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Protein

Interleukin-13

Gene

IL13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-BTA-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:30114 IL13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001554521 – 132Interleukin-13Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 76By similarity
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi64 ↔ 90By similarity
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9XSV9

Expressioni

Gene expression databases

BgeeiENSBTAG00000015953 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021212

Structurei

3D structure databases

ProteinModelPortaliQ9XSV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
GeneTreeiENSGT00390000003225
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiQ9XSV9
KOiK05435
OMAiVYCAALE
OrthoDBiEOG091G10SR
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLLTAVIV LICFGGLTSP SPVPSATALK ELIEELVNIT QNQKVPLCNG
60 70 80 90 100
SMVWSLNLTS SMYCAALDSL ISISNCSVIQ RTKRMLNALC PHKPSAKQVS
110 120 130
SEYVRDTKIE VAQFLKDLLR HSRIVFRNER FN
Length:132
Mass (Da):14,651
Last modified:March 18, 2008 - v2
Checksum:i61A662EB85C161F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84R → K in CAB46636 (PubMed:10436181).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132441 Genomic DNA Translation: CAB46636.1
EU276077 mRNA Translation: ABX72075.1
AF072807 mRNA Translation: AAD22748.1
RefSeqiNP_776514.1, NM_174089.1
UniGeneiBt.12928

Genome annotation databases

EnsembliENSBTAT00000021212; ENSBTAP00000021212; ENSBTAG00000015953
GeneIDi281247
KEGGibta:281247

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132441 Genomic DNA Translation: CAB46636.1
EU276077 mRNA Translation: ABX72075.1
AF072807 mRNA Translation: AAD22748.1
RefSeqiNP_776514.1, NM_174089.1
UniGeneiBt.12928

3D structure databases

ProteinModelPortaliQ9XSV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021212

Proteomic databases

PaxDbiQ9XSV9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021212; ENSBTAP00000021212; ENSBTAG00000015953
GeneIDi281247
KEGGibta:281247

Organism-specific databases

CTDi3596
VGNCiVGNC:30114 IL13

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
GeneTreeiENSGT00390000003225
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiQ9XSV9
KOiK05435
OMAiVYCAALE
OrthoDBiEOG091G10SR
TreeFamiTF336383

Enzyme and pathway databases

ReactomeiR-BTA-6785807 Interleukin-4 and Interleukin-13 signaling

Gene expression databases

BgeeiENSBTAG00000015953 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL13_BOVIN
AccessioniPrimary (citable) accession number: Q9XSV9
Secondary accession number(s): A9QWR5, Q9TV84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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