UniProtKB - Q9XSW8 (GLHA_CANLF)
Protein
Glycoprotein hormones alpha chain
Gene
CGA
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity
GO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of steroid biosynthetic process Source: UniProtKB
- regulation of signaling receptor activity Source: UniProtKB
- thyroid hormone generation Source: GO_Central
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chainAlternative name(s): Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Short name: FSH-alpha Follitropin alpha chain Luteinizing hormone alpha chain Short name: LSH-alpha Lutropin alpha chain Thyroid-stimulating hormone alpha chain Short name: TSH-alpha Thyrotropin alpha chain |
Gene namesi | Name:CGA |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
- follicle-stimulating hormone complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000011635 | 25 – 120 | Glycoprotein hormones alpha chainAdd BLAST | 96 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 59 | By similarity | ||
Disulfide bondi | 38 ↔ 88 | By similarity | ||
Disulfide bondi | 56 ↔ 110 | By similarity | ||
Disulfide bondi | 60 ↔ 112 | By similarity | ||
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 87 ↔ 115 | By similarity | ||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9XSW8 |
Interactioni
Subunit structurei
Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
By similarityGO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000004531 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S1PK, Eukaryota |
InParanoidi | Q9XSW8 |
OrthoDBi | 1430707at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9XSW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDCYRKYAAV ILAALSVFLH ILHSFPDGEF TMQGCPECKL KENKYFSKLG
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG
110 120
NAKVENHTEC HCSTCYYHKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF160250 mRNA Translation: AAD42900.1 |
RefSeqi | NP_001002988.1, NM_001002988.1 |
Genome annotation databases
GeneIDi | 403483 |
KEGGi | cfa:403483 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF160250 mRNA Translation: AAD42900.1 |
RefSeqi | NP_001002988.1, NM_001002988.1 |
3D structure databases
SMRi | Q9XSW8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000004531 |
Proteomic databases
PaxDbi | Q9XSW8 |
Genome annotation databases
GeneIDi | 403483 |
KEGGi | cfa:403483 |
Organism-specific databases
CTDi | 1081 |
Phylogenomic databases
eggNOGi | ENOG502S1PK, Eukaryota |
InParanoidi | Q9XSW8 |
OrthoDBi | 1430707at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA_CANLF | |
Accessioni | Q9XSW8Primary (citable) accession number: Q9XSW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families