UniProtKB - Q9XFS9 (DXR_ARATH)
1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic
DXR
Functioni
Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). Required for chloroplast development.
3 PublicationsMiscellaneous
Catalytic activityi
- EC:1.1.1.267
Cofactori
: isopentenyl diphosphate biosynthesis via DXP pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate. This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 204 | SubstrateBy similarity | 1 | |
Metal bindingi | 229 | Divalent metal cationBy similarity | 1 | |
Metal bindingi | 231 | Divalent metal cationBy similarity | 1 | |
Binding sitei | 231 | SubstrateBy similarity | 1 | |
Binding sitei | 255 | SubstrateBy similarity | 1 | |
Binding sitei | 278 | SubstrateBy similarity | 1 | |
Metal bindingi | 300 | Divalent metal cationBy similarity | 1 | |
Binding sitei | 300 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 86 – 115 | NADPBy similarityAdd BLAST | 30 |
GO - Molecular functioni
- 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: GO_Central
- manganese ion binding Source: GO_Central
- NADPH binding Source: GO_Central
GO - Biological processi
- isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Isoprene biosynthesis |
Ligand | Metal-binding, NADP |
Enzyme and pathway databases
BioCyci | ARA:AT5G62790-MONOMER |
BRENDAi | 1.1.1.267, 399 |
UniPathwayi | UPA00056;UER00092 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic (EC:1.1.1.267)Short name: 1-deoxyxylulose-5-phosphate reductoisomerase Short name: DXP reductoisomerase Alternative name(s): 2-C-methyl-D-erythritol 4-phosphate synthase Protein PIGMENT-DEFECTIVE EMBRYO 129 |
Gene namesi | Name:DXR Synonyms:ISPC, PDE129 Ordered Locus Names:At5g62790 ORF Names:MQB2.11 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G62790 |
Subcellular locationi
Chloroplast
- chloroplast stroma 2 Publications
Chloroplast
- chloroplast stroma Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chloroplast, PlastidPathology & Biotechi
Disruption phenotypei
Chemistry databases
ChEMBLi | CHEMBL2285354 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | ChloroplastSequence analysis | ||
ChainiPRO_0000007395 | ? – 477 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic |
Proteomic databases
PaxDbi | Q9XFS9 |
PRIDEi | Q9XFS9 |
ProteomicsDBi | 222040 [Q9XFS9-1] |
PTM databases
iPTMneti | Q9XFS9 |
Expressioni
Inductioni
Gene expression databases
ExpressionAtlasi | Q9XFS9, baseline and differential |
Genevisiblei | Q9XFS9, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 21643, 2 interactors |
STRINGi | 3702.AT5G62790.2 |
Chemistry databases
BindingDBi | Q9XFS9 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 56 – 80 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG502QPJ7, Eukaryota |
HOGENOMi | CLU_035714_4_0_1 |
InParanoidi | Q9XFS9 |
OMAi | FIDGSVM |
PhylomeDBi | Q9XFS9 |
Family and domain databases
HAMAPi | MF_00183, DXP_reductoisom, 1 hit |
InterProi | View protein in InterPro IPR003821, DXP_reductoisomerase IPR013644, DXP_reductoisomerase_C IPR013512, DXP_reductoisomerase_N IPR026877, DXPR_C IPR036169, DXPR_C_sf IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR30525, PTHR30525, 1 hit |
Pfami | View protein in Pfam PF08436, DXP_redisom_C, 1 hit PF02670, DXP_reductoisom, 1 hit PF13288, DXPR_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF69055, SSF69055, 1 hit |
TIGRFAMsi | TIGR00243, Dxr, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketThis entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMTLNSLSPA ESKAISFLDT SRFNPIPKLS GGFSLRRRNQ GRGFGKGVKC
60 70 80 90 100
SVKVQQQQQP PPAWPGRAVP EAPRQSWDGP KPISIVGSTG SIGTQTLDIV
110 120 130 140 150
AENPDKFRVV ALAAGSNVTL LADQVRRFKP ALVAVRNESL INELKEALAD
160 170 180 190 200
