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Protein

Potassium voltage-gated channel subfamily E member 1

Gene

KCNE1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 1
Alternative name(s):
Delayed rectifier potassium channel subunit IsK
IKs producing slow voltage-gated potassium channel subunit beta Mink
Minimal potassium channel
Gene namesi
Name:KCNE1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 66HelicalSequence analysisAdd BLAST23
Topological domaini67 – 129CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442771 – 129Potassium voltage-gated channel subfamily E member 1Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei102Phosphoserine; by PKCBy similarity1

Post-translational modificationi

Phosphorylation inhibits the potassium current.By similarity
N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000006281

Structurei

3D structure databases

SMRiQ9XSP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY71 Eukaryota
ENOG410Y1SF LUCA
HOGENOMiHOG000113207
HOVERGENiHBG052226
InParanoidiQ9XSP1
KOiK04894
TreeFamiTF335976

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
IPR005424 K_chnl_volt-dep_bsu_KCNE1
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR01604 KCNE1CHANNEL
PR00168 KCNECHANNEL

Sequencei

Sequence statusi: Complete.

Q9XSP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILPNTTATT PFLNALWQGT AHQGGNTSGL ARRSPGGDDS QLEALYILMV
60 70 80 90 100
LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDTWQEK DKAYLQARVL
110 120
ESYKACYVIE NQLAVERPNA HLPEIKPLS
Length:129
Mass (Da):14,505
Last modified:November 1, 1999 - v1
Checksum:iF696A686CFF8DB95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62404 mRNA Translation: AAD41532.1
RefSeqiNP_001009206.1, NM_001009206.1

Genome annotation databases

GeneIDi493681
KEGGifca:493681

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62404 mRNA Translation: AAD41532.1
RefSeqiNP_001009206.1, NM_001009206.1

3D structure databases

SMRiQ9XSP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000006281

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493681
KEGGifca:493681

Organism-specific databases

CTDi3753

Phylogenomic databases

eggNOGiENOG410IY71 Eukaryota
ENOG410Y1SF LUCA
HOGENOMiHOG000113207
HOVERGENiHBG052226
InParanoidiQ9XSP1
KOiK04894
TreeFamiTF335976

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
IPR005424 K_chnl_volt-dep_bsu_KCNE1
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR01604 KCNE1CHANNEL
PR00168 KCNECHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE1_FELCA
AccessioniPrimary (citable) accession number: Q9XSP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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