The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q9XG85 (PROF1_PARJU)
Protein
Profilin-1
Gene
PRO1
Organism
Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
Status
Functioni
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Profilin-1Alternative name(s): Pollen allergen Par j 3.0101 Allergen: Par j 3.0101 |
Gene namesi | Name:PRO1 |
Organismi | Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa) |
Taxonomic identifieri | 33127 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Rosales › Urticaceae › Parietaria |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 510, Par j 3 511, Par j 3.0101 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000199661 | 2 – 132 | Profilin-1Add BLAST | 131 |
Interactioni
Subunit structurei
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Family & Domainsi
Sequence similaritiesi
Belongs to the profilin family.Curated
Family and domain databases
CDDi | cd00148, PROF, 1 hit |
InterProi | View protein in InterPro IPR005455, PFN IPR036140, PFN_sf IPR027310, Profilin_CS |
PANTHERi | PTHR11604, PTHR11604, 1 hit |
Pfami | View protein in Pfam PF00235, Profilin, 1 hit |
PRINTSi | PR00392, PROFILIN PR01640, PROFILINPLNT |
SMARTi | View protein in SMART SM00392, PROF, 1 hit |
SUPFAMi | SSF55770, SSF55770, 1 hit |
PROSITEi | View protein in PROSITE PS00414, PROFILIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9XG85-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWQAYVDDH LMCDVGDGNT PASAAIIGHD GSVWAQSANF PQLKPEEVTG
60 70 80 90 100
IMNDFNEAGF LAPTGLFLGG TKYMVIQGES GAVIRGKKGS GGATLKKTGQ
110 120 130
AIVIGIYDEP MTPGQCNLVV ERLGDYLLEQ GL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y15208 mRNA Translation: CAB44256.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y15208 mRNA Translation: CAB44256.1 |
3D structure databases
AlphaFoldDBi | Q9XG85 |
SMRi | Q9XG85 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 510, Par j 3 511, Par j 3.0101 |
Family and domain databases
CDDi | cd00148, PROF, 1 hit |
InterProi | View protein in InterPro IPR005455, PFN IPR036140, PFN_sf IPR027310, Profilin_CS |
PANTHERi | PTHR11604, PTHR11604, 1 hit |
Pfami | View protein in Pfam PF00235, Profilin, 1 hit |
PRINTSi | PR00392, PROFILIN PR01640, PROFILINPLNT |
SMARTi | View protein in SMART SM00392, PROF, 1 hit |
SUPFAMi | SSF55770, SSF55770, 1 hit |
PROSITEi | View protein in PROSITE PS00414, PROFILIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PROF1_PARJU | |
Accessioni | Q9XG85Primary (citable) accession number: Q9XG85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- Allergens
Nomenclature of allergens and list of entries - SIMILARITY comments
Index of protein domains and families