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UniProtKB - Q9X5V3 (ATCU_RHILV)
Protein
Copper-transporting P-type ATPase
Gene
actP
Organism
Rhizobium leguminosarum bv. viciae
Status
Functioni
Involved in copper efflux.
Catalytic activityi
- EC:7.2.2.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 530 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 729 | MagnesiumBy similarity | 1 | |
Metal bindingi | 733 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity Source: InterPro
- P-type divalent copper transporter activity Source: UniProtKB-EC
Keywordsi
Molecular function | Translocase |
Biological process | Copper transport, Ion transport, Transport |
Ligand | ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:actP |
Organismi | Rhizobium leguminosarum bv. viciae |
Taxonomic identifieri | 387 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Hyphomicrobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium › |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 256 – 276 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 285 – 305 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 445 – 465 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 474 – 494 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 602 – 622 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 638 – 658 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 742 – 762 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 800 – 820 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046326 | 1 – 841 | Copper-transporting P-type ATPaseAdd BLAST | 841 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | Q9X5V3 |
Expressioni
Inductioni
Transcriptionally regulated by HmrR in response to Cu+ ions.
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.10.620.20, 2 hits 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR009078, Ferritin-like_SF IPR036412, HAD-like_sf IPR023214, HAD_sf IPR045800, HMBD IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom IPR012348, RNR-like IPR011017, TRASH_dom IPR007029, YHS_dom |
Pfami | View protein in Pfam PF19335, HMBD, 1 hit PF04945, YHS, 2 hits |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00746, TRASH, 2 hits |
SUPFAMi | SSF47240, SSF47240, 2 hits SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9X5V3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIKQEDDHH HSHAHGDNHC HCGHDQEKAA DAIVRDPICG MTVDPQAGKP
60 70 80 90 100
SLGHGGRIYH FCSEHCRTKF AAAPEDYLTA KDPVCGMSVD RSTARYFLKA
110 120 130 140 150
EGEKFYFCSA ACQAKFEADP AAYRDGQRPT AKPAPKGTLY TCPMHPEVVS
160 170 180 190 200
DRPGDCPKCG MALEPMGIPP TDEGPNPELV DFVRRLWVSA ILALPLLALG
210 220 230 240 250
MGPMLGLPLR EAIGEPQATF IELLLATPVV LWAALPFFRR AWASVVNRSP
260 270 280 290 300
NMWTLIGLGV GTAYLYSVVA TLAPGIFPMS FRGHGAAVPV YFEAAAVIVA
310 320 330 340 350
LVFVGQVLEL KARERTGSAI RALLDLAPKT ARRIDAEGNE SDVPVDDINV
360 370 380 390 400
ADRLRVRPGE RVPVDGSVLE GQSTVDESMI SGEPLPVEKS KGDPLTGGTI
410 420 430 440 450
NKNGTFVMSA EKVGADTVLS RIVDMVAKAQ RSRAPIQGAV DRVSAVFVPA
460 470 480 490 500
VVAVALLAFL AWAAIGPEPR MANGLLAAVA VLIIACPCAL GLATPMSIMI
510 520 530 540 550
ATGRGAGEGV LIKDAEALER FSKGDTLIVD KTGTLTEGKP KLTDIAAFGR
560 570 580 590 600
VGEDRLLSLA ASLERGSEHP LAEAIVSGAE ERGVPFVEVT GFEAKTGKGV
610 620 630 640 650
QGIADGTMVA LGNSAMLADL GIDPAALSEK TEALRGDGKT VMFVVFDGAL
660 670 680 690 700
AGLVAVADRI KPTTAAAIQA LHDSGLKIIM ATGDNERTAR AVAKSLGIDE
710 720 730 740 750
VRADVLPEGK KALIDELRSK GAIIAMAGDG VNDAPALAAA DVGIAMGTGA
760 770 780 790 800
DVAMESAGIT LVKGDLTGIV RARRLAEATM RNIRQNLGFA FGYNALGVPV
810 820 830 840
AAGVLYPILG LLLSPMIAAA AMSLSSVSVI SNALRLRFAK L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF127795 Genomic DNA Translation: AAD26860.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF127795 Genomic DNA Translation: AAD26860.1 |
3D structure databases
SMRi | Q9X5V3 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q9X5V3 |
Family and domain databases
Gene3Di | 1.10.620.20, 2 hits 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR009078, Ferritin-like_SF IPR036412, HAD-like_sf IPR023214, HAD_sf IPR045800, HMBD IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom IPR012348, RNR-like IPR011017, TRASH_dom IPR007029, YHS_dom |
Pfami | View protein in Pfam PF19335, HMBD, 1 hit PF04945, YHS, 2 hits |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00746, TRASH, 2 hits |
SUPFAMi | SSF47240, SSF47240, 2 hits SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATCU_RHILV | |
Accessioni | Q9X5V3Primary (citable) accession number: Q9X5V3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |