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Entry version 146 (02 Jun 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Cell death abnormality protein 1

Gene

ced-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in programmed cell death, also called apoptosis, in both somatic and germ cells (PubMed:11163239, PubMed:6857247, PubMed:1936965, PubMed:15744306, PubMed:16740477, PubMed:18351800, PubMed:26598553, PubMed:27650246, PubMed:12944970).

Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse (PubMed:15744306).

Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation (PubMed:16740477, PubMed:18351800).

Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (PubMed:18606143).

10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell death abnormality protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ced-11 PublicationImported
ORF Names:Y47H9C.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y47H9C.4a ; CE20264 ; WBGene00000415 ; ced-1
Y47H9C.4b ; CE30361 ; WBGene00000415 ; ced-1
Y47H9C.4c ; CE30362 ; WBGene00000415 ; ced-1
Y47H9C.4d ; CE40433 ; WBGene00000415 ; ced-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 910ExtracellularSequence analysisAdd BLAST892
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei911 – 931HelicalSequence analysisAdd BLAST21
Topological domaini932 – 1111CytoplasmicSequence analysisAdd BLAST180

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Accumulation of cell corpses (PubMed:26598553). Appears immunocompromised resulting in susceptibility to bacterial infection (PubMed:6857247, PubMed:1936965, PubMed:18606143). Reduced or lack of association of ppk-3 and rab-7 with the phagosomal surface (PubMed:18351800). Defective in the recruitment of lysosomes to phagosomes (PubMed:16740477). Double knockout with the P-granule component pgl-1 results in an increased number of cell corpses in the gonad as compared to the ced-1 single mutant (PubMed:26598553). Conversely, double knockout with pgl-1 or pgl-3 results in reduced somatic cell apoptosis (PubMed:27650246). Double knockout with the synthetic multivulva class B protein hpl-2 results in reduced somatic cell apoptosis at 25 degrees Celsius (PubMed:27650246). Triple knockout with hpl-2 and pgl-1 partially recovers the reduced somatic cell apoptotic cell defect in the ced-1 and hpl-2 double knockout (PubMed:27650246). Triple knockout with hpl-2 and pgl-1 and knockdown with either ced-3 or ced-4 reduces the somatic cell apoptosis defect in the ced-1, hpl-2 and pgl-1 triple knockout (PubMed:27650246). Double knockout with hpl-2 and knockdown with either pgl-1, pgl-3, glh-1 or glh-4 RNAi rescues the reduced somatic cell apoptotic cell defect in the ced-1 and hpl-2 double knockout (PubMed:27650246). Knockout with RNAi-mediated knockdown of synthetic multivulva class B proteins lin-9, lin-35, lin-37 or lin-54 results in reduced somatic cell apoptosis (PubMed:27650246).7 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi124P → L in n1995; increase in corpses in L1 head. 1 Publication1
Mutagenesisi136C → Y in n2091; increase in corpses in L1 head. 1 Publication1
Mutagenesisi330C → Y in n2089; increase in corpses in L1 head. 1 Publication1
Mutagenesisi375 – 1111Missing in e1735; defective clearance of apoptotic cell corpses in embryos. 1 PublicationAdd BLAST737
Mutagenesisi448C → Y in e1797, n2000, and n2092; increase in corpses in L1 head. 1 Publication1
Mutagenesisi501C → Y in n1951; increase in corpses in L1 head. 1 Publication1
Mutagenesisi803C → Y in e1801; increase in corpses in L1 head. 1 Publication1
Mutagenesisi962N → A: 85% loss of activity. 1 Publication1
Mutagenesisi965Y → A: 71% loss of activity. 1 Publication1
Mutagenesisi1019Y → A: 54% loss of activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037993219 – 1111Cell death abnormality protein 1Sequence analysisAdd BLAST1093

