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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Uch-L5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86NucleophileUniRule annotation1
Active sitei162Proton donorUniRule annotation1
Sitei177Important for enzyme activityUniRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: FlyBase

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
  • protein deubiquitination Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5689603 UCH proteinases

Protein family/group databases

MEROPSiC12.A05

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:Uch-L5Imported
Synonyms:BcDNA.LD24440Imported, BcDNA:LD24440Imported, Dmel\CG3431Imported, dUCH37Imported, l(3)j2B8Imported, p37AImported, Q9XZ61Imported, UCHImported, UCH 37Imported, Uch-L3Imported, uch-L3Imported, uch-l5Imported, Uch37Imported, Uchl3Imported, uchl3Imported
ORF Names:CG3431Imported, Dmel_CG3431Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0011327 Uch-L5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

PRIDEiQ9XZ61

Expressioni

Gene expression databases

BgeeiFBgn0011327

Interactioni

Protein-protein interaction databases

IntActiQ9XZ61, 3 interactors
STRINGi7227.FBpp0076200

Structurei

3D structure databases

SMRiQ9XZ61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 208UCH_1InterPro annotationAdd BLAST201

Sequence similaritiesi

Belongs to the peptidase C12 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2778 Eukaryota
ENOG410XP0P LUCA
GeneTreeiENSGT00510000046560
HOGENOMiHOG000266301
KOiK05610
OMAiTIQNACA
OrthoDBiEOG091G0EO2

Family and domain databases

Gene3Di3.40.532.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001578 Peptidase_C12_UCH
IPR036959 Peptidase_C12_UCH_sf
IPR017390 Ubiquitinyl_hydrolase_UCH37
PANTHERiPTHR10589 PTHR10589, 1 hit
PfamiView protein in Pfam
PF01088 Peptidase_C12, 1 hit
PIRSFiPIRSF038120 Ubiquitinyl_hydrolase_UCH37, 1 hit
PRINTSiPR00707 UBCTHYDRLASE
SUPFAMiSSF54001 SSF54001, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XZ61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGAGNWCL IESDPGVFTE LIREFGCDGA QVEEIWSLDS ESFKNLEPIH
60 70 80 90 100
GLIFLFKWVQ EDEPAGKVVL DRENIFFAKQ VINNACATQA ILSLLMNLDH
110 120 130 140 150
EDIKLGETLT NFKEFCQCFD PYNKGLTLSN ASQIRTVHNS FARPTLFELD
160 170 180 190 200
TKNQKKDDDV YHFVGYMPIG GRLYELDGLR EGPIDLGEIK SEQNWIDVVR
210 220 230 240 250
PIIEKRMQRY SDGEIHFNLM ALISDRQRIY EQQIEKLLNP APNAMDTEED
260 270 280 290 300
RQAEISSLRT YIEYEIQKKK RYKVENVRRK HNYLPFIVEL LKILGENGQL
310 320
MPIYEKAKQR ALEREQAQRK KDTD
Length:324
Mass (Da):37,673
Last modified:November 1, 1999 - v1
Checksum:i7355CC51596CA298
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132567 mRNA Translation: AAD27866.1
AF145312 mRNA Translation: AAF08393.1
AE014296 Genomic DNA Translation: AAF50257.1
BT001294 mRNA Translation: AAN71049.1
AE014296 Genomic DNA Translation: AGB94327.1
RefSeqiNP_001261632.1, NM_001274703.1
NP_524003.1, NM_079279.3
UniGeneiDm.2640

Genome annotation databases

EnsemblMetazoaiFBtr0076472; FBpp0076200; FBgn0011327
FBtr0333867; FBpp0306000; FBgn0011327
GeneIDi39102
KEGGidme:Dmel_CG3431
UCSCiCG3431-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9XZ61_DROME
AccessioniPrimary (citable) accession number: Q9XZ61
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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