level).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00002173 Expressed in 4 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with myo-1, myo-2, unc-54/myo-4 and nmy-2.

Also interacts with iri-1.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		42664, 13 interactors

STRING: functional protein association networks

More...STRINGi		6239.F33D4.2a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini192 – 246MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini319 – 379MIR 2PROSITE-ProRule annotationAdd BLAST61
Domaini386 – 466MIR 3PROSITE-ProRule annotationAdd BLAST81
Domaini490 – 551MIR 4PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni357 – 361Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni625 – 628Inositol 1,4,5-trisphosphate binding1 Publication4
Regioni689 – 691Inositol 1,4,5-trisphosphate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.By similarity2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.Sequence analysis

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3533 Eukaryota
ENOG410XR97 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000167397

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007660

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y0A1

KEGG Orthology (KO)

More...KOi		K04958

Identification of Orthologs from Complete Genome Data

More...OMAi		PRHAPYK

Database of Orthologous Groups

More...OrthoDBi		94996at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y0A1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00779 INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472 MIR, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50919 MIR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform a1 Publication (identifier: Q9Y0A1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPSYGRVRK KVSIISIPEF VPEHYEYENE TTASGGASGG GSTRIEFDFD 
        60         70         80         90        100
DFEEQIMRKS SMALPSRKLT IANSIDHGNN GNLHIGDIIS LYTESSSNQE 
       110        120        130        140        150
QRGFLSTLGL VDDRCIVELK DGRPESPPKK FRDCLFKVCP VNRYAAQKHL 
       160        170        180        190        200
WTEQKRFQTG DSMFDDDLMN KLKVAADKER EENESEFQKT LGNVIQYGSM 
       210        220        230        240        250
VQLLHVKSNK YITVQKNSPA KRERNAMKVY LDRAGNEGSW FIIEPAYKHY 
       260        270        280        290        300
AIGDNVSAGN KISLIPNSVS TTQAGHVKSQ LHLSSFNLLD HQSAAEVNCL 
       310        320        330        340        350
NEPTEWQVFM FLLFDENQQN SVKSGDVVRL FHADQQTFLT LDTIPKQNPP 
       360        370        380        390        400
TDVVFLRMTN RPSAADATSS RALWEVQVVQ TNAYRGGTAK WNKAYRFKHL 
       410        420        430        440        450
ATDMYLSAEP SQVQVKPAMN GRRASLIYSK TNNPMAMYSD GPNGVTNEST 
       460        470        480        490        500
DTTQQNIPSV WVLGPTKSEF PEEDANLLFQ LDPSTFMKSN KEVPRRSYVR 
       510        520        530        540        550
LLHQSSDKWV HATNATEKQN LHYSSKNEKG WVKVICEKNR VDKETFALLP 
       560        570        580        590        600
VNPDEVRDLD FANDACKALR NFIKLIKIGQ VISKESINST TQLLIDCILF 
       610        620        630        640        650
VTNSSDHLAD PLKISDFSPS RDRQKLLREQ EVLNQVFLLL KAPFLPRQGT 
       660        670        680        690        700
TELGPLLSSP SELSDSRNEI FKTMFQLCYC LLKYSQVSYR KNQEFLAEKF 
       710        720        730        740        750
GEIQEQIGFD LMAEDTMTAV LHNNPKLLEK YVKTPHVERF VELVRNNRQG 
       760        770        780        790        800
KFLDYLADLC VCRGEANKKI QELICTSVLS SKHRDIFMDT KIIDGEIEVG 
       810        820        830        840        850
WAPNFRKLVD IAEGAKSNSD DAEHLDYYRH QLDLLSQMCQ EQQYLAIDPP 
       860        870        880        890        900
PERRLMNISQ QLPAELVLQC MSDNRLPYDL RGSFTRLMLH LHVVRGSPMS 
       910        920        930        940        950
AIRHARLWWS IPENVNVSTY ESVSVEAYSD GSRMRIGEGI AHKVLATVET 
       960        970        980        990       1000
YLMGLRNQSM EERQSVNSSK LTYEIVNLAK ALAQFNFYSF NDLLQLTQNL 
      1010       1020       1030       1040       1050
LAIINEGPAT EQVPSHRAMV NAIRNMSKSM MRGGNKENSK DLAKTPSVTA 
      1060       1070       1080       1090       1100
EEAGRTKEGR ALNVKTKLIV AEILQFVMDV RRDYRITMAL SWFKNVFPCD 
      1110       1120       1130       1140       1150
EDGSLMHSAS INERMASELY DAIYRSSGHE LHLDGRDGQL LLAILLQMTM 
      1160       1170       1180       1190       1200
SDYPPLTSIA LKVFFRHFTQ YQELLEDLKQ VQLLVSNNDV ENYRQIDRDL 
      1210       1220       1230       1240       1250
FILKNLTEKS ELWVHGDRHH SIDTKEVDEK ERTTEHDLLD HDLKSPRAFD 
      1260       1270       1280       1290       1300
SGDSMEALMA VLNEHYPSIR NECLQLLNRL LIKDDRNDAA VALQELSDKA 
      1310       1320       1330       1340       1350
PLIAYPLIRQ MLVRLTGMCY RKGDPKPDTM NQQLLKNMRV YEVVLEFISV 
      1360       1370       1380       1390       1400
PHDKKHDHDM MKLITLSHEF LRSFCKTNKE NQSRLYKFIS YEKDAKEGML 
      1410       1420       1430       1440       1450
RVETIEEVGT LVAIFRNNRE LASNVPEELI AHIVGLIEHN SRNPIFLELL 
      1460       1470       1480       1490       1500
QALVCVYDKE IESGQEKVAN EICAASDEVR QLYVDNASFE ELEAMMKDEK 
      1510       1520       1530       1540       1550
ESKGRSSDSR RKLKYHIELV RLLAMCTRGK NGNTELKCAS QIPMDHIVRV 
      1560       1570       1580       1590       1600
VTAKQCLVEV KTVYLQLLLH CYIDTDAEMK DAYKTEYVDH ILNNLLEDIR 
      1610       1620       1630       1640       1650
SLRVEKLTGA ETATLEHYIC HTVTEVLIKF FEAPYSALQQ AKVDVHHHKK 
      1660       1670       1680       1690       1700
TFSEVLLELT YLEKGKLRGS KSSRNWYRVA ECIKRLTKWA EEHNITLPAT 
      1710       1720       1730       1740       1750
LAGPQMSGQT SVRQKWQQAA SSAKWIGIGK RLNRQNTLNP GHRLYGTSNS 
      1760       1770       1780       1790       1800
MTEHTSANVV TCYHMMIGEF KFYLHPLHAA EGSVLVEVLH TPELLFPEGS 
      1810       1820       1830       1840       1850
ALRDQCARGG VVAKLIQHCK TLMQNKQDNL CARVLQTLCK MCDCTKQQLT 
      1860       1870       1880       1890       1900
HQGQQLRQLL LQRYFGHHNN HHPPLDRQQS KIGEVIEAVK EKKEETWSQE 
      1910       1920       1930       1940       1950
RDLYAIQCKL NDAGASDLVT DIIIMEPSRE IFLKAIHLAR ALLHEGNDKV 
      1960       1970       1980       1990       2000
QHSFYMRMKQ KDIHEPFFKA ILTRIQTAQN RLKSDMMSCS DSKPKVSLSA 
      2010       2020       2030       2040       2050
TVSRRSSTVL TPLIDAGDTG FNGALFEVPQ QVRHPSISEM SQLSNDLTHS 
      2060       2070       2080       2090       2100
IPDLAPYQDE EKSTDALPPE VALVEPILRV LQLLCENHNS LLQNFLRKQS 
      2110       2120       2130       2140       2150
DRTNHNLVSE TLSFLDTVCG STKGSLGVFG EIGEHNFSLI TQTLATLTEF 
      2160       2170       2180       2190       2200
CQGPCHENQN TMAMQENGLN IIISLVLNEI KPLADDHMEL ALEIKSQASK 
      2210       2220       2230       2240       2250
LLLAIMESRH DGENANRVLR NMANMSGGPK QLVHAIKQAY EMTNSNHHML 
      2260       2270       2280       2290       2300
KSISRDLFRQ AEDDLKKKSG PQITVNTVTL PEINVDASGI VSIHTEKNIS 
      2310       2320       2330       2340       2350
SSLDDKFNDD DIPSVDPREV GHNIYILAHQ LAIHDGELEI WLDGSDEKKD 
      2360       2370       2380       2390       2400
DLTREALNYY KERTAQIEIV RRDRTLERVV FPINDICSYL TKDTKDYVYN 
      2410       2420       2430       2440       2450
NTERDNQGSK VTEFFDEWET MYHEMIWQRK LQDRKWLSWC AFRLPLWTRL 
      2460       2470       2480       2490       2500
SFHFAFIVNA LVARYYPLPE HSNSSISLGN LYSWFAVFSS FLLAHYLRHD 
      2510       2520       2530       2540       2550
KIYLHKTSLL ILASLCFLLL SSIGVTLTLY IFGILQLVNK IVHVVAFVSN 
      2560       2570       2580       2590       2600
KGLEDRPIAE ILACRNLHYL LVYLFICILG LLVHPMIYCI LLFDIIFTEE 
      2610       2620       2630       2640       2650
TLQNVIASVT RNYQSIVWTG LLALILLYFF SILGFLYFRH DFYLEVDPVE 
      2660       2670       2680       2690       2700
NDSSATISSG IPSETCPSEG CPGLQPSEKD DNDDEKKVKS CETLWMCILQ 
      2710       2720       2730       2740       2750
TGYQGLRNGG GIGDVLRNPA PWEDMFIWRV AYDMTFFVVL IVIVLNLIFG 
      2760       2770       2780       2790       2800
VIIDTFGDLR AEKNEKEQIL KNNCFICGLD RSRFDNRSVT FETHRETEHN 
      2810       2820       2830       2840       2850
IWHYLYYIVM LQIKDETEFT GPESYVAQCV KDRNLDWFPR MQALSLQDSE 
      2860       2870       2880       2890 
LDTDQSEVKQ MKDQLLQMMT LMREIISQNE ESRAFMEQFQ PR
Note: Produced by alternative promoter usage.1 Publication
Length:2,892
Mass (Da):330,837
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1C598FE554B83CF
GO
Isoform d1 Publication (identifier: Q9Y0A1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: Produced by alternative promoter usage.1 Publication
Show »
Length:2,836
Mass (Da):324,566
Checksum:i3A2385BC8AC870F9
GO
Isoform e2 Publications (identifier: Q9Y0A1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
     423-430: RASLIYSK → PPLLSALSQKSRPMLER
     1853-1853: G → GHRVYNSSVEKG
     1998-2006: Missing.

