UniProtKB - Q9XYM0 (CRK_DROME)
Protein
Adapter molecule Crk
Gene
Crk
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development.1 Publication
GO - Molecular functioni
- receptor tyrosine kinase binding Source: FlyBase
GO - Biological processi
- border follicle cell migration Source: FlyBase
- ephrin receptor signaling pathway Source: UniProtKB
- imaginal disc fusion, thorax closure Source: FlyBase
- myoblast fusion Source: FlyBase
- phagocytosis, engulfment Source: FlyBase
- positive regulation of JNK cascade Source: FlyBase
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of GTPase activity Source: UniProtKB
- vascular endothelial growth factor receptor signaling pathway Source: FlyBase
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
Reactomei | R-DME-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-DME-912631, Regulation of signaling by CBL |
SignaLinki | Q9XYM0 |
Names & Taxonomyi
Protein namesi | Recommended name: Adapter molecule Crk |
Gene namesi | Name:Crk ORF Names:CG1587 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0024811, Crk |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079350 | 1 – 271 | Adapter molecule CrkAdd BLAST | 271 |
Proteomic databases
PaxDbi | Q9XYM0 |
Expressioni
Tissue specificityi
Embryonic zygotic expression is seen in invaginating presumptive mesoderm and ectodermally derived tissues during gastrulation. At stage 8, expression is also seen in anterior and posterior midgut and cephalic furrow. By stage 9, expression is highest in visceral mesoderm of anterior and posterior midgut, ventral nerve cord and somatic mesoderm.1 Publication
Developmental stagei
Expressed both maternally and zygotically throughout embryogenesis, declines during larval stages and reappears during pupation.1 Publication
Gene expression databases
Bgeei | FBgn0024811, Expressed in cleaving embryo and 40 other tissues |
ExpressionAtlasi | Q9XYM0, baseline and differential |
Genevisiblei | Q9XYM0, DM |
Interactioni
Binary interactionsi
Q9XYM0
With | #Exp. | IntAct |
---|---|---|
mbc [Q9VCH4] | 3 | EBI-99477,EBI-177001 |
GO - Molecular functioni
- receptor tyrosine kinase binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 68612, 16 interactors |
DIPi | DIP-21287N |
IntActi | Q9XYM0, 5 interactors |
MINTi | Q9XYM0 |
STRINGi | 7227.FBpp0088181 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 104 | SH2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 106 – 166 | SH3 1PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 199 – 260 | SH3 2PROSITE-ProRule annotationAdd BLAST | 62 |
Sequence similaritiesi
Belongs to the CRK family.Curated
Keywords - Domaini
Repeat, SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG4792, Eukaryota |
GeneTreei | ENSGT00820000127055 |
HOGENOMi | CLU_060542_0_0_1 |
InParanoidi | Q9XYM0 |
OMAi | SKDEEQW |
PhylomeDBi | Q9XYM0 |
Family and domain databases
CDDi | cd11759, SH3_CRK_C, 1 hit cd11758, SH3_CRK_N, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035458, CRK_SH3_C IPR035457, CRK_SH3_N IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9XYM0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTFDVSDRN SWYFGPMSRQ DATEVLMNER ERGVFLVRDS NSIAGDYVLC
60 70 80 90 100
VREDTKVSNY IINKVQQQDQ IVYRIGDQSF DNLPKLLTFY TLHYLDTTPL
110 120 130 140 150
KRPACRRVEK VIGKFDFVGS DQDDLPFQRG EVLTIVRKDE DQWWTARNSS
160 170 180 190 200
GKIGQIPVPY IQQYDDYMDE DAIDKNEPSI SGSSNVFEST LKRTDLNRKL
210 220 230 240 250
PAYARVKQSR VPNAYDKTAL KLEIGDIIKV TKTNINGQWE GELNGKNGHF
260 270
PFTHVEFVDD CDLSKNSTEI C
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH9XVM6 | H9XVM6_DROME | Crk oncogene, isoform E | Crk CRK, crk, D-CRK, D-Crk, DCrk | 263 | Annotation score: | ||
Q95RW2 | Q95RW2_DROME | Crk oncogene, isoform B | Crk CRK, crk, D-CRK, D-Crk, DCrk | 253 | Annotation score: | ||
H9XVM7 | H9XVM7_DROME | Crk oncogene, isoform D | Crk CRK, crk, D-CRK, D-Crk, DCrk | 184 | Annotation score: | ||
X2JCS2 | X2JCS2_DROME | Crk oncogene, isoform G | Crk CRK, crk, D-CRK, D-Crk, DCrk | 84 | Annotation score: | ||
X2JD84 | X2JD84_DROME | Crk oncogene, isoform H | Crk CRK, crk, D-CRK, D-Crk, DCrk | 64 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF112976 mRNA Translation: AAD28428.1 AE014135 Genomic DNA Translation: AAF59362.1 AE014135 Genomic DNA Translation: AAN06519.1 BT012456 mRNA Translation: AAS93727.1 |
RefSeqi | NP_651908.1, NM_143651.6 NP_726549.1, NM_166743.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0089112; FBpp0088181; FBgn0024811 FBtr0089113; FBpp0088182; FBgn0024811 |
GeneIDi | 43775 |
KEGGi | dme:Dmel_CG1587 |
UCSCi | CG1587-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF112976 mRNA Translation: AAD28428.1 AE014135 Genomic DNA Translation: AAF59362.1 AE014135 Genomic DNA Translation: AAN06519.1 BT012456 mRNA Translation: AAS93727.1 |
RefSeqi | NP_651908.1, NM_143651.6 NP_726549.1, NM_166743.3 |
3D structure databases
SMRi | Q9XYM0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 68612, 16 interactors |
DIPi | DIP-21287N |
IntActi | Q9XYM0, 5 interactors |
MINTi | Q9XYM0 |
STRINGi | 7227.FBpp0088181 |
Proteomic databases
PaxDbi | Q9XYM0 |
Genome annotation databases
EnsemblMetazoai | FBtr0089112; FBpp0088181; FBgn0024811 FBtr0089113; FBpp0088182; FBgn0024811 |
GeneIDi | 43775 |
KEGGi | dme:Dmel_CG1587 |
UCSCi | CG1587-RA, d. melanogaster |
Organism-specific databases
CTDi | 1398 |
FlyBasei | FBgn0024811, Crk |
Phylogenomic databases
eggNOGi | KOG4792, Eukaryota |
GeneTreei | ENSGT00820000127055 |
HOGENOMi | CLU_060542_0_0_1 |
InParanoidi | Q9XYM0 |
OMAi | SKDEEQW |
PhylomeDBi | Q9XYM0 |
Enzyme and pathway databases
Reactomei | R-DME-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-DME-912631, Regulation of signaling by CBL |
SignaLinki | Q9XYM0 |
Miscellaneous databases
BioGRID-ORCSi | 43775, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43775 |
PROi | PR:Q9XYM0 |
Gene expression databases
Bgeei | FBgn0024811, Expressed in cleaving embryo and 40 other tissues |
ExpressionAtlasi | Q9XYM0, baseline and differential |
Genevisiblei | Q9XYM0, DM |
Family and domain databases
CDDi | cd11759, SH3_CRK_C, 1 hit cd11758, SH3_CRK_N, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035458, CRK_SH3_C IPR035457, CRK_SH3_N IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRK_DROME | |
Accessioni | Q9XYM0Primary (citable) accession number: Q9XYM0 Secondary accession number(s): Q53XD2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families