UniProtKB - Q9XWI6 (EIF3B_CAEEL)
Protein
Eukaryotic translation initiation factor 3 subunit B
Gene
eif-3.B
Organism
Caenorhabditis elegans
Status
Functioni
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation
GO - Molecular functioni
- translation initiation factor activity Source: UniProtKB
- translation initiation factor binding Source: InterPro
GO - Biological processi
- formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
- regulation of translational initiation Source: UniProtKB
- translational initiation Source: GO_Central
Keywordsi
Molecular function | Initiation factor, RNA-binding |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
Reactomei | R-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-CEL-72649, Translation initiation complex formation R-CEL-72689, Formation of a pool of free 40S subunits R-CEL-72695, Formation of the ternary complex, and subsequently, the 43S complex R-CEL-72702, Ribosomal scanning and start codon recognition |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 3 subunit BUniRule annotationShort name: eIF3bUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 9UniRule annotation |
Gene namesi | ORF Names:Y54E2A.11Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | Y54E2A.11a ; CE47851 ; WBGene00001225 ; eif-3.B Y54E2A.11b ; CE47908 ; WBGene00001225 ; eif-3.B |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- eukaryotic 43S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic 48S preinitiation complex Source: UniProtKB-UniRule
- eukaryotic translation initiation factor 3 complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Extended lifespan in adults.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000363789 | 1 – 725 | Eukaryotic translation initiation factor 3 subunit BAdd BLAST | 725 |
Proteomic databases
EPDi | Q9XWI6 |
PaxDbi | Q9XWI6 |
PeptideAtlasi | Q9XWI6 |
PRIDEi | Q9XWI6 |
Expressioni
Gene expression databases
Bgeei | WBGene00001225, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Subunit structurei
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
UniRule annotationGO - Molecular functioni
- translation initiation factor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 40419, 28 interactors |
DIPi | DIP-26989N |
IntActi | Q9XWI6, 2 interactors |
STRINGi | 6239.Y54E2A.11a.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 130 | RRMUniRule annotationAdd BLAST | 85 | |
Repeati | 202 – 240 | WD 1Add BLAST | 39 | |
Repeati | 242 – 280 | WD 2Add BLAST | 39 | |
Repeati | 354 – 395 | WD 3Add BLAST | 42 | |
Repeati | 462 – 504 | WD 4Add BLAST | 43 | |
Repeati | 510 – 552 | WD 5Add BLAST | 43 | |
Repeati | 554 – 594 | WD 6Add BLAST | 41 |
Sequence similaritiesi
Belongs to the eIF-3 subunit B family.UniRule annotation
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG2314, Eukaryota |
GeneTreei | ENSGT00550000074913 |
HOGENOMi | CLU_011152_1_0_1 |
InParanoidi | Q9XWI6 |
OMAi | LIDFSPN |
OrthoDBi | 1194797at2759 |
Family and domain databases
CDDi | cd12278, RRM_eIF3B, 1 hit |
Gene3Di | 2.120.10.30, 1 hit 2.130.10.10, 1 hit 3.30.70.330, 1 hit |
HAMAPi | MF_03001, eIF3b, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR011400, EIF3B IPR034363, eIF3B_RRM IPR012677, Nucleotide-bd_a/b_plait_sf IPR013979, TIF_beta_prop-like IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR14068, PTHR14068, 1 hit |
Pfami | View protein in Pfam PF08662, eIF2A, 1 hit |
PIRSFi | PIRSF036424, eIF3b, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform aImported (identifier: Q9XWI6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVEIDFNKEN EEDFSDPPGF VDDVTDDVLV PDVLHKKPTI DEFEDNCVFI
60 70 80 90 100
AGIPVVGADR LGKLQSVLKK VLERLDPAVK LYIPPSPEGG CLGVLLTEWA
110 120 130 140 150
DQRSAQFAVK SLNGYAFDKN HTFTARSFKD MKQLEAPSDH WTTPEKQAYN
160 170 180 190 200
DVGDLWWWLQ NERCRDQFAI SHDKLGVPTV GVFTNMKGND PELAGDADKA
210 220 230 240 250
ERANWTETVF TWSPHGSYLS TIHKQGIILW GGKDYARAHR FAHTNVQYID
260 270 280 290 300
FSPCETYLVT YAAPEESNSW GDCEKDSLRI WDVRTGELKK AFSTFELTGR
310 320 330 340 350
TQLPTWPFFR WSFDEKYFAC LKAPEKDKLE REQKINGISI FESEKFELYE
