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Protein

Thiol:disulfide interchange protein DsbA

Gene

dsbA

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbA
Gene namesi
Name:dsbA
Ordered Locus Names:STY3883, t3623
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003426520 – 207Thiol:disulfide interchange protein DsbAAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 52Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9X6N0

Interactioni

Protein-protein interaction databases

STRINGi220341.STY3883

Structurei

3D structure databases

ProteinModelPortaliQ9X6N0
SMRiQ9X6N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 158ThioredoxinPROSITE-ProRule annotationAdd BLAST139

Sequence similaritiesi

Belongs to the thioredoxin family. DsbA subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4108Z33 Bacteria
COG0526 LUCA
HOGENOMiHOG000265316
KOiK03673
OMAiNAIHKQK

Family and domain databases

CDDicd03019 DsbA_DsbA, 1 hit
InterProiView protein in InterPro
IPR001853 DSBA-like_thioredoxin_dom
IPR023205 DsbA/DsbL
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF01323 DSBA, 1 hit
PIRSFiPIRSF001488 Tdi_protein, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9X6N0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIWLALAG MVLAFSASAA QISDGKQYIT LDKPVAGEPQ VLEFFSFYCP
60 70 80 90 100
HCYQFEEVLH VSDNVKKKLP KGTKMTKYHV EFLGPLGKEL TQAWAVAMAL
110 120 130 140 150
GVEDKVTVPL FEAVQKTQTV QSAADIRKVF VDAGVKGEDY DAAWNSFVVK
160 170 180 190 200
SLVAQQEKAA ADLQLQGVPA MFVNGKYQIN PQGMDTSSMD VFVQQYADTV

KYLVDKK
Length:207
Mass (Da):22,910
Last modified:November 1, 1999 - v1
Checksum:i85D668B745FD3BE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141380 Genomic DNA Translation: AAD31509.1
AL513382 Genomic DNA Translation: CAD03102.1
AE014613 Genomic DNA Translation: AAO71124.1
RefSeqiNP_458051.1, NC_003198.1
WP_000725369.1, NZ_QAVU01000016.1

Genome annotation databases

EnsemblBacteriaiAAO71124; AAO71124; t3623
CAD03102; CAD03102; CAD03102
GeneIDi1250130
KEGGistt:t3623
sty:STY3883
PATRICifig|220341.7.peg.3964

Similar proteinsi

Entry informationi

Entry nameiDSBA_SALTI
AccessioniPrimary (citable) accession number: Q9X6N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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