KCNE1

Functionⁱ

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).By similarity

GO - Molecular functionⁱ

delayed rectifier potassium channel activity Source: UniProtKB
ion channel binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
potassium channel regulator activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

membrane repolarization during action potential
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
membrane repolarization during ventricular cardiac muscle cell action potential Source: GOC
negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
potassium ion export
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein N-linked glycosylation Source: UniProtKB
protein O-linked glycosylation Source: UniProtKB
regulation of heart rate by cardiac conduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of ventricular cardiac muscle cell membrane repolarization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ventricular cardiac muscle cell action potential
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Potassium channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium voltage-gated channel subfamily E member 1 Alternative name(s): Delayed rectifier potassium channel subunit IsK IKs producing slow voltage-gated potassium channel subunit beta Mink Minimal potassium channel
Gene namesⁱ	Name:KCNE1
Organismⁱ	Felis catus (Cat) (Felis silvestris catus)
Taxonomic identifierⁱ	9685 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis
Proteomesⁱ	UP000011712 Componentⁱ: Unplaced

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	44 – 66	HelicalSequence analysisAdd BLAST		23
Topological domainⁱ	67 – 129	CytoplasmicSequence analysisAdd BLAST		63

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144277	1 – 129	Potassium voltage-gated channel subfamily E member 1Add BLAST		129

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	26	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	102	Phosphoserine; by PKCBy similarity	1

Post-translational modificationⁱ

Phosphorylation inhibits the potassium current.By similarity

N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Interactionⁱ

Subunit structureⁱ

Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).By similarity

GO - Molecular functionⁱ

ion channel binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9685.ENSFCAP00000006281

STRINGⁱ

9685.ENSFCAP00000006281

Structureⁱ

3D structure databases

SMRⁱ	Q9XSP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the potassium channel KCNE family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IY71 Eukaryota ENOG410Y1SF LUCA
HOGENOMⁱ	HOG000113207
HOVERGENⁱ	HBG052226
InParanoidⁱ	Q9XSP1
KEGG Orthology (KO) More...KOⁱ	K04894
TreeFamⁱ	TF335976

Family and domain databases

InterProⁱ	View protein in InterPro IPR000369 K_chnl_KCNE IPR005424 K_chnl_volt-dep_bsu_KCNE1
PANTHERⁱ	PTHR15282 PTHR15282, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02060 ISK_Channel, 1 hit
PRINTSⁱ	PR01604 KCNE1CHANNEL PR00168 KCNECHANNEL

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9XSP1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MILPNTTATT PFLNALWQGT AHQGGNTSGL ARRSPGGDDS QLEALYILMV 
        60         70         80         90        100
LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDTWQEK DKAYLQARVL 
       110        120 
ESYKACYVIE NQLAVERPNA HLPEIKPLS

Length:129

Mass (Da):14,505

Last modified:November 1, 1999 - v1

Checksum:ⁱF696A686CFF8DB95

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62404 mRNA Translation: AAD41532.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001009206.1, NM_001009206.1

Genome annotation databases

GeneIDⁱ	493681
KEGGⁱ	fca:493681

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9XSP1	Potassium voltage-gated channel subfamily E member 1		FELCA		129	UniRef90_Q9XSP1
UPI00042BA5DA		PANTA		129
UPI000905094A		PANPR		129
UPI000DF42568		PUMCO		129
UPI00072EBB84		ACIJB		126

Protein	Similar proteins		Species	Score	Length	Source
Q9XSP1	Potassium voltage-gated channel subfamily E member 1		RAT		130	UniRef50_P15383
Potassium voltage-gated channel subfamily E member 1		PIG		130
Potassium voltage-gated channel subfamily E member 1		MOUSE		129
Potassium voltage-gated channel subfamily E member 1		RABIT		130
Potassium voltage-gated channel subfamily E member 1		CAVPO		125
+126

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62404 mRNA Translation: AAD41532.1
RefSeqⁱ	NP_001009206.1, NM_001009206.1

3D structure databases

SMRⁱ	Q9XSP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9685.ENSFCAP00000006281

STRINGⁱ

9685.ENSFCAP00000006281

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	493681
KEGGⁱ	fca:493681

Organism-specific databases

CTDⁱ	3753

CTDⁱ

3753

Phylogenomic databases

eggNOGⁱ	ENOG410IY71 Eukaryota ENOG410Y1SF LUCA
HOGENOMⁱ	HOG000113207
HOVERGENⁱ	HBG052226
InParanoidⁱ	Q9XSP1
KOⁱ	K04894
TreeFamⁱ	TF335976

Family and domain databases

InterProⁱ	View protein in InterPro IPR000369 K_chnl_KCNE IPR005424 K_chnl_volt-dep_bsu_KCNE1
PANTHERⁱ	PTHR15282 PTHR15282, 1 hit
Pfamⁱ	View protein in Pfam PF02060 ISK_Channel, 1 hit
PRINTSⁱ	PR01604 KCNE1CHANNEL PR00168 KCNECHANNEL
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCNE1_FELCA
Accessionⁱ	Q9XSP1Primary (citable) accession number: Q9XSP1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9XSP1 (KCNE1_FELCA)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Potassium voltage-gated channel subfamily E member 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