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Entry version 111 (02 Dec 2020)
Sequence version 2 (23 Oct 2007)
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Protein

Pre-mRNA-splicing regulator female-lethal(2)D

Gene

fl(2)d

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:1695150, PubMed:27919077). M6A methylation is also required for neuronal functions (PubMed:27919077). Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b (PubMed:10101174).1 Publication2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, mRNA processing, mRNA splicing, Sexual differentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-72203, Processing of Capped Intron-Containing Pre-mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing regulator female-lethal(2)D1 Publication
Alternative name(s):
dFL(2)D1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fl(2)d1 PublicationImported
ORF Names:CG6315Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000662, fl(2)d

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003086301 – 536Pre-mRNA-splicing regulator female-lethal(2)DAdd BLAST536

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y091

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y091

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed in early embryonic stages with enrichment in the neuroectoderm at later stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000662, Expressed in cleaving embryo and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y091, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y091, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27919077, PubMed:28675155, PubMed:29535189, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:29535189, PubMed:29555755). The MACOM subcomplex is composed of fl2d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:27919077, PubMed:28675155, PubMed:29535189, PubMed:29555755).

Interacts with vir and msk (PubMed:12444081).

Part of a complex containing fl2d, Sxl and vir (PubMed:12444081).

5 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62282, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y091, 34 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086773

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y091

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili254 – 319Sequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 69His-richAdd BLAST14
Compositional biasi70 – 164Gln-richAdd BLAST95
Compositional biasi400 – 403Poly-Val4
Compositional biasi475 – 481Poly-Ala7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fl(2)d family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2991, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013931

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038094_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y091

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQQCADA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y091

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033757, WTAP
IPR029732, WTAP/Mum2

The PANTHER Classification System

More...
PANTHERi
PTHR15217, PTHR15217, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17098, Wtap, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q9Y091-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVAAMTMDD QRPCMNSYDK MPPTKYEQNL NILNSSQNSG ATGGPASPTP
60 70 80 90 100
SGLEDHHHHH HPHPHHHHHQ EQQQQQQQQQ HLQQQQQQQQ QQHAAAVAEA
110 120 130 140 150
VAAAEQRQRL LEDEIENLKL EQVRMAQQCA DAQRREKILM RRLANKEQEF
160 170 180 190 200
QDYVSQIAEY KAQQAPTALA LRTALLDPAV NLLFERLKKE LKATKAKLEE
210 220 230 240 250
TQNELSAWKF TPDSNTGKRL MAKCRLLYQE NEELGKMTSN GRLAKLETEL
260 270 280 290 300
AMQKSFSEEV KKSQSELDDF LQELDEDVEG MQSTILFLQQ ELKTTRDRIQ
310 320 330 340 350
TLEKENAQLK QAIKDEVVAP AAATNGGTNT TINKLETIHE DACMANNPTN
360 370 380 390 400
PDCYNGNTNN EQIAAVPQIP LSDDGSNMNG NAARLARKRN YQEEEALPTV
410 420 430 440 450
VVVPTPTPVG NNVQEAPPIR EVTAPRTLPP KKSKLRGITT RRNSQLEEDH
460 470 480 490 500
QPVTTPVAVP MIVDNAVAGM ASEEAAAAAA AVNNSNTGII PETGVQVGVP
510 520 530
VEGGDPGAPA APGRILTRRR SVRMQQNGSG AVDYST
Note: Major.
Length:536
Mass (Da):59,268
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i732DF06E999ECBEF
GO
Isoform B (identifier: Q9Y091-2) [UniParc]FASTAAdd to basket
Also known as: s

