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Protein

Transmembrane protein 47

Gene

TMEM47

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309). During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity).By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 47
Alternative name(s):
Brain cell membrane protein 1
Transmembrane 4 superfamily member 10
Gene namesi
Name:TMEM47
Synonyms:BCMP1, TM4SF10
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:47584 TMEM47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000725722 – 181Transmembrane protein 47Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9XSV3

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSCAFG00000013807 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactioni

Subunit structurei

Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B (PubMed:26990309). Interacts with FYB1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020352

Structurei

3D structure databases

ProteinModelPortaliQ9XSV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM47 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000124678
HOVERGENiHBG080233
InParanoidiQ9XSV3
OMAiWTRDIGY
OrthoDBiEOG091G0S9P
TreeFamiTF312855

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
PANTHERiPTHR14399 PTHR14399, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAGSGMEE VRVSVLTPLK LVGLVCIFLA LCLDLGAVLS PAWVTADHQY
60 70 80 90 100
YLSLWESCRK PASLDIWHCE STLSSDWQIA TLALLLGGAA IILIAFLVGL
110 120 130 140 150
ISICVGSRRR FYRPVAVMLF AAVVLQVCSL VLYPIKFIET VSLKIYHEFN
160 170 180
WGYGLAWGAT IFSFGGAILY CLNPKNYEDY Y
Length:181
Mass (Da):19,998
Last modified:November 1, 1999 - v1
Checksum:iA73A03FD0C3B3FBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243320 mRNA Translation: CAB45864.1
RefSeqiNP_001003045.1, NM_001003045.1
UniGeneiCfa.89

Genome annotation databases

EnsembliENSCAFT00000021914; ENSCAFP00000020352; ENSCAFG00000013807
GeneIDi403572
KEGGicfa:403572

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243320 mRNA Translation: CAB45864.1
RefSeqiNP_001003045.1, NM_001003045.1
UniGeneiCfa.89

3D structure databases

ProteinModelPortaliQ9XSV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020352

Proteomic databases

PaxDbiQ9XSV3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000021914; ENSCAFP00000020352; ENSCAFG00000013807
GeneIDi403572
KEGGicfa:403572

Organism-specific databases

CTDi83604
VGNCiVGNC:47584 TMEM47

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000124678
HOVERGENiHBG080233
InParanoidiQ9XSV3
OMAiWTRDIGY
OrthoDBiEOG091G0S9P
TreeFamiTF312855

Gene expression databases

BgeeiENSCAFG00000013807 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
PANTHERiPTHR14399 PTHR14399, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM47_CANLF
AccessioniPrimary (citable) accession number: Q9XSV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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