Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Contulakin-G

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an agonist of neurotensin receptors. It binds to human neurotensin type 1 receptor (NTSR1), rat neurotensin types 1 and 2 receptors (NTSR1/NTSR2) and mouse neurotensin type 3 receptor (SORT1).1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Contulakin-G
Alternative name(s):
CGX-1160
OrganismiConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifieri6491 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusGastridium

Organism-specific databases

ConoServeri1263 contulakin-G precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Is under phase II clinical trials under the name CGX-1160 by Cognetix Inc. It is efficacious in a wide range of preclinical pain models (acute, post-surgical, inflammatory, and neuropathic), and is particularly efficacious in models of chronic pain.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003508323 – 501 PublicationAdd BLAST28
PeptideiPRO_000003508451 – 66Contulakin-GAdd BLAST16
PropeptideiPRO_000003508567 – 7610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51Pyrrolidone carboxylic acid1 Publication1
GlycosylationiCAR_00016460O-linked (GalNAc...) threonine1

Post-translational modificationi

O-glycosylated. The glycosylation seems to enhance the affinity to the neurotensin receptors.

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Pyrrolidone carboxylic acid

PTM databases

GlyConnecti111
UniCarbKBiQ9XYR5

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin C superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XYR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTAYWVMVM MMVWIAAPLS EGGKLNDVIR GLVPDDITPQ LILGSLISRR
60 70
QSEEGGSNAT KKPYILRASD QVASGP
Length:76
Mass (Da):8,261
Last modified:November 1, 1999 - v1
Checksum:iD8094EB30C6AAFD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121108 mRNA Translation: AAD30031.1
PIRiA59043

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121108 mRNA Translation: AAD30031.1
PIRiA59043

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

GlyConnecti111
UniCarbKBiQ9XYR5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1263 contulakin-G precursor

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCONG_CONGE
AccessioniPrimary (citable) accession number: Q9XYR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Pharmaceutical

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again