Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (02 Dec 2020)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Add a publicationFeedback
Protein

Bardet-Biedl syndrome 7 protein homolog

Gene

osm-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:17000880, PubMed:22022287, PubMed:22922713, PubMed:26150102). Plays a role in the removal of degraded mechanosensory receptors within the cilia (PubMed:26150102). Plays a role in guanylyl cyclase localization in the ring-like structures at the base of the finger compartment in AFD sensory neurons (PubMed:25335890). In ciliated sensory neurons, required for the sensation of nitric oxide and avoidance of NO-producing organisms like P.aeruginosa (PubMed:30014846).By similarity7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5620922, BBSome-mediated cargo-targeting to cilium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bardet-Biedl syndrome 7 protein homologBy similarity
Alternative name(s):
Osmotic avoidance abnormal protein 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:osm-12Imported
Synonyms:bbs-7Imported
ORF Names:Y75B8A.12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
Y75B8A.12 ; CE23024 ; WBGene00003892 ; osm-12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants have normal body morphology, but with reduced body length and width, delayed larval development and decreased roaming movements (PubMed:22022287). May exhibit defective chemotaxis tendencies (PubMed:15231740). Defective cilia structure and function (PubMed:15231740, PubMed:22022287, PubMed:26150102). This is characterized by increased accumulation and mislocalization of intraflagellar transport proteins and impaired movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:22922713, PubMed:26150102). Defective polycystin-mediated cilia signaling and mislocalized and increased accumulation of mechanosensory receptors pkd-2, osm-9 and odr-10 within cilia (PubMed:26150102). Impaired localization of the guanylyl cyclase proteins, gcy-8, gcy-18 and gcy-23, within AFD sensory neurons, with accumulation along the dendrite as well as in the finger compartment of AFD neurons (PubMed:25335890).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi233 – 721Missing in n1606; results in defective avoidance of nitric oxide and P.aeruginosa. 1 PublicationAdd BLAST489
Mutagenesisi314G → E in my13; results in cilia with structural defects and increased accumulation of the mechanosensory receptor, pkd-2. Mutants may have slightly altered chemotactic tendencies and have vacuoles in amphid sheath cells. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004349961 – 721Bardet-Biedl syndrome 7 protein homologCuratedAdd BLAST721

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XW70

PRoteomics IDEntifications database

More...
PRIDEi
Q9XW70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in ciliated cells including amphid and both inner and outer labial neurons of the head and in both phasmid neurons PHA and PHB in the tail at larval stages L1 and L2.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003892, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of BBSome complex, that contains at least bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9 (By similarity).

Interacts with bbs-1 (PubMed:22922713).

By similarity1 Publication

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-428, BBSome complex

Database of interacting proteins

More...
DIPi
DIP-25936N

Protein interaction database and analysis system

More...
IntActi
Q9XW70, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y75B8A.12

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XW70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPS5, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012346

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018704_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XW70

Identification of Orthologs from Complete Genome Data

More...
OMAi
TDLYVDW

Database of Orthologous Groups

More...
OrthoDBi
341332at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XW70

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016575, Bardet-Biedl_syndrome_7_prot
IPR011047, Quinoprotein_ADH-like_supfam

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF011091, BBS7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998, SSF50998, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XW70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNYSRTDFA QVGTTNRGCM RVIPSDKEKE HDLIVVGGQN GSLICLSRKS
60 70 80 90 100
NDTTIIFKTQ PGYPVQSLAL GGPASSKKKD KIFVASQNTV RGVNRKGKTF
110 120 130 140 150
FSMETNMAEV ANRMFVRGLD VVLTGRKSYS RYHDTVDSNS YLCTEDIHDV
160 170 180 190 200
VSLVFEEAWG SREYTSILAC GNSTLQIIEG NNFAYDVRLD SVPFTVSLFM
210 220 230 240 250
GDGGHTKLLV LYGTKTGRLG LVSVPQGGGK ILWEIDTTSG ACVTTIVCFN
260 270 280 290 300
VTGGQFPDII VGKEDGLIEI YVIDETDHAH LFGTFSCDES ITGISCGHVS
310 320 330 340 350
SKSEIDIIIC TFTGWLFSLA KTSRPMIENL PVAANFSVKM QQLRSEVEEL
360 370 380 390 400
QTKVNEERLR YEEITKRQGS GTGSTFFHSF QVHENFEYSA AHGAYNLTIE
410 420 430 440 450
LVIPIDFVVV QSQLPIRLME VEKNASVVSE VRQDALNPWP LLASYRCQAN
460 470 480 490 500
VCRLELRVQA NEGDSGVINL YVCPKVMPKC AQITTHYIKA LSSHMRSHDF
510 520 530 540 550
DLYRPMNTLQ FTGNFSIAEA HAWLHNLLPN VPSKCPPADT ITNNYQCSVN
560 570 580 590 600
GGTQLQVVYS KGSAVFRSDC MTTICIIRDK VSEQTMKMQI RVEVACELNQ
610 620 630 640 650
DSVNHCLKLI DPKITSMLNI EKNKLYAAAL KELESNNDDV FSFLSAANAK
660 670 680 690 700
ILKDHDAIYE KSEGVSIEDS GVLAILENLM VARGKLTGRS SKGRGDAIRD
710 720
LISTDYSLEN MQTLFKNAMN D
Length:721
Mass (Da):79,889
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFDB5EB3398582A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA22100.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T27399

NCBI Reference Sequences

More...
RefSeqi
NP_499585.1, NM_067184.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y75B8A.12.1; Y75B8A.12.1; WBGene00003892

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
190704

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y75B8A.12

UCSC genome browser

More...
UCSCi
Y75B8A.12, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA22100.1
PIRiT27399
RefSeqiNP_499585.1, NM_067184.1

3D structure databases

SMRiQ9XW70
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-428, BBSome complex
DIPiDIP-25936N
IntActiQ9XW70, 3 interactors
STRINGi6239.Y75B8A.12

Proteomic databases

PaxDbiQ9XW70
PRIDEiQ9XW70

Genome annotation databases

EnsemblMetazoaiY75B8A.12.1; Y75B8A.12.1; WBGene00003892
GeneIDi190704
KEGGicel:CELE_Y75B8A.12
UCSCiY75B8A.12, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
190704
WormBaseiY75B8A.12 ; CE23024 ; WBGene00003892 ; osm-12

Phylogenomic databases

eggNOGiENOG502QPS5, Eukaryota
GeneTreeiENSGT00390000012346
HOGENOMiCLU_018704_1_0_1
InParanoidiQ9XW70
OMAiTDLYVDW
OrthoDBi341332at2759
PhylomeDBiQ9XW70

Enzyme and pathway databases

ReactomeiR-CEL-5620922, BBSome-mediated cargo-targeting to cilium

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XW70

Gene expression databases

BgeeiWBGene00003892, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016575, Bardet-Biedl_syndrome_7_prot
IPR011047, Quinoprotein_ADH-like_supfam
PIRSFiPIRSF011091, BBS7, 1 hit
SUPFAMiSSF50998, SSF50998, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBBS7_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XW70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 9, 2015
Last sequence update: November 1, 1999
Last modified: December 2, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again