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Entry version 164 (08 May 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Insulin receptor substrate 1

Gene

chico

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.By similarity4 Publications

Miscellaneous

'Chico' means 'small boy' in Spanish.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Growth regulation, Oogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109704 PI3K Cascade
R-DME-110478 Insulin signaling pathway
R-DME-112399 IRS-mediated signalling
R-DME-112412 SOS-mediated signalling
R-DME-1257604 PIP3 activates AKT signaling
R-DME-198203 PI3K/AKT activation
R-DME-5673001 RAF/MAP kinase cascade
R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-74749 Signal attenuation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9XTN2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin receptor substrate 1
Short name:
dIRS
Alternative name(s):
Protein chico
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chico
Synonyms:IRS
ORF Names:CG5686
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0024248 chico

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Female sterile. Extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000842351 – 968Insulin receptor substrate 1Add BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei286Phosphoserine1 Publication1
Modified residuei287Phosphoserine1 Publication1
Modified residuei342Phosphoserine1 Publication1
Modified residuei411Phosphotyrosine; by INSRBy similarity1
Modified residuei555Phosphoserine1 Publication1
Modified residuei911Phosphotyrosine; by INSRBy similarity1
Modified residuei932Phosphoserine1 Publication1
Modified residuei935Phosphoserine1 Publication1
Modified residuei948Phosphotyrosine; by INSRBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XTN2

PRoteomics IDEntifications database

More...
PRIDEi
Q9XTN2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9XTN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during G1, S and G2 phase of the cell cycle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0024248 Expressed in 5 organ(s), highest expression level in adult brain (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9XTN2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9XTN2 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Bindings to phosphatidylinositol 3-kinase and SHP2.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
InRP092083EBI-176370,EBI-92063

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
72865, 37 interactors

Database of interacting proteins

More...
DIPi
DIP-23631N

Protein interaction database and analysis system

More...
IntActi
Q9XTN2, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079677

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XTN2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 109PHPROSITE-ProRule annotationCuratedAdd BLAST102
Domaini122 – 236IRS-type PTBPROSITE-ProRule annotationAdd BLAST115

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi411 – 414YXXM motif 14
Motifi641 – 644YXXM motif 24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi855 – 858Poly-Ser4
Compositional biasi870 – 873Poly-Ala4
Compositional biasi956 – 963Poly-Ser8

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXEK Eukaryota
ENOG410Z9EP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170368

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XTN2

KEGG Orthology (KO)

