UniProtKB - Q9XZI6 (PICAL_CAEEL)
Phosphatidylinositol-binding clathrin assembly protein unc-11
unc-11
Functioni
Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin.
1 PublicationGO - Molecular functioni
- 1-phosphatidylinositol binding Source: UniProtKB
- clathrin binding Source: WormBase
- clathrin heavy chain binding Source: GO_Central
- phosphatidylinositol-4,5-bisphosphate binding Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- clathrin coat assembly Source: InterPro
- clathrin-dependent endocytosis Source: GO_Central
- locomotion Source: WormBase
- positive regulation of necrotic cell death Source: WormBase
- post-embryonic development Source: WormBase
- protein localization to postsynaptic membrane Source: UniProtKB
- receptor-mediated endocytosis Source: UniProtKB
- regulation of receptor localization to synapse Source: UniProtKB
- synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central
- synaptic vesicle endocytosis Source: WormBase
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- vesicle budding from membrane Source: GO_Central
Keywordsi
Biological process | Endocytosis |
Enzyme and pathway databases
Reactomei | R-CEL-432722, Golgi Associated Vesicle Biogenesis R-CEL-8856825, Cargo recognition for clathrin-mediated endocytosis R-CEL-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol-binding clathrin assembly protein unc-11Alternative name(s): AP180-like adaptor protein Uncoordinated protein 11 |
Gene namesi | Name:unc-11 ORF Names:C32E8.10 |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C32E8.10a ; CE23562 ; WBGene00006751 ; unc-11 C32E8.10b ; CE27812 ; WBGene00006751 ; unc-11 C32E8.10c ; CE24822 ; WBGene00006751 ; unc-11 C32E8.10d ; CE23564 ; WBGene00006751 ; unc-11 C32E8.10e ; CE23565 ; WBGene00006751 ; unc-11 C32E8.10f ; CE23566 ; WBGene00006751 ; unc-11 C32E8.10h ; CE27813 ; WBGene00006751 ; unc-11 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- clathrin-coated pit 1 Publication
- clathrin-coated vesicle 1 Publication
Note: Colocalized with clathrin in the Golgi area.
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- clathrin-coated pit Source: UniProtKB
- extrinsic component of presynaptic endocytic zone membrane Source: GO_Central
- presynaptic membrane Source: WormBase
Other locations
- clathrin-coated vesicle Source: GO_Central
- synaptic vesicle Source: GO_Central
Keywords - Cellular componenti
Coated pit, Cytoplasmic vesicle, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187065 | 1 – 586 | Phosphatidylinositol-binding clathrin assembly protein unc-11Add BLAST | 586 |
Proteomic databases
EPDi | Q9XZI6 |
PeptideAtlasi | Q9XZI6 |
PTM databases
iPTMneti | Q9XZI6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | WBGene00006751, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues |
Interactioni
Subunit structurei
Binds clathrin and phosphatidylinositol 4,5-bisphosphate.
By similarityBinary interactionsi
Q9XZI6
With | #Exp. | IntAct |
---|---|---|
eya-1 [O17670] | 4 | EBI-311866,EBI-311862 |
itsn-1 [Q9U2T9] | 3 | EBI-311866,EBI-2414252 |
magu-1 [Q95XW5] | 3 | EBI-311866,EBI-2317194 |
sorb-1 [G5EC32] | 3 | EBI-311866,EBI-325337 |
GO - Molecular functioni
- clathrin binding Source: WormBase
- clathrin heavy chain binding Source: GO_Central
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 37426, 10 interactors |
DIPi | DIP-25315N |
IntActi | Q9XZI6, 8 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 161 | ENTHPROSITE-ProRule annotationCuratedAdd BLAST | 133 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 450 – 474 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183068 |
