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Entry version 133 (08 May 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Copper-transporting ATPase 2

Gene

ATP7B

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi124Copper 1PROSITE-ProRule annotation1
Metal bindingi127Copper 1PROSITE-ProRule annotation1
Metal bindingi209Copper 2PROSITE-ProRule annotation1
Metal bindingi212Copper 2PROSITE-ProRule annotation1
Metal bindingi320Copper 3PROSITE-ProRule annotation1
Metal bindingi323Copper 3PROSITE-ProRule annotation1
Metal bindingi411Copper 4PROSITE-ProRule annotation1
Metal bindingi414Copper 4PROSITE-ProRule annotation1
Metal bindingi540Copper 5PROSITE-ProRule annotation1
Metal bindingi543Copper 5PROSITE-ProRule annotation1
Metal bindingi616Copper 6PROSITE-ProRule annotation1
Metal bindingi619Copper 6PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei10674-aspartylphosphate intermediateBy similarity1
Metal bindingi1307MagnesiumPROSITE-ProRule annotation1
Metal bindingi1311MagnesiumPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Copper-transporting ATPase 2 (EC:7.2.2.8By similarity)
Alternative name(s):
Copper pump 2
Wilson disease-associated protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP7B
Synonyms:WND
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 694CytoplasmicSequence analysisAdd BLAST694
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei695 – 716HelicalSequence analysisAdd BLAST22
Topological domaini717 – 737ExtracellularSequence analysisAdd BLAST21
Transmembranei738 – 757HelicalSequence analysisAdd BLAST20
Topological domaini758 – 764CytoplasmicSequence analysis7
Transmembranei765 – 785HelicalSequence analysisAdd BLAST21
Topological domaini786 – 804ExtracellularSequence analysisAdd BLAST19
Transmembranei805 – 825HelicalSequence analysisAdd BLAST21
Topological domaini826 – 959CytoplasmicSequence analysisAdd BLAST134
Transmembranei960 – 982HelicalSequence analysisAdd BLAST23
Topological domaini983 – 1012ExtracellularSequence analysisAdd BLAST30
Transmembranei1013 – 1034HelicalSequence analysisAdd BLAST22
Topological domaini1035 – 1362CytoplasmicSequence analysisAdd BLAST328
Transmembranei1363 – 1380HelicalSequence analysisAdd BLAST18
Topological domaini1381 – 1391ExtracellularSequence analysisAdd BLAST11
Transmembranei1392 – 1411HelicalSequence analysisAdd BLAST20
Topological domaini1412 – 1505CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463161 – 1505Copper-transporting ATPase 2Add BLAST1505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei519PhosphoserineBy similarity1
Modified residuei1438PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9XT50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

The short isoform is expressed primarily in the liver with lower levels present in the intestine, hypothalamus and ovary. The long isoform is expressed in the liver.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with COMMD1/MURR1 (By similarity).

Interacts with DCTN4, in a copper-dependent manner (By similarity).

Interacts with ATOX1 (By similarity).

Interacts (via C-terminus) with ZBTB16/PLZF (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9940.ENSOARP00000009727

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XT50

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 180HMA 1PROSITE-ProRule annotationAdd BLAST67
Domaini199 – 265HMA 2PROSITE-ProRule annotationAdd BLAST67
Domaini310 – 376HMA 3PROSITE-ProRule annotationAdd BLAST67
Domaini401 – 467HMA 4PROSITE-ProRule annotationAdd BLAST67
Domaini530 – 596HMA 5PROSITE-ProRule annotationAdd BLAST67
Domaini606 – 672HMA 6PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi968 – 971Poly-Ile4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K17686

