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Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

ALAS2

Organism
Delphinapterus leucas (Beluga whale)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.
Proteins known to be involved in this subpathway in this organism are:
  1. 5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS1), 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158SubstrateBy similarity1
Binding sitei275SubstrateBy similarity1
Binding sitei294SubstrateBy similarity1
Binding sitei327Pyridoxal phosphateBy similarity1
Binding sitei355Pyridoxal phosphateBy similarity1
Binding sitei383Pyridoxal phosphateBy similarity1
Active sitei386By similarity1
Binding sitei415Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei416Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei503SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processHeme biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-E
Alternative name(s):
5-aminolevulinic acid synthase 2
Delta-ALA synthase 2
Delta-aminolevulinate synthase 2
Gene namesi
Name:ALAS2
Synonyms:ALS2
OrganismiDelphinapterus leucas (Beluga whale)
Taxonomic identifieri9749 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiMonodontidaeDelphinapterus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – ?44MitochondrionSequence analysisAdd BLAST44
ChainiPRO_0000001222?45 – 5825-aminolevulinate synthase, erythroid-specific, mitochondrialAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei386N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer. Interacts with SUCLA2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XT75
SMRiQ9XT75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005954

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR010961 4pyrrol_synth_NH2levulA_synth
IPR015118 5aminolev_synth_preseq
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PF09029 Preseq_ALAS, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01821 5aminolev_synth, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XT75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLQRCPVLI RSPTAILGKM IKTHQFLIGI GRCPILATQG TTCSQIHLKA
60 70 80 90 100
TKAGGDSPSW AKSHCPFMLL ELQDGKSKIV QKAAPEVQED VKTFKTDLPI
110 120 130 140 150
SLASTSLRKP FFSPQEPEKN SEKVTHLIQN NMAGNHVFGY DQFFRNKIME
160 170 180 190 200
KKQDHTYRVF KTVNRWADAY PFAEHFFEAS VASKDVSVWC SNDYLGMSRH
210 220 230 240 250
PRVLQATQET LQRHGAGAGG TRNISGTSRF HVELEQELAE LHQKDSALLF
260 270 280 290 300
SSCFVANDST LFTLAKILPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN
310 320 330 340 350
DPDHLKKLLK KSNPETPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF
360 370 380 390 400
VDEVHAVGLY GSRGAGIGER DGIMHKIDII SGTLGKAFGC VGGYIASTRD
410 420 430 440 450
LVDMVRSYAA GFIFTTSLPP MVLSGALESV RLLKGEEGQA LRRAHQRNVK
460 470 480 490 500
HMRQLLMDRG LPVIPCPSHI IPIRVGDAAL NSRICDLLLS KHGIYVQAIN
510 520 530 540 550
YPTVPRGEEL LRLAPSPHHS PQMMEDFVEK LLAAWTEVGL PLQDVSIAAC
560 570 580
NFCRRPVHFE LMSEWERSYF GNMGPQYVTT YA
Length:582
Mass (Da):64,555
Last modified:November 1, 1999 - v1
Checksum:i7C15EBF6C154C34D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086786 mRNA Translation: AAD41464.1

Similar proteinsi

Entry informationi

Entry nameiHEM0_DELLE
AccessioniPrimary (citable) accession number: Q9XT75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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