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 106Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi71 ↔ 80Sequence analysis
Disulfide bondi105 ↔ 117Sequence analysis
Disulfide bondi121 ↔ 130Sequence analysis
Disulfide bondi125 ↔ 136Sequence analysis
Disulfide bondi138 ↔ 147Sequence analysis
Disulfide bondi160 ↔ 172Sequence analysis
Disulfide bondi166 ↔ 179Sequence analysis
Disulfide bondi181 ↔ 190Sequence analysis
Disulfide bondi203 ↔ 215Sequence analysis
Disulfide bondi209 ↔ 221Sequence analysis
Disulfide bondi223 ↔ 232Sequence analysis
Disulfide bondi245 ↔ 257Sequence analysis
Disulfide bondi251 ↔ 264Sequence analysis
Disulfide bondi266 ↔ 275Sequence analysis
Glycosylationi333N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi425 ↔ 439Sequence analysis
Disulfide bondi431 ↔ 446Sequence analysis
Disulfide bondi448 ↔ 457Sequence analysis
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi685 ↔ 697Sequence analysis
Disulfide bondi691 ↔ 704Sequence analysis
Disulfide bondi706 ↔ 715Sequence analysis
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1019Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Tyr-1019, within the YXXL motif, is thought to initiate phagosomal formation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9XWD6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XWD6

PeptideAtlas

More...
PeptideAtlasi
Q9XWD6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9XWD6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in engulfing cells and syncytium hypodermal cells. Ced-7 is necessary for clustering around cell corpses prior to engulfment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000415, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with ced-6 (via PTB domain).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
38467, 6 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9XWD6

Protein interaction database and analysis system

More...
IntActi
Q9XWD6, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9XWD6

STRING: functional protein association networks

More...
STRINGi
6239.Y47H9C.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XWD6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 113EMIPROSITE-ProRule annotationAdd BLAST73
Domaini118 – 148EGF-like 1PROSITE-ProRule annotationAdd BLAST31
Domaini156 – 191EGF-like 2PROSITE-ProRule annotationAdd BLAST36
Domaini199 – 233EGF-like 3PROSITE-ProRule annotationAdd BLAST35
Domaini241 – 276EGF-like 4PROSITE-ProRule annotationAdd BLAST36
Domaini421 – 458EGF-like 5PROSITE-ProRule annotationAdd BLAST38
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati629 – 680FUSequence analysisAdd BLAST52
Domaini681 – 716EGF-like 6PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni940 – 993DisorderedSequence analysisAdd BLAST54
Regioni1006 – 1111DisorderedSequence analysisAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi962 – 965NPXYSequence analysis4
Motifi1019 – 1022YXXLSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi959 – 989Polar residuesSequence analysisAdd BLAST31
Compositional biasi1026 – 1049Polar residuesSequence analysisAdd BLAST24
Compositional biasi1071 – 1111Polar residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NPXY motif thought to be involved in signal transduction that activates the cell corpse internalization process.1 Publication