Note: Produced by alternative promoter usage and alternative splicing.2 Publications
Show »
Length:2,857
Mass (Da):327,200
Checksum:i8B991F12BEC94E2F
GO
Isoform f2 Publications (identifier: Q9Y0A1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG

Note: Produced by alternative promoter usage and alternative splicing.2 Publications
Show »
Length:2,846
Mass (Da):325,914
Checksum:i0186413338AB3BA2
GO
Isoform gCurated (identifier: Q9Y0A1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
     1731-1759: RLNRQNTLNPGHRLYGTSNSMTEHTSANV → PVITLVVETQSSKYAQSWSSTLWNIKLYD
     1760-2892: Missing.

Note: Produced by alternative promoter usage and alternative splicing.Curated
Show »
Length:1,713
Mass (Da):196,076
Checksum:i5FEDC945C48A2A2C
GO
Isoform hCurated (identifier: Q9Y0A1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     47-61: FDFDDFEEQIMRKSS → MDYDYRRRVLERNIG
     1730-1730: K → KMSQDSQSDYDSDSSQGPCQIS

Note: Produced by alternative promoter usage and alternative splicing.Curated
Show »
Length:2,867
Mass (Da):328,162
Checksum:iADC0DFB98DF8150C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0533371 – 56Missing in isoform d. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0533381 – 46Missing in isoform e, isoform f, isoform g and isoform h. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_05333947 – 61FDFDD…MRKSS → MDYDYRRRVLERNIG in isoform e, isoform f, isoform g and isoform h. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_053340423 – 430RASLIYSK → PPLLSALSQKSRPMLER in isoform e. 1 Publication8
Alternative sequenceiVSP_0533411730K → KMSQDSQSDYDSDSSQGPCQ IS in isoform h. Curated1
Alternative sequenceiVSP_0533421731 – 1759RLNRQ…TSANV → PVITLVVETQSSKYAQSWSS TLWNIKLYD in isoform g. CuratedAdd BLAST29
Alternative sequenceiVSP_0533451760 – 2892Missing in isoform g. CuratedAdd BLAST1133
Alternative sequenceiVSP_0533431853G → GHRVYNSSVEKG in isoform e. 1 Publication1
Alternative sequenceiVSP_0533441998 – 2006Missing in isoform e. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF168688 mRNA Translation: AAF05302.1
AJ243179 mRNA Translation: CAB45860.1
AJ243180 mRNA Translation: CAB45861.1
AJ243181 mRNA Translation: CAB45862.1
AJ243182 mRNA Translation: CAB45863.1
FO080445 Genomic DNA Translation: CCD63763.1
FO080445 Genomic DNA Translation: CCD63764.1
FO080445 Genomic DNA Translation: CCD63765.1
FO080445 Genomic DNA Translation: CCD63766.1
FO080445 Genomic DNA Translation: CCD63767.1
FO080445 Genomic DNA Translation: CCD63775.1

