UniProtKB - Q9XYM5 (Q9XYM5_DROME)
Protein
Submitted name:
LD27861p
Gene
Su(var)2-10
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
: protein sumoylation Pathwayi
This protein is involved in the pathway protein sumoylation, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 310 – 387 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 78 |
GO - Molecular functioni
- RNA polymerase II transcription factor binding Source: GO_Central
- SUMO transferase activity Source: InterPro
- transcription coregulator activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- compound eye development Source: FlyBase
- defense response to Gram-negative bacterium Source: FlyBase
- double-strand break repair via homologous recombination Source: FlyBase
- imaginal disc growth Source: FlyBase
- positive regulation of innate immune response Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00886 |
Names & Taxonomyi
Protein namesi | Submitted name: LD27861pImportedSubmitted name: Suppressor of variegation 2-10, isoform EImportedSubmitted name: Zimp-BImported |
Gene namesi | Name:Su(var)2-10Imported Synonyms:CLOT2057Imported, Dmel\CG8068Imported, DmPiasImported, DPIASImported, DpiasImported, dPIASImported, dpiasImported, i184Imported, l(2)03697Imported, PIASImported, piasImported, Su(var)-10Imported, SU(VAR)2-10Imported, Su(Var)2-10Imported, Su-var(2)10Imported, Suvar(2)10Imported, ZIMPImported, zimpImported, ZimpAImported, ZimpBImported ORF Names:CG8068Imported, Dmel_CG8068Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003612, Su(var)2-10 |
Subcellular locationi
Nucleus
- Nucleus speckle ARBA annotation
Nucleus
- nucleus Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotationInteractioni
GO - Molecular functioni
- RNA polymerase II transcription factor binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 36 | SAPInterPro annotationAdd BLAST | 35 | |
Domaini | 113 – 278 | PINITInterPro annotationAdd BLAST | 166 | |
Domaini | 310 – 387 | SP-RING-typeInterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 402 – 426 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 439 – 522 | DisorderedSequence analysisAdd BLAST | 84 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 402 – 422 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 452 – 468 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 488 – 522 | PolarSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the PIAS family.ARBA annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 310 – 387 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 78 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00990000203531 |
HOGENOMi | CLU_020768_1_0_1 |
OMAi | YSHMQLP |
OrthoDBi | 1205949at2759 |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR027226, PIAS1/PIAS3 IPR023321, PINIT IPR038654, PINIT_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR004181, Znf_MIZ IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10782:SF11, PTHR10782:SF11, 1 hit |
Pfami | View protein in Pfam PF14324, PINIT, 1 hit PF02891, zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466, PINIT, 1 hit PS50800, SAP, 1 hit PS51044, ZF_SP_RING, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
Q9XYM5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQMLRVVEL QKILSFLNIS FAGRKTDLQS RILSFLRTNL ELLAPKVQEV
60 70 80 90 100
YAQSVQEQNA TLQYIDPTRM YSHIQLPPTV QPNPVGLVGS GQGVQVPGGQ
110 120 130 140 150
MNVVGGAPFL HTHSINSQLP IHPDVRLKKL AFYDVLGTLI KPSTLVPRNT
160 170 180 190 200
QRVQEVPFYF TLTPQQATEI ASNRDIRNSS KVEHAIQVQL RFCLVETSCD
210 220 230 240 250
QEDCFPPNVN VKVNNKLCQL PNVIPTNRPN VEPKRPPRPV NVTSNVKLSP
260 270 280 290 300
TVTNTITVQW CPDYTRSYCL AVYLVKKLTS TQLLQRMKTK GVKPADYTRG
310 320 330 340 350
LIKEKLTEDA DCEIATTMLK VSLNCPLGKM KMLLPCRAST CSHLQCFDAS
360 370 380 390 400
LYLQMNERKP TWNCPVCDKP AIYDNLVIDG YFQEVLGSSL LKSDDTEIQL
410 420 430 440 450
HQDGSWSTPG LRSETQILDT PSKPAQKVEV ISDDIELISD DAKPVKRDLS
460 470 480 490 500
PAQDEQPTST SNSETVDLTL SDSDDDMPLA KRRPPAKQAV ASSTSNGSGG
510 520
GQRAYTPAQQ PQQSGTLDPF LQ
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA1Z7P5 | A1Z7P5_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 640 | Annotation score: | ||
Q7KNF5 | Q7KNF5_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 554 | Annotation score: | ||
Q5BIG7 | Q5BIG7_DROME | RE55465p | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 533 | Annotation score: | ||
A0A0B4JD03 | A0A0B4JD03_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 537 | Annotation score: | ||
A0A0B4JCQ7 | A0A0B4JCQ7_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 537 | Annotation score: | ||
Q8IGK3 | Q8IGK3_DROME | RE73180p | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 601 | Annotation score: | ||
A1Z7P7 | A1Z7P7_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 569 | Annotation score: | ||
A1Z7P8 | A1Z7P8_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 604 | Annotation score: | ||
A1Z7P9 | A1Z7P9_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 565 | Annotation score: | ||
A1Z7Q1 | A1Z7Q1_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 593 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF114486 Genomic DNA Translation: AAD29288.1 AY058583 mRNA Translation: AAL13812.1 AE013599 Genomic DNA Translation: AAM68809.1 |
RefSeqi | NP_724756.1, NM_165652.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0088576; FBpp0087657; FBgn0003612 |
GeneIDi | 35927 |
UCSCi | CG8068-RE, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF114486 Genomic DNA Translation: AAD29288.1 AY058583 mRNA Translation: AAL13812.1 AE013599 Genomic DNA Translation: AAM68809.1 |
RefSeqi | NP_724756.1, NM_165652.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblMetazoai | FBtr0088576; FBpp0087657; FBgn0003612 |
GeneIDi | 35927 |
UCSCi | CG8068-RE, d. melanogaster |
Organism-specific databases
CTDi | 35927 |
FlyBasei | FBgn0003612, Su(var)2-10 |
Phylogenomic databases
GeneTreei | ENSGT00990000203531 |
HOGENOMi | CLU_020768_1_0_1 |
OMAi | YSHMQLP |
OrthoDBi | 1205949at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00886 |
Miscellaneous databases
BioGRID-ORCSi | 35927, 0 hits in 3 CRISPR screens |
GenomeRNAii | 35927 |
Gene expression databases
Bgeei | FBgn0003612, Expressed in embryo and 40 other tissues |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR027226, PIAS1/PIAS3 IPR023321, PINIT IPR038654, PINIT_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR004181, Znf_MIZ IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10782:SF11, PTHR10782:SF11, 1 hit |
Pfami | View protein in Pfam PF14324, PINIT, 1 hit PF02891, zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466, PINIT, 1 hit PS50800, SAP, 1 hit PS51044, ZF_SP_RING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9XYM5_DROME | |
Accessioni | Q9XYM5Primary (citable) accession number: Q9XYM5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1999 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |