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Protein

Transient receptor potential cation channel subfamily V member 5

Gene

Trpv5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine (PubMed:10085067, PubMed:11035011, PubMed:12574114, PubMed:29323279). Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:29323279). A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay (PubMed:11035011). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).By similarity4 Publications

Enzyme regulationi

Activated by WNK3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi542Calcium; shared with neighboring subunits1 Publication1

GO - Molecular functioni

  • calcium channel activity Source: UniProtKB
  • calmodulin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • calcium ion homeostasis Source: UniProtKB
  • calcium ion import across plasma membrane Source: UniProtKB
  • calcium ion transmembrane transport Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • protein homotetramerization Source: UniProtKB
  • protein tetramerization Source: UniProtKB
  • regulation of urine volume Source: UniProtKB

Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Protein family/group databases

TCDBi1.A.4.2.3 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 5
Short name:
TrpV5
Alternative name(s):
Epithelial calcium channel 12 Publications
Short name:
ECaC12 Publications
Osm-9-like TRP channel 3
Short name:
OTRPC3
Gene namesi
Name:Trpv5
Synonyms:Ecac11 Publication
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 327Cytoplasmic1 PublicationAdd BLAST327
Transmembranei328 – 348Helical1 PublicationAdd BLAST21
Topological domaini349 – 385Extracellular1 PublicationAdd BLAST37
Transmembranei386 – 408Helical1 PublicationAdd BLAST23
Topological domaini409 – 419Cytoplasmic1 PublicationAdd BLAST11
Transmembranei420 – 442Helical1 PublicationAdd BLAST23
Topological domaini443 – 448Extracellular1 Publication6
Transmembranei449 – 469Helical1 PublicationAdd BLAST21
Topological domaini470 – 492Cytoplasmic1 PublicationAdd BLAST23
Transmembranei493 – 513Helical1 PublicationAdd BLAST21
Intramembranei524 – 544Pore-forming1 PublicationAdd BLAST21
Transmembranei557 – 577Helical1 PublicationAdd BLAST21
Topological domaini578 – 730Cytoplasmic1 PublicationAdd BLAST153

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi425F → A: Decreased inhibition by the synthetic drug econazole. 1 Publication1
Mutagenesisi535E → A: Minor effects on Ca(2+) permeation. 1 Publication1
Mutagenesisi542D → A: Abolishes Ca(2+) permeation and Ca(2+)-dependent current decay; no effect on monovalent cations permeation. 1 Publication1
Mutagenesisi542D → E, N or M: Attenuates Ca(2+) permeation and Ca(2+)-dependent current decay. 1 Publication1
Mutagenesisi542D → K: Abolishes channel activity. 1 Publication1
Mutagenesisi550D → A: Minor effects on Ca(2+) permeation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153521 – 730Transient receptor potential cation channel subfamily V member 5Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei685PhosphothreonineBy similarity1
Modified residuei689PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9XSM3

PTM databases

iPTMnetiQ9XSM3

Expressioni

Tissue specificityi

Detected in kidney cortex, in distal convoluted tubules and cortical collecting ducts (at protein level) (PubMed:10085067). Detected in duodenum, jejunum, ileum, kidney and placenta (PubMed:10085067).1 Publication

Gene expression databases

BgeeiENSOCUG00000007559

Interactioni

Subunit structurei

Homotetramer (PubMed:29323279). Probably forms heterotetramers with TRPV6 (PubMed:12574114). Interacts with TRPV6 (PubMed:12574114). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-46154N
IntActiQ9XSM3, 1 interactor
STRINGi9986.ENSOCUP00000006536

Structurei

3D structure databases

ProteinModelPortaliQ9XSM3
SMRiQ9XSM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 74ANK 1Sequence analysisAdd BLAST31
Repeati78 – 107ANK 2Sequence analysisAdd BLAST30
Repeati116 – 145ANK 3Sequence analysisAdd BLAST30
Repeati162 – 191ANK 4Sequence analysisAdd BLAST30
Repeati195 – 228ANK 5Sequence analysisAdd BLAST34
Repeati239 – 268ANK 6Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni598 – 602Interaction with S100A10By similarity5
Regioni650 – 653Involved in Ca(2+)-dependent inactivation4
Regioni701 – 730Involved in Ca(2+)-dependent inactivationAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00550000074425
HOGENOMiHOG000234397
HOVERGENiHBG061442
InParanoidiQ9XSM3
KOiK04974
OMAiYFGQTVL
OrthoDBiEOG091G0314
TreeFamiTF314711

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008346 TRPV5
IPR008344 TRPV5/TRPV6
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF11 PTHR10582:SF11, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01415 ANKYRIN
PR01765 ECACCHANNEL
PR01767 ECACCHANNEL2
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q9XSM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGACPPKAKG PWAQLQKLLI SWPVGEQDWE QYRDRVNMLQ QERIRDSPLL
60 70 80 90 100
QAAKENDLRL LKILLLNQSC DFQQRGAVGE TALHVAALYD NLEAATLLME
110 120 130 140 150
AAPELAKEPA LCEPFVGQTA LHIAVMNQNL NLVRALLARG ASVSARATGA
160 170 180 190 200
AFRRSPHNLI YYGEHPLSFA ACVGSEEIVR LLIEHGADIR AQDSLGNTVL
210 220 230 240 250
HILILQPNKT FACQMYNLLL SYDEHSDHLQ SLELVPNHQG LTPFKLAGVE
260 270 280 290 300
GNTVMFQHLM QKRKHVQWTC GPLTSTLYDL TEIDSWGEEL SFLELVVSSK
310 320 330 340 350
KREARQILEQ TPVKELVSFK WKKYGRPYFC VLASLYILYM ICFTTCCIYR
360 370 380 390 400
PLKLRDDNRT DPRDITILQQ KLLQEAYVTH QDNIRLVGEL VTVTGAVIIL
410 420 430 440 450
LLEIPDIFRV GASRYFGQTI LGGPFHVIII TYASLVLLTM VMRLTNMNGE
460 470 480 490 500
VVPLSFALVL GWCSVMYFAR GFQMLGPFTI MIQKMIFGDL MRFCWLMAVV
510 520 530 540 550
ILGFASAFHI TFQTEDPNNL GEFSDYPTAL FSTFELFLTI IDGPANYSVD
560 570 580 590 600
LPFMYCITYA AFAIIATLLM LNLFIAMMGD THWRVAQERD ELWRAQVVAT
610 620 630 640 650
TVMLERKMPR FLWPRSGICG YEYGLGDRWF LRVENHHDQN PLRVLRYVEA
660 670 680 690 700
FKCSDKEDGQ EQLSEKRPST VESGMLSRAS VAFQTPSLSR TTSQSSNSHR
710 720 730
GWEILRRNTL GHLNLGLDLG EGDGEEVYHF
Length:730
Mass (Da):82,814
Last modified:November 1, 1999 - v1
Checksum:i0CB9FBAD916B1400
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133128 mRNA Translation: CAB40138.1
RefSeqiNP_001076126.1, NM_001082657.1
UniGeneiOcu.3235

Genome annotation databases

EnsembliENSOCUT00000007559; ENSOCUP00000006536; ENSOCUG00000007559
GeneIDi100009364
KEGGiocu:100009364

Similar proteinsi

Entry informationi

Entry nameiTRPV5_RABIT
AccessioniPrimary (citable) accession number: Q9XSM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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