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Entry version 128 (26 Feb 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Exocyst complex component 5

Gene

Sec10

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-264876 Insulin processing
R-DME-5620916 VxPx cargo-targeting to cilium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sec10Imported
ORF Names:CG6159Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0266673 Sec10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189471 – 710Exocyst complex component 5Add BLAST710

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XTM1

PRoteomics IDEntifications database

More...
PRIDEi
Q9XTM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0266673 Expressed in embryonic/larval hemocyte (Drosophila) and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9XTM1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9XTM1 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67796, 43 interactors

Database of interacting proteins

More...
DIPi
DIP-18020N

Protein interaction database and analysis system

More...
IntActi
Q9XTM1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083932

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XTM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili44 – 96Sequence analysisAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3745 Eukaryota
ENOG410XSQQ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020771_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XTM1

KEGG Orthology (KO)

More...
KOi
K19984

Identification of Orthologs from Complete Genome Data

More...
OMAi
AKRMLKW

Database of Orthologous Groups

More...
OrthoDBi
225235at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XTM1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like

The PANTHER Classification System

More...
PANTHERi
PTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07393 Sec10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XTM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSQYMEEFE QEPFEVGEFI ERLTWRTNNE LQNSEDFHPV ALHDTFIQTI
60 70 80 90 100
KDLKILQEKQ QSKCERLEES LRQEKESHAK KIAKLQERHQ TAIDVFGQLD
110 120 130 140 150
EKINSVAGKI MHLGEQLENV NTPRSRSVEA QKLLNFMSEF LAAGPVIVND
160 170 180 190 200
IFADAARLSE AADVIQKLYA ISQDLPPGNF AESKRKIEKK YDEVERRLIE
210 220 230 240 250
EFATAQKSED IERMKTLAQI LSQFKGYTQC VDAYIEQSQM QPYSGKDIFI
260 270 280 290 300
GIVPLCKHHY EIIQKVFANP QQVMSKFILN IYQLKLHQYA MTKLEDKKDE
310 320 330 340 350
EKYLRTLYEL YSRTLKLSTD LQIYMSTIDD DLLQKLTQQI FIKHLAGYAE
360 370 380 390 400
METKCLTAKC STELEKFYAS KKHQKTATTK GFRRNMEVLI ATRANINIAA
410 420 430 440 450
IEDYGGETFL SEELAINMLQ EAKASLKRCR LLSNETELPG NAIKLNDILL
460 470 480 490 500
RFLMHEHVDY ALELGLQAVP LAEGRVFPQL YFFDVVQKTN IIVHLLDKLC
510 520 530 540 550
HTSVIPCVSN TPKYSDYVFK KRILMEQIET KLDQGLDRSI SAVIGWVKVY
560 570 580 590 600
LQYEQKKTDY KPETDVDTIS SAACLQVVQN LQPVIVQIKK CVDGENLQNV
610 620 630 640 650
LTEFGTRLHR VIYDHLQTMQ FNTAGAMCAI CDVNEYRKCI RELDSPLVTQ
660 670 680 690 700
LFDILHALCN LLLVKPQNLQ EVCTGDTLNY LDKSVVRQFI QLRTDFRIIK
710
NTNYLKGIIE
Length:710
Mass (Da):82,031
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i256F78D2C15AD41A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13643 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ242993 Genomic DNA Translation: CAB44702.1
AJ242992 mRNA Translation: CAB44701.1
AE014297 Genomic DNA Translation: AAF56241.1
AY058414 mRNA Translation: AAL13643.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_651218.1, NM_142961.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084547; FBpp0083932; FBgn0266673

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42863

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6159

UCSC genome browser

More...
UCSCi
CG6159-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242993 Genomic DNA Translation: CAB44702.1
AJ242992 mRNA Translation: CAB44701.1
AE014297 Genomic DNA Translation: AAF56241.1
AY058414 mRNA Translation: AAL13643.1 Different initiation.
RefSeqiNP_651218.1, NM_142961.5

3D structure databases

SMRiQ9XTM1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi67796, 43 interactors
DIPiDIP-18020N
IntActiQ9XTM1, 2 interactors
STRINGi7227.FBpp0083932

Proteomic databases

PaxDbiQ9XTM1
PRIDEiQ9XTM1

Genome annotation databases

EnsemblMetazoaiFBtr0084547; FBpp0083932; FBgn0266673
GeneIDi42863
KEGGidme:Dmel_CG6159
UCSCiCG6159-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42863
FlyBaseiFBgn0266673 Sec10

Phylogenomic databases

eggNOGiKOG3745 Eukaryota
ENOG410XSQQ LUCA
HOGENOMiCLU_020771_1_0_1
InParanoidiQ9XTM1
KOiK19984
OMAiAKRMLKW
OrthoDBi225235at2759
PhylomeDBiQ9XTM1

Enzyme and pathway databases

ReactomeiR-DME-264876 Insulin processing
R-DME-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42863

Protein Ontology

More...
PROi
PR:Q9XTM1

Gene expression databases

BgeeiFBgn0266673 Expressed in embryonic/larval hemocyte (Drosophila) and 33 other tissues
ExpressionAtlasiQ9XTM1 baseline and differential
GenevisibleiQ9XTM1 DM

Family and domain databases

InterProiView protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like
PANTHERiPTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit
PfamiView protein in Pfam
PF07393 Sec10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XTM1
Secondary accession number(s): Q95TZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1999
Last modified: February 26, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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