UniProtKB - Q9XID4 (ARFL_ARATH)
Protein
Auxin response factor 12
Gene
ARF12
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 126 – 228 | TF-B3PROSITE-ProRule annotationAdd BLAST | 103 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: TAIR
- transcription regulatory region sequence-specific DNA binding Source: TAIR
GO - Biological processi
- auxin-activated signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Auxin signaling pathway, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Auxin response factor 12 |
Gene namesi | Name:ARF12 Ordered Locus Names:At1g34310 ORF Names:F23M19.4 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G34310 |
TAIRi | locus:2026145, AT1G34310 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000111516 | 1 – 593 | Auxin response factor 12Add BLAST | 593 |
Proteomic databases
PaxDbi | Q9XID4 |
PRIDEi | Q9XID4 |
ProteomicsDBi | 240328 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9XID4, baseline and differential |
Genevisiblei | Q9XID4, AT |
Interactioni
Subunit structurei
Homodimers and heterodimers.
By similarityProtein-protein interaction databases
BioGRIDi | 25563, 9 interactors |
IntActi | Q9XID4, 12 interactors |
STRINGi | 3702.AT1G34310.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 511 – 592 | PB1PROSITE-ProRule annotationAdd BLAST | 82 |
Domaini
Interactions between auxin response factors (ARFs) and Aux/IAA proteins occur through their C-terminal dimerization domains III and IV.
Sequence similaritiesi
Belongs to the ARF family.Curated
Phylogenomic databases
eggNOGi | ENOG502QTME, Eukaryota |
HOGENOMi | CLU_002626_4_4_1 |
OMAi | TIYNERM |
OrthoDBi | 551703at2759 |
PhylomeDBi | Q9XID4 |
Family and domain databases
CDDi | cd10017, B3_DNA, 1 hit |
Gene3Di | 2.40.330.10, 1 hit |
InterProi | View protein in InterPro IPR033389, AUX/IAA_dom IPR010525, Auxin_resp IPR003340, B3_DNA-bd IPR015300, DNA-bd_pseudobarrel_sf IPR000270, PB1_dom |
Pfami | View protein in Pfam PF02309, AUX_IAA, 2 hits PF06507, Auxin_resp, 1 hit PF02362, B3, 1 hit |
SMARTi | View protein in SMART SM01019, B3, 1 hit |
SUPFAMi | SSF101936, SSF101936, 1 hit |
PROSITEi | View protein in PROSITE PS50863, B3, 1 hit PS51745, PB1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9XID4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESGNVVNAQ PELSGIIDGS KSYVYEQLWK LCAGPLCDIP KLGEKVYYFP
60 70 80 90 100
QGHIELVETS TREELNELQP ICDLPSKLQC RVIAIHLKVE NNSDETYAEI
110 120 130 140 150
TLMPDTTQVV IPTQNENQFR PLVNSFTKVL TASDTSAHGG FFVPKKHAIE
160 170 180 190 200
CLPSLDMSQP LPAQELLAID LHGNQWRFNH NYRGTPQRHL LTTGWNAFTT
210 220 230 240 250
SKKLVAGDVI VFVRGETGEL RVGIRRARHQ QGNIPSSIVS IDCMRHGVVA
260 270 280 290 300
SAKHAFDNQC MFTVVYKPRS SKFIVSYDKF LDAVNNKFNV GSRFTMRLEG
310 320 330 340 350
DDFSERRCFG TIIGVSDFSP HWKCSEWRSL EVQWDEFTSF PGPKKVSPWD
360 370 380 390 400
IEHLMPAINV PRSFLLKNKR LREVNEIGSS SSHLLPPILT QGQENEQLSV
410 420 430 440 450
ASPMNISLRY RDATEDAMNP SKLLMSYPVQ PMPKLNYNNQ MVTEMEENIT
460 470 480 490 500
TKTGTNFRLF GVTLDTPPVI KDPIEEIGSE ISKLTEGKKF GLSQTLRSPT
510 520 530 540 550
EIQNKQFSSS RTCTKVQMQG VTIGRAVDLS VLNGYDQLIL ELEKLFDIKG
560 570 580 590
QLQTRNQWEI AFTDSDEDKM LVGDDPWPEF CNMVKKIFIQ KRR
Sequence cautioni
The sequence AAD39615 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY669792 mRNA Translation: AAT67076.1 AC007454 Genomic DNA Translation: AAD39615.1 Sequence problems. CP002684 Genomic DNA Translation: AEE31695.1 |
PIRi | C86467 |
RefSeqi | NP_174691.2, NM_103153.2 |
Genome annotation databases
EnsemblPlantsi | AT1G34310.1; AT1G34310.1; AT1G34310 |
GeneIDi | 840331 |
Gramenei | AT1G34310.1; AT1G34310.1; AT1G34310 |
KEGGi | ath:AT1G34310 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY669792 mRNA Translation: AAT67076.1 AC007454 Genomic DNA Translation: AAD39615.1 Sequence problems. CP002684 Genomic DNA Translation: AEE31695.1 |
PIRi | C86467 |
RefSeqi | NP_174691.2, NM_103153.2 |
3D structure databases
SMRi | Q9XID4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 25563, 9 interactors |
IntActi | Q9XID4, 12 interactors |
STRINGi | 3702.AT1G34310.1 |
Proteomic databases
PaxDbi | Q9XID4 |
PRIDEi | Q9XID4 |
ProteomicsDBi | 240328 |
Genome annotation databases
EnsemblPlantsi | AT1G34310.1; AT1G34310.1; AT1G34310 |
GeneIDi | 840331 |
Gramenei | AT1G34310.1; AT1G34310.1; AT1G34310 |
KEGGi | ath:AT1G34310 |
Organism-specific databases
Araporti | AT1G34310 |
TAIRi | locus:2026145, AT1G34310 |
Phylogenomic databases
eggNOGi | ENOG502QTME, Eukaryota |
HOGENOMi | CLU_002626_4_4_1 |
OMAi | TIYNERM |
OrthoDBi | 551703at2759 |
PhylomeDBi | Q9XID4 |
Miscellaneous databases
PROi | PR:Q9XID4 |
Gene expression databases
ExpressionAtlasi | Q9XID4, baseline and differential |
Genevisiblei | Q9XID4, AT |
Family and domain databases
CDDi | cd10017, B3_DNA, 1 hit |
Gene3Di | 2.40.330.10, 1 hit |
InterProi | View protein in InterPro IPR033389, AUX/IAA_dom IPR010525, Auxin_resp IPR003340, B3_DNA-bd IPR015300, DNA-bd_pseudobarrel_sf IPR000270, PB1_dom |
Pfami | View protein in Pfam PF02309, AUX_IAA, 2 hits PF06507, Auxin_resp, 1 hit PF02362, B3, 1 hit |
SMARTi | View protein in SMART SM01019, B3, 1 hit |
SUPFAMi | SSF101936, SSF101936, 1 hit |
PROSITEi | View protein in PROSITE PS50863, B3, 1 hit PS51745, PB1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARFL_ARATH | |
Accessioni | Q9XID4Primary (citable) accession number: Q9XID4 Secondary accession number(s): Q5IRX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families