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Entry version 148 (02 Jun 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Nuclear RNA export factor 1

Gene

nxf-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in RNA export from the nucleus to the cytoplasm.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-159227, Transport of the SLBP independent Mature mRNA
R-CEL-159230, Transport of the SLBP Dependant Mature mRNA
R-CEL-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNA export factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nxf-1
ORF Names:C15H11.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
C15H11.3a ; CE08180 ; WBGene00003834 ; nxf-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205361 – 628Nuclear RNA export factor 1Add BLAST628

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9XVS7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XVS7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003834, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nucleoporins, Nup98, Nup153 and Nup214.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
56231, 33 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C15H11.3a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XVS7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 179RRMAdd BLAST80
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati245 – 270LRR 1Add BLAST26
Repeati271 – 294LRR 2Add BLAST24
Domaini365 – 526NTF2PROSITE-ProRule annotationAdd BLAST162
Domaini576 – 628TAP-CPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 83DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 83Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.By similarity
The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for its localization to the nuclear rim.
The RNA-binding domain is a non-canonical RNP-type domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3763, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XVS7

Identification of Orthologs from Complete Genome Data

More...
OMAi
HADEEFT

Database of Orthologous Groups

More...
OrthoDBi
1051093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XVS7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14342, UBA_TAP-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675, LRR_dom_sf
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR005637, TAP_C_dom
IPR015245, Tap_RNA-bd
IPR009060, UBA-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10662, PTHR10662, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09162, Tap-RNA_bind, 1 hit
PF03943, TAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00804, TAP_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit
SSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50177, NTF2_DOMAIN, 1 hit
PS51281, TAP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9XVS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERDGCFGNC WLRRWEKSDM NRKGFGGHRD AKQLSRTKNR FARLDPDTQS
60 70 80 90 100
RYEDDDEPAV PVRASLTSAS SRGRGGSSRG FGQSAASIAN TGVRNADIVY
110 120 130 140 150
KCRATGAAKK VDAKWLIKQL NQIIENFKPL LWTDNARGDF EWYVRDEDTA
160 170 180 190 200
STIRANNRRV VHKESGTRVE FYTSKVPAPW MKLKREEIEI IHRVVDKRHN
210 220 230 240 250
AENRVLDLSN FHEDEEFKAK DMMMNLTKGN VMLTVLDHID DKYGNIVALS
260 270 280 290 300
LSNNRIRHLD YASALVSIAK FVMELDLSHN HISTEKELEK FAGLPVERFF
310 320 330 340 350
FEGNPVVESF TQRAAYISYI HQSFPRCNML DGVEVQPLVV GPDLDIHDAM
360 370 380 390 400
PFRAGYYPNP QIRVLVEQFV TSYFDFYDGP DGQRTRRNLH NAYDADASTF
410 420 430 440 450
SLTIEHLRGS SHARHHNDEC FAQYAGVSHN VLKQERFARH RASRSARGAM
460 470 480 490 500
DIAVALSKLP TSSHMRDTFI VDVFLQSNDL LGFTVQGLFC DGDLTQTPSP
510 520 530 540 550
SFFSRSFLVS PRENDSVAVI SDQLFITVAS LDRLEKFKKL YDQSIANGAA
560 570 580 590 600
VEQVSAVQIA QIGVNGMGFD GAPALPIREE MIKAMCQFSG MIPPFSEKCL
610 620
ADCAWNFDFA CQKFNEIKSS VPAEAFAH
Length:628
Mass (Da):70,962
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AF6B9DE2A798A7D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5BM32B5BM32_CAEEL
Nuclear RNA export factor 1
nxf-1 C15H11.3, CELE_C15H11.3
609Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z81035 Genomic DNA Translation: CAB02734.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T19316

NCBI Reference Sequences

More...
RefSeqi
NP_506567.1, NM_074166.3

Genome annotation databases

UCSC genome browser

More...
UCSCi
C15H11.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81035 Genomic DNA Translation: CAB02734.1
PIRiT19316
RefSeqiNP_506567.1, NM_074166.3

3D structure databases

SMRiQ9XVS7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi56231, 33 interactors
STRINGi6239.C15H11.3a

Proteomic databases

EPDiQ9XVS7
PaxDbiQ9XVS7

Genome annotation databases

UCSCiC15H11.3, c. elegans

Organism-specific databases

WormBaseiC15H11.3a ; CE08180 ; WBGene00003834 ; nxf-1

Phylogenomic databases

eggNOGiKOG3763, Eukaryota
InParanoidiQ9XVS7
OMAiHADEEFT
OrthoDBi1051093at2759
PhylomeDBiQ9XVS7

Enzyme and pathway databases

ReactomeiR-CEL-159227, Transport of the SLBP independent Mature mRNA
R-CEL-159230, Transport of the SLBP Dependant Mature mRNA
R-CEL-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XVS7

Gene expression databases

BgeeiWBGene00003834, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

Family and domain databases

CDDicd14342, UBA_TAP-C, 1 hit
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675, LRR_dom_sf
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR005637, TAP_C_dom
IPR015245, Tap_RNA-bd
IPR009060, UBA-like_sf
PANTHERiPTHR10662, PTHR10662, 1 hit
PfamiView protein in Pfam
PF09162, Tap-RNA_bind, 1 hit
PF03943, TAP_C, 1 hit
SMARTiView protein in SMART
SM00804, TAP_C, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50177, NTF2_DOMAIN, 1 hit
PS51281, TAP_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXF1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XVS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1999
Last modified: June 2, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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