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Entry version 137 (26 Feb 2020)
Sequence version 2 (26 Jun 2007)
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Protein
Submitted name:

FERM domain-containing protein

Gene

frm-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FERM domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:frm-7Imported
ORF Names:C51F7.1Imported, CELE_C51F7.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
C51F7.1 ; CE40926 ; WBGene00001493 ; frm-7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9XXK4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XXK4

PeptideAtlas

More...
PeptideAtlasi
Q9XXK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001493 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C51F7.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9XXK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 356FERMInterPro annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni371 – 407DisorderedSequence analysisAdd BLAST37
Regioni436 – 536DisorderedSequence analysisAdd BLAST101
Regioni584 – 607DisorderedSequence analysisAdd BLAST24
Regioni723 – 757DisorderedSequence analysisAdd BLAST35
Regioni880 – 914DisorderedSequence analysisAdd BLAST35
Regioni928 – 947DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 32PolarSequence analysisAdd BLAST17
Compositional biasi436 – 464PolyampholyteSequence analysisAdd BLAST29
Compositional biasi467 – 511PolarSequence analysisAdd BLAST45
Compositional biasi586 – 604PolarSequence analysisAdd BLAST19
Compositional biasi723 – 745PolarSequence analysisAdd BLAST23
Compositional biasi931 – 947Pro-richSequence analysisAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4371 Eukaryota
ENOG410XSKD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_306350_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XXK4

KEGG Orthology (KO)

More...
KOi
K16822

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWVINER

Database of Orthologous Groups

More...
OrthoDBi
187776at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit
cd13185 FERM_C_FRMD1_FRMD6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018980 FERM_PH-like_C
IPR041781 FRMD6-FERM_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XXK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSPGSARGD VTSRLPVHLQ QPSSSSFSDP EVFTSTHNIR PGQTFVSVQT
60 70 80 90 100
LTKESFHVAI SSKTKVHDVL WKCGERLSLS DDKLFGLAFR QPTEGIGGDQ
110 120 130 140 150
PRHEYYFLDP AAKIMKYAQK QPRFANWHSK SSENRPILVL YFRVRVYIDQ
160 170 180 190 200
VGLLSCPKAR EHYYLQLKDN FLDHWAGRNS VSEERCWYMA ALALITDKGN
210 220 230 240 250
DYLGYFRAEQ YFPLWVINER GLEYIRNNLP AACEDIINEG RYKAMEKFMI
260 270 280 290 300
EAGRSPFALN CHLYGLRRHK MDNTDNAVLG INAKGIEMCD IGEDGDRIPL
310 320 330 340 350
RSLSWSRVAK LSFNRKKMTI IGSDGTKMSL YAQTEHKAKY LLELCKAVHQ
360 370 380 390 400
TLLVMSHLHA TMAPPPKPYL EMSVDGISTS STSGIGSGDH DKDSDSLSSA
410 420 430 440 450
CGDRCHGSMS SKLRLRIKMD SNLDVKIEKM ELDHIRQERA ASQSSKASDE
460 470 480 490 500
SERSRLEVRH QTYHPAHELS GATSSTYTVT TAQDTATRPS SMDNASQTIE
510 520 530 540 550
SGSSRSIVDV NFNNKNRERH ESSTSTSGTH VLFSSKDATP PIETAVVSST
560 570 580 590 600
MSMSVPLDSD TNQSINDRLL SMSASDLRAM AERSYSPPAQ WTTNVPSTGS
610 620 630 640 650
SSPPEMMARD KLTRSETRID SQNEMWLNQP VESFNGGGTA GRFVKKNSSG
660 670 680 690 700
NRNANAINRV HSMPSHYHVN GYYRNSNQIL TYEDAPIHHG PTLLTHAQSL
710 720 730 740 750
HVPGTVARPR NPPPYESTFQ PIFAVGPKTS SSPPPQSQPS LTASTGPLPA
760 770 780 790 800
EIAGDRQASF PPASVTPTQF LEEAGAFSTE KMENYPLILQ LLKEHRQSQG
810 820 830 840 850
QLNAITMTNG IYNSSQAGIL SHNRRPSSCN DLSSLDGGVI NGGAFVLPTH
860 870 880 890 900
RGDYYFDSAT LSQNLHLSSF VPMTTSTTTT SSATMTSSLI TASSHQQPLQ
910 920 930 940
PSQQHHQQLQ HQQSIKPTNN FARIEQHNGD LILPPPPPYQ QPQQLVN
Length:947
Mass (Da):104,965
Last modified:June 26, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12264F232E0C9313
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA19422.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T20140

NCBI Reference Sequences

More...
RefSeqi
NP_506085.2, NM_073684.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C51F7.1.1; C51F7.1.1; WBGene00001493

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C51F7.1

UCSC genome browser

More...
UCSCi
C51F7.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA19422.2
PIRiT20140
RefSeqiNP_506085.2, NM_073684.4

3D structure databases

SMRiQ9XXK4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.C51F7.1

Proteomic databases

EPDiQ9XXK4
PaxDbiQ9XXK4
PeptideAtlasiQ9XXK4

Genome annotation databases

EnsemblMetazoaiC51F7.1.1; C51F7.1.1; WBGene00001493
GeneIDi179687
KEGGicel:CELE_C51F7.1
UCSCiC51F7.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179687
WormBaseiC51F7.1 ; CE40926 ; WBGene00001493 ; frm-7

Phylogenomic databases

eggNOGiKOG4371 Eukaryota
ENOG410XSKD LUCA
GeneTreeiENSGT00940000162787
HOGENOMiCLU_306350_0_0_1
InParanoidiQ9XXK4
KOiK16822
OMAiLWVINER
OrthoDBi187776at2759

Gene expression databases

BgeeiWBGene00001493 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd13185 FERM_C_FRMD1_FRMD6, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018980 FERM_PH-like_C
IPR041781 FRMD6-FERM_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9XXK4_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XXK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: June 26, 2007
Last modified: February 26, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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