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Note: Minor.Curated
Show »
Length:412
Mass (Da):45,100
Checksum:iEC8782C615653DD2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K713A0A0B4K713_DROME
Female lethal d, isoform C
fl(2)d Dmel\CG6315, Fl(2)d, Fl(2d), v(2)k16105, CG6315
412Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71E → EQ in CAB46637 (PubMed:10790389).Curated1
Sequence conflicti82L → LQQ in CAB46637 (PubMed:10790389).Curated1
Sequence conflicti366V → A in CAB46637 (PubMed:10790389).Curated1
Sequence conflicti366V → A in CAB46726 (PubMed:10790389).Curated1
Sequence conflicti371L → P in CAB46637 (PubMed:10790389).Curated1
Sequence conflicti371L → P in CAB46726 (PubMed:10790389).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0290411 – 124Missing in isoform B. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ243599 mRNA Translation: CAB46637.1
AJ243607 mRNA Translation: CAB46726.1
AE013599 Genomic DNA Translation: AAF58334.1
AE013599 Genomic DNA Translation: AAM71007.1
AY069478 mRNA Translation: AAL39623.1

NCBI Reference Sequences

More...
RefSeqi
NP_001246305.1, NM_001259376.2 [Q9Y091-2]
NP_001246306.1, NM_001259377.2 [Q9Y091-2]
NP_523732.2, NM_079008.4 [Q9Y091-1]
NP_725327.1, NM_166010.3 [Q9Y091-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087647; FBpp0086773; FBgn0000662 [Q9Y091-1]
FBtr0087648; FBpp0086774; FBgn0000662 [Q9Y091-2]
FBtr0304696; FBpp0293239; FBgn0000662 [Q9Y091-2]
FBtr0304697; FBpp0293240; FBgn0000662 [Q9Y091-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6315

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243599 mRNA Translation: CAB46637.1
AJ243607 mRNA Translation: CAB46726.1
AE013599 Genomic DNA Translation: AAF58334.1
AE013599 Genomic DNA Translation: AAM71007.1
AY069478 mRNA Translation: AAL39623.1
RefSeqiNP_001246305.1, NM_001259376.2 [Q9Y091-2]
NP_001246306.1, NM_001259377.2 [Q9Y091-2]
NP_523732.2, NM_079008.4 [Q9Y091-1]
NP_725327.1, NM_166010.3 [Q9Y091-2]

3D structure databases

SMRiQ9Y091
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi62282, 31 interactors
IntActiQ9Y091, 34 interactors
STRINGi7227.FBpp0086773

Proteomic databases

PaxDbiQ9Y091
PRIDEiQ9Y091

Genome annotation databases

EnsemblMetazoaiFBtr0087647; FBpp0086773; FBgn0000662 [Q9Y091-1]
FBtr0087648; FBpp0086774; FBgn0000662 [Q9Y091-2]
FBtr0304696; FBpp0293239; FBgn0000662 [Q9Y091-2]
FBtr0304697; FBpp0293240; FBgn0000662 [Q9Y091-2]
GeneIDi36527
KEGGidme:Dmel_CG6315

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36527
FlyBaseiFBgn0000662, fl(2)d

Phylogenomic databases

eggNOGiKOG2991, Eukaryota
GeneTreeiENSGT00390000013931
HOGENOMiCLU_038094_0_0_1
InParanoidiQ9Y091
OMAiGQQCADA
PhylomeDBiQ9Y091

Enzyme and pathway databases

ReactomeiR-DME-72203, Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36527, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36527

Protein Ontology

More...
PROi
PR:Q9Y091

Gene expression databases

BgeeiFBgn0000662, Expressed in cleaving embryo and 39 other tissues
ExpressionAtlasiQ9Y091, baseline and differential
GenevisibleiQ9Y091, DM

Family and domain databases

InterProiView protein in InterPro
IPR033757, WTAP
IPR029732, WTAP/Mum2
PANTHERiPTHR15217, PTHR15217, 1 hit
PfamiView protein in Pfam
PF17098, Wtap, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFL2D_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y091
Secondary accession number(s): A1Z9H6
, Q7K100, Q7KA73, Q9U974
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: December 2, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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