UniProtKB - Q9XSP1 (KCNE1_FELCA)
Protein
Potassium voltage-gated channel subfamily E member 1
Gene
KCNE1
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Functioni
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).By similarity
GO - Molecular functioni
- delayed rectifier potassium channel activity Source: UniProtKB
- ion channel binding Source: GO_Central
- potassium channel regulator activity Source: UniProtKB
GO - Biological processi
- membrane repolarization during action potential Source: GO_Central
- membrane repolarization during ventricular cardiac muscle cell action potential Source: GOC
- negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
- potassium ion export across plasma membrane Source: GO_Central
- regulation of heart rate by cardiac conduction Source: GO_Central
- regulation of ventricular cardiac muscle cell membrane repolarization Source: GO_Central
- ventricular cardiac muscle cell action potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily E member 1Alternative name(s): Delayed rectifier potassium channel subunit IsK IKs producing slow voltage-gated potassium channel subunit beta Mink Minimal potassium channel |
Gene namesi | Name:KCNE1 |
Organismi | Felis catus (Cat) (Felis silvestris catus) |
Taxonomic identifieri | 9685 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
- Apical cell membrane By similarity
Other locations
- Membrane raft By similarity
Note: Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (By similarity).By similarity
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 44 – 66 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 67 – 129 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144277 | 1 – 129 | Potassium voltage-gated channel subfamily E member 1Add BLAST | 129 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 102 | Phosphoserine; by PKCBy similarity | 1 |
Post-translational modificationi
Phosphorylation inhibits the potassium current.By similarity
N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinInteractioni
Subunit structurei
Interacts with KCNB1.
Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG.
Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).
By similarityGO - Molecular functioni
- ion channel binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000006281 |
Family & Domainsi
Sequence similaritiesi
Belongs to the potassium channel KCNE family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SG7D, Eukaryota |
InParanoidi | Q9XSP1 |
TreeFami | TF335976 |
Family and domain databases
InterProi | View protein in InterPro IPR000369, K_chnl_KCNE IPR005424, K_chnl_volt-dep_bsu_KCNE1 |
PANTHERi | PTHR15282, PTHR15282, 1 hit |
Pfami | View protein in Pfam PF02060, ISK_Channel, 1 hit |
PRINTSi | PR01604, KCNE1CHANNEL PR00168, KCNECHANNEL |
i Sequence
Sequence statusi: Complete.
Q9XSP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILPNTTATT PFLNALWQGT AHQGGNTSGL ARRSPGGDDS QLEALYILMV
60 70 80 90 100
LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDTWQEK DKAYLQARVL
110 120
ESYKACYVIE NQLAVERPNA HLPEIKPLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62404 mRNA Translation: AAD41532.1 |
RefSeqi | NP_001009206.1, NM_001009206.1 |
Genome annotation databases
GeneIDi | 493681 |
KEGGi | fca:493681 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62404 mRNA Translation: AAD41532.1 |
RefSeqi | NP_001009206.1, NM_001009206.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000006281 |
Genome annotation databases
GeneIDi | 493681 |
KEGGi | fca:493681 |
Organism-specific databases
CTDi | 3753 |
Phylogenomic databases
eggNOGi | ENOG502SG7D, Eukaryota |
InParanoidi | Q9XSP1 |
TreeFami | TF335976 |
Family and domain databases
InterProi | View protein in InterPro IPR000369, K_chnl_KCNE IPR005424, K_chnl_volt-dep_bsu_KCNE1 |
PANTHERi | PTHR15282, PTHR15282, 1 hit |
Pfami | View protein in Pfam PF02060, ISK_Channel, 1 hit |
PRINTSi | PR01604, KCNE1CHANNEL PR00168, KCNECHANNEL |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNE1_FELCA | |
Accessioni | Q9XSP1Primary (citable) accession number: Q9XSP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families