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Entry version 121 (17 Jun 2020)
Sequence version 2 (16 May 2012)
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Protein

Protein arginine N-methyltransferase 7

Gene

prmt-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei140By similarity1
Active sitei149By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3214858 RMTs methylate histone arginines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein arginine N-methyltransferase 7 (EC:2.1.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prmt-7
Synonyms:pmrt-2
ORF Names:W06D4.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
W06D4.4 ; CE45537 ; WBGene00012298 ; prmt-7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003739071 – 647Protein arginine N-methyltransferase 7Add BLAST647

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9XW42

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XW42

PeptideAtlas

More...
PeptideAtlasi
Q9XW42

PRoteomics IDEntifications database

More...
PRIDEi
Q9XW42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00012298 Expressed in germ line (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
38159, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.W06D4.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1647
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9XW42

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 332SAM-dependent MTase PRMT-type 1PROSITE-ProRule annotationAdd BLAST321
Domaini337 – 647SAM-dependent MTase PRMT-type 2PROSITE-ProRule annotationAdd BLAST311

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1501 Eukaryota
ENOG410XPR8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156879

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015180_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XW42

KEGG Orthology (KO)

More...
KOi
K11438

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPWRDHW

Database of Orthologous Groups

More...
OrthoDBi
408622at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025799 Arg_MeTrfase
IPR041698 Methyltransf_25
IPR014644 MeTrfase_PRMT7
IPR029063 SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13649 Methyltransf_25, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036946 Arg_N-mtase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51678 SAM_MT_PRMT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XW42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLEKINQKT GEREWVVAEE DYDMAQELAR SRFGDMILDF DRNDKFLAGL
60 70 80 90 100
KTTIAEKKHE NTDGKVHVLD IGTGTGLLSL MAAREGADKV TALEVFKPMG
110 120 130 140 150
DCARHITSNS PWSDKITVIS ERSTDVSQIG GSRADIIVAE VFDTELIGEG
160 170 180 190 200
ALRTFKEALE RLAKPGCRVV PSTGNVYIVP VESHLLKMFN DIPRLNGEKD
210 220 230 240 250
EEPLGRCSGT AAVFDVQLSE MKTHEFRELS EPIVAFKFDF EHEEKIIFDE
260 270 280 290 300
SFVREAVAHS SGTIDALLMW WDIDMDRNGT TFIDMGPKWK NKNNYAWRDH
310 320 330 340 350
WMQAVYYLPE KKKVEMNQTF EIVCNHDEFS LWFSNVGKDK SRSYCVCGLH
360 370 380 390 400
SMLSRQTVYH VNEMFENQKF KDEVDKLSKG LHVATVGEGS FLGLLAAKTA
410 420 430 440 450
KRVTIIDGNE RFRDIFFKYI HYYKLTNVEI IEKVTSLTDS PDIVLAEPFY
460 470 480 490 500
MSAMNPWNHL RFLYDVEVLK MMHGDELRVE PHMGVLKAIP EKFEDLQNIA
510 520 530 540 550
SDVGTVNGFD LSFFDEISTK ARTATDAIVD EQSLWEYAGI VKGDAVEILR
560 570 580 590 600
FPIDGRVSSQ KCVVNIDNMS SSNAIPMWME WEFGGINLST GLLSISSAGV
610 620 630 640
PEWNKGYKQG VYFPITALRN DKSLCLHALF DKSTGDINFQ FGKSEDS
Length:647
Mass (Da):73,326
Last modified:May 16, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7281F8E7CE65CFAB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL034364 Genomic DNA Translation: CAA22252.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T26236

NCBI Reference Sequences

More...
RefSeqi
NP_492436.2, NM_060035.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W06D4.4.1; W06D4.4.1; WBGene00012298

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172727

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W06D4.4

UCSC genome browser

More...
UCSCi
W06D4.4.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034364 Genomic DNA Translation: CAA22252.2
PIRiT26236
RefSeqiNP_492436.2, NM_060035.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WSTX-ray2.39A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R1-647[»]
3X0DX-ray2.15A1-647[»]
SMRiQ9XW42
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi38159, 1 interactor
STRINGi6239.W06D4.4

Proteomic databases

EPDiQ9XW42
PaxDbiQ9XW42
PeptideAtlasiQ9XW42
PRIDEiQ9XW42

Genome annotation databases

EnsemblMetazoaiW06D4.4.1; W06D4.4.1; WBGene00012298
GeneIDi172727
KEGGicel:CELE_W06D4.4
UCSCiW06D4.4.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172727
WormBaseiW06D4.4 ; CE45537 ; WBGene00012298 ; prmt-7

Phylogenomic databases

eggNOGiKOG1501 Eukaryota
ENOG410XPR8 LUCA
GeneTreeiENSGT00940000156879
HOGENOMiCLU_015180_0_0_1
InParanoidiQ9XW42
KOiK11438
OMAiVPWRDHW
OrthoDBi408622at2759

Enzyme and pathway databases

ReactomeiR-CEL-3214858 RMTs methylate histone arginines

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XW42

Gene expression databases

BgeeiWBGene00012298 Expressed in germ line (C elegans) and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR025799 Arg_MeTrfase
IPR041698 Methyltransf_25
IPR014644 MeTrfase_PRMT7
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF13649 Methyltransf_25, 1 hit
PIRSFiPIRSF036946 Arg_N-mtase, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
PROSITEiView protein in PROSITE
PS51678 SAM_MT_PRMT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANM7_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XW42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 16, 2012
Last modified: June 17, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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