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Entry version 107 (02 Jun 2021)
Sequence version 2 (18 May 2010)
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Protein

Paired amphipathic helix protein Sin3-like 6

Gene

SNL6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3-like 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNL6
Ordered Locus Names:At1g10450
ORF Names:T10O24.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G10450

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003940441 – 1173Paired amphipathic helix protein Sin3-like 6Add BLAST1173

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XIK6

PRoteomics IDEntifications database

More...
PRIDEi
Q9XIK6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234533

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9XIK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9XIK6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9XIK6, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9XIK6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G10450.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XIK6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 148PAH 1PROSITE-ProRule annotationAdd BLAST70
Domaini162 – 232PAH 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 75DisorderedSequence analysisAdd BLAST36
Regioni236 – 337DisorderedSequence analysisAdd BLAST102
Regioni655 – 697DisorderedSequence analysisAdd BLAST43
Regioni740 – 813DisorderedSequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 74Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi251 – 283Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi300 – 317Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi318 – 337Polar residuesSequence analysisAdd BLAST20
Compositional biasi671 – 689Polar residuesSequence analysisAdd BLAST19
Compositional biasi750 – 774Polar residuesSequence analysisAdd BLAST25
Compositional biasi775 – 810Basic and acidic residuesSequence analysisAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4204, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007140_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9XIK6

Database of Orthologous Groups

More...
OrthoDBi
253485at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XIK6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1160.11, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013194, HDAC_interact_dom
IPR003822, PAH
IPR036600, PAH_sf
IPR039774, Sin3-like
IPR031693, Sin3_C

The PANTHER Classification System

More...
PANTHERi
PTHR12346, PTHR12346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671, PAH, 2 hits
PF08295, Sin3_corepress, 1 hit
PF16879, Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00761, HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47762, SSF47762, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51477, PAH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9XIK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDLLLGTTI PSYFSWLGLF PRFLVWFGFL KASFFCSSRN QSAGESGRRL
60 70 80 90 100
KMKRAREDVH TDTQKRKPEV SSRGETNKLP RTIDALTYLK AVKDIFHDNK
110 120 130 140 150
EKYESFLELM KEFKAQTIDT NGVIERIKVL FKGYRDLLLG FNTFLPKGYK
160 170 180 190 200
ITLLPEEEKP KIRVDFKDAI GFVTKIKTRF GDDEHAYKRF LDILNLYRKE
210 220 230 240 250
KKSISEVYEE VTMLFKGHED LLMEFVNFLP NCPESAPSTK NAVPRHKGTA
260 270 280 290 300
TTAMHSDKKR KQRCKLEDYS GHSDQREDGD ENLVTCSADS PVGEGQPGYF
310 320 330 340 350
RDYENREDTE TDTADRTEKS AASGSQDIGN HKSTTKYVGT PINELDLSEC
360 370 380 390 400
TQCTPSYRLL PKDYAVEIPS YRNTLGKKTL NDHLVSVTSG SEDYSFSHMR
410 420 430 440 450
KNQYEESLFR CEDDRYEMDM LLGSVSSAIK QVEILLEKMN NNTISVDSTI
460 470 480 490 500
CIEKHLSAMN LRCIERLYGD NGLDVMDLLK KNMHSALPVI LTRLKQKQEE
510 520 530 540 550
WARCHSDFQK VWAEVYAKNH HKSLDHRSFY FKQQDSKNLS TKCLVAEVKD
560 570 580 590 600
ISEKKHQEDL LQAIAVRVMP LFTPDLEFNY CDTQIHEDLY LLIKYYCEEI
610 620 630 640 650
CATEQSDKVM KLWITFLEPI FGILSRSQDN LALEDVSKLK NNRELQDACL
660 670 680 690 700
AVKETASGSN RKHPISPKRL SKDNTKMQGS SSREDVSANI KVKTAQPDKL
710 720 730 740 750
QDDAAMTNEV IQSSKFVSPK NDQIMEDEGN HMVNAASVEK HELEEGELSP
760 770 780 790 800
TASREQSNFE VNGQNAFKPL QKVTDNVRSN KDKQSCDKKG AKNKTRAEDD
810 820 830 840 850
KQENCHKLSE NNKTASEMLV SGTKVSCHEE NNRVMNCNGR GSVAGEMANG
860 870 880 890 900
NQGEDGSFAF SERFLQTVKP VAKHLSWPLQ ASETCSQNDS QVFYGNDSYY
910 920 930 940 950
VLFRLHQMLY ERIQTAKKHS EKKWKAADNT TPDSYPRFMD ALYNLLDGSI
960 970 980 990 1000
DNTKFEDECR AIFGAQSYVL FTLDKLVQKF VKHLHSVASD ETDTKLLQLH
1010 1020 1030 1040 1050
AYENYRKPGK FFDLVYHENA CALLHEANIY RIRYSSEGTR LSIQLMNSGN
1060 1070 1080 1090 1100
NQLEVMGVAM EPAFADYLQN KCLKSVNDEE NHGLFLNRNK KKFTSLDESR
1110 1120 1130 1140 1150
GMPVAMERLN IINEMECRMA CSSSKVKYVA NTSDLLYRSK QGKPNSRVSE
1160 1170
ILKQRRISRF HIMLNCRLCA LPL
Length:1,173
Mass (Da):134,417
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F4DC113B65134BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A178WJA6A0A178WJA6_ARATH
Paired amphipathic helix Sin3-like ...
SNL6 SIN3-like 6, At1g10450, T10O24.5, T10O24_5
1,122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD39565 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AEE28580 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007067 Genomic DNA Translation: AAD39565.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28580.1 Different initiation.
CP002684 Genomic DNA Translation: ANM59404.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C86238

