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Protein

Proteasome subunit pbs-5

Gene

pbs-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins (PubMed:27528192). This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity).By similarity1 Publication

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.A09

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit pbs-5Imported (EC:3.4.25.1By similarity)
Gene namesi
Name:pbs-5Imported
ORF Names:K05C4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK05C4.1 ; CE19969 ; WBGene00003951 ; pbs-5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Constitutive skn-1-dependent expression of the proteasomal subunit rpt-3. Double knockout with ddi-1, sel-1, sel-9, png-1 or skn-1a results in failed expression of the proteasomal subunit rpt-3.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004423371 – 284Proteasome subunit pbs-5CuratedAdd BLAST284
PropeptideiPRO_00004423361 – 64Removed in mature formBy similarityAdd BLAST64

Keywords - PTMi

Zymogen

Proteomic databases

EPDiQ9XUV0
PaxDbiQ9XUV0
PeptideAtlasiQ9XUV0

Expressioni

Gene expression databases

BgeeiWBGene00003951

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.By similarity

Protein-protein interaction databases

DIPiDIP-25961N
IntActiQ9XUV0, 4 interactors
STRINGi6239.K05C4.1.2

Structurei

3D structure databases

ProteinModelPortaliQ9XUV0
SMRiQ9XUV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0175 Eukaryota
ENOG410XQRP LUCA
GeneTreeiENSGT00510000046395
HOGENOMiHOG000091082
InParanoidiQ9XUV0
KOiK02737
OMAiTMCAGVT
OrthoDBiEOG091G0BPS
PhylomeDBiQ9XUV0

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR000243 Pept_T1A_subB
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XUV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGETFDDFE NDEGEMAMAK QNLIAEPARA DFTFAKLPLG IQPVDFMKTH
60 70 80 90 100
FAETAGKSMQ FRKGTTTLAF VYEPATPADK GGIIVAVDSR ASSGEYISSK
110 120 130 140 150
SVMKILDIGD RMVATMAGGA ADCQFWTRIV AKYCTLYELR EKTSITVSAA
160 170 180 190 200
SKYFANTLYG YRGQGLSVGS MVAGYDKKGP QIFKVDSEGD RCQLKVCSVG
210 220 230 240 250
SGSLNAYGIL DNHYKPKMTD DEARKLGLRA IMHATYRDSG SGGVCNLCHI
260 270 280
TPTEKIRLPP MDVSKLWYEF ADELGRDITY NPVE
Length:284
Mass (Da):31,230
Last modified:November 1, 1999 - v1
Checksum:iA382E295F2C50604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB04567.1
PIRiT23336
RefSeqiNP_493558.1, NM_061157.4
UniGeneiCel.4934

Genome annotation databases

EnsemblMetazoaiK05C4.1; K05C4.1; WBGene00003951
GeneIDi173334
KEGGicel:CELE_K05C4.1
UCSCiK05C4.1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPBS5_CAEEL
AccessioniPrimary (citable) accession number: Q9XUV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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