CGA

Functionⁱ

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity

GO - Molecular functionⁱ

follicle-stimulating hormone activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: UniProtKB
positive regulation of steroid biosynthetic process Source: UniProtKB
regulation of signaling receptor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycoprotein hormones alpha chain Alternative name(s): Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Short name: FSH-alpha Follitropin alpha chain Luteinizing hormone alpha chain Short name: LSH-alpha Lutropin alpha chain Thyroid-stimulating hormone alpha chain Short name: TSH-alpha Thyrotropin alpha chain
Gene namesⁱ	Name:CGA
Organismⁱ	Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifierⁱ	9615 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus
Proteomesⁱ	UP000002254 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	By similarityAdd BLAST		24
ChainⁱPRO_0000011635	25 – 120	Glycoprotein hormones alpha chainAdd BLAST		96

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	35 ↔ 59	By similarity
Disulfide bondⁱ	38 ↔ 88	By similarity
Disulfide bondⁱ	56 ↔ 110	By similarity
Disulfide bondⁱ	60 ↔ 112	By similarity
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	87 ↔ 115	By similarity
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9XSW8
PRIDEⁱ	Q9XSW8

Interactionⁱ

Subunit structureⁱ

Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.By similarity

GO - Molecular functionⁱ

follicle-stimulating hormone activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9615.ENSCAFP00000004531

STRINGⁱ

9615.ENSCAFP00000004531

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9XSW8
SMRⁱ	Q9XSW8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycoprotein hormones subunit alpha family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWI0 Eukaryota ENOG4111Q75 LUCA
HOGENOMⁱ	HOG000232008
HOVERGENⁱ	HBG000452
InParanoidⁱ	Q9XSW8
KEGG Orthology (KO) More...KOⁱ	K08522

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone
PANTHERⁱ	PTHR11509 PTHR11509, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00236 Hormone_6, 1 hit
PRINTSⁱ	PR00274 GLYCOHORMONE
SMARTⁱ	View protein in SMART SM00067 GHA, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9XSW8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDCYRKYAAV ILAALSVFLH ILHSFPDGEF TMQGCPECKL KENKYFSKLG 
        60         70         80         90        100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG 
       110        120
NAKVENHTEC HCSTCYYHKS

Length:120

Mass (Da):13,411

Last modified:November 1, 1999 - v1

Checksum:ⁱ69C95E24C1245B0B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF160250 mRNA Translation: AAD42900.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001002988.1, NM_001002988.1
UniGeneⁱ	Cfa.195

Genome annotation databases

GeneIDⁱ	403483
KEGGⁱ	cfa:403483

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9XSW8	Glycoprotein hormones alpha chain		MOUSE		120	UniRef90_P01216
Glycoprotein hormones alpha chain		PIG		120
Glycoprotein hormones alpha chain		PANTA		120
Glycoprotein hormones alpha chain		RABIT		120
Glycoprotein hormones alpha chain		SHEEP		120
+80

Protein	Similar proteins		Species	Score	Length	Source
Q9XSW8	Glycoprotein hormones alpha chain		MOUSE		120	UniRef50_P01216
Glycoprotein hormones alpha chain		MESAU		120
Glycoprotein hormones alpha chain		FELCA		120
Glycoprotein hormones alpha chain		PIG		120
Glycoprotein hormones alpha chain		AILFU		120
+202

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF160250 mRNA Translation: AAD42900.1
RefSeqⁱ	NP_001002988.1, NM_001002988.1
UniGeneⁱ	Cfa.195

3D structure databases

ProteinModelPortalⁱ	Q9XSW8
SMRⁱ	Q9XSW8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9615.ENSCAFP00000004531

STRINGⁱ

9615.ENSCAFP00000004531

Proteomic databases

PaxDbⁱ	Q9XSW8
PRIDEⁱ	Q9XSW8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	403483
KEGGⁱ	cfa:403483

Organism-specific databases

CTDⁱ	1081

CTDⁱ

1081

Phylogenomic databases

eggNOGⁱ	ENOG410IWI0 Eukaryota ENOG4111Q75 LUCA
HOGENOMⁱ	HOG000232008
HOVERGENⁱ	HBG000452
InParanoidⁱ	Q9XSW8
KOⁱ	K08522

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone
PANTHERⁱ	PTHR11509 PTHR11509, 1 hit
Pfamⁱ	View protein in Pfam PF00236 Hormone_6, 1 hit
PRINTSⁱ	PR00274 GLYCOHORMONE
SMARTⁱ	View protein in SMART SM00067 GHA, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLHA_CANLF
Accessionⁱ	Q9XSW8Primary (citable) accession number: Q9XSW8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1999
	Last modified:	July 18, 2018
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - Q9XSW8 (GLHA_CANLF)

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Glycoprotein hormones alpha chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