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Protein

Iron-sulfur assembly protein IscA, chloroplastic

Gene

ISCA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the assembly of chloroplastic iron-sulfur proteins. Is able to transfer iron-sulfur clusters to apo-ferredoxin.1 Publication

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi104IronBy similarity1
Metal bindingi170IronBy similarity1
Metal bindingi172IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandIron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur assembly protein IscA, chloroplastic
Alternative name(s):
Plastid SufA-like protein
Protein scaffold protein AtCpIscA
Gene namesi
Name:ISCA
Ordered Locus Names:At1g10500
ORF Names:T10O24.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G10500
TAIRilocus:2194594 AT1G10500

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55ChloroplastSequence analysisAdd BLAST55
ChainiPRO_000007703356 – 180Iron-sulfur assembly protein IscA, chloroplasticAdd BLAST125

Proteomic databases

PaxDbiQ9XIK3
PRIDEiQ9XIK3

Expressioni

Tissue specificityi

Ubiquitous with higher expression level in green, photosynthetic tissues.1 Publication

Gene expression databases

ExpressionAtlasiQ9XIK3 baseline and differential
GenevisibleiQ9XIK3 AT

Interactioni

Subunit structurei

Homodimer; may form tetramers and higher multimers.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G10500.1

Structurei

3D structure databases

ProteinModelPortaliQ9XIK3
SMRiQ9XIK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HesB/IscA family. Ycf83 subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1120 Eukaryota
COG0316 LUCA
HOGENOMiHOG000228314
InParanoidiQ9XIK3
KOiK22063
OMAiPQMIRIG
OrthoDBiEOG09360QNQ
PhylomeDBiQ9XIK3

Family and domain databases

Gene3Di2.60.300.12, 1 hit
InterProiView protein in InterPro
IPR000361 FeS_biogenesis
IPR016092 FeS_cluster_insertion
IPR017870 FeS_cluster_insertion_CS
IPR035903 HesB-like_dom_sf
PfamiView protein in Pfam
PF01521 Fe-S_biosyn, 1 hit
SUPFAMiSSF89360 SSF89360, 1 hit
TIGRFAMsiTIGR00049 TIGR00049, 1 hit
PROSITEiView protein in PROSITE
PS01152 HESB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XIK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFATGITTS SNPTFLGLKI SNTSLRSVVS CNSISFPSLS YVNLNLNRRN
60 70 80 90 100
RLSVRSASVP AAPAMEGLKP AISLSENALK HLSKMRSERG EDLCLRIGVK
110 120 130 140 150
QGGCSGMSYT MDFENRANAR PDDSTIEYQG FTIVCDPKSM LFLFGMQLDY
160 170 180
SDALIGGGFS FSNPNATQTC GCGKSFAAEM
Length:180
Mass (Da):19,337
Last modified:February 21, 2006 - v2
Checksum:iFAF5D859F06B7AFF
GO

Sequence cautioni

The sequence AAD39571 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY971959 mRNA Translation: AAY40769.1
AC007067 Genomic DNA Translation: AAD39571.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28586.1
BT010894 mRNA Translation: AAR24672.1
BT011763 mRNA Translation: AAS65934.1
PIRiF86238
RefSeqiNP_172520.1, NM_100924.3
UniGeneiAt.23708
At.66809

Genome annotation databases

EnsemblPlantsiAT1G10500.1; AT1G10500.1; AT1G10500
GeneIDi837590
GrameneiAT1G10500.1; AT1G10500.1; AT1G10500
KEGGiath:AT1G10500

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY971959 mRNA Translation: AAY40769.1
AC007067 Genomic DNA Translation: AAD39571.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28586.1
BT010894 mRNA Translation: AAR24672.1
BT011763 mRNA Translation: AAS65934.1
PIRiF86238
RefSeqiNP_172520.1, NM_100924.3
UniGeneiAt.23708
At.66809

3D structure databases

ProteinModelPortaliQ9XIK3
SMRiQ9XIK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G10500.1

Proteomic databases

PaxDbiQ9XIK3
PRIDEiQ9XIK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G10500.1; AT1G10500.1; AT1G10500
GeneIDi837590
GrameneiAT1G10500.1; AT1G10500.1; AT1G10500
KEGGiath:AT1G10500

Organism-specific databases

AraportiAT1G10500
TAIRilocus:2194594 AT1G10500

Phylogenomic databases

eggNOGiKOG1120 Eukaryota
COG0316 LUCA
HOGENOMiHOG000228314
InParanoidiQ9XIK3
KOiK22063
OMAiPQMIRIG
OrthoDBiEOG09360QNQ
PhylomeDBiQ9XIK3

Miscellaneous databases

PROiPR:Q9XIK3

Gene expression databases

ExpressionAtlasiQ9XIK3 baseline and differential
GenevisibleiQ9XIK3 AT

Family and domain databases

Gene3Di2.60.300.12, 1 hit
InterProiView protein in InterPro
IPR000361 FeS_biogenesis
IPR016092 FeS_cluster_insertion
IPR017870 FeS_cluster_insertion_CS
IPR035903 HesB-like_dom_sf
PfamiView protein in Pfam
PF01521 Fe-S_biosyn, 1 hit
SUPFAMiSSF89360 SSF89360, 1 hit
TIGRFAMsiTIGR00049 TIGR00049, 1 hit
PROSITEiView protein in PROSITE
PS01152 HESB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiISCAP_ARATH
AccessioniPrimary (citable) accession number: Q9XIK3
Secondary accession number(s): Q6NM99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 21, 2006
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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