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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60NucleophileUniRule annotation1
Binding sitei132SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:ML1955
ORF Names:MLCB1222.25c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1955

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000574141 – 286tRNA pseudouridine synthase AAdd BLAST286

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1955

Structurei

3D structure databases

ProteinModelPortaliQ9X796
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
OrthoDBiPOG091H010Q

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPPNISED VRLRLDIAYD GTDFAGWAVQ AGQRTVAGLD EAFTTVFRTP
60 70 80 90 100
VRLRAAGRTD TGVHATGQVA HVDIPGTALS KANPRSPHTG DPEFLPLLRR
110 120 130 140 150
LSRLLPVDVR VLDIACAPVG FDARFSALRR HYRYRLSTAP YGVQPNQARY
160 170 180 190 200
VTAWPRELDL DSMSAASRDL LGLRDFAVFC RHRHGATTIR ELQRLEWSRE
210 220 230 240 250
GYLITAHITA DAFCWSMVRS LIGALLAVGD HRRTIGWCGE LLTKASRSSD
260 270 280
FTTAPAHGLT FIRVDYPPDD ELAERAVITR DLRSSF
Length:286
Mass (Da):31,867
Last modified:October 19, 2002 - v2
Checksum:i72B04A866FF32488
GO

Sequence cautioni

The sequence CAB39831 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC30910 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049491 Genomic DNA Translation: CAB39831.1 Different initiation.
AL583923 Genomic DNA Translation: CAC30910.1 Different initiation.
PIRiF87153

Genome annotation databases

EnsemblBacteriaiCAC30910; CAC30910; CAC30910

Similar proteinsi

Entry informationi

Entry nameiTRUA_MYCLE
AccessioniPrimary (citable) accession number: Q9X796
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 19, 2002
Last modified: July 18, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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