NCBI Reference Sequences

More...RefSeqi		NP_001023170.1, NM_001027999.3 [Q9Y0A1-1]
NP_001023171.1, NM_001028000.3 [Q9Y0A1-2]
NP_001023172.1, NM_001028001.2 [Q9Y0A1-3]
NP_001023173.1, NM_001028002.2 [Q9Y0A1-4]
NP_001023174.1, NM_001028003.2 [Q9Y0A1-5]
NP_001255305.1, NM_001268376.1 [Q9Y0A1-6]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		F33D4.2a.1; F33D4.2a.1; WBGene00002173 [Q9Y0A1-1]
F33D4.2d.1; F33D4.2d.1; WBGene00002173 [Q9Y0A1-2]
F33D4.2e.1; F33D4.2e.1; WBGene00002173 [Q9Y0A1-3]
F33D4.2f.1; F33D4.2f.1; WBGene00002173 [Q9Y0A1-4]
F33D4.2g.1; F33D4.2g.1; WBGene00002173 [Q9Y0A1-5]
F33D4.2h.1; F33D4.2h.1; WBGene00002173 [Q9Y0A1-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		177546

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_F33D4.2

UCSC genome browser

More...UCSCi		F33D4.2a.2 c. elegans

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168688 mRNA Translation: AAF05302.1
AJ243179 mRNA Translation: CAB45860.1
AJ243180 mRNA Translation: CAB45861.1
AJ243181 mRNA Translation: CAB45862.1
AJ243182 mRNA Translation: CAB45863.1
FO080445 Genomic DNA Translation: CCD63763.1
FO080445 Genomic DNA Translation: CCD63764.1
FO080445 Genomic DNA Translation: CCD63765.1
FO080445 Genomic DNA Translation: CCD63766.1
FO080445 Genomic DNA Translation: CCD63767.1
FO080445 Genomic DNA Translation: CCD63775.1
RefSeqiNP_001023170.1, NM_001027999.3 [Q9Y0A1-1]
NP_001023171.1, NM_001028000.3 [Q9Y0A1-2]
NP_001023172.1, NM_001028001.2 [Q9Y0A1-3]
NP_001023173.1, NM_001028002.2 [Q9Y0A1-4]
NP_001023174.1, NM_001028003.2 [Q9Y0A1-5]
NP_001255305.1, NM_001268376.1 [Q9Y0A1-6]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi42664, 13 interactors
STRINGi6239.F33D4.2a

Protein family/group databases

TCDBi1.A.3.2.16 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Proteomic databases

EPDiQ9Y0A1
PaxDbiQ9Y0A1
PeptideAtlasiQ9Y0A1
PRIDEiQ9Y0A1

Genome annotation databases

EnsemblMetazoaiF33D4.2a.1; F33D4.2a.1; WBGene00002173 [Q9Y0A1-1]
F33D4.2d.1; F33D4.2d.1; WBGene00002173 [Q9Y0A1-2]
F33D4.2e.1; F33D4.2e.1; WBGene00002173 [Q9Y0A1-3]
F33D4.2f.1; F33D4.2f.1; WBGene00002173 [Q9Y0A1-4]
F33D4.2g.1; F33D4.2g.1; WBGene00002173 [Q9Y0A1-5]
F33D4.2h.1; F33D4.2h.1; WBGene00002173 [Q9Y0A1-6]
GeneIDi177546
KEGGicel:CELE_F33D4.2
UCSCiF33D4.2a.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		177546
WormBaseiF33D4.2a ; CE37905 ; WBGene00002173 ; itr-1
F33D4.2d ; CE37906 ; WBGene00002173 ; itr-1
F33D4.2e ; CE28017 ; WBGene00002173 ; itr-1
F33D4.2f ; CE28018 ; WBGene00002173 ; itr-1
F33D4.2g ; CE31690 ; WBGene00002173 ; itr-1
F33D4.2h ; CE44684 ; WBGene00002173 ; itr-1

Phylogenomic databases

eggNOGiKOG3533 Eukaryota
ENOG410XR97 LUCA
GeneTreeiENSGT00940000167397
HOGENOMiHOG000007660
InParanoidiQ9Y0A1
KOiK04958
OMAiPRHAPYK
OrthoDBi94996at2759
PhylomeDBiQ9Y0A1

Enzyme and pathway databases

ReactomeiR-CEL-114508 Effects of PIP2 hydrolysis
R-CEL-139853 Elevation of cytosolic Ca2+ levels
R-CEL-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-CEL-5578775 Ion homeostasis
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9Y0A1

Gene expression databases

BgeeiWBGene00002173 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPR_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y0A1
Secondary accession number(s): D3NQ87
, G5EBF6, Q8MXI9, Q9U3B3, Q9Y0A0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: November 1, 1999
Last modified: October 16, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again