Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 121 (16 Oct 2019)
Sequence version 2 (23 Apr 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Exocyst complex component 4

Gene

sec-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-264876 Insulin processing
R-CEL-5620916 VxPx cargo-targeting to cilium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sec-8
ORF Names:Y106G6H.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y106G6H.7 ; CE32512 ; WBGene00004753 ; sec-8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189371 – 893Exocyst complex component 4Add BLAST893

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9XWS2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XWS2

PeptideAtlas

More...
PeptideAtlasi
Q9XWS2

PRoteomics IDEntifications database

More...
PRIDEi
Q9XWS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Pseudocoelom.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004753 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
38340, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-712 Exocyst

STRING: functional protein association networks

More...
STRINGi
6239.Y106G6H.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XWS2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3691 Eukaryota
ENOG410Z8N0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001439

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016654

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XWS2

KEGG Orthology (KO)

More...
KOi
K06111

Identification of Orthologs from Complete Genome Data

More...
OMAi
KEHRRNA

Database of Orthologous Groups

More...
OrthoDBi
96167at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XWS2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst

The PANTHER Classification System

More...
PANTHERi
PTHR14146 PTHR14146, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04048 Sec8_exocyst, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XWS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNENGATPVA AARRHRPLPA ERATSNSNET GLLINVIRSL TSSVSEDQRE
60 70 80 90 100
VEKSRLEKGY KESGALIDRL VKNHQQDVEK CLVSFRDVSS KISNCRERIH
110 120 130 140 150
NVRNALHTVK SLLELRRDDL KKLWHENAQQ KSVCEIMAKL EELREAPSKI
160 170 180 190 200
ENLISKEQYQ QAADTVTESR ELINGRLSRV EGLSHLSAEI ERFTKILIDK
210 220 230 240 250
INDTLVNMLV VEPFEKHLLH IVRTIPEHRI NQNAYCHSLS TKSRSGSGSV
260 270 280 290 300
SSFSDVSAKS RIVSSVEALS TLFRTVEERH WDVDRLMMLG KNMIDKMIVN
310 320 330 340 350
TVQVMKIGAN IDESNEGDTT HLKQLMQLLS AQFDSASQQH AEFGVLVEKQ
360 370 380 390 400
LGRKDVVTSF WRSAQSAIEV VVSEHLDINP LLEKQNVLGT ASRKQLFRFE
410 420 430 440 450
NTACATPNAN SSSHRTKAVI CKPSAYNIKV IFPILSRLME TTEKNINDSP
460 470 480 490 500
CELRRFMHSF VMEVFVERVK GELASRIEGA LRGGEAVRVS TNKKILPSCE
510 520 530 540 550
KVLNLCKEVQ DLIVSIDLYA DRFAALWLLV LTDYFKNMTD VYDRMTPKNP
560 570 580 590 600
DPSLPNSEAL PTRRQKISAA WTADDDISRL LMSLPNWHAA SISPMTPAVE
610 620 630 640 650
SELDVGERNK RESEILIGNL GTQAQNSLSE SDLITDMNDI KMFASLHESL
660 670 680 690 700
RWFSDEIREL VHSLPANVKM MLDTCMVQVR LKDGQMIDNN SVPSAIEDCV
710 720 730 740 750
RRLESIADSC LLLLHIEIRV HCFFHLAPLA KYRNTSSHNE VDPEVVALGK
760 770 780 790 800
DLHQFHDNLK DVLSPAKLSY VFDGLGHLCA SLFIHYSQFM PRLTEAAKKR
810 820 830 840 850
VCRNVWGVQQ RLSRITNRRE SDLDRARAFF DLLLDNTPDG ILAIVPEKRS
860 870 880 890
QFTATELNYL LALSVRSDKT LASQPGALEK RQMVLNSILN QKK
Length:893
Mass (Da):101,015
Last modified:April 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10EBF7356E83F3A0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL032631 Genomic DNA Translation: CAA21575.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T26430

NCBI Reference Sequences

More...
RefSeqi
NP_492732.2, NM_060331.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y106G6H.7.1; Y106G6H.7.1; WBGene00004753

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172924

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y106G6H.7

UCSC genome browser

More...
UCSCi
Y106G6H.7 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL032631 Genomic DNA Translation: CAA21575.2
PIRiT26430
RefSeqiNP_492732.2, NM_060331.5

3D structure databases

SMRiQ9XWS2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi38340, 3 interactors
ComplexPortaliCPX-712 Exocyst
STRINGi6239.Y106G6H.7

Proteomic databases

EPDiQ9XWS2
PaxDbiQ9XWS2
PeptideAtlasiQ9XWS2
PRIDEiQ9XWS2

Genome annotation databases

EnsemblMetazoaiY106G6H.7.1; Y106G6H.7.1; WBGene00004753
GeneIDi172924
KEGGicel:CELE_Y106G6H.7
UCSCiY106G6H.7 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172924
WormBaseiY106G6H.7 ; CE32512 ; WBGene00004753 ; sec-8

Phylogenomic databases

eggNOGiKOG3691 Eukaryota
ENOG410Z8N0 LUCA
GeneTreeiENSGT00390000001439
HOGENOMiHOG000016654
InParanoidiQ9XWS2
KOiK06111
OMAiKEHRRNA
OrthoDBi96167at2759
PhylomeDBiQ9XWS2

Enzyme and pathway databases

ReactomeiR-CEL-264876 Insulin processing
R-CEL-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XWS2

Gene expression databases

BgeeiWBGene00004753 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst
PANTHERiPTHR14146 PTHR14146, 1 hit
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC4_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XWS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: April 23, 2003
Last modified: October 16, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again