InParanoidi | Q9XZI6 |
OMAi | PAQQTPW |
OrthoDBi | 755817at2759 |
PhylomeDBi | Q9XZI6 |
Family and domain databases
Gene3Di | 1.20.58.150, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR011417, ANTH_dom IPR014712, ANTH_dom_sf IPR045192, AP180-like IPR013809, ENTH IPR008942, ENTH_VHS |
PANTHERi | PTHR22951, PTHR22951, 1 hit |
Pfami | View protein in Pfam PF07651, ANTH, 1 hit |
SMARTi | View protein in SMART SM00273, ENTH, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50942, ENTH, 1 hit |
s (9)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQTIEKALHQ PMPFTTGGQT ISDRLTAAKH SLAGSQLGKT ICKATTEEVM
60 70 80 90 100
APKKKHLDYL LHCTNEPNVS IPSMANLLIE RTQNPNWTVV YKALITIHNI
110 120 130 140 150
MCYGNERFSQ YLASCNTTFN LTAFVDKVGG AGGYDMSTHV RRYAKYIGEK
160 170 180 190 200
INTYRMCAFD FCKVKRGRED GLLRTMHTDK LLKTIPILQN QIDALLEFSV
210 220 230 240 250
TTSELNNGVI NCSFILLFRD LIRLFACYND GIINVLEKYF DMNKKQCRDA
260 270 280 290 300
LDTYKSFLTR LDKVAEFLRV AESVGIDRGE IPDLTRAPAS LLEALEAHLI
310 320 330 340 350
HLEGGKAPPP TQQHVAPHQF TTGFAFSQQP QPALGDAERQ RYIELEQERL
360 370 380 390 400
RQFEDQKKSI NSANPFANDV ASAAPAPATS AAQPDLLDMF QSSAAPAPQT
410 420 430 440 450
ADVTNPFGNF AAPSAFPTNV PPPAAHSAPF GVQPAPQHSA APFYANLHQA
460 470 480 490 500
PPMQSQAPNG HQAAPFGYPN AHPDDLARMT AQMSLNQQGA PAGWNTTTSA
510 520 530 540 550
VSNNPFGATS APQPMYTAPM GMYQQPFGAQ PMWNPAMAAY GQQYGYGQPV
560 570 580
PPQQQHQIQL VHAAMAAKNA AQAQQAQAAS ADPFGL
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050679 | 1 – 388 | Missing in isoform f. CuratedAdd BLAST | 388 | |
Alternative sequenceiVSP_050680 | 383 – 512 | Missing in isoform E. 1 PublicationAdd BLAST | 130 | |
Alternative sequenceiVSP_020098 | 383 – 467 | QPDLL…AAPFG → HQCIRLQWECINNHLVLSQC GILRWQHTVNNMDTDNLFHH NSNTKFNWFMQRWLQRTLHK LNRPRPPQPIHLDYSLVVYF SLSLS in isoform e. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_050681 | 397 – 449 | Missing in isoform D. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_020099 | 397 – 408 | APQTA…TNPFG → LLQCNRKLQMVS in isoform d. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_020100 | 409 – 460 | Missing in isoform d. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_050682 | 419 – 458 | Missing in isoform C and isoform B. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_020101 | 459 | N → NEPENPFITAPAAPQMHNAP PVPPPPASQGAPAPINPFAD PSATAASSAQPFGDPDDFKF EQKNVKIKILIP in isoform c. 1 Publication | 1 | |
Alternative sequenceiVSP_020102 | 468 – 586 | Missing in isoform e. 1 PublicationAdd BLAST | 119 | |
Alternative sequenceiVSP_050683 | 489 | G → GYR in isoform B and isoform D. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144257 mRNA Translation: AAD37365.1 AF144258 mRNA Translation: AAD37366.1 AF144259 mRNA Translation: AAD37367.1 AF144260 mRNA Translation: AAD37368.1 AF144261 mRNA Translation: AAD37369.1 AF144262 mRNA Translation: AAD37370.1 FO080749 Genomic DNA Translation: CCD66409.1 FO080749 Genomic DNA Translation: CCD66410.1 FO080749 Genomic DNA Translation: CCD66411.1 FO080749 Genomic DNA Translation: CCD66412.1 FO080749 Genomic DNA Translation: CCD66413.1 FO080749 Genomic DNA Translation: CCD66414.1 FO080749 Genomic DNA Translation: CCD66415.1 |
RefSeqi | NP_001021014.1, NM_001025843.2 [Q9XZI6-3] NP_001021015.1, NM_001025844.1 NP_001021016.1, NM_001025845.2 [Q9XZI6-2] NP_491227.1, NM_058826.1 [Q9XZI6-1] NP_491228.1, NM_058827.3 NP_491229.1, NM_058828.1 NP_491230.1, NM_058829.3 [Q9XZI6-6] |
Genome annotation databases
