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Entry version 118 (02 Jun 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.5.1.4, the general secretory pathway (sec) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocase subunit SecY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secY
Ordered Locus Names:TM_1480
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243274 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008183 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17CytoplasmicAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 32Helical; Name=Helix 1Add BLAST15
Topological domaini33 – 73PeriplasmicAdd BLAST41
Transmembranei74 – 95Discontinuously helical; Name=Helix 2Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei74 – 77Helical; Name=Helix 2A4
Intramembranei78 – 847
Intramembranei85 – 95Helical; Name=Helix 2BAdd BLAST11
Topological domaini96 – 120CytoplasmicAdd BLAST25
Transmembranei121 – 133Helical; Name=Helix 3Add BLAST13
Topological domaini134 – 161PeriplasmicAdd BLAST28
Transmembranei162 – 178Helical; Name=Helix 4Add BLAST17
Topological domaini179 – 182Cytoplasmic4
Transmembranei183 – 198Helical; Name=Helix 5Add BLAST16
Topological domaini199 – 213PeriplasmicAdd BLAST15
Transmembranei214 – 226Helical; Name=Helix 6Add BLAST13
Topological domaini227 – 270CytoplasmicAdd BLAST44
Transmembranei271 – 283Helical; Name=Helix 7Add BLAST13
Topological domaini284 – 302PeriplasmicAdd BLAST19
Transmembranei303 – 315Helical; Name=Helix 8Add BLAST13
Topological domaini316 – 367CytoplasmicAdd BLAST52
Transmembranei368 – 382Helical; Name=Helix 9Add BLAST15
Topological domaini383 – 389Periplasmic7
Transmembranei390 – 403Helical; Name=Helix 10Add BLAST14
Topological domaini404 – 431CytoplasmicAdd BLAST28

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004142131 – 431Protein translocase subunit SecYAdd BLAST431

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins.

Interacts with the ribosome.

Interacts with SecDF, and other proteins may be involved.

Interacts with SecA.

1 Publication

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-59807N

Protein interaction database and analysis system

More...
IntActi
Q9X1I9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
243274.THEMA_06900

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9X1I9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9X1I9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG0201, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9X1I9

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIMWLGE

Database of Orthologous Groups

More...
OrthoDBi
1567535at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.3370.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01465, SecY, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026593, SecY
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10906, PTHR10906, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00344, SecY, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004557, SecY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103491, SSF103491, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00967, 3a0501s007, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9X1I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWQAFKNAFK IPELRDRIIF TFLALIVFRM GIYIPVPGLN LEAWGEIFRR
60 70 80 90 100
IAETAGVAGI LSFYDVFTGG ALSRFSVFTM SVTPYITASI ILQLLASVMP
110 120 130 140 150
SLKEMLREGE EGRKKFAKYT RRLTLLIGGF QAFFVSFSLA RSNPDMVAPG
160 170 180 190 200
VNVLQFTVLS TMSMLAGTMF LLWLGERITE KGIGNGISIL IFAGIVARYP
210 220 230 240 250
SYIRQAYLGG LNLLEWIFLI AVALITIFGI ILVQQAERRI TIQYARRVTG
260 270 280 290 300
RRVYGGASTY LPIKVNQGGV IPIIFASAIV SIPSAIASIT NNETLKNLFR
310 320 330 340 350
AGGFLYLLIY GLLVFFFTYF YSVVIFDPRE ISENIRKYGG YIPGLRPGRS
360 370 380 390 400
TEQYLHRVLN RVTFIGAVFL VVIALLPYLV QGAIKVNVWI GGTSALIAVG
410 420 430
VALDIIQQME THMVMRHYEG FIKKGKIRGR R
Length:431
Mass (Da):48,170
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FFDBBAD1F8F0B61
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36546.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H72247

NCBI Reference Sequences

More...
RefSeqi
NP_229280.1, NC_000853.1
WP_004081795.1, NZ_CP011107.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD36546; AAD36546; TM_1480

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tma:TM1480

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36546.1
PIRiH72247
RefSeqiNP_229280.1, NC_000853.1
WP_004081795.1, NZ_CP011107.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DINX-ray4.50C/F1-431[»]
SMRiQ9X1I9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59807N
IntActiQ9X1I9, 3 interactors
STRINGi243274.THEMA_06900

Protein family/group databases

TCDBi3.A.5.1.4, the general secretory pathway (sec) family

Genome annotation databases

EnsemblBacteriaiAAD36546; AAD36546; TM_1480
KEGGitma:TM1480

Phylogenomic databases

eggNOGiCOG0201, Bacteria
InParanoidiQ9X1I9
OMAiFIMWLGE
OrthoDBi1567535at2

Miscellaneous databases

EvolutionaryTraceiQ9X1I9

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465, SecY, 1 hit
InterProiView protein in InterPro
IPR026593, SecY
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf
PANTHERiPTHR10906, PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344, SecY, 1 hit
PIRSFiPIRSF004557, SecY, 1 hit
SUPFAMiSSF103491, SSF103491, 1 hit
TIGRFAMsiTIGR00967, 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECY_THEMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9X1I9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: November 1, 1999
Last modified: June 2, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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