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Entry version 119 (02 Jun 2021)
Sequence version 4 (03 Oct 2012)
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Protein

Protein unc-80

Gene

unc-80

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane.

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-80
Alternative name(s):
Uncoordinated protein 80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-80
ORF Names:F25C8.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F25C8.3a ; CE41563 ; WBGene00006812 ; unc-80
F25C8.3b ; CE47117 ; WBGene00006812 ; unc-80
F25C8.3c ; CE47217 ; WBGene00006812 ; unc-80
F25C8.3d ; CE43592 ; WBGene00006812 ; unc-80
F25C8.3e ; CE47428 ; WBGene00006812 ; unc-80

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2088 – 2108HelicalSequence analysisAdd BLAST21
Transmembranei2318 – 2338HelicalSequence analysisAdd BLAST21
Transmembranei2352 – 2372HelicalSequence analysisAdd BLAST21
Transmembranei2953 – 2973HelicalSequence analysisAdd BLAST21
Transmembranei2995 – 3015HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Fainters phenotype, characterized by defects in locomotion, vesicle depletion, and electrophysiological defects in synaptojanin mutants.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003678081 – 3263Protein unc-80Add BLAST3263

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9XV66

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XV66

PeptideAtlas

More...
PeptideAtlasi
Q9XV66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the nervous system. Expressed in both acetylcholine and GABA motor neurons.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006812, Expressed in material anatomical entity and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
45330, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F25C8.3d

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XV66

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni491 – 527DisorderedSequence analysisAdd BLAST37
Regioni627 – 666DisorderedSequence analysisAdd BLAST40
Regioni939 – 1010DisorderedSequence analysisAdd BLAST72
Regioni1042 – 1076DisorderedSequence analysisAdd BLAST35
Regioni1380 – 1475DisorderedSequence analysisAdd BLAST96
Regioni1633 – 1660DisorderedSequence analysisAdd BLAST28
Regioni1680 – 1721DisorderedSequence analysisAdd BLAST42
Regioni3078 – 3166DisorderedSequence analysisAdd BLAST89
Regioni3178 – 3198DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi638 – 666Polar residuesSequence analysisAdd BLAST29
Compositional biasi939 – 969Polar residuesSequence analysisAdd BLAST31
Compositional biasi979 – 1010Polar residuesSequence analysisAdd BLAST32
Compositional biasi1380 – 1405Polar residuesSequence analysisAdd BLAST26
Compositional biasi1445 – 1459Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1460 – 1475Polar residuesSequence analysisAdd BLAST16
Compositional biasi1633 – 1648Polar residuesSequence analysisAdd BLAST16
Compositional biasi1680 – 1720Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi3080 – 3106Polar residuesSequence analysisAdd BLAST27
Compositional biasi3107 – 3124Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi3135 – 3166Polar residuesSequence analysisAdd BLAST32
Compositional biasi3180 – 3198Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-80 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSTP, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00640000091496