EnsemblMetazoai | C32E8.10a.1; C32E8.10a.1; WBGene00006751 [Q9XZI6-1] C32E8.10b.1; C32E8.10b.1; WBGene00006751 [Q9XZI6-3] C32E8.10c.1; C32E8.10c.1; WBGene00006751 [Q9XZI6-7] C32E8.10d.1; C32E8.10d.1; WBGene00006751 [Q9XZI6-8] C32E8.10e.1; C32E8.10e.1; WBGene00006751 [Q9XZI6-9] C32E8.10f.1; C32E8.10f.1; WBGene00006751 [Q9XZI6-6] C32E8.10h.1; C32E8.10h.1; WBGene00006751 [Q9XZI6-2] |
GeneIDi | 171952 |
KEGGi | cel:CELE_C32E8.10 |
UCSCi | C32E8.10f, c. elegans [Q9XZI6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144257 mRNA Translation: AAD37365.1 AF144258 mRNA Translation: AAD37366.1 AF144259 mRNA Translation: AAD37367.1 AF144260 mRNA Translation: AAD37368.1 AF144261 mRNA Translation: AAD37369.1 AF144262 mRNA Translation: AAD37370.1 FO080749 Genomic DNA Translation: CCD66409.1 FO080749 Genomic DNA Translation: CCD66410.1 FO080749 Genomic DNA Translation: CCD66411.1 FO080749 Genomic DNA Translation: CCD66412.1 FO080749 Genomic DNA Translation: CCD66413.1 FO080749 Genomic DNA Translation: CCD66414.1 FO080749 Genomic DNA Translation: CCD66415.1 |
RefSeqi | NP_001021014.1, NM_001025843.2 [Q9XZI6-3] NP_001021015.1, NM_001025844.1 NP_001021016.1, NM_001025845.2 [Q9XZI6-2] NP_491227.1, NM_058826.1 [Q9XZI6-1] NP_491228.1, NM_058827.3 NP_491229.1, NM_058828.1 NP_491230.1, NM_058829.3 [Q9XZI6-6] |
3D structure databases
SMRi | Q9XZI6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 37426, 10 interactors |
DIPi | DIP-25315N |
IntActi | Q9XZI6, 8 interactors |
PTM databases
iPTMneti | Q9XZI6 |
Proteomic databases
EPDi | Q9XZI6 |
PeptideAtlasi | Q9XZI6 |
Genome annotation databases
EnsemblMetazoai | C32E8.10a.1; C32E8.10a.1; WBGene00006751 [Q9XZI6-1] C32E8.10b.1; C32E8.10b.1; WBGene00006751 [Q9XZI6-3] C32E8.10c.1; C32E8.10c.1; WBGene00006751 [Q9XZI6-7] C32E8.10d.1; C32E8.10d.1; WBGene00006751 [Q9XZI6-8] C32E8.10e.1; C32E8.10e.1; WBGene00006751 [Q9XZI6-9] C32E8.10f.1; C32E8.10f.1; WBGene00006751 [Q9XZI6-6] C32E8.10h.1; C32E8.10h.1; WBGene00006751 [Q9XZI6-2] |
GeneIDi | 171952 |
KEGGi | cel:CELE_C32E8.10 |
UCSCi | C32E8.10f, c. elegans [Q9XZI6-1] |
Organism-specific databases
CTDi | 171952 |
WormBasei | C32E8.10a ; CE23562 ; WBGene00006751 ; unc-11 C32E8.10b ; CE27812 ; WBGene00006751 ; unc-11 C32E8.10c ; CE24822 ; WBGene00006751 ; unc-11 C32E8.10d ; CE23564 ; WBGene00006751 ; unc-11 C32E8.10e ; CE23565 ; WBGene00006751 ; unc-11 C32E8.10f ; CE23566 ; WBGene00006751 ; unc-11 C32E8.10h ; CE27813 ; WBGene00006751 ; unc-11 |
Phylogenomic databases
GeneTreei | ENSGT00950000183068 |
InParanoidi | Q9XZI6 |
OMAi | PAQQTPW |
OrthoDBi | 755817at2759 |
PhylomeDBi | Q9XZI6 |
Enzyme and pathway databases
Reactomei | R-CEL-432722, Golgi Associated Vesicle Biogenesis R-CEL-8856825, Cargo recognition for clathrin-mediated endocytosis R-CEL-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
PROi | PR:Q9XZI6 |
Gene expression databases
Bgeei | WBGene00006751, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues |
Family and domain databases
Gene3Di | 1.20.58.150, 1 hit 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR011417, ANTH_dom IPR014712, ANTH_dom_sf IPR045192, AP180-like IPR013809, ENTH IPR008942, ENTH_VHS |
PANTHERi | PTHR22951, PTHR22951, 1 hit |
Pfami | View protein in Pfam PF07651, ANTH, 1 hit |
SMARTi | View protein in SMART SM00273, ENTH, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit |
PROSITEi | View protein in PROSITE PS50942, ENTH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PICAL_CAEEL | |
Accessioni | Q9XZI6Primary (citable) accession number: Q9XZI6 Secondary accession number(s): Q95Q72 Q9XZI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families