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Entry version 162 (29 Sep 2021)
Sequence version 2 (06 Jun 2002)
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Protein

Gamma-tubulin complex component 3

Gene

Grip91

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-tubulin complex component 3Imported
Alternative name(s):
Gamma-ring complex protein 91 kDa1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Grip911 PublicationImported
Synonyms:l(1)dd41 Publication
ORF Names:CG10988Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001612, Grip91

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0001612

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781211 – 917Gamma-tubulin complex component 3Add BLAST917

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XYP8

PRoteomics IDEntifications database

More...
PRIDEi
Q9XYP8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0001612, Expressed in cleaving embryo and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9XYP8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9XYP8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Gamma-tubulin small complex (Gamma TuSC) is a heterotetrameric complex which contains two molecules of gamma-tubulin, and one molecule each of Dgrip84 and Dgrip91. The gamma-tubulin in this complex binds preferentially to GDP over GTP.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
71426, 14 interactors

Database of interacting proteins

More...
DIPi
DIP-19100N

Protein interaction database and analysis system

More...
IntActi
Q9XYP8, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073672

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XYP8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2000, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003736_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XYP8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CCTANDI

Database of Orthologous Groups

More...
OrthoDBi
480444at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XYP8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR041470, GCP_N

The PANTHER Classification System

More...
PANTHERi
PTHR19302, PTHR19302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XYP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDRIAGID VATNSTDISN IINEMIICIK GKQMPEVHEK AMDHLSKMIA
60 70 80 90 100
ANSRVIRDSN MLTERECVQK IMKLLSARNK KEEGKTVSDH FNELYRKLTL
110 120 130 140 150
TKCDPHMRHS LMTHLLTMTD NSDAEKAVAS EDPRTQCDNL TQILVSRLNS
160 170 180 190 200
ISSSIASLNE MGVVNGNGVG AAAVTGAAAV TGAAAVTGAA AVTGAAASHS
210 220 230 240 250
YDATQSSIGL RKQSLPNYLD ATKMLPESRH DIVMSAIYSF TGVQGKYLKK
260 270 280 290 300
DVVTGRFKLD QQNIKFLTTG QAGMLLRLSE LGYYHDRVVK FSDVSTGFNA
310 320 330 340 350
IGSMGQALIS KLKEELANFH GQVAMLHDEM QRFRQASVNG IANKGKKDSG
360 370 380 390 400
PDAGDEMTLF KLLAWYIKPL HRMQWLTKIA DACQVKKGGD LASTVYDFLD
410 420 430 440 450
NGNDMVNKLV EDLLTAICGP LVRMISKWIL EGGISDMHRE FFVKSIKDVG
460 470 480 490 500
VDRLWHDKFR LRLPMLPKFV PMDMANKILM TGKSINFLRE ICEEQGMMKE
510 520 530 540 550
RDELMKVMES SASQIFSYTP DTSWHAAVET CYQQTSKHVL DIMVGPHKLL
560 570 580 590 600
DHLHGMRRYL LLGQGDFISI LIENMKNELE RPGLDIYAND LTSMLDSALR
610 620 630 640 650
CTNAQYDDPD ILNHLDVIVQ RPFNGDIGWN IISLQYIVHG PLAAMLESTM
660 670 680 690 700
PTYKVLFKPL WRMKHMEFVL SMKIWKEQMG NAKALRTMKS EIGKASHRLN
710 720 730 740 750
LFTSEIMHFI HQMQYYVLFE VIECNWVELQ KKMQKATTLD EILEAHEKFL
760 770 780 790 800
QTILVGCFVS NKASVEHSLE VVYENIIELE KWQSSFYKDC FKELNARKEL
810 820 830 840 850
SKIVEKSEKK GVYGLTNKMI LQRDQEAKIF AEKMDIACRG LEVIATDYEK
860 870 880 890 900
AVSTFLMSLN SSDDPNLQLF GTRLDFNEYY KKRDTNLSKP LTFEHMRMSN
910
VFAVNSRFVI CTPSTQE
Length:917
Mass (Da):103,707
Last modified:June 6, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AEE88C211D256BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79N → Y in AAD27817 (PubMed:10037793).Curated1
Sequence conflicti118M → I in AAD27817 (PubMed:10037793).Curated1
Sequence conflicti413L → F in AAD27817 (PubMed:10037793).Curated1
Sequence conflicti479L → F in AAD27817 (PubMed:10037793).Curated1
Sequence conflicti583G → A in AAD27817 (PubMed:10037793).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF118380 mRNA Translation: AAD27817.1
AE014298 Genomic DNA Translation: AAF48309.1
AY069292 mRNA Translation: AAL39437.1

NCBI Reference Sequences

More...
RefSeqi
NP_524919.2, NM_080180.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073841; FBpp0073672; FBgn0001612

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
48481

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG10988

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118380 mRNA Translation: AAD27817.1
AE014298 Genomic DNA Translation: AAF48309.1
AY069292 mRNA Translation: AAL39437.1
RefSeqiNP_524919.2, NM_080180.4

3D structure databases

SMRiQ9XYP8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi71426, 14 interactors
DIPiDIP-19100N
IntActiQ9XYP8, 5 interactors
STRINGi7227.FBpp0073672

Proteomic databases

PaxDbiQ9XYP8
PRIDEiQ9XYP8

Genome annotation databases

EnsemblMetazoaiFBtr0073841; FBpp0073672; FBgn0001612
GeneIDi48481
KEGGidme:Dmel_CG10988

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
48481
FlyBaseiFBgn0001612, Grip91
VEuPathDBiVectorBase:FBgn0001612

Phylogenomic databases

eggNOGiKOG2000, Eukaryota
GeneTreeiENSGT00940000157872
HOGENOMiCLU_003736_3_0_1
InParanoidiQ9XYP8
OMAiCCTANDI
OrthoDBi480444at2759
PhylomeDBiQ9XYP8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
48481, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
48481

Protein Ontology

More...
PROi
PR:Q9XYP8

Gene expression databases

BgeeiFBgn0001612, Expressed in cleaving embryo and 38 other tissues
ExpressionAtlasiQ9XYP8, baseline and differential
GenevisibleiQ9XYP8, DM

Family and domain databases

InterProiView protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR041470, GCP_N
PANTHERiPTHR19302, PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XYP8
Secondary accession number(s): Q9VY94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: September 29, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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