Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 80 (07 Oct 2020)
Sequence version 2 (09 Feb 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Alpha-latrocrustotoxin-Lt1a

Gene
N/A
Organism
Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Crustacean-selective presynaptic neurotoxin that induces neurotransmitter exocytosis. Binds to neurexin-1-alpha (NRXN1), adhesion G protein-coupled receptor L1 (ADGRL1, also known as latrophilin-1), and receptor-type tyrosine-protein phosphatase S (PTPRS), and induces neurotransmitter exocytosis through two calcium-dependent mechanisms (membrane pore formation and signaling via latrophilin) and a yet to be defined calcium-independent mechanism (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeurotoxin, Presynaptic neurotoxin, Toxin
Biological processExocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-latrocrustotoxin-Lt1a
Short name:
Alpha-LCT-Lt1a
Alternative name(s):
Alpha-latrocrustotoxin
Short name:
Alpha-LCT
Crusta1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6925 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaTheridiidaeLatrodectus

Organism-specific databases

ArachnoServer: Spider toxin database

More...
ArachnoServeri
AS000061, alpha-Latrocrustotoxin-Lt1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the lethal dose (LD), paralytic dose (PD), effect dose (ED) or lethal concentration (LC) of a protein toxin.<p><a href='/help/toxic_dose' target='_top'>More...</a></p>Toxic dosei

LD50 is 100 µg/kg to the crayfish Procambarus cubensis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000391353‹1 – 28CuratedAdd BLAST›28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000006705329 – 1192Alpha-latrocrustotoxin-Lt1aCuratedAdd BLAST1164
PropeptideiPRO_00003913541193 – 1413CuratedAdd BLAST221

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Processed by furin-like proteases at both the N- and C-termini.

