UniProtKB - Q9XYP7 (GCP2_DROME)
Protein
Gamma-tubulin complex component 2 homolog
Gene
Grip84
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- gamma-tubulin binding Source: FlyBase
GO - Biological processi
- astral microtubule organization Source: FlyBase
- centrosome cycle Source: FlyBase
- cytoplasmic microtubule organization Source: GO_Central
- meiotic cell cycle Source: FlyBase
- microtubule nucleation Source: UniProtKB
- mitotic cell cycle Source: FlyBase
- regulation of cell cycle Source: FlyBase
- spermatogenesis Source: FlyBase
- spindle assembly Source: FlyBase
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-tubulin complex component 2 homologAlternative name(s): Gamma-ring complex protein 84 kDa Short name: d84p Short name: dGrip84 |
Gene namesi | Name:Grip84 ORF Names:CG3917 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0026430, Grip84 |
Subcellular locationi
Cytoskeleton
- centrosome Curated
Cytoskeleton
- equatorial microtubule organizing center Source: GO_Central
- gamma-tubulin complex Source: GO_Central
- gamma-tubulin small complex Source: UniProtKB
- microtubule Source: UniProtKB-KW
- spindle pole Source: InterPro
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078115 | 1 – 852 | Gamma-tubulin complex component 2 homologAdd BLAST | 852 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 73 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9XYP7 |
PRIDEi | Q9XYP7 |
PTM databases
iPTMneti | Q9XYP7 |
Expressioni
Gene expression databases
Bgeei | FBgn0026430, Expressed in secondary oocyte and 46 other tissues |
ExpressionAtlasi | Q9XYP7, baseline and differential |
Genevisiblei | Q9XYP7, DM |
Interactioni
Subunit structurei
Gamma-tubulin small complex (Gamma TuSC) is a heterotetrameric complex which contains two molecules of gamma-tubulin, and one molecule each of Dgrip84 and Dgrip91. The gamma-tubulin in this complex binds preferentially to GDP over GTP.
GO - Molecular functioni
- gamma-tubulin binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 59246, 16 interactors |
IntActi | Q9XYP7, 1 interactor |
MINTi | Q9XYP7 |
STRINGi | 7227.FBpp0074544 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 27 | Poly-Ser | 10 |
Sequence similaritiesi
Belongs to the TUBGCP family.Curated
Phylogenomic databases
eggNOGi | KOG2001, Eukaryota |
GeneTreei | ENSGT00940000156697 |
InParanoidi | Q9XYP7 |
OMAi | HHGGIKD |
PhylomeDBi | Q9XYP7 |
Family and domain databases
InterProi | View protein in InterPro IPR007259, GCP IPR040457, GCP_C IPR041470, GCP_N |
PANTHERi | PTHR19302, PTHR19302, 1 hit |
Pfami | View protein in Pfam PF04130, GCP_C_terminal, 1 hit PF17681, GCP_N_terminal, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9XYP7-1) [UniParc]FASTAAdd to basket
Also known as: B
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYALLVFVER YSECKPVSES SSSTSLSAMG LPHGNKTSDV NSAAGSVPTT
60 70 80 90 100
LAIASTSTIL TTSQNVSGST RLSLTQSQDF PTSTPVNCKK ATESDTTPVV
110 120 130 140 150
FVRRGPMDRN RGAGKDERND LSVIKERVLN AVSDQSLSGY RSVTNKTGNS
160 170 180 190 200
PKSMPNDLVT LTDVPDEYRT HLLWEYYKVD GDKVPRAEIA AMPLLSQESM
210 220 230 240 250
LLDELLHCLT GIRESLLVPQ KPIISAVGLA KYDTDFDIHT HLDRSLTHQV
260 270 280 290 300
REILPLASYF MGVQKIIAAT DGLGQVMNSL NEALQELTHD FYLIIVQAEQ
310 320 330 340 350
ELRHNRLTLQ KLLYYLQPTM WVMHEVWSSL VIIQLSDSRD AEVLTYLHER
360 370 380 390 400
IKRLEGNKDA QQLIIGLVRK AAKPYMRMLQ MWIQKGVIVD RHREFLVVDN
410 420 430 440 450
EVIHRDELPE HYSDDYWERR YTLRDEQIPS FLAKYSDKIL RTGKYLNVIR
460 470 480 490 500
QCGKRVMPTQ EMNLEFDPTS ERHVSVINDA YYFAARMLLD VLLTENDLMG
510 520 530 540 550
HLQSVKRYLL LNQGDFTMQF MDACEDELTK NVDHVLPMTL ENLLGLTLRI
560 570 580 590 600
SSARNDPYKD DLHCELLPYD LVTQMSKIMK KEENWQAQPR LDLSGLECFA
610 620 630 640 650