NCBI Reference Sequences

More...
RefSeqi
NP_001321764.1, NM_001331906.1
NP_001321765.1, NM_001331907.1
NP_172515.2, NM_100919.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G10450.3; AT1G10450.3; AT1G10450

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837584

Gramene; a comparative resource for plants

More...
Gramenei
AT1G10450.3; AT1G10450.3; AT1G10450

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G10450

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007067 Genomic DNA Translation: AAD39565.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28580.1 Different initiation.
CP002684 Genomic DNA Translation: ANM59404.1
PIRiC86238
RefSeqiNP_001321764.1, NM_001331906.1
NP_001321765.1, NM_001331907.1
NP_172515.2, NM_100919.5

3D structure databases

SMRiQ9XIK6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9XIK6, 1 interactor
STRINGi3702.AT1G10450.1

PTM databases

iPTMnetiQ9XIK6

Proteomic databases

PaxDbiQ9XIK6
PRIDEiQ9XIK6
ProteomicsDBi234533

Genome annotation databases

EnsemblPlantsiAT1G10450.3; AT1G10450.3; AT1G10450
GeneIDi837584
GrameneiAT1G10450.3; AT1G10450.3; AT1G10450
KEGGiath:AT1G10450

Organism-specific databases

AraportiAT1G10450

Phylogenomic databases

eggNOGiKOG4204, Eukaryota
HOGENOMiCLU_007140_1_0_1
InParanoidiQ9XIK6
OrthoDBi253485at2759
PhylomeDBiQ9XIK6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XIK6

Gene expression databases

ExpressionAtlasiQ9XIK6, baseline and differential
GenevisibleiQ9XIK6, AT

Family and domain databases

Gene3Di1.20.1160.11, 2 hits
InterProiView protein in InterPro
IPR013194, HDAC_interact_dom
IPR003822, PAH
IPR036600, PAH_sf
IPR039774, Sin3-like
IPR031693, Sin3_C
PANTHERiPTHR12346, PTHR12346, 1 hit
PfamiView protein in Pfam
PF02671, PAH, 2 hits
PF08295, Sin3_corepress, 1 hit
PF16879, Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761, HDAC_interact, 1 hit
SUPFAMiSSF47762, SSF47762, 2 hits
PROSITEiView protein in PROSITE
PS51477, PAH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNL6_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XIK6
Secondary accession number(s): F4I4C3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: June 2, 2021
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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