LDYKLEIIPG EQGVIEVARH PEAVTVVTGI VGCAGLKPTV AAIEAGKDIA
210 220 230 240 250
LANKETLIAG GPFVLPLANK HNVKILPADS EHSAIFQCIQ GLPEGALRKI
260 270 280 290 300
ILTASGGAFR DWPVEKLKEV KVADALKHPN WNMGKKITVD SATLFNKGLE
310 320 330 340 350
VIEAHYLFGA EYDDIEIVIH PQSIIHSMIE TQDSSVLAQL GWPDMRLPIL
360 370 380 390 400
YTMSWPDRVP CSEVTWPRLD LCKLGSLTFK KPDNVKYPSM DLAYAAGRAG
410 420 430 440 450
GTMTGVLSAA NEKAVEMFID EKISYLDIFK VVELTCDKHR NELVTSPSLE
460 470
EIVHYDLWAR EYAANVQLSS GARPVHA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF4K7T6 | F4K7T6_ARATH | 1-deoxy-D-xylulose-5-phosphate redu... | DXR MQB2.90, MQB2_90, PDE129, PIGMENT-DEFECTIVE EMBRYO 129, At5g62790 | 497 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148852 mRNA Translation: AAF73140.1 AB009053 Genomic DNA Translation: BAB10848.1 CP002688 Genomic DNA Translation: AED97657.1 AY045634 mRNA Translation: AAK73992.1 AY050802 mRNA Translation: AAK92737.1 AY054682 mRNA Translation: AAK96873.1 AY081453 mRNA Translation: AAM10015.1 AY091405 mRNA Translation: AAM14344.1 AY098952 mRNA Translation: AAM19962.1 AY084775 mRNA Translation: AAM61343.1 AJ242588 mRNA Translation: CAB43344.1 |
PIRi | T52570 |
RefSeqi | NP_201085.1, NM_125674.3 [Q9XFS9-1] |
Genome annotation databases
EnsemblPlantsi | AT5G62790.1; AT5G62790.1; AT5G62790 [Q9XFS9-1] |
GeneIDi | 836400 |
Gramenei | AT5G62790.1; AT5G62790.1; AT5G62790 [Q9XFS9-1] |
KEGGi | ath:AT5G62790 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148852 mRNA Translation: AAF73140.1 AB009053 Genomic DNA Translation: BAB10848.1 CP002688 Genomic DNA Translation: AED97657.1 AY045634 mRNA Translation: AAK73992.1 AY050802 mRNA Translation: AAK92737.1 AY054682 mRNA Translation: AAK96873.1 AY081453 mRNA Translation: AAM10015.1 AY091405 mRNA Translation: AAM14344.1 AY098952 mRNA Translation: AAM19962.1 AY084775 mRNA Translation: AAM61343.1 AJ242588 mRNA Translation: CAB43344.1 |
PIRi | T52570 |
RefSeqi | NP_201085.1, NM_125674.3 [Q9XFS9-1] |
3D structure databases
SMRi | Q9XFS9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 21643, 2 interactors |
STRINGi | 3702.AT5G62790.2 |
Chemistry databases
BindingDBi | Q9XFS9 |
ChEMBLi | CHEMBL2285354 |
PTM databases
iPTMneti | Q9XFS9 |
Proteomic databases
PaxDbi | Q9XFS9 |
PRIDEi | Q9XFS9 |
ProteomicsDBi | 222040 [Q9XFS9-1] |
Genome annotation databases
EnsemblPlantsi | AT5G62790.1; AT5G62790.1; AT5G62790 [Q9XFS9-1] |
GeneIDi | 836400 |
Gramenei | AT5G62790.1; AT5G62790.1; AT5G62790 [Q9XFS9-1] |
KEGGi | ath:AT5G62790 |
Organism-specific databases
Araporti | AT5G62790 |
Phylogenomic databases
eggNOGi | ENOG502QPJ7, Eukaryota |
HOGENOMi | CLU_035714_4_0_1 |
InParanoidi | Q9XFS9 |
OMAi | FIDGSVM |
PhylomeDBi | Q9XFS9 |
Enzyme and pathway databases
UniPathwayi | UPA00056;UER00092 |
BioCyci | ARA:AT5G62790-MONOMER |
BRENDAi | 1.1.1.267, 399 |
Miscellaneous databases
PROi | PR:Q9XFS9 |
Gene expression databases
ExpressionAtlasi | Q9XFS9, baseline and differential |
Genevisiblei | Q9XFS9, AT |
Family and domain databases
HAMAPi | MF_00183, DXP_reductoisom, 1 hit |
InterProi | View protein in InterPro IPR003821, DXP_reductoisomerase IPR013644, DXP_reductoisomerase_C IPR013512, DXP_reductoisomerase_N IPR026877, DXPR_C IPR036169, DXPR_C_sf IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR30525, PTHR30525, 1 hit |
Pfami | View protein in Pfam PF08436, DXP_redisom_C, 1 hit PF02670, DXP_reductoisom, 1 hit PF13288, DXPR_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF69055, SSF69055, 1 hit |
TIGRFAMsi | TIGR00243, Dxr, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DXR_ARATH | |
Accessioni | Q9XFS9Primary (citable) accession number: Q9XFS9 Secondary accession number(s): Q9M6U2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families