Keywords - PTMi

Cleavage on pair of basic residues

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the venom gland.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XZC0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati457 – 490ANK 1Add BLAST34
Repeati494 – 524ANK 2Add BLAST31
Repeati528 – 557ANK 3Add BLAST30
Repeati562 – 592ANK 4Add BLAST31
Repeati596 – 625ANK 5Add BLAST30
Repeati629 – 658ANK 6Add BLAST30
Repeati664 – 694ANK 7Add BLAST31
Repeati699 – 729ANK 8Add BLAST31
Repeati733 – 762ANK 9Add BLAST30
Repeati766 – 795ANK 10Add BLAST30
Repeati799 – 828ANK 11Add BLAST30
Repeati832 – 861ANK 12Add BLAST30
Repeati866 – 895ANK 13Add BLAST30
Repeati899 – 928ANK 14Add BLAST30
Repeati965 – 995ANK 15Add BLAST31
Repeati996 – 1026ANK 16Add BLAST31
Repeati1031 – 1072ANK 17Add BLAST42
Repeati1077 – 1106ANK 18Add BLAST30
Repeati1109 – 1139ANK 19Add BLAST31
Repeati1143 – 1172ANK 20Add BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 5 hits
PF13606, Ank_3, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XZC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VSIFIFHFSA NILVRNSEMK GKRVISKREM SKADQCTFLS YQSVAYGTLG
60 70 80 90 100
DVAGDVSSIE GADLVATPIA AGGHLAKGAT DAAMIAMDCS SIPFDEIKQQ
110 120 130 140 150
LNQRFNEVDK KLQKGAEALE NVTELAEKTY SSVEKMRVEM REGFNHVIAT
160 170 180 190 200
IENANTKQII TGINQIIQYF NDERENINNR QKEDYVAKLQ EPASGNFLLY
210 220 230 240 250
LRKSRTSEDG SLHSLLFKII NQELAIPNNA ADNNAIRALF ALFYGTQTFI
260 270 280 290 300
SIMFYLVKQY SYLADYHYQN GNLAEFNSNF DHMKTVFQDF KFTLIGINTS
310 320 330 340 350
NSKPLVNTVL SIIEDVKNKR FIRNLRSNLY QKIIKSTKSL LDLREKITKM
360 370 380 390 400
DLPIIEDTPK SSVLINFREK SSSVPRIETP ILKWTPGTVV KYAIQYEQDG
410 420 430 440 450
KYSKISKWSN PITVQRLANP YITIDKDRRN RLVFRQFGNE KPELISILDS
460 470 480 490 500
SQNEFRDIHR DLYNAAQMPY KETALGICRK LIDSGAQVGA SFEMGRKSIH
510 520 530 540 550
ASATAGNDDV ARLLLAKNNG LLNVPDKNGY TPLHIASERK NNDFVKFLLE
560 570 580 590 600
KGADVNVRTF ANELTPLHLA ARQDFTIIVK TLMEKRGIDV NAKERAGFTP
610 620 630 640 650
LHLSITSNSR AARTLINETP AGINIKSNSG LTPLHLAVLQ NNLSAAKVLV
660 670 680 690 700
KSNKKVKLNE MDNNGMTPLH YASMLGNLEF VKYFTSEQGI DVNAKTKVKN
710 720 730 740 750
WTPLHLAILF KKFDVAQSLL QVRNIDISTR ADQAITPLHL AAATGNSQIV
760 770 780 790 800
KTILNSGAVV DQETANGFTA LHLAIMNPNT ETPQFLIAKG ANINAKTNDG
810 820 830 840 850
STPLHFAAAL GKTNIFQLLM DKGANIKAEN LINQMPIHEA VVNGHLAIVK
860 870 880 890 900
MLIEQDSSLM NAKNMRDEYP FYLAAEKRYK DVFNYLESKG ADVNEKNNDG
910 920 930 940 950
NTLLHLFSIN GEVEVVQFLI QNGADFRLRN KERKSFFDLA VEFGHAGIVG
960 970 980 990 1000
YAIEENKVDL QEPYRGKTIL YHAICDSVKY DRIEVVRYFV ETLNEDQCSP
1010 1020 1030 1040 1050
LQEAAAYAHL DLVKYFVQER GINPTAFNND NQVSPLCIAI VGAPCGFVKS
1060 1070 1080 1090 1100
CDTPERLDVV EYLVDKTPDI NKECDTQQST PVSSAVYGNK VSILNYLIRN
1110 1120 1130 1140 1150
GADPNKKVRG DPPLFIAAMI GQYDIVKSLV EQHKIDVNTR NKEQFTPLHA
1160 1170 1180 1190 1200
AASNDHIDVV KYLIQKGADV NAKGDENLKP IDLAGEKSKA YLRSLGRRFF
1210 1220 1230 1240 1250
RNESPSKSFE IDKFNAIMPE VSMSGKVSHD SNFIQHISSG TRSKSNFNSA
1260 1270 1280 1290 1300
KNKMYAENSH VRSIDVNGAL LLLDFMVRVF SNRKMNYAAS ISGIKSRSNS
1310 1320 1330 1340 1350
EAQAEALILT ERFEHLLNAL IADQSIDSLD FSNVHSRIYK AIINGNPNGI
1360 1370 1380 1390 1400
SEMLCSYAKE YSELDPEKIE KLLQEFETLT FTKSSEIQIN EKFSHALFET
1410
CGLNRPTNVL QIK
Length:1,413
Mass (Da):158,223
Last modified:February 9, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98E263D6CE982EC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF134162 Genomic DNA Translation: AAD33043.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134162 Genomic DNA Translation: AAD33043.1

3D structure databases

SMRiQ9XZC0
ModBaseiSearch...

Organism-specific databases

ArachnoServeriAS000061, alpha-Latrocrustotoxin-Lt1a

Family and domain databases

Gene3Di1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796, Ank_2, 5 hits
PF13606, Ank_3, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 20 hits
SUPFAMiSSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 12 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCTA_LATTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XZC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 9, 2010
Last modified: October 7, 2020
This is version 80 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again