360 370 380 390 400
GRPVNIENIK QFEWSPTSTV LAYYSECTDA VPAEFGLLQV PSMQRLRSAR
410 420 430 440 450
VHNVADAQMF WQKSGKRLAF YTMRFKKKEY RETGEVKYVG GCQYHVDIFE
460 470 480 490 500
IDKKDVSLMN LPLSEPFIHF DWDPEGDKFC VLVGNTAKAT PQVYKIEANS
510 520 530 540 550
HAPKLVSKLD AGVHFNEVQF APKGGWLAVL AKVSAGGNVY FIDTSLSEAK
560 570 580 590 600
RTNVIEHPLF NKGYWDPTGR YFVTCSTLGG RAGADLGYRI FTFQGRELCR
610 620 630 640 650
KNLDRLAQFK WRPRPPVKLS EQKQREIKKN LKKTAAKFIK QDDDEKCRAS
660 670 680 690 700
QEVVEKRRKI MAAFDIIRSR NREQLDATRD ERISLRNGVD TEAQLDEDEF
710 720
VDEEITIALS TSKTQAPLTE EEMRD
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047618 | 149 – 193 | YNDVG…NDPEL → KTTLVPTVSLIPTFNTLISR RVRPTLLPTPLRKSRTAGET VRRIV in isoform b. CuratedAdd BLAST | 45 | |
Alternative sequenceiVSP_047619 | 194 – 725 | Missing in isoform b. CuratedAdd BLAST | 532 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284602 Genomic DNA Translation: CAA21681.2 BX284602 Genomic DNA Translation: CAE46682.2 |
PIRi | T27148 |
RefSeqi | NP_001022469.2, NM_001027298.5 [Q9XWI6-1] NP_001022470.2, NM_001027299.5 |
Genome annotation databases
EnsemblMetazoai | Y54E2A.11a.1; Y54E2A.11a.1; WBGene00001225 [Q9XWI6-1] Y54E2A.11a.2; Y54E2A.11a.2; WBGene00001225 [Q9XWI6-1] Y54E2A.11a.3; Y54E2A.11a.3; WBGene00001225 [Q9XWI6-1] Y54E2A.11b.1; Y54E2A.11b.1; WBGene00001225 [Q9XWI6-2] |
GeneIDi | 175138 |
KEGGi | cel:CELE_Y54E2A.11 |
UCSCi | Y54E2A.11a.2, c. elegans |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284602 Genomic DNA Translation: CAA21681.2 BX284602 Genomic DNA Translation: CAE46682.2 |
PIRi | T27148 |
RefSeqi | NP_001022469.2, NM_001027298.5 [Q9XWI6-1] NP_001022470.2, NM_001027299.5 |
3D structure databases
SMRi | Q9XWI6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 40419, 28 interactors |
DIPi | DIP-26989N |
IntActi | Q9XWI6, 2 interactors |
STRINGi | 6239.Y54E2A.11a.1 |
Proteomic databases
EPDi | Q9XWI6 |
PaxDbi | Q9XWI6 |
PeptideAtlasi | Q9XWI6 |
PRIDEi | Q9XWI6 |
Genome annotation databases
EnsemblMetazoai | Y54E2A.11a.1; Y54E2A.11a.1; WBGene00001225 [Q9XWI6-1] Y54E2A.11a.2; Y54E2A.11a.2; WBGene00001225 [Q9XWI6-1] Y54E2A.11a.3; Y54E2A.11a.3; WBGene00001225 [Q9XWI6-1] Y54E2A.11b.1; Y54E2A.11b.1; WBGene00001225 [Q9XWI6-2] |
GeneIDi | 175138 |
KEGGi | cel:CELE_Y54E2A.11 |
UCSCi | Y54E2A.11a.2, c. elegans |
Organism-specific databases
CTDi | 175138 |
WormBasei | Y54E2A.11a ; CE47851 ; WBGene00001225 ; eif-3.B Y54E2A.11b ; CE47908 ; WBGene00001225 ; eif-3.B |
Phylogenomic databases
eggNOGi | KOG2314, Eukaryota |
GeneTreei | ENSGT00550000074913 |
HOGENOMi | CLU_011152_1_0_1 |
InParanoidi | Q9XWI6 |
OMAi | LIDFSPN |
OrthoDBi | 1194797at2759 |
Enzyme and pathway databases
Reactomei | R-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-CEL-72649, Translation initiation complex formation R-CEL-72689, Formation of a pool of free 40S subunits R-CEL-72695, Formation of the ternary complex, and subsequently, the 43S complex R-CEL-72702, Ribosomal scanning and start codon recognition |
Miscellaneous databases
PROi | PR:Q9XWI6 |
Gene expression databases
Bgeei | WBGene00001225, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
CDDi | cd12278, RRM_eIF3B, 1 hit |
Gene3Di | 2.120.10.30, 1 hit 2.130.10.10, 1 hit 3.30.70.330, 1 hit |
HAMAPi | MF_03001, eIF3b, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR011400, EIF3B IPR034363, eIF3B_RRM IPR012677, Nucleotide-bd_a/b_plait_sf IPR013979, TIF_beta_prop-like IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR14068, PTHR14068, 1 hit |
Pfami | View protein in Pfam PF08662, eIF2A, 1 hit |
PIRSFi | PIRSF036424, eIF3b, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EIF3B_CAEEL | |
Accessioni | Q9XWI6Primary (citable) accession number: Q9XWI6 Secondary accession number(s): Q7K785 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 10, 2009 |
Last sequence update: | July 24, 2013 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Translation initiation factors
List of translation initiation factor entries - Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families