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Entry version 178 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
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Protein
Submitted name:

Brinker

Gene

brk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BrinkerImported
Submitted name:
BrkImported
Submitted name:
Putative transcription factorImported
Submitted name:
RE18244pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:brkImported
Synonyms:brinkerImported, BRKImported, BrkImported, brk-RAImported, Dm brkImported, Dmel\CG9653Imported, ssg-1Imported
ORF Names:CG9653Imported, Dmel_CG9653Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0024250, brk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0024250, Expressed in embryo and 60 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9XTN4, 21 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071007

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 100BrkDBDInterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45DisorderedSequence analysisAdd BLAST45
Regioni147 – 179DisorderedSequence analysisAdd BLAST33
Regioni222 – 264DisorderedSequence analysisAdd BLAST43
Regioni287 – 327DisorderedSequence analysisAdd BLAST41
Regioni422 – 592DisorderedSequence analysisAdd BLAST171

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili98 – 121Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 43PolarSequence analysisAdd BLAST43
Compositional biasi147 – 172BasicSequence analysisAdd BLAST26
Compositional biasi224 – 264PolarSequence analysisAdd BLAST41
Compositional biasi445 – 488PolyampholyteSequence analysisAdd BLAST44
Compositional biasi489 – 506AcidicSequence analysisAdd BLAST18
Compositional biasi549 – 592PolarSequence analysisAdd BLAST44

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S9FA, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_391952_0_0_1

Identification of Orthologs from Complete Genome Data

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OMAi
CCPKGSP

Database of Orthologous Groups

More...
OrthoDBi
1005731at2759

Family and domain databases

Database of protein disorder

More...
DisProti
DP01864

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018586, Brinker_DNA-bd
IPR005012, Daxx

The PANTHER Classification System

More...
PANTHERi
PTHR12766:SF7, PTHR12766:SF7, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09607, BrkDBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XTN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSSSEQLNG SGALNFKRPK DSSENATNSH TNNGNSSGSP KMGSRRIFTP
60 70 80 90 100
HFKLQVLESY RNDNDCKGNQ RATARKYNIH RRQIQKWLQC ESNLRSSVAN
110 120 130 140 150
NQQQQQQQQQ QQQQQQQQQQ LLPQQSVSPT PAVKVFHQLS HPLVHQLHHH
160 170 180 190 200
HAAAVGHHHH HAAHHHAAHH HHAAAAAAAA AAAAAAAAAH HHAAHHLLAA
210 220 230 240 250
NGMVPHPLAA HPHLHVPVAM HPQMQHQKEQ QQQQQQLQQE QQQQDQQQSQ
260 270 280 290 300
QETPATIATN GSNQGSSNVL SAAKIAAVVA AAMATSNGNP TPTATIPASS
310 320 330 340 350
SSSSNTLPSS NNSSCHNSSS SSNSCNSNQV PIQVPILSGS PGSTSSASHI
360 370 380 390 400
PHVPFAYHHN LHGYLENRLE AVATPAPMDL SLGSSARRQM QLHEKDPSGV
410 420 430 440 450
DLTFRKRKVI TSPMQPDKIS KLEEVIKKEP ETETENEDVE VDVETEQPEE
460 470 480 490 500
HKLPSKQVKL FKPYLLDDDE EQDHHHHHHH HRQEDLDEGA AEEEQDDEEE
510 520 530 540 550
SRYADDDEVD SKEAADKKQR RLKKKPSAIN EQREPIIWSN HPYPGGCVSP
560 570 580 590 600
GSSITSSFQC PTSMQQQQTF PVAGGSPNQQ FQDNCSSSKA TTPLSPFSAP
610 620 630 640 650
ALSPTGFCCP KGSPVSGYES SSSTYSDSGS NYSLNLQLHA VYNDNLMYMQ
660 670 680 690 700
QQQQQQQQQH HLQHQQHLQR WLDQESLATA RTSSVNRPLI LVADTAPTNL

TLVA
Length:704
Mass (Da):77,514
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECF542995CD98B11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF125986 mRNA Translation: AAD22080.1
AE014298 Genomic DNA Translation: AAF46251.3
BT053738 mRNA Translation: ACK77656.1
AB023583 mRNA Translation: BAA76710.1

NCBI Reference Sequences

More...
RefSeqi
NP_511069.3, NM_078514.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071048; FBpp0071007; FBgn0024250

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9653

UCSC genome browser

More...
UCSCi
CG9653-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125986 mRNA Translation: AAD22080.1
AE014298 Genomic DNA Translation: AAF46251.3
BT053738 mRNA Translation: ACK77656.1
AB023583 mRNA Translation: BAA76710.1
RefSeqiNP_511069.3, NM_078514.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GLONMR-A43-101[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ9XTN4, 21 interactors
STRINGi7227.FBpp0071007

Genome annotation databases

EnsemblMetazoaiFBtr0071048; FBpp0071007; FBgn0024250
GeneIDi31665
KEGGidme:Dmel_CG9653
UCSCiCG9653-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31665
FlyBaseiFBgn0024250, brk

Phylogenomic databases

eggNOGiENOG502S9FA, Eukaryota
HOGENOMiCLU_391952_0_0_1
OMAiCCPKGSP
OrthoDBi1005731at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31665, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31665

Gene expression databases

BgeeiFBgn0024250, Expressed in embryo and 60 other tissues

Family and domain databases

DisProtiDP01864
InterProiView protein in InterPro
IPR018586, Brinker_DNA-bd
IPR005012, Daxx
PANTHERiPTHR12766:SF7, PTHR12766:SF7, 2 hits
PfamiView protein in Pfam
PF09607, BrkDBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9XTN4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XTN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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