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Entry version 120 (05 Jun 2019)
Sequence version 1 (01 Nov 1999)
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Protein
Submitted name:

Cytokinesis, Apoptosis, RNA-associated

Gene

car-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cytokinesis, Apoptosis, RNA-associatedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:car-1Imported
ORF Names:CELE_Y18D10A.17Imported, Y18D10A.17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y18D10A.17 ; CE21413 ; WBGene00012484 ; car-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9XW17

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XW17

PeptideAtlas

More...
PeptideAtlasi
Q9XW17

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00012484 Expressed in 6 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-26312N

Protein interaction database and analysis system

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IntActi
Q9XW17, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y18D10A.17

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9XW17

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini178 – 214DFDFInterPro annotationAdd BLAST37
Domaini227 – 243FFDInterPro annotationAdd BLAST17
Domaini251 – 271TFGInterPro annotationAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni101 – 148DisorderedSequence analysisAdd BLAST48
Regioni277 – 340DisorderedSequence analysisAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi227 – 243FFD boxPROSITE-ProRule annotationAdd BLAST17
Motifi251 – 271TFG boxPROSITE-ProRule annotationAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi117 – 148PolarSequence analysisAdd BLAST32

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1073 Eukaryota
ENOG41122RA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231251

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XW17

KEGG Orthology (KO)

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KOi
K18749

Identification of Orthologs from Complete Genome Data

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OMAi
FGAVGVX

Database of Orthologous Groups

More...
OrthoDBi
1569369at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XW17

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01736 LSm14_N, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR025761 FFD_box
IPR025609 Lsm14-like_N
IPR010920 LSM_dom_sf
IPR025768 TFG_box

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09532 FDF, 1 hit
PF12701 LSM14, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01199 FDF, 1 hit
SM01271 LSM14, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50182 SSF50182, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51512 DFDF, 1 hit
PS51513 FFD, 1 hit
PS51536 TFG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XW17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNQTPYIGS KISLISKLDI RYEGILYTVD TNDSTIALAK VRSFGTEKRP
60 70 80 90 100
TANPVAARDD VYEYIIFKAS DIKDLIVCDT PKMANIGGGL PYDPAIISVS
110 120 130 140 150
SRSAPASDGA PAASAGSSRA GTPSRNSPLG QIIQNQRPGR GGYQQNFQAN
160 170 180 190 200
RGYNNYRGGF AGGYNNQRGH NNYGVPRVNH REKLKFESDF DFEKANEKFQ
210 220 230 240 250
EVLVDNLEKL NIEDKAEPEV EEKKDAAFYD KKTSFFDNIS CESLEKAEGK
260 270 280 290 300
TGRPDWKKER ETNQETFGHN AVRSLNYRRG FGGRGRGGNR GYGGYNNGYQ
310 320 330 340
HQHQHRGGYN GGYRQNNGGY RRGGYAPRDN QGNTAAAAEQ
Length:340
Mass (Da):37,610
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70466FA0B449ABB6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA22317.1

Protein sequence database of the Protein Information Resource

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PIRi
T26526

NCBI Reference Sequences

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RefSeqi
NP_493254.1, NM_060853.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y18D10A.17; Y18D10A.17; WBGene00012484

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173158

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y18D10A.17

UCSC genome browser

More...
UCSCi
Y18D10A.17 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA22317.1
PIRiT26526
RefSeqiNP_493254.1, NM_060853.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6F9SX-ray3.03B184-268[»]
SMRiQ9XW17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26312N
IntActiQ9XW17, 2 interactors
STRINGi6239.Y18D10A.17

Proteomic databases

EPDiQ9XW17
PaxDbiQ9XW17
PeptideAtlasiQ9XW17

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
173158
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY18D10A.17; Y18D10A.17; WBGene00012484
GeneIDi173158
KEGGicel:CELE_Y18D10A.17
UCSCiY18D10A.17 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173158
WormBaseiY18D10A.17 ; CE21413 ; WBGene00012484 ; car-1

Phylogenomic databases

eggNOGiKOG1073 Eukaryota
ENOG41122RA LUCA
GeneTreeiENSGT00940000168901
HOGENOMiHOG000231251
InParanoidiQ9XW17
KOiK18749
OMAiFGAVGVX
OrthoDBi1569369at2759
PhylomeDBiQ9XW17

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XW17

Gene expression databases

BgeeiWBGene00012484 Expressed in 6 organ(s), highest expression level in adult organism

Family and domain databases

CDDicd01736 LSm14_N, 1 hit
InterProiView protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR025761 FFD_box
IPR025609 Lsm14-like_N
IPR010920 LSM_dom_sf
IPR025768 TFG_box
PfamiView protein in Pfam
PF09532 FDF, 1 hit
PF12701 LSM14, 1 hit
SMARTiView protein in SMART
SM01199 FDF, 1 hit
SM01271 LSM14, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
PROSITEiView protein in PROSITE
PS51512 DFDF, 1 hit
PS51513 FFD, 1 hit
PS51536 TFG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9XW17_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XW17
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: June 5, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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