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Entry version 162 (26 Feb 2020)
Sequence version 1 (01 Nov 1999)
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Protein
Submitted name:

DNaJ domain (Prokaryotic heat shock protein)

Gene

dnj-27

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress responseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNaJ domain (Prokaryotic heat shock protein)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnj-27Imported
ORF Names:CELE_Y47H9C.5Imported, Y47H9C.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y47H9C.5a ; CE20265 ; WBGene00001045 ; dnj-27

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500433699419 – 788Sequence analysisAdd BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi146 ↔ 149Redox-activeUniRule annotation
Disulfide bondi467 ↔ 470Redox-activeUniRule annotation
Disulfide bondi581 ↔ 584Redox-activeUniRule annotation
Disulfide bondi699 ↔ 702Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9XWE1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XWE1

PeptideAtlas

More...
PeptideAtlasi
Q9XWE1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001045 Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-26501N

STRING: functional protein association networks

More...
STRINGi
6239.Y47H9C.5a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XWE1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 85JInterPro annotationAdd BLAST66
Domaini100 – 220ThioredoxinInterPro annotationAdd BLAST121
Domaini397 – 548ThioredoxinInterPro annotationAdd BLAST152
Domaini638 – 781ThioredoxinInterPro annotationAdd BLAST144

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0191 Eukaryota
KOG0713 Eukaryota
COG0484 LUCA
COG0526 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155558

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023279_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XWE1

KEGG Orthology (KO)

More...
KOi
K09530

Identification of Orthologs from Complete Genome Data

More...
OMAi
APTWRKF

Database of Orthologous Groups

More...
OrthoDBi
522268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XWE1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06257 DnaJ, 1 hit
cd03004 PDI_a_ERdj5_C, 3 hits
cd03003 PDI_a_ERdj5_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit
3.40.30.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR021170 ERdj5
IPR035674 ERdj5_TRX_C
IPR035673 ERdj5_TRX_N
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 4 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037293 DnaJ_homolog_subfam-C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00625 JDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00271 DnaJ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9XWE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAIVLLSVL ISCYLVIAED YYELLGVERD ADDRTIRKAF KKLAIKKHPD
60 70 80 90 100
RNTDDPNAHD EFVKINKAYE VLKDENLRKK YDQFGEKGLE DGFQGGNNYQ
110 120 130 140 150
SWQFYNDNFG IYDDDQEIVT LNRADFQRMV SDSNEIWFIN FYSTYCSHCH
160 170 180 190 200
QLAPTWRKFA REIEGTIRVG AVNCAEDPQL CQSQRVNAYP SLVFYPTGEF
210 220 230 240 250
YQGHRDVELM VDFAIQRLKS EVLHLNSENW KALSEDWEPY NRLPWVVDMC
260 270 280 290 300
GGDHIDCLSS TTRRKLSSML DGLANVATID CNAEEALCSK FNPITSGVMW
310 320 330 340 350
FPARKLVKKS QINIESMDAQ EISKSVIQYL DELEDISVES LQRLLEGNDP
360 370 380 390 400
DEPIAVWMLA NDAQSTERKD FRRLPALVTT QIFKFDCSKS SEICDELLDK
410 420 430 440 450
TKLPQFMVFK TTGGYEIDYA GSKDFHAAST FIREASKSHI HVLNRDSYEY
460 470 480 490 500
AISGGEFYII DYFAPWCPPC MKLLGEYRRF HTATSEDSML HTVAIGSLDC
510 520 530 540 550
VKYKDLCQQA GVQSYPTSIV YTPDGKTHKM VGYHNVDYIL EFLDNSLNPS
560 570 580 590 600
VMEMSPEQFE ELVMNRKDEE TWLVDFFAPW CGPCQQLAPE LQKAARQIAA
610 620 630 640 650
FDENAHVASI DCQKYAQFCT NTQINSYPTV RMYPAKKTKQ PRRSPFYDYP
660 670 680 690 700
NHMWRNSDSI QRWVYNFLPT EVVSLGNDFH TTVLDSSEPW IVDFFAPWCG
710 720 730 740 750
HCIQFAPIYD QIAKELAGKV NFAKIDCDQW PGVCQGAQVR AYPTIRLYTG
760 770 780
KTGWSRQGDQ GIGIGTQHKE QFIQIVRQQL KLDEHDEL
Length:788
Mass (Da):90,770
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3D1C34D858ECD5B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q25AR9Q25AR9_CAEEL
DNaJ domain (Prokaryotic heat shock...
dnj-27 CELE_Y47H9C.5, Y47H9C.5
318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA21734.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T26967

NCBI Reference Sequences

More...
RefSeqi
NP_001040704.1, NM_001047239.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y47H9C.5a.1; Y47H9C.5a.1; WBGene00001045

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173065

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y47H9C.5

UCSC genome browser

More...
UCSCi
Y47H9C.5a c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA21734.1
PIRiT26967
RefSeqiNP_001040704.1, NM_001047239.3

3D structure databases

SMRiQ9XWE1
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-26501N
STRINGi6239.Y47H9C.5a

Proteomic databases

EPDiQ9XWE1
PaxDbiQ9XWE1
PeptideAtlasiQ9XWE1

Genome annotation databases

EnsemblMetazoaiY47H9C.5a.1; Y47H9C.5a.1; WBGene00001045
GeneIDi173065
KEGGicel:CELE_Y47H9C.5
UCSCiY47H9C.5a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173065
WormBaseiY47H9C.5a ; CE20265 ; WBGene00001045 ; dnj-27

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
KOG0713 Eukaryota
COG0484 LUCA
COG0526 LUCA
GeneTreeiENSGT00940000155558
HOGENOMiCLU_023279_0_0_1
InParanoidiQ9XWE1
KOiK09530
OMAiAPTWRKF
OrthoDBi522268at2759
PhylomeDBiQ9XWE1

Gene expression databases

BgeeiWBGene00001045 Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd03004 PDI_a_ERdj5_C, 3 hits
cd03003 PDI_a_ERdj5_N, 1 hit
Gene3Di1.10.287.110, 1 hit
3.40.30.10, 6 hits
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR021170 ERdj5
IPR035674 ERdj5_TRX_C
IPR035673 ERdj5_TRX_N
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 4 hits
PIRSFiPIRSF037293 DnaJ_homolog_subfam-C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 5 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9XWE1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XWE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: February 26, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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