FTYEVKWPCS LVLNHISISK YQMLFRQLFY CKHVERQLCK IWKENSIARQ
660 670 680 690 700
FEPQAASLYR AAFTLRQRMM NAIQNLEYYM MIEIIEPNWH IFIEKMKTVE
710 720 730 740 750
NVDNVLRLHQ DFLDSCLKNC MLTESSHLNR SIFKLCKICL KYCEFIQITQ
760 770 780 790 800
RYFQDAELRS MVRDSADSSE SEQESLHCPQ IETPLDPTDT FSERVRRFDL
810 820 830 840 850
EFTQLLISFL KQINSMAKKN TADCFMNLVH RINFNAFYTD QMDKMCVEDA
IG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE1JJQ4 | E1JJQ4_DROME | Gamma-tubulin complex component | Grip84 DGrip84, Dgrip84, Dgrips84, Dmel\CG3917, GCP2 | 833 | Annotation score: | ||
X2JG40 | X2JG40_DROME | Gamma-tubulin complex component | Grip84 DGrip84, Dgrip84, Dgrips84, Dmel\CG3917, GCP2 | 819 | Annotation score: | ||
E1JJQ3 | E1JJQ3_DROME | Gamma-tubulin complex component | Grip84 DGrip84, Dgrip84, Dgrips84, Dmel\CG3917, GCP2 | 893 | Annotation score: | ||
Q8IQW7 | Q8IQW7_DROME | Gamma-tubulin complex component | Grip84 DGrip84, Dgrip84, Dgrips84, Dmel\CG3917, GCP2 | 926 | Annotation score: |
Sequence cautioni
The sequence AAL28696 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 171 | H → S AA sequence (PubMed:10037793).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001619 | 747 – 779 | Missing in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118379 mRNA Translation: AAD27816.1 AE014298 Genomic DNA Translation: AAF48971.2 AE014298 Genomic DNA Translation: AAN09502.1 AY061148 mRNA Translation: AAL28696.1 Different initiation. |
RefSeqi | NP_001285444.1, NM_001298515.1 [Q9XYP7-2] NP_523409.1, NM_078685.3 [Q9XYP7-2] NP_728265.1, NM_167663.2 [Q9XYP7-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0074776; FBpp0074545; FBgn0026430 [Q9XYP7-1] FBtr0074777; FBpp0074546; FBgn0026430 [Q9XYP7-2] FBtr0343590; FBpp0310187; FBgn0026430 [Q9XYP7-2] |
GeneIDi | 32946 |
KEGGi | dme:Dmel_CG3917 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118379 mRNA Translation: AAD27816.1 AE014298 Genomic DNA Translation: AAF48971.2 AE014298 Genomic DNA Translation: AAN09502.1 AY061148 mRNA Translation: AAL28696.1 Different initiation. |
RefSeqi | NP_001285444.1, NM_001298515.1 [Q9XYP7-2] NP_523409.1, NM_078685.3 [Q9XYP7-2] NP_728265.1, NM_167663.2 [Q9XYP7-1] |
3D structure databases
SMRi | Q9XYP7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 59246, 16 interactors |
IntActi | Q9XYP7, 1 interactor |
MINTi | Q9XYP7 |
STRINGi | 7227.FBpp0074544 |
PTM databases
iPTMneti | Q9XYP7 |
Proteomic databases
PaxDbi | Q9XYP7 |
PRIDEi | Q9XYP7 |
Genome annotation databases
EnsemblMetazoai | FBtr0074776; FBpp0074545; FBgn0026430 [Q9XYP7-1] FBtr0074777; FBpp0074546; FBgn0026430 [Q9XYP7-2] FBtr0343590; FBpp0310187; FBgn0026430 [Q9XYP7-2] |
GeneIDi | 32946 |
KEGGi | dme:Dmel_CG3917 |
Organism-specific databases
CTDi | 32946 |
FlyBasei | FBgn0026430, Grip84 |
Phylogenomic databases
eggNOGi | KOG2001, Eukaryota |
GeneTreei | ENSGT00940000156697 |
InParanoidi | Q9XYP7 |
OMAi | HHGGIKD |
PhylomeDBi | Q9XYP7 |
Miscellaneous databases
BioGRID-ORCSi | 32946, 0 hits in 1 CRISPR screen |
GenomeRNAii | 32946 |
PROi | PR:Q9XYP7 |
Gene expression databases
Bgeei | FBgn0026430, Expressed in secondary oocyte and 46 other tissues |
ExpressionAtlasi | Q9XYP7, baseline and differential |
Genevisiblei | Q9XYP7, DM |
Family and domain databases
InterProi | View protein in InterPro IPR007259, GCP IPR040457, GCP_C IPR041470, GCP_N |
PANTHERi | PTHR19302, PTHR19302, 1 hit |
Pfami | View protein in Pfam PF04130, GCP_C_terminal, 1 hit PF17681, GCP_N_terminal, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GCP2_DROME | |
Accessioni | Q9XYP7Primary (citable) accession number: Q9XYP7 Secondary accession number(s): Q95RT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | June 6, 2002 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families