Database of Orthologous Groups

More...
OrthoDBi
649559at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00371 HMA, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00403 HMA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55008 SSF55008, 6 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 6 hits
PS50846 HMA_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: Q9XT50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERAGDQAPG NPEPSSLATL GDPQVTLLTV HKRWSFKRSP GTGGSSRPVI
60 70 80 90 100
SEEECPPPSE EGEFSQKVLN GSEEISSKQI LSKLFQPAMK QSFAFDNNGY
110 120 130 140 150
EDDLDGVCPS QTAAGTISIV GMTCQSCVKS IEGRVSSLKG IVSIKVSLEQ
160 170 180 190 200
SSAEVRYVPS VVSLMQICHQ IEDMGFQASV AEGKATSWAS RVSPTSEAVV
210 220 230 240 250
KLRVEGMTCQ SCVSSIEGKI GKLQGVMRVR VSLSNQEAVI TYQPYLIQPQ
260 270 280 290 300
DLRDHITDMG FEAVIKNKVA PVSLGPIDVR RLQSTLSVAP PAPVNQNDNN
310 320 330 340 350
SETPGGQGVP LHLRVDGMHC KSCVLNIEDN IGQLPGVQSI HVSLESRTAR
360 370 380 390 400
VQYNPSLVSP GALRRAIEAL PPGNFKVSFP NGAEGSGPDS RTPPAPSAPC
410 420 430 440 450
TMMLAIAGMT CKSCVQSIEG LISQRVGVHQ ISVFLAEGTA VVLYDPSRTH
460 470 480 490 500
PEELRAAVED MGFEASILAE NCSSNQVGNH SAGSAVGPEA AGAPVPMQGE
510 520 530 540 550
APQPGGLHTN HIPHQSPKSL LASTTVAPKK CFLQISGMTC ASCVSNIERN
560 570 580 590 600
LQKEPGILSV LVALMAGKAE VKYNPEAIQP LEIAKLVQDL GFEAAVMEDY
610 620 630 640 650
TGSDGDLELM ITGMTCASCV HNIESKLRRT EGITYASVAL ATSKAHVKFD
660 670 680 690 700
PEIIGPRDIV KLIEEIGFRA SLAQRIPNAH HLDHKVEIKQ WKNSFLCSLV
710 720 730 740 750
FGIPVMGLMI YMLIPSHEPQ SSVLDHNVIP GLSILNLIFF ILCTFVQFLG
760 770 780 790 800
GWYFYVQAYK SLRHGMANMD VLIVLATSIA YVYSLVILVV AVAEKAERSP
810 820 830 840 850
VTFFDTPPML FVFIALGRWL EHVVKSKTSE ALARLMSLQA TEATVVTLGE
860 870 880 890 900
DNVIIREEQV PMELVQRGDI IKVVPGGKFP VDGKVLEGNT MADESLITGE
910 920 930 940 950
AMPVTKKPGS MVIAGSMNAH GSVLITATHV GNDTTLAQIV KLVEEAQMSK
960 970 980 990 1000
APIQQLADRF SGYFVPFIII ISTVTLVVWI VIGFIDFGVV QKYFPAPSKG
1010 1020 1030 1040 1050
ISQAEVVLRF AFQTSITVLC IACPCSLGLA TPTAVMVGTG VAAQNGILIK
1060 1070 1080 1090 1100
GGKPLEMAHK IKTVMFDKTG TITHGVPKVS RVLLLVDLAT LPLRKVLAVV
1110 1120 1130 1140 1150
GTAEASSEHP LGVAVTRYCK EELGTETLGC CMDFQAVPGC GISCKVSSVE
1160 1170 1180 1190 1200
SILAQGERLQ GPPTAHQNRV GSEPSETDAA TQTFSVLIGN REWMRRNGLT
1210 1220 1230 1240 1250
VTSDVRDAMT DHETKGQTAI LVAIDGVLCG MIAVADSVKQ EAALAVHTLK
1260 1270 1280 1290 1300
SMGVDVVLIT GDNRKTARAI ATQVGINKVF AEVLPSHKVA KVQELQNQGK
1310 1320 1330 1340 1350
RVAMVGDGVN DSPALAQADV GIAIGTGTDV AIEAADVVLI RNDLLDVVAS
1360 1370 1380 1390 1400
IHLSRRTVWR IRLNLVLALI YNLIGIPVAA GVFIPIGVVL QPWMGSAAMA
1410 1420 1430 1440 1450
ASSVSVVLSS LQLKCYRKPD LARYEAQAHG HMKPLSASQV SVRVGMDDRR
1460 1470 1480 1490 1500
RDSPRASAWD QVSYVSQVSL SPLKSDKLSR HSGAADDRGD KWSLLLNDRD

EEQGI
Length:1,505
Mass (Da):161,019
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63202B55EB2CA8B5
GO
Isoform Short (identifier: Q9XT50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     62-79: GEFSQKVLNGSEEISSKQ → MKPEEERPIIDREKASRR

Show »
Length:1,444
Mass (Da):154,808
Checksum:iFC168B09E685E5D3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0004291 – 61Missing in isoform Short. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_00043062 – 79GEFSQ…ISSKQ → MKPEEERPIIDREKASRR in isoform Short. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF118225 mRNA Translation: AAD39371.1
AF032881 mRNA Translation: AAB94620.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009732.1, NM_001009732.1 [Q9XT50-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
443046

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
oas:443046

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118225 mRNA Translation: AAD39371.1
AF032881 mRNA Translation: AAB94620.1
RefSeqiNP_001009732.1, NM_001009732.1 [Q9XT50-1]

3D structure databases

SMRiQ9XT50
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9940.ENSOARP00000009727

Proteomic databases

PRIDEiQ9XT50

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443046
KEGGioas:443046

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
540

Phylogenomic databases

KOiK17686
OrthoDBi649559at2759

Family and domain databases

CDDicd00371 HMA, 6 hits
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 6 hits
SUPFAMiSSF55008 SSF55008, 6 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 6 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 6 hits
PS50846 HMA_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATP7B_SHEEP
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XT50
Secondary accession number(s): O46518
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: May 8, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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