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Entry version 128 (08 May 2019)
Sequence version 2 (26 Apr 2004)
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Protein

Auxin response factor 12

Gene

ARF12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi126 – 228TF-B3PROSITE-ProRule annotationAdd BLAST103

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processAuxin signaling pathway, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Auxin response factor 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARF12
Ordered Locus Names:At1g34310
ORF Names:F23M19.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G34310

The Arabidopsis Information Resource

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TAIRi
locus:2026145 AT1G34310

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001115161 – 593Auxin response factor 12Add BLAST593

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9XID4

PRoteomics IDEntifications database

More...
PRIDEi
Q9XID4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9XID4 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9XID4 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimers and heterodimers.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
25563, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9XID4, 12 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G34310.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9XID4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini511 – 592PB1PROSITE-ProRule annotationAdd BLAST82

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Interactions between auxin response factors (ARFs) and Aux/IAA proteins occur through their C-terminal dimerization domains III and IV.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARF family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000241141

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIYNERM

Database of Orthologous Groups

More...
OrthoDBi
551703at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9XID4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10017 B3_DNA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.330.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033389 AUX/IAA_dom
IPR010525 Auxin_resp
IPR003340 B3_DNA-bd
IPR015300 DNA-bd_pseudobarrel_sf
IPR000270 PB1_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02309 AUX_IAA, 2 hits
PF06507 Auxin_resp, 1 hit
PF02362 B3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01019 B3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101936 SSF101936, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50863 B3, 1 hit
PS51745 PB1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9XID4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGNVVNAQ PELSGIIDGS KSYVYEQLWK LCAGPLCDIP KLGEKVYYFP
60 70 80 90 100
QGHIELVETS TREELNELQP ICDLPSKLQC RVIAIHLKVE NNSDETYAEI
110 120 130 140 150
TLMPDTTQVV IPTQNENQFR PLVNSFTKVL TASDTSAHGG FFVPKKHAIE
160 170 180 190 200
CLPSLDMSQP LPAQELLAID LHGNQWRFNH NYRGTPQRHL LTTGWNAFTT
210 220 230 240 250
SKKLVAGDVI VFVRGETGEL RVGIRRARHQ QGNIPSSIVS IDCMRHGVVA
260 270 280 290 300
SAKHAFDNQC MFTVVYKPRS SKFIVSYDKF LDAVNNKFNV GSRFTMRLEG
310 320 330 340 350
DDFSERRCFG TIIGVSDFSP HWKCSEWRSL EVQWDEFTSF PGPKKVSPWD
360 370 380 390 400
IEHLMPAINV PRSFLLKNKR LREVNEIGSS SSHLLPPILT QGQENEQLSV
410 420 430 440 450
ASPMNISLRY RDATEDAMNP SKLLMSYPVQ PMPKLNYNNQ MVTEMEENIT
460 470 480 490 500
TKTGTNFRLF GVTLDTPPVI KDPIEEIGSE ISKLTEGKKF GLSQTLRSPT
510 520 530 540 550
EIQNKQFSSS RTCTKVQMQG VTIGRAVDLS VLNGYDQLIL ELEKLFDIKG
560 570 580 590
QLQTRNQWEI AFTDSDEDKM LVGDDPWPEF CNMVKKIFIQ KRR
Length:593
Mass (Da):67,218
Last modified:April 26, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01DCBAB5889B2ECA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD39615 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY669792 mRNA Translation: AAT67076.1
AC007454 Genomic DNA Translation: AAD39615.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE31695.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C86467

NCBI Reference Sequences

More...
RefSeqi
NP_174691.2, NM_103153.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G34310.1; AT1G34310.1; AT1G34310

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
840331

Gramene; a comparative resource for plants

More...
Gramenei
AT1G34310.1; AT1G34310.1; AT1G34310

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G34310

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669792 mRNA Translation: AAT67076.1
AC007454 Genomic DNA Translation: AAD39615.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE31695.1
PIRiC86467
RefSeqiNP_174691.2, NM_103153.2

3D structure databases

SMRiQ9XID4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi25563, 9 interactors
IntActiQ9XID4, 12 interactors
STRINGi3702.AT1G34310.1

Proteomic databases

PaxDbiQ9XID4
PRIDEiQ9XID4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G34310.1; AT1G34310.1; AT1G34310
GeneIDi840331
GrameneiAT1G34310.1; AT1G34310.1; AT1G34310
KEGGiath:AT1G34310

Organism-specific databases

AraportiAT1G34310
TAIRilocus:2026145 AT1G34310

Phylogenomic databases

HOGENOMiHOG000241141
OMAiTIYNERM
OrthoDBi551703at2759
PhylomeDBiQ9XID4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9XID4

Gene expression databases

ExpressionAtlasiQ9XID4 differential
GenevisibleiQ9XID4 AT

Family and domain databases

CDDicd10017 B3_DNA, 1 hit
Gene3Di2.40.330.10, 1 hit
InterProiView protein in InterPro
IPR033389 AUX/IAA_dom
IPR010525 Auxin_resp
IPR003340 B3_DNA-bd
IPR015300 DNA-bd_pseudobarrel_sf
IPR000270 PB1_dom
PfamiView protein in Pfam
PF02309 AUX_IAA, 2 hits
PF06507 Auxin_resp, 1 hit
PF02362 B3, 1 hit
SMARTiView protein in SMART
SM01019 B3, 1 hit
SUPFAMiSSF101936 SSF101936, 1 hit
PROSITEiView protein in PROSITE
PS50863 B3, 1 hit
PS51745 PB1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARFL_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9XID4
Secondary accession number(s): Q5IRX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: May 8, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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