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KOi
K16172

Identification of Orthologs from Complete Genome Data

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OMAi
SKIPRCD

Database of Orthologous Groups

More...
OrthoDBi
187805at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XTN2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01204 PTB_IRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10614 PTHR10614, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02174 IRS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00628 INSULINRSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9XTN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASISDDGMA LSGYLKKLKT MKKKFFVLYE ETSTSAARLE YYDTEKKFLQ
60 70 80 90 100
RAEPKRVIYL KNCFNINRRL DTKHRFVIVL SSRDGGFGIV LENENDLRKW
110 120 130 140 150
LDKLLVLQRN IANSNGTAHS PYDHVWQVVI QKKGISEKVG ITGTYHCCLT
160 170 180 190 200
SKSLTFVCIG PEKTPNGEDR VASIEILLTT IRRCGHASPQ CIFYVELGRQ
210 220 230 240 250
SVLGSGDLWM ETDNAAIATN MHNTILSAMS AKTESNTNLI NVYQNRPDLS
260 270 280 290 300
HEPMRKRSSS ANEASKPINV NVIQNSQNSL ELRSCSSPHN YGFGRERCDS
310 320 330 340 350
LPTRNGTLSE SSNQTYFGSN HGLRSNTISG IRPHSTNKHS NSPTFTMPLR
360 370 380 390 400
CSESEESSIS VDESDDNGSF SHYRLNTRSS ETAIPEENID DFASAELFSK
410 420 430 440 450
VTEQNVSDEN YIPMNPVNPT DAIHEKEKAD MQRLEDASLH FNFPEHASEK
460 470 480 490 500
LAKDFDLDSD NQCCRPIRAY SIGNKVEHLK FNKRLGHLND TGQNPNRVRA
510 520 530 540 550
YSVGSKSKIP RCDLQRVVLV EDNKHEFTAN RSQSSITKEG TSYGSSANRQ
560 570 580 590 600
KKSTSAPLLS LKNQINSDRM SDLMEIDFSQ ATNLEKQKFI KNNEIPKYIE
610 620 630 640 650
NVFPKAPRTD SSSLTLHATS QKDIFNGTKL NNTAITSEDG YLEMKPVGNG
660 670 680 690 700
YTPSSNCLPM KVEKLKLSDY QTAPPLTATA APVHDLNKIS TYNISAEKWR
710 720 730 740 750
EQPSRSEEKK SNSPLNDNTF SSKPTNVEST SKSHDVHSAN QIDCEKVCAQ
760 770 780 790 800
SSDKLNNHLA DKIVENNNLD IGGHEEKKLV HSISSEDYTQ IKDKSNDFTK
810 820 830 840 850
FNEAGYKILQ IKSDSSLISS KLYQKGIHKD NLERSQRLTE SVNTIPDNAT
860 870 880 890 900
ATAVSSSSLT KFNINSAKPA AAADSRSTGT DPSTPQNILQ IKDLNFPSRS
910 920 930 940 950
SSRISQPELH YASLDLPHCS GQNPAKYLKR GSRESPPVSA CPEDGNTYAK
960
IDFDQSDSSS SSSNIFNT
Length:968
Mass (Da):107,832
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04E9856F37F7A4CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PCQ8M9PCQ8_DROME
Chico, isoform B
chico anon-WO0078940.1, anon-WO0078940.4, BcDNA.GH11263, BcDNA:GH11263, chic
968Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD55429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti29Y → C in strain: S108. 1 Publication1
Natural varianti165P → T in strain: FSP2, FSP15, FSP16, FSP19, FSP23, FSP29, RR8, RR11, RR17, RR18, RR35, RR52, S76, SL5_131, SL5_29, T28 and T39. 1 Publication1
Natural varianti334Missing in strain: S108. 1 Publication1
Natural varianti429A → V in strain: FSP19, RR33 and S108. 1 Publication1
Natural varianti452A → T in strain: RR33, S108, T28 and T39. 1 Publication1
Natural varianti664K → R in strain: FSP2, FSP3, FSP15, FSP19, FSP23, FSP25, FSP29, RR8, RR11, RR17, RR18, RR33, RR35, RR52, S76, S107, S108, T9, T15, T28, T39 and T41. 1 Publication1
Natural varianti675P → S in strain: S103. 1 Publication1
Natural varianti676L → I in strain: FSP3, FSP15, FSP19, FSP23, FSP25, RR8, RR11, RR17, RR33, RR35, RR52, S76, S97, S107, S108, T9, T28, T39 and T41. 1 Publication1
Natural varianti721S → G in strain: FSP2, FSP3, FSP15, FSP23, FSP25, FSP29, RR8, RR11, RR17, RR18, RR33, RR35, RR52, S108, T9, T15, T28, T39 and T41. 1 Publication1
Natural varianti722S → L in strain: FSP2, FSP3, FSP15, FSP16, FSP19, FSP23, FSP25, FSP29, RR8, RR11, RR17, RR18, RR33, RR35, RR52, S76, S97, S103, S107, S108, SL5_131, SL5_29, T9, T15, T28, T39 and T41. 1 Publication1
Natural varianti744C → S in strain: FSP3, FSP15, FSP16, FSP23, FSP25, FSP29, RR8, RR11, RR17, RR33, RR35, RR52, S108, T9, T15, T28, T39 and T41. 1 Publication1
Natural varianti758Missing in strain: FSP2, FSP3, FSP15, FSP16, FSP23, FSP25. FSP29, RR8, RR11, RR17, RR18, RR35, RR52, S97, S103, S108, SL5_131, SL5_29, T9, T15 and T41. 1 Publication1
Natural varianti808I → M in strain: RR8 and T41. 1 Publication1
Natural varianti851A → V in strain: FSP19. 1 Publication1
Natural varianti873A → T in strain: FSP16. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF154826 mRNA Translation: AAD40880.1
AF092046 mRNA Translation: AAD43005.1
GQ927177 Genomic DNA Translation: ACY01718.1
GQ927178 Genomic DNA Translation: ACY01719.1
GQ927179 Genomic DNA Translation: ACY01720.1
GQ927180 Genomic DNA Translation: ACY01721.1
GQ927181 Genomic DNA Translation: ACY01722.1
GQ927182 Genomic DNA Translation: ACY01723.1
GQ927183 Genomic DNA Translation: ACY01724.1
GQ927184 Genomic DNA Translation: ACY01725.1
GQ927185 Genomic DNA Translation: ACY01726.1
GQ927186 Genomic DNA Translation: ACY01727.1
GQ927187 Genomic DNA Translation: ACY01728.1
GQ927188 Genomic DNA Translation: ACY01729.1
GQ927189 Genomic DNA Translation: ACY01730.1
GQ927190 Genomic DNA Translation: ACY01731.1
GQ927191 Genomic DNA Translation: ACY01732.1
GQ927192 Genomic DNA Translation: ACY01733.1
GQ927193 Genomic DNA Translation: ACY01734.1
GQ927194 Genomic DNA Translation: ACY01735.1
GQ927195 Genomic DNA Translation: ACY01736.1
GQ927196 Genomic DNA Translation: ACY01737.1
GQ927197 Genomic DNA Translation: ACY01738.1
GQ927198 Genomic DNA Translation: ACY01739.1
GQ927199 Genomic DNA Translation: ACY01740.1
GQ927200 Genomic DNA Translation: ACY01741.1
GQ927201 Genomic DNA Translation: ACY01742.1
GQ927202 Genomic DNA Translation: ACY01743.1
GQ927203 Genomic DNA Translation: ACY01744.1
AE014134 Genomic DNA Translation: AAF52882.1
BT016137 mRNA Translation: AAV37022.1
AF181643 mRNA Translation: AAD55429.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_001188772.1, NM_001201843.2
NP_001260316.1, NM_001273387.1
NP_723540.1, NM_164899.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080088; FBpp0079677; FBgn0024248
FBtr0303904; FBpp0292907; FBgn0024248
FBtr0333412; FBpp0305604; FBgn0024248

