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Protein

Mitochondrial import inner membrane translocase subunit Tim9

Gene

TIM9

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Translocation, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim9
Gene namesi
Name:TIM9
Ordered Locus Names:Os12g0571200, LOC_Os12g38310
ORF Names:OsJ_36586Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001936071 – 93Mitochondrial import inner membrane translocase subunit Tim9Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 67By similarity
Disulfide bondi47 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9XGX7

Expressioni

Gene expression databases

ExpressionAtlasiQ9XGX7 differential
GenevisibleiQ9XGX7 OS

Interactioni

Subunit structurei

Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. The complex associates with the TIM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os12g38310.1

Structurei

3D structure databases

ProteinModelPortaliQ9XGX7
SMRiQ9XGX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 67Twin CX3C motifAdd BLAST25

Domaini

The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).By similarity

Sequence similaritiesi

Belongs to the small Tim family.Curated

Phylogenomic databases

eggNOGiKOG3479 Eukaryota
ENOG4111TUA LUCA
HOGENOMiHOG000185786
InParanoidiQ9XGX7
KOiK17777
OMAiCCNDFTS
OrthoDBiEOG09360W8Q

Family and domain databases

Gene3Di1.10.287.810, 1 hit
InterProiView protein in InterPro
IPR004217 Tim10-like
IPR035427 Tim10-like_dom_sf
IPR039094 TIM9
PANTHERiPTHR10898 PTHR10898, 1 hit
PfamiView protein in Pfam
PF02953 zf-Tim10_DDP, 1 hit
SUPFAMiSSF144122 SSF144122, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XGX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKSMLGDLD GLPEEDKMRM AAMVDQLQIR DSLRMYNSLV ERCFTDCVDT
60 70 80 90
FRRKTLDKQE ESCVRRCAEK FLKHSMRVGM RFAELNQGVA TPD
Length:93
Mass (Da):10,840
Last modified:March 21, 2006 - v2
Checksum:i1BF0BCB5FC3FED37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92P → T in AAD40019 (PubMed:10611480).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF150113 mRNA Translation: AAD40019.1
DP000011 Genomic DNA Translation: ABA99662.1
AP008218 Genomic DNA Translation: BAF30103.1
AP014968 Genomic DNA Translation: BAT17740.1
CM000149 Genomic DNA Translation: EEE53462.1
AK120784 mRNA Translation: BAH00171.1
PIRiT51188
RefSeqiXP_015620238.1, XM_015764752.1
UniGeneiOs.2313

Genome annotation databases

EnsemblPlantsiOs12t0571200-01; Os12t0571200-01; Os12g0571200
GeneIDi4352583
GrameneiOs12t0571200-01; Os12t0571200-01; Os12g0571200
KEGGiosa:4352583

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF150113 mRNA Translation: AAD40019.1
DP000011 Genomic DNA Translation: ABA99662.1
AP008218 Genomic DNA Translation: BAF30103.1
AP014968 Genomic DNA Translation: BAT17740.1
CM000149 Genomic DNA Translation: EEE53462.1
AK120784 mRNA Translation: BAH00171.1
PIRiT51188
RefSeqiXP_015620238.1, XM_015764752.1
UniGeneiOs.2313

3D structure databases

ProteinModelPortaliQ9XGX7
SMRiQ9XGX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os12g38310.1

Proteomic databases

PaxDbiQ9XGX7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOs12t0571200-01; Os12t0571200-01; Os12g0571200
GeneIDi4352583
GrameneiOs12t0571200-01; Os12t0571200-01; Os12g0571200
KEGGiosa:4352583

Phylogenomic databases

eggNOGiKOG3479 Eukaryota
ENOG4111TUA LUCA
HOGENOMiHOG000185786
InParanoidiQ9XGX7
KOiK17777
OMAiCCNDFTS
OrthoDBiEOG09360W8Q

Gene expression databases

ExpressionAtlasiQ9XGX7 differential
GenevisibleiQ9XGX7 OS

Family and domain databases

Gene3Di1.10.287.810, 1 hit
InterProiView protein in InterPro
IPR004217 Tim10-like
IPR035427 Tim10-like_dom_sf
IPR039094 TIM9
PANTHERiPTHR10898 PTHR10898, 1 hit
PfamiView protein in Pfam
PF02953 zf-Tim10_DDP, 1 hit
SUPFAMiSSF144122 SSF144122, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTIM9_ORYSJ
AccessioniPrimary (citable) accession number: Q9XGX7
Secondary accession number(s): Q0IMG2, Q2QNC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 21, 2006
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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Main funding by: National Institutes of Health

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