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000167451

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XWD6

Identification of Orthologs from Complete Genome Data

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OMAi
VYNDTEQ

Database of Orthologous Groups

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OrthoDBi
561378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XWD6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR011489, EMI_domain
IPR006212, Furin_repeat
IPR002049, Laminin_EGF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 17 hits
SM00180, EGF_Lam, 16 hits
SM00261, FU, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 15 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 6 hits
PS51041, EMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q9XWD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLILLVLLA TWQVVVDTRA PTFPDKLTQQ LQQQGTTEPQ GDHVCTVKTI
60 70 80 90 100
VDDYELKKVI HTVVYNDTEQ CLNPLTGFQC TVEKRGQKAS YQRQLVKKEK
110 120 130 140 150
YVKQCCDGYY QTKDHFCLPD CNPPCKKGKC IEPGKCECDP GYGGKYCASS
160 170 180 190 200
CSVGTWGLGC SKSCDCENGA NCDPELGTCI CTSGFQGERC EKPCPDNKWG
210 220 230 240 250
PNCVKSCPCQ NGGKCNKEGK CVCSDGWGGE FCLNKCEEGK FGAECKFECN
260 270 280 290 300
CQNGATCDNT NGKCICKSGY HGALCENECS VGFFGSGCTQ KCDCLNNQNC
310 320 330 340 350
DSSSGECKCI GWTGKHCDIG CSRGRFGLQC KQNCTCPGLE FSDSNASCDA
360 370 380 390 400
KTGQCQCESG YKGPKCDERK CDAEQYGADC SKTCTCVREN TLMCAPNTGF
410 420 430 440 450
CRCKPGFYGD NCELACSKDS YGPNCEKQAM CDWNHASECN PETGSCVCKP
460 470 480 490 500
GRTGKNCSEP CPLDFYGPNC AHQCQCNQRG VGCDGADGKC QCDRGWTGHR
510 520 530 540 550
CEHHCPADTF GANCEKRCKC PKGIGCDPIT GECTCPAGLQ GANCDIGCPE
560 570 580 590 600
GSYGPGCKLH CKCVNGKCDK ETGECTCQPG FFGSDCSTTC SKGKYGESCE
610 620 630 640 650
LSCPCSDASC SKQTGKCLCP LGTKGVSCDQ KCDPNTFGFL CQETVTPSPC
660 670 680 690 700
ASTDPKNGVC LSCPPGSSGI HCEHNCPAGS YGDGCQQVCS CADGHGCDPT
710 720 730 740 750
TGECICEPGY HGKTCSEKCP DGKYGYGCAL DCPKCASGST CDHINGLCIC
760 770 780 790 800
PAGLEGALCT RPCSAGFWGN GCRQVCRCTS EYKQCNAQTG ECSCPAGFQG
810 820 830 840 850
DRCDKPCEDG YYGPDCIKKC KCQGTATSSC NRVSGACHCH PGFTGEFCHA
860 870 880 890 900
LCPESTFGLK CSKECPKDGC GDGYECDAAI GCCHVDQMSC GKAKQEFEAL
910 920 930 940 950
NGAGRSTGLT WFFVLLIVAL CGGLGLIALF YRNKYQKEKD PDMPTVSFHK
960 970 980 990 1000
APNNDEGREF QNPLYSRQSV FPDSDAFSSE NNGNHQGGPP NGLLTLEEEE
1010 1020 1030 1040 1050
LENKKIHGRS AAGRGNNDYA SLDEVAGEGS SSSASASASR RGLNSSEQSR
1060 1070 1080 1090 1100
RPLLEEHDEE EFDEPHENSI SPAHAVTTSN HNENPYADIS SPDPVTQNSA
1110
NKKRAQDNLY T
Length:1,111
Mass (Da):118,804
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA39F374C008F9874
GO
Isoform bImported (identifier: Q9XWD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1042-1082: Missing.

Show »
Length:1,070
Mass (Da):114,181
Checksum:i75254D0DD5643AE5
GO
Isoform cImported (identifier: Q9XWD6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1017-1082: Missing.
     1083-1083: E → K

Show »
Length:1,045
Mass (Da):111,723
Checksum:i0A6D57A3A80BCDCA
GO
Isoform dImported (identifier: Q9XWD6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MRLILLVLLA...QGDHVCTVKT → MCVPRDIGSR...PKFEFSYIFF
     50-1111: Missing.

Show »
Length:49
Mass (Da):5,762
Checksum:i7AC8FDAF4DC6A65A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0531331 – 49MRLIL…CTVKT → MCVPRDIGSRVKTHTPTSHH RTPSPRTLRTKNVLRTICTP KFEFSYIFF in isoform d. CuratedAdd BLAST49
Alternative sequenceiVSP_05313450 – 1111Missing in isoform d. CuratedAdd BLAST1062
Alternative sequenceiVSP_0531351017 – 1082Missing in isoform c. CuratedAdd BLAST66
Alternative sequenceiVSP_0531361042 – 1082Missing in isoform b. CuratedAdd BLAST41
Alternative sequenceiVSP_0531371083E → K in isoform c. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF332568 mRNA Translation: AAG60061.1
BX284601 Genomic DNA Translation: CAA21739.1
BX284601 Genomic DNA Translation: CAD27614.1
BX284601 Genomic DNA Translation: CAD27615.1
BX284601 Genomic DNA Translation: CAL44979.1

Protein sequence database of the Protein Information Resource

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PIRi
T26972

NCBI Reference Sequences

More...
RefSeqi
NP_001021772.1, NM_001026601.3 [Q9XWD6-2]
NP_001021773.1, NM_001026602.3
NP_001076621.1, NM_001083152.2 [Q9XWD6-4]
NP_740922.1, NM_170927.4 [Q9XWD6-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y47H9C.4a.1; Y47H9C.4a.1; WBGene00000415 [Q9XWD6-1]
Y47H9C.4b.1; Y47H9C.4b.1; WBGene00000415 [Q9XWD6-2]
Y47H9C.4c.1; Y47H9C.4c.1; WBGene00000415 [Q9XWD6-3]
Y47H9C.4d.1; Y47H9C.4d.1; WBGene00000415 [Q9XWD6-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y47H9C.4

UCSC genome browser

More...
UCSCi
Y47H9C.4a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332568 mRNA Translation: AAG60061.1
BX284601 Genomic DNA Translation: CAA21739.1
BX284601 Genomic DNA Translation: CAD27614.1
BX284601 Genomic DNA Translation: CAD27615.1
BX284601 Genomic DNA Translation: CAL44979.1
PIRiT26972
RefSeqiNP_001021772.1, NM_001026601.3 [Q9XWD6-2]
NP_001021773.1, NM_001026602.3
NP_001076621.1, NM_001083152.2 [Q9XWD6-4]
NP_740922.1, NM_170927.4 [Q9XWD6-1]

3D structure databases

SMRiQ9XWD6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi38467, 6 interactors
ELMiQ9XWD6
IntActiQ9XWD6, 1 interactor
MINTiQ9XWD6
STRINGi6239.Y47H9C.4a

PTM databases

iPTMnetiQ9XWD6

Proteomic databases

EPDiQ9XWD6
PaxDbiQ9XWD6
PeptideAtlasiQ9XWD6

Genome annotation databases

EnsemblMetazoaiY47H9C.4a.1; Y47H9C.4a.1; WBGene00000415 [Q9XWD6-1]
Y47H9C.4b.1; Y47H9C.4b.1; WBGene00000415 [Q9XWD6-2]
Y47H9C.4c.1; Y47H9C.4c.1; WBGene00000415 [Q9XWD6-3]
Y47H9C.4d.1; Y47H9C.4d.1; WBGene00000415 [Q9XWD6-4]
GeneIDi173064
KEGGicel:CELE_Y47H9C.4
UCSCiY47H9C.4a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173064
WormBaseiY47H9C.4a ; CE20264 ; WBGene00000415 ; ced-1
Y47H9C.4b ; CE30361 ; WBGene00000415 ; ced-1
Y47H9C.4c ; CE30362 ; WBGene00000415 ; ced-1
Y47H9C.4d ; CE40433 ; WBGene00000415 ; ced-1

Phylogenomic databases

eggNOGiKOG1218, Eukaryota
GeneTreeiENSGT00940000167451
InParanoidiQ9XWD6
OMAiVYNDTEQ
OrthoDBi561378at2759
PhylomeDBiQ9XWD6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XWD6

Gene expression databases

BgeeiWBGene00000415, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR011489, EMI_domain
IPR006212, Furin_repeat
IPR002049, Laminin_EGF
PfamiView protein in Pfam
PF00053, Laminin_EGF, 5 hits
SMARTiView protein in SMART
SM00181, EGF, 17 hits
SM00180, EGF_Lam, 16 hits
SM00261, FU, 5 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 15 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 6 hits
PS51041, EMI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCED1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XWD6
Secondary accession number(s): Q0E7J9, Q8T3A6, Q8T3A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 1, 1999
Last modified: June 2, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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