Database of genes from NCBI RefSeq genomes

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GeneIDi
64880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5686

UCSC genome browser

More...
UCSCi
CG5686-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154826 mRNA Translation: AAD40880.1
AF092046 mRNA Translation: AAD43005.1
GQ927177 Genomic DNA Translation: ACY01718.1
GQ927178 Genomic DNA Translation: ACY01719.1
GQ927179 Genomic DNA Translation: ACY01720.1
GQ927180 Genomic DNA Translation: ACY01721.1
GQ927181 Genomic DNA Translation: ACY01722.1
GQ927182 Genomic DNA Translation: ACY01723.1
GQ927183 Genomic DNA Translation: ACY01724.1
GQ927184 Genomic DNA Translation: ACY01725.1
GQ927185 Genomic DNA Translation: ACY01726.1
GQ927186 Genomic DNA Translation: ACY01727.1
GQ927187 Genomic DNA Translation: ACY01728.1
GQ927188 Genomic DNA Translation: ACY01729.1
GQ927189 Genomic DNA Translation: ACY01730.1
GQ927190 Genomic DNA Translation: ACY01731.1
GQ927191 Genomic DNA Translation: ACY01732.1
GQ927192 Genomic DNA Translation: ACY01733.1
GQ927193 Genomic DNA Translation: ACY01734.1
GQ927194 Genomic DNA Translation: ACY01735.1
GQ927195 Genomic DNA Translation: ACY01736.1
GQ927196 Genomic DNA Translation: ACY01737.1
GQ927197 Genomic DNA Translation: ACY01738.1
GQ927198 Genomic DNA Translation: ACY01739.1
GQ927199 Genomic DNA Translation: ACY01740.1
GQ927200 Genomic DNA Translation: ACY01741.1
GQ927201 Genomic DNA Translation: ACY01742.1
GQ927202 Genomic DNA Translation: ACY01743.1
GQ927203 Genomic DNA Translation: ACY01744.1
AE014134 Genomic DNA Translation: AAF52882.1
BT016137 mRNA Translation: AAV37022.1
AF181643 mRNA Translation: AAD55429.1 Different initiation.
RefSeqiNP_001188772.1, NM_001201843.2
NP_001260316.1, NM_001273387.1
NP_723540.1, NM_164899.3

3D structure databases

SMRiQ9XTN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi72865, 37 interactors
DIPiDIP-23631N
IntActiQ9XTN2, 7 interactors
STRINGi7227.FBpp0079677

PTM databases

iPTMnetiQ9XTN2

Proteomic databases

PaxDbiQ9XTN2
PRIDEiQ9XTN2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080088; FBpp0079677; FBgn0024248
FBtr0303904; FBpp0292907; FBgn0024248
FBtr0333412; FBpp0305604; FBgn0024248
GeneIDi64880
KEGGidme:Dmel_CG5686
UCSCiCG5686-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30067
FlyBaseiFBgn0024248 chico

Phylogenomic databases

eggNOGiENOG410IXEK Eukaryota
ENOG410Z9EP LUCA
GeneTreeiENSGT00940000170368
InParanoidiQ9XTN2
KOiK16172
OMAiSKIPRCD
OrthoDBi187805at2759
PhylomeDBiQ9XTN2

Enzyme and pathway databases

ReactomeiR-DME-109704 PI3K Cascade
R-DME-110478 Insulin signaling pathway
R-DME-112399 IRS-mediated signalling
R-DME-112412 SOS-mediated signalling
R-DME-1257604 PIP3 activates AKT signaling
R-DME-198203 PI3K/AKT activation
R-DME-5673001 RAF/MAP kinase cascade
R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-74749 Signal attenuation
SignaLinkiQ9XTN2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
chico fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64880

Protein Ontology

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PROi
PR:Q9XTN2

Gene expression databases

BgeeiFBgn0024248 Expressed in 5 organ(s), highest expression level in adult brain (Drosophila)
ExpressionAtlasiQ9XTN2 baseline and differential
GenevisibleiQ9XTN2 DM

Family and domain databases

CDDicd01204 PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10614 PTHR10614, 1 hit
PfamiView protein in Pfam
PF02174 IRS, 1 hit
PRINTSiPR00628 INSULINRSI
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRS1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XTN2
Secondary accession number(s): D0UY43
, D0UY45, D0UY46, D0UY47, D0UY49, D0UY50, D0UY51, D0UY52, D0UY54, D0UY55, D0UY61, D0UY62, D0UY64, D0UY65, D0UY66, D0UY67, D0UY68, Q5U0V5, Q9U4G2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1999
Last modified: May 8, 2019
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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