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Entry version 90 (07 Apr 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Ceruloplasmin

Gene

CP

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu cationBy similarityNote: Binds 6 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi120Copper 1; type 2By similarity1
Metal bindingi122Copper 2; type 3By similarity1
Metal bindingi180Copper 2; type 3By similarity1
Metal bindingi182Copper 3; type 3By similarity1
Metal bindingi295Copper 4; type 1By similarity1
Metal bindingi338Copper 4; type 1By similarity1
Metal bindingi343Copper 4; type 1By similarity1
Metal bindingi650Copper 5; type 1By similarity1
Metal bindingi693Copper 5; type 1By similarity1
Metal bindingi698Copper 5; type 1By similarity1
Metal bindingi703Copper 5; type 1By similarity1
Metal bindingi977Copper 6; type 1By similarity1
Metal bindingi980Copper 1; type 2By similarity1
Metal bindingi982Copper 3; type 3By similarity1
Metal bindingi1022Copper 3; type 3By similarity1
Metal bindingi1023Copper 6; type 1By similarity1
Metal bindingi1024Copper 2; type 3By similarity1
Metal bindingi1028Copper 6; type 1By similarity1
Metal bindingi1033Copper 6; type 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ceruloplasmin (EC:1.16.3.1)
Alternative name(s):
Ferroxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022794020 – 1048CeruloplasminAdd BLAST1029

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi556N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei716PhosphoserineBy similarity1
Glycosylationi756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi920N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9XT27

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma. Also expressed in the hypothalamus, spleen and uterus. No expression in the cortex, heart, intestine or kidney.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9940.ENSOARP00000005423

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XT27

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 357F5/8 type A 1Add BLAST338
Domaini20 – 200Plastocyanin-like 1Add BLAST181
Domaini209 – 355Plastocyanin-like 2Add BLAST147
Domaini370 – 712F5/8 type A 2Add BLAST343
Domaini370 – 554Plastocyanin-like 3Add BLAST185
Domaini564 – 710Plastocyanin-like 4Add BLAST147
Domaini724 – 1044F5/8 type A 3Add BLAST321
Domaini724 – 894Plastocyanin-like 5Add BLAST171
Domaini902 – 1040Plastocyanin-like 6Add BLAST139

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1263, Eukaryota

Database of Orthologous Groups

More...
OrthoDBi
454773at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.420, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001117, Cu-oxidase
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR002355, Cu_oxidase_Cu_BS
IPR008972, Cupredoxin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00394, Cu-oxidase, 1 hit
PF07731, Cu-oxidase_2, 1 hit
PF07732, Cu-oxidase_3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503, SSF49503, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00079, MULTICOPPER_OXIDASE1, 3 hits
PS00080, MULTICOPPER_OXIDASE2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XT27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIFLLCIFL ILCGTSVWAK DKHYYIGIIE TAWNYASDHA EKKLISVDTE
60 70 80 90 100
HSNIYLQNGP NRIGSVYKKA VYLQYTDENF RTVIEKPVWL GFLGPIIKAE
110 120 130 140 150
TGDKVYVHLK NFASRPYTFH AHGLTYYKEH EGAIYPDNTT DLQKADDKVQ
160 170 180 190 200
PGEQCLYILH ANPEQGPGEE DSNCVTRIYH SHIDAPKDIA SGLIGPLIHC
210 220 230 240 250
KKDSLDEEKE KNIDKEFVVM FSVVDENLSW YLEENIKTYC SEPEKVEQDN
260 270 280 290 300
EDFQESNRMY SVNGYAFGSL PGLSMCAEDR VKWYLFGMGN EIDVHAAFFH
310 320 330 340 350
GQVLTSKNYR VDTINLFPAT LFDAFMVAQN PGQWMLSCQN LNHLKAGLQA
360 370 380 390 400
FFWVQDCKKS SSEDNIHGKN VRHYYIAAEE VIWNYAPSGI DAFTKENLRA
410 420 430 440 450
PGSASEAFFE QGPTRIGGSY KKLVYREYTD ASFSNQKERG PEEEHLGILG
460 470 480 490 500
PVIAAEVGDT IRVTFHNKAA HPLSIEPIGV RVDKNNEGTY YSPTGSGPPP
510 520 530 540 550
SGSHVAPKGT FTYEWTVPKE VGPTYKDPVC LAKMYYSGST KDIFTGLIGP
560 570 580 590 600
MKICRNGSLL ANGRLKNVDK EFYLFPTVFD ENESLLLDDN IKMFTTAPDQ
610 620 630 640 650
VDKENEDFQE SNKMHSMNGF MYGNQPGLSM CQGDSVMWYL FSAGNEVDIH
660 670 680 690 700
GIYFSGNTYL SRGERRDTAN LFPQTSLSLF MQPDTAGTFD VECLTTDHYT
710 720 730 740 750
GGMKQKYTVS QCGQRSEDLY LYLGERTYYI AAVEVEWDYS PSRKWEKELH
760 770 780 790 800
HLQEQNLSNA FLDKEEFYIG SKYKKVVYRQ FTDSTFQVPV ERKGEEEHLG
810 820 830 840 850
ILGPQLHADV GDKVNIIFKN MATRPYSIHA HGVKTESSTV TPTAPGETRT
860 870 880 890 900
YIWKIPERSG AGMGDSPCIP WVYYSTVDRV KDLFSGLIGP LIVCRKHYLK
910 920 930 940 950
VSNPIKKLEF SLLFLVFDEN ESWYLDDNIK TYSDHPEKVD KANEEFMESN
960 970 980 990 1000
KMHAINGRMF GNLQGLTMHV GNEVDLHSVH FHGHSFQYQH RGIYTSDVFD
1010 1020 1030 1040
LFPGTYQTLE MTPKTPGIWL LHCHVTDHIH AGMETTYTVL PNEEIKSG
Length:1,048
Mass (Da):119,126
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i925F16D7B0549CBB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF134814 mRNA Translation: AAD41477.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009733.1, NM_001009733.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
443053

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
oas:443053

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134814 mRNA Translation: AAD41477.1
RefSeqiNP_001009733.1, NM_001009733.1

3D structure databases

SMRiQ9XT27
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9940.ENSOARP00000005423

Proteomic databases

PRIDEiQ9XT27

Genome annotation databases

GeneIDi443053
KEGGioas:443053

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1356

Phylogenomic databases

eggNOGiKOG1263, Eukaryota
OrthoDBi454773at2759

Family and domain databases

Gene3Di2.60.40.420, 5 hits
InterProiView protein in InterPro
IPR001117, Cu-oxidase
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR002355, Cu_oxidase_Cu_BS
IPR008972, Cupredoxin
PfamiView protein in Pfam
PF00394, Cu-oxidase, 1 hit
PF07731, Cu-oxidase_2, 1 hit
PF07732, Cu-oxidase_3, 3 hits
SUPFAMiSSF49503, SSF49503, 6 hits
PROSITEiView protein in PROSITE
PS00079, MULTICOPPER_OXIDASE1, 3 hits
PS00080, MULTICOPPER_OXIDASE2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCERU_SHEEP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XT27
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1999
Last modified: April 7, 2021
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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