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Protein

Eukaryotic translation initiation factor 4E-binding protein Mextli homolog

Gene

mxt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in promoting translation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-binding protein Mextli homologCurated
Gene namesi
Name:mxt-1Imported
Synonyms:mxt1 Publication
ORF Names:Y18D10A.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY18D10A.8 ; CE21404 ; WBGene00012478 ; mxt-1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi493M → D: Reduced binding to ife-3. 1 Publication1
Mutagenesisi497I → D: Reduced binding to ife-3; when associated with D-504. 1 Publication1
Mutagenesisi504I → D: Reduced binding to ife-3; when associated with D-497. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004362641 – 507Eukaryotic translation initiation factor 4E-binding protein Mextli homologCuratedAdd BLAST507

Proteomic databases

EPDiQ9XW13
PaxDbiQ9XW13
PeptideAtlasiQ9XW13

Expressioni

Gene expression databases

BgeeiWBGene00012478 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Interactioni

Subunit structurei

Interacts with eukaryotic translation initiation factor ife-3.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3482 Eukaryotic translation initiation factor 4E-Mxt complex
DIPiDIP-27212N
IntActiQ9XW13, 10 interactors
STRINGi6239.Y18D10A.8

Structurei

Secondary structure

1507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9XW13
SMRiQ9XW13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 307KHPROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi133 – 218Pro-richPROSITE-ProRule annotationAdd BLAST86
Compositional biasi350 – 359Poly-AspSequence analysis10

Domaini

Binds to ife-3 using a bipartite interface in the C-terminal domain which comprises a canonical helix which engages the ife-3 dorsal surface and a non-canonical helix which engages the ife-3 lateral surface.1 Publication

Phylogenomic databases

eggNOGiENOG410IG5Y Eukaryota
ENOG4110RAK LUCA
GeneTreeiENSGT00520000058221
InParanoidiQ9XW13
OMAiIMGVKGR
OrthoDBiEOG091G05VC
PhylomeDBiQ9XW13

Family and domain databases

Gene3Di1.25.40.180, 1 hit
3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR016021 MIF4-like_sf
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XW13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHNYDDFGG GKMQGAPQVP RNTLLSVDQQ LQLMNTINNM VRASQFTSQL
60 70 80 90 100
ANTIFTLCAQ LKTSGSMLEQ SHKNELNKVF TSLRQACCRD NGQLGTPCRL
110 120 130 140 150
KIMELVELRA MNWRTNLAHS QYYVNRPEGQ HDPAPTVGIP PSATSPPTQV
160 170 180 190 200
TSSVTSPVPS SPQPPMQFVP QNPMMFQDPM AANHNAGGIF FIPAASTWMN
210 220 230 240 250
PLMPMPPNPF LPHSMIPPDH QMFLRQRSLN KKPNNLMNKT LQLRHEMIIR
260 270 280 290 300
NSDSGKIMGV KGRRVAAVEQ LTNTVISFQK VDSKSKERTL TITASTMEDI
310 320 330 340 350
ERAKDMIIDT IRRNMSPMRT DMSIPPPNQY SGMSSENQSI PSQQNTANID
360 370 380 390 400
EDDDDDDEDI KLEQTSDGKL TFHCDDPELL AAAQEALSAY LRVRARPSAE
410 420 430 440 450
EREKKKERRK SMPLQQTARD QQEPVMLKPA KTFHGSTPNL ADGLAATTTV
460 470 480 490 500
VVASIPQPMV PNVHASGDNP IRYNRDTLMT ARDTKRAPIP DEMLQEINRV

APDILIA
Length:507
Mass (Da):56,571
Last modified:November 1, 1999 - v1
Checksum:i3D9DDE0D40F088F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA22321.1
PIRiT26530
RefSeqiNP_493246.1, NM_060845.5
UniGeneiCel.6611

Genome annotation databases

EnsemblMetazoaiY18D10A.8; Y18D10A.8; WBGene00012478
GeneIDi173151
KEGGicel:CELE_Y18D10A.8
UCSCiY18D10A.8 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA22321.1
PIRiT26530
RefSeqiNP_493246.1, NM_060845.5
UniGeneiCel.6611

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ABXX-ray1.66B471-507[»]
5ABYX-ray1.95B/D/F471-507[»]
ProteinModelPortaliQ9XW13
SMRiQ9XW13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3482 Eukaryotic translation initiation factor 4E-Mxt complex
DIPiDIP-27212N
IntActiQ9XW13, 10 interactors
STRINGi6239.Y18D10A.8

Proteomic databases

EPDiQ9XW13
PaxDbiQ9XW13
PeptideAtlasiQ9XW13

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY18D10A.8; Y18D10A.8; WBGene00012478
GeneIDi173151
KEGGicel:CELE_Y18D10A.8
UCSCiY18D10A.8 c. elegans

Organism-specific databases

CTDi173151
WormBaseiY18D10A.8 ; CE21404 ; WBGene00012478 ; mxt-1

Phylogenomic databases

eggNOGiENOG410IG5Y Eukaryota
ENOG4110RAK LUCA
GeneTreeiENSGT00520000058221
InParanoidiQ9XW13
OMAiIMGVKGR
OrthoDBiEOG091G05VC
PhylomeDBiQ9XW13

Miscellaneous databases

PROiPR:Q9XW13

Gene expression databases

BgeeiWBGene00012478 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

Gene3Di1.25.40.180, 1 hit
3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR016021 MIF4-like_sf
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMXT_CAEEL
AccessioniPrimary (citable) accession number: Q9XW13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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