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XV66

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYQWAEA

Database of Orthologous Groups

More...
OrthoDBi
82175at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR031542, UNC80_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15778, UNC80, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform d (identifier: Q9XV66-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHVRYLQHEH TGTVQLLLMP LSTAASFKSA KWTEEEGEEE CDSVPLPIQT
60 70 80 90 100
FLWRQTNPFL GDKIGKLHEA SCVTFERVVV QNILHGLSPS LSNALASVSR
110 120 130 140 150
WKLVRAALPH VIQCCGSLLL ANVGEKKLPT SLQKILYILH WMLIDSSSEC
160 170 180 190 200
IENASTKDDR SVCQSRTQGL FNISSIQLFI YLIAPLADVI SEEEVVDNIR
210 220 230 240 250
LESGLKVWQA IWQFRQPDVW CFSAPVKQRR DELPQITFAR RQNPAQLDTQ
260 270 280 290 300
GIYLGKDENT VRRPSIVPPP KPPRTDVTVL NEKRKLEEEK MKMKEDYVAI
310 320 330 340 350
EIEAPSLKPN DLLIDMSQGV RNKEFERTSS IVRSVSEYKT NLCGQKEKLA
360 370 380 390 400
TVSKSRTSDA FDSSPTSDSS ANMLEEVEGI KFSENENCSL SAVFFSSDQA
410 420 430 440 450
PLVNLSDICS GFSIEEPHDS TQSSVEVPQH PVLESSMFLS TTSSASDVPP
460 470 480 490 500
FVLTRASTAE DTTSSCSQQT VIPLAMPVTT ETTTLPVTLP KSALTKTTNE
510 520 530 540 550
NRRTDHQRMP STQKSVSGST DDELDEGSFS DPTIASYLDV AVIRALLITH
560 570 580 590 600
WQEKGVYWAL SYIHNRLIEI KAYMIIRKST RQRSNSLPSG ERKLSVAPEQ
610 620 630 640 650
LTNPVWDDLK IENKPEEGRS HLHVAFNDTE RRKSSDNCLA PHPTTNSRRS
660 670 680 690 700
SLNTLSRRGI NRSNPSLSNS VEVLSIRDDA EDDVSNISSK SIEKENTKLN
710 720 730 740 750
AVFYPEALGS TNFIEKDGKI SATVIVQTVN QVMDRCTGVR QCELALNIAD
760 770 780 790 800
VLLGTPLEQT ETFFVQLNIM VFKIYLCLGC PHGCNEGVKS PHGDFLRAKA
810 820 830 840 850
KAILAGLERV QPDKFKNILN DYVDNYGTQQ VIDLLHSITS FCRSELTALD
860 870 880 890 900
GRRASESRVP SYRNTFNEKD KGIEGRIINA TYKTLITKIS VISAELSLPE
910 920 930 940 950
NMSLQQDVRL LVNFVQEHHG NPFRRVGLSA LKDATCKNPT TSDFHTKEDQ
960 970 980 990 1000
TGGSPGAQSQ KQSNDQASLR RGLFKKKNEK SGGTTTGNDD SEGDSSPSTP
1010 1020 1030 1040 1050
RTVSSMDDGV SPLASTSYYK KKSAPKLHFA FGLLKSVKPD MDEEISDNEN
1060 1070 1080 1090 1100
EEGTSNEEAG LPQRRPLRQS SKQVKARLPI DSKGGMRLWG TYVPPPNYID
1110 1120 1130 1140 1150
AKGIFDGARR FAFLLETARP GTFPDAPLIA AIMHLKSPVL ARASLLLECA
1160 1170 1180 1190 1200
NLVSRCNRGQ WPEWIRSSHH RTFSLGGALA NRGTPSATRR MHSLQRQAGR
1210 1220 1230 1240 1250
YFYQWGVQIG EHISKLLELS ENKSKKTLQM EDTIEDFFDD GIVNNQNGEK
1260 1270 1280 1290 1300
CPIALQFIAV LLLQEITAFL RETFKTIPRS KNSKPQTGNS GWDKLLSHRR
1310 1320 1330 1340 1350
WSILSNTFNA QQTGSVNSIT EINSSIHLND KERRISFSAT EEDSPRGSKD
1360 1370 1380 1390 1400
AIDEINAVDK KGSIHMQVVR PPSLSARLFS RQSTHEESGG SAQGSTKSTT
1410 1420 1430 1440 1450
YVPETGRRIA TGRQRLLKRG SPMATGTQPS LESSHKRKSF RNRKQSKQAH
1460 1470 1480 1490 1500
LEEEEKSDGG SLTSQQSPIV QRMRAASMRQ SSNFLALFHH AIPEFLDAGA
1510 1520 1530 1540 1550
THILSARESL KPTDDGLQSP VESVHPVIIP HSNHGSAHSQ QPVVLKSSMD
1560 1570 1580 1590 1600
DEEQHMLSNL PWIKVLIKFS NSFDLECNHV GVCSAKCFQR VHRQCFRMIE
1610 1620 1630 1640 1650
SLSTLYGMER NVSTRADKRN LLADNWQAKQ QALRKQTETN SARASIHARQ
1660 1670 1680 1690 1700
STAVPRRESA MVGQPEFASK AIKMMLMEKM QQEKEKEKEK EKEEKDALKK
1710 1720 1730 1740 1750
QSVEQDHSST DTEEDAQLPE KNKPMLTYLR SLVLQLVHSP ISSVLKCCLL
1760 1770 1780 1790 1800
LSVEQHKQMI EVCWKMLIHE DPHVVASAAS MFIVASVKKS EESLLIIKTA
1810 1820 1830 1840 1850
LDSQDPQVRT SGIQRFYTLW RNRFHAWLKM EDGAQASFKV PPPGIDFTLP
1860 1870 1880 1890 1900
SPAIGQSQLP VVDPPWMPHL KTKIEELSLK EEEHATSQTI MTMTRTRRKQ
1910 1920 1930 1940 1950
KQEMVKRAVR EAEERQSEQR QLFRLRSSAI VSLAAYEPAL FHHQQEQTEE
1960 1970 1980 1990 2000
SDNSHQHARH VMPVAQPLFP SALLSVVPQI IELLDDPQVD NNGVSVGDVA
2010 2020 2030 2040 2050
KKVIWTCIVE DPSLFLRHFL EKLTNRDRQV LISEYAPTPA YEALMSQLRK
2060 2070 2080 2090 2100
LVLRFHPLPS QAAHSLLNYL FGFVMHYVRA QCEGSEKAIG MALSICWLLS
2110 2120 2130 2140 2150
PNIHGLYFKD LKQTLKKEQC DQALMITANV PSAKKIIVHG LDSTSGGIPS
2160 2170 2180 2190 2200
QFPVHEDTQF HQILNDSLEF FNIDEDDLNC FYLTDTKTGV IHLPAAYVRD
2210 2220 2230 2240 2250
YYFFHRSFYP QLTLVKLSPE VAEKKMKETA FHQKFIECGK VLLTHNILKY
2260 2270 2280 2290 2300
SPQHVIAQRV FFLHDEFTHL PSFPRKSLET CFGMYFGPGG EQLKAMESMH
2310 2320 2330 2340 2350
KFVWAKMMSD MFEKMENAFM FADLHLFINV INGIMIMHCE DVLILRRCAA
2360 2370 2380 2390 2400
TYISISIHFN TLFASQGFFL IMPTLLRCYS QRQTNKVFCG VVEFICRQFY
2410 2420 2430 2440 2450
TLHRKPFLLQ MCGAIANIID NSSNDFEINP MRVKAKYWFN LIKKMEEITD
2460 2470 2480 2490 2500
EDPLDILGLV PYEKPLKALD LCYRDDPNTF CALTDAMASC ICVCAFSPES
2510 2520 2530 2540 2550
KRSHHMLLIM QAMLPHMMKR LEEETLQSGN SPAAVKHEIS QWITMAVEMK
2560 2570 2580 2590 2600
ALINSCEQLV RGPTRAFDLV NSVSERGKSF VADSPQFFDP PTTNEDENSR
2610 2620 2630 2640 2650
PYHLKEKRST AVAWEAAEVE EQQKETYRRP RDTLLQLIAA YIEMASVRLK
2660 2670 2680 2690 2700
ELTKLGANLE HAKIPDVLDH KCYVKLGEVA LALLKVAPYD LSTTTCHGLQ
2710 2720 2730 2740 2750
KYFQIILPVT DWSIESNRSA LNIILRRLDK TLSKIAKRQS FRKRAIWIAL
2760 2770 2780 2790 2800
SSWINGICDT LNAFPYIAHL HPLRTITQLC LRMMVGDPCV EDSAASTALH
2810 2820 2830 2840 2850
PTTVLHPTPP PQTFANAVLR LTTILMQALG QFAFSLDFVT STEGMGVSSE
2860 2870 2880 2890 2900
RLEAVLCHVL IPLFLRIPNN PKEQSIFQAK DLSQCLTVMQ NAISPPLVKQ
2910 2920 2930 2940 2950
QAPPLISTST LTTTFIRGAQ DVTGRQGSVS VTDRGHSATV STHRIVRESI
2960 2970 2980 2990 3000
CQAIYLGLKV LMLTFGKLLA PMWPRVARIV KDLLAKKPGA PTSMAFVDFL
3010 3020 3030 3040 3050
LHSNLPISLF ILPMIQNKMK QKPGTDQEAA WQTEILEKLD AKSHNIVPPS
3060 3070 3080 3090 3100
ILLVKCYQEL QQLKEELTMK PIEMTRSYTP TMADPHSDSS AASTAPRGAS
3110 3120 3130 3140 3150
SRQSIDRRTS VHMKKVLPTM KEDIPEDPED SEDVIDSNST GQVTSRISKS
3160 3170 3180 3190 3200
PSIPLNKTHQ SSRTRSVSGF GMWRSVRRKS RHVSSAEESS EERGSVELHD
3210 3220 3230 3240 3250
VGHHSALHEP NRTPNRRSTE ALVLPLHESI DTNRHRFVSF STPKKTHEVS
3260
EDVFQITEQH QLV
Length:3,263
Mass (Da):366,998
Last modified:October 3, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i288614628F597E23
GO
Isoform a (identifier: Q9XV66-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1460-1497: Missing.

Show »
Length:3,225
Mass (Da):362,743
Checksum:i0B966F205E9580D7
GO
Isoform b (identifier: Q9XV66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1460-1497: Missing.
     1636-1644: Missing.
     2030-2041: Missing.

Show »
Length:3,204
Mass (Da):360,479
Checksum:i7908AFAB6FE91B11
GO
Isoform c (identifier: Q9XV66-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     1460-1497: Missing.
     2030-2041: Missing.

Show »
Length:3,195
Mass (Da):359,280
Checksum:iBD905161C0564364
GO
Isoform e (identifier: Q9XV66-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1363-1406: Missing.
     1460-1497: Missing.
     1636-1644: Missing.
     2030-2041: Missing.

Show »
Length:3,160
Mass (Da):355,806
Checksum:i7F212513ADF02E51
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0441991 – 18Missing in isoform c. CuratedAdd BLAST18
Alternative sequenceiVSP_0442031363 – 1406Missing in isoform e. CuratedAdd BLAST44
Alternative sequenceiVSP_0442001460 – 1497Missing in isoform a, isoform b, isoform c and isoform e. CuratedAdd BLAST38
Alternative sequenceiVSP_0442011636 – 1644Missing in isoform b and isoform e. Curated9
Alternative sequenceiVSP_0442022030 – 2041Missing in isoform b, isoform c and isoform e. CuratedAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z81512 Genomic DNA Translation: CAB04172.3
Z81512 Genomic DNA Translation: CAE46668.2
Z81512 Genomic DNA Translation: CAR64667.2
Z81512 Genomic DNA Translation: CAX65056.1
Z81512 Genomic DNA Translation: CCG28158.1

NCBI Reference Sequences

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RefSeqi
NP_001023839.2, NM_001028668.2 [Q9XV66-1]
NP_001023840.2, NM_001028669.3 [Q9XV66-2]
NP_001129895.2, NM_001136423.2 [Q9XV66-3]
NP_001256961.1, NM_001270032.1 [Q9XV66-4]
NP_001256962.1, NM_001270033.1 [Q9XV66-5]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F25C8.3a.1; F25C8.3a.1; WBGene00006812 [Q9XV66-1]
F25C8.3b.1; F25C8.3b.1; WBGene00006812 [Q9XV66-2]
F25C8.3c.1; F25C8.3c.1; WBGene00006812 [Q9XV66-3]
F25C8.3c.2; F25C8.3c.2; WBGene00006812 [Q9XV66-3]
F25C8.3d.1; F25C8.3d.1; WBGene00006812 [Q9XV66-4]
F25C8.3e.1; F25C8.3e.1; WBGene00006812 [Q9XV66-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
180374

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F25C8.3

UCSC genome browser

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UCSCi
F25C8.3a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81512 Genomic DNA Translation: CAB04172.3
Z81512 Genomic DNA Translation: CAE46668.2
Z81512 Genomic DNA Translation: CAR64667.2
Z81512 Genomic DNA Translation: CAX65056.1
Z81512 Genomic DNA Translation: CCG28158.1
RefSeqiNP_001023839.2, NM_001028668.2 [Q9XV66-1]
NP_001023840.2, NM_001028669.3 [Q9XV66-2]
NP_001129895.2, NM_001136423.2 [Q9XV66-3]
NP_001256961.1, NM_001270032.1 [Q9XV66-4]
NP_001256962.1, NM_001270033.1 [Q9XV66-5]

3D structure databases

SMRiQ9XV66
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi45330, 1 interactor
STRINGi6239.F25C8.3d

Proteomic databases

EPDiQ9XV66
PaxDbiQ9XV66
PeptideAtlasiQ9XV66

Genome annotation databases

EnsemblMetazoaiF25C8.3a.1; F25C8.3a.1; WBGene00006812 [Q9XV66-1]
F25C8.3b.1; F25C8.3b.1; WBGene00006812 [Q9XV66-2]
F25C8.3c.1; F25C8.3c.1; WBGene00006812 [Q9XV66-3]
F25C8.3c.2; F25C8.3c.2; WBGene00006812 [Q9XV66-3]
F25C8.3d.1; F25C8.3d.1; WBGene00006812 [Q9XV66-4]
F25C8.3e.1; F25C8.3e.1; WBGene00006812 [Q9XV66-5]
GeneIDi180374
KEGGicel:CELE_F25C8.3
UCSCiF25C8.3a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
180374
WormBaseiF25C8.3a ; CE41563 ; WBGene00006812 ; unc-80
F25C8.3b ; CE47117 ; WBGene00006812 ; unc-80
F25C8.3c ; CE47217 ; WBGene00006812 ; unc-80
F25C8.3d ; CE43592 ; WBGene00006812 ; unc-80
F25C8.3e ; CE47428 ; WBGene00006812 ; unc-80

Phylogenomic databases

eggNOGiENOG502QSTP, Eukaryota
GeneTreeiENSGT00640000091496
InParanoidiQ9XV66
OMAiFYQWAEA
OrthoDBi82175at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9XV66

Gene expression databases

BgeeiWBGene00006812, Expressed in material anatomical entity and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR031542, UNC80_N
PfamiView protein in Pfam
PF15778, UNC80, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC80_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XV66
Secondary accession number(s): B5U8P2
, C1P651, H9G315, Q7JKT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 3, 2012
Last modified: June 2, 